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Items: 1 to 50 of 101

1.

The 11β-hydroxysteroid dehydrogenase isoforms: pivotal catalytic activities yield potent C11-oxy C19 steroids with 11βHSD2 favouring 11-ketotestosterone, 11-ketoandrostenedione and 11-ketoprogesterone biosynthesis.

Gent R, du Toit T, Bloem LM, Swart AC.

J Steroid Biochem Mol Biol. 2019 Feb 27;189:116-126. doi: 10.1016/j.jsbmb.2019.02.013. [Epub ahead of print]

PMID:
30825506
2.

Letter to the Editor concerning: "the non-visualized appendix and secondary signs on ultrasound for pediatric appendicitis in the community hospital setting".

Rogerson T, Do-Wyeld M, Cundy TP, Gent R, Goh DW.

Pediatr Surg Int. 2019 Feb 2. doi: 10.1007/s00383-019-04446-9. [Epub ahead of print] No abstract available.

PMID:
30712084
3.

Early atherosclerosis is associated with retinal microvascular changes in adolescents with type 1 diabetes.

Peña AS, Liew G, Anderson J, Giles LC, Gent R, Wong TY, Couper JJ.

Pediatr Diabetes. 2018 Dec;19(8):1467-1470. doi: 10.1111/pedi.12764. Epub 2018 Sep 25.

PMID:
30175493
4.

Impact of Aging, Cytomegalovirus Infection, and Long-Term Treatment for Human Immunodeficiency Virus on CD8+ T-Cell Subsets.

Veel E, Westera L, van Gent R, Bont L, Otto S, Ruijsink B, Rabouw HH, Mudrikova T, Wensing A, Hoepelman AIM, Borghans JAM, Tesselaar K.

Front Immunol. 2018 Mar 21;9:572. doi: 10.3389/fimmu.2018.00572. eCollection 2018.

5.

Diagnosis and management of omental infarction in children: Our 10 year experience with ultrasound.

McCusker R, Gent R, Goh DW.

J Pediatr Surg. 2018 Jul;53(7):1360-1364. doi: 10.1016/j.jpedsurg.2018.02.047. Epub 2018 Feb 15.

PMID:
29550035
6.

The in vitro metabolism of 11β-hydroxyprogesterone and 11-ketoprogesterone to 11-ketodihydrotestosterone in the backdoor pathway.

van Rooyen D, Gent R, Barnard L, Swart AC.

J Steroid Biochem Mol Biol. 2018 Apr;178:203-212. doi: 10.1016/j.jsbmb.2017.12.014. Epub 2017 Dec 23.

PMID:
29277707
7.

Effect of Metformin on Vascular Function in Children With Type 1 Diabetes: A 12-Month Randomized Controlled Trial.

Anderson JJA, Couper JJ, Giles LC, Leggett CE, Gent R, Coppin B, Peña AS.

J Clin Endocrinol Metab. 2017 Dec 1;102(12):4448-4456. doi: 10.1210/jc.2017-00781.

PMID:
29040598
8.

Adrenal C11-oxy C21 steroids contribute to the C11-oxy C19 steroid pool via the backdoor pathway in the biosynthesis and metabolism of 21-deoxycortisol and 21-deoxycortisone.

Barnard L, Gent R, van Rooyen D, Swart AC.

J Steroid Biochem Mol Biol. 2017 Nov;174:86-95. doi: 10.1016/j.jsbmb.2017.07.034. Epub 2017 Jul 31.

PMID:
28774496
9.

Children With Type 1 Diabetes Have Delayed Flow-Mediated Dilation.

Pillay S, Anderson J, Couper J, Maftei O, Gent R, Peña AS.

Can J Diabetes. 2018 Jun;42(3):276-280. doi: 10.1016/j.jcjd.2017.06.011. Epub 2017 Jul 25.

PMID:
28754435
10.

Dietary sodium intake relates to vascular health in children with type 1 diabetes.

Anderson J, Couper JJ, Toome S, Mpundu-Kaambwa C, Giles LC, Gent R, Coppin B, Peña AS.

Pediatr Diabetes. 2018 Feb;19(1):138-142. doi: 10.1111/pedi.12537. Epub 2017 May 10.

PMID:
28488397
11.

Immunomodulation by hyperimmunoglobulins after solid organ transplantation: Beyond prevention of viral infection.

van Gent R, Metselaar HJ, Kwekkeboom J.

Transplant Rev (Orlando). 2017 Apr;31(2):78-86. doi: 10.1016/j.trre.2017.01.001. Epub 2017 Jan 19. Review.

PMID:
28131494
12.

Benchmarking the value of ultrasound for acute appendicitis in children.

Cundy TP, Gent R, Frauenfelder C, Lukic L, Linke RJ, Goh DW.

J Pediatr Surg. 2016 Dec;51(12):1939-1943. doi: 10.1016/j.jpedsurg.2016.09.009. Epub 2016 Sep 15.

PMID:
27670963
13.

Sputum Induction in Children Is Feasible and Useful in a Bustling General Hospital Practice.

Bart IY, Mourits M, van Gent R, van Leuken MH, Hilbink M, Warris A, Wever PC, de Vries E.

Glob Pediatr Health. 2016 Mar 4;3:2333794X16636504. doi: 10.1177/2333794X16636504. eCollection 2016.

14.

An Extra 1,000 Steps Per Day Relates to Improved Cardiovascular Health in Children With Type 1 Diabetes.

Anderson J, Couper JJ, Mpundu-Kaambwa C, Giles LC, Gent R, Coppin B, Peña AS.

Diabetes Care. 2016 Aug;39(8):e108-9. doi: 10.2337/dc16-0526. Epub 2016 Jun 15. No abstract available.

PMID:
27307286
15.

Re: Thyroid Cancer Among Young People in Fukushima.

Wakeford R, Auvinen A, Gent RN, Jacob P, Kesminiene A, Laurier D, Schüz J, Shore R, Walsh L, Zhang W.

Epidemiology. 2016 May;27(3):e20-1. doi: 10.1097/EDE.0000000000000466. No abstract available.

PMID:
26841059
16.

Delayed brachial artery dilation response and increased resting blood flow velocity in young children with mild sleep-disordered breathing.

Kontos A, van den Heuvel C, Pamula Y, Martin J, Lushington K, Baumert M, Willoughby S, Gent R, Couper J, Kennedy D.

Sleep Med. 2015 Dec;16(12):1451-6. doi: 10.1016/j.sleep.2015.08.004. Epub 2015 Sep 6.

PMID:
26611941
17.

Quantification of naive and memory T-cell turnover during HIV-1 infection.

Vrisekoop N, Drylewicz J, Van Gent R, Mugwagwa T, Van Lelyveld SF, Veel E, Otto SA, Ackermans MT, Vermeulen JN, Huidekoper HH, Prins JM, Miedema F, de Boer RJ, Tesselaar K, Borghans JA.

AIDS. 2015 Oct 23;29(16):2071-80. doi: 10.1097/QAD.0000000000000822.

PMID:
26213901
18.

Cytomegalovirus-Induced Expression of CD244 after Liver Transplantation Is Associated with CD8+ T Cell Hyporesponsiveness to Alloantigen.

de Mare-Bredemeijer EL, Shi XL, Mancham S, van Gent R, van der Heide-Mulder M, de Boer R, Heemskerk MH, de Jonge J, van der Laan LJ, Metselaar HJ, Kwekkeboom J.

J Immunol. 2015 Aug 15;195(4):1838-48. doi: 10.4049/jimmunol.1500440. Epub 2015 Jul 13.

19.

Differences in Anti-Inflammatory Actions of Intravenous Immunoglobulin between Mice and Men: More than Meets the Eye.

Tjon AS, van Gent R, Geijtenbeek TB, Kwekkeboom J.

Front Immunol. 2015 Apr 28;6:197. doi: 10.3389/fimmu.2015.00197. eCollection 2015. Review.

20.

CMV Primary Infection Is Associated With Donor-Specific T Cell Hyporesponsiveness and Fewer Late Acute Rejections After Liver Transplantation.

Shi XL, de Mare-Bredemeijer EL, Tapirdamaz Ö, Hansen BE, van Gent R, van Campenhout MJ, Mancham S, Litjens NH, Betjes MG, van der Eijk AA, Xia Q, van der Laan LJ, de Jonge J, Metselaar HJ, Kwekkeboom J.

Am J Transplant. 2015 Sep;15(9):2431-42. doi: 10.1111/ajt.13288. Epub 2015 May 5.

21.

The IVIg dilemma: a way out?

van Gent R, Kwekkeboom J.

Am J Transplant. 2015 Jun;15(6):1725-6. doi: 10.1111/ajt.13253. Epub 2015 Apr 1. No abstract available.

22.

Human graft-derived mesenchymal stromal cells potently suppress alloreactive T-cell responses.

de Mare-Bredemeijer EL, Mancham S, Verstegen MM, de Ruiter PE, van Gent R, O'Neill D, Tilanus HW, Metselaar HJ, de Jonge J, Kwekkeboom J, Hall SR, van der Laan LJ.

Stem Cells Dev. 2015 Jun 15;24(12):1436-47. doi: 10.1089/scd.2014.0485. Epub 2015 Apr 28.

PMID:
25744002
23.

Lack of evidence for progression of atherosclerosis during puberty in type 1 diabetes.

Peña AS, Maftei O, Harrington J, Anderson J, Hirte C, Gent R, Couper J.

Pediatr Diabetes. 2016 May;17(3):199-205. doi: 10.1111/pedi.12265. Epub 2015 Feb 16.

PMID:
25683127
24.

Acetylation of C/EBPε is a prerequisite for terminal neutrophil differentiation.

Bartels M, Govers AM, Fleskens V, Lourenço AR, Pals CE, Vervoort SJ, van Gent R, Brenkman AB, Bierings MB, Ackerman SJ, van Loosdregt J, Coffer PJ.

Blood. 2015 Mar 12;125(11):1782-92. doi: 10.1182/blood-2013-12-543850. Epub 2015 Jan 7.

25.

Flow-mediated dilatation, using time course data, shows maturation of the brachial artery from young children to mid-adolescents.

Kontos A, Pamula Y, Martin J, Gent R, Lushington K, Baumert M, Willoughby S, Richardson M, Couper J, Kennedy D.

Clin Exp Pharmacol Physiol. 2015 Mar;42(3):240-5. doi: 10.1111/1440-1681.12349.

PMID:
25491271
26.

A NOS3 polymorphism determines endothelial response to folate in children with type 1 diabetes or obesity.

Wiltshire EJ, Peña AS, MacKenzie K, Bose-Sundernathan T, Gent R, Couper JJ.

J Pediatr. 2015 Feb;166(2):319-25.e1. doi: 10.1016/j.jpeds.2014.10.050. Epub 2014 Dec 2.

PMID:
25477161
27.

Rotterdam: main port for organ transplantation research in the Netherlands.

Kwekkeboom J, van der Laan LJ, Betjes MG, Manintveld OC, Hoek RA, Cransberg K, de Bruin RW, Dor FJ, de Jonge J, Boor PP, van Gent R, van Besouw NM, Boer K, Litjens NH, Hesselink DA, Hoogduijn MJ, Massey E, Rowshani AT, van de Wetering J, de Jong H, Hendriks RW, Metselaar HJ, van Gelder T, Weimar W, IJzermans JN, Baan CC.

Transpl Immunol. 2014 Oct;31(4):200-6. doi: 10.1016/j.trim.2014.09.005. Epub 2014 Sep 18.

PMID:
25240732
28.

Early atherosclerosis relates to urinary albumin excretion and cardiovascular risk factors in adolescents with type 1 diabetes: Adolescent type 1 Diabetes cardio-renal Intervention Trial (AdDIT).

Maftei O, Pena AS, Sullivan T, Jones TW, Donaghue KC, Cameron FJ, Davis E, Cotterill A, Craig ME, Gent R, Dalton N, Daneman D, Dunger D, Deanfield J, Couper JJ; AdDIT Study Group.

Diabetes Care. 2014 Nov;37(11):3069-75. doi: 10.2337/dc14-0700. Epub 2014 Jul 28.

PMID:
25071076
29.

The effect of 3% and 6% hypertonic saline in viral bronchiolitis: a randomised controlled trial.

Teunissen J, Hochs AH, Vaessen-Verberne A, Boehmer AL, Smeets CC, Brackel H, van Gent R, Wesseling J, Logtens-Stevens D, de Moor R, Rosias PP, Potgieter S, Faber MR, Hendriks HJ, Janssen-Heijnen ML, Loza BF.

Eur Respir J. 2014 Oct;44(4):913-21. doi: 10.1183/09031936.00159613. Epub 2014 Jun 25.

30.

SIRT1 mediates FOXA2 breakdown by deacetylation in a nutrient-dependent manner.

van Gent R, Di Sanza C, van den Broek NJ, Fleskens V, Veenstra A, Stout GJ, Brenkman AB.

PLoS One. 2014 May 29;9(5):e98438. doi: 10.1371/journal.pone.0098438. eCollection 2014.

31.

Intravenous immunoglobulin treatment in humans suppresses dendritic cell function via stimulation of IL-4 and IL-13 production.

Tjon AS, van Gent R, Jaadar H, Martin van Hagen P, Mancham S, van der Laan LJ, te Boekhorst PA, Metselaar HJ, Kwekkeboom J.

J Immunol. 2014 Jun 15;192(12):5625-34. doi: 10.4049/jimmunol.1301260. Epub 2014 May 7.

32.

Prevention of immunoglobulin G immobilization eliminates artifactual stimulation of dendritic cell maturation by intravenous immunoglobulin in vitro.

Tjon AS, Jaadar H, van Gent R, van Kooten PJ, Achatbi N, Metselaar HJ, Kwekkeboom J.

Transl Res. 2014 Jun;163(6):557-64. doi: 10.1016/j.trsl.2014.01.007. Epub 2014 Jan 13.

PMID:
24491358
33.

T-cell inhibitory capacity of hyperimmunoglobulins is influenced by the production process.

van Gent R, Jaadar H, Tjon AS, Mancham S, Kwekkeboom J.

Int Immunopharmacol. 2014 Mar;19(1):142-4. doi: 10.1016/j.intimp.2014.01.007. Epub 2014 Jan 22.

PMID:
24462495
34.

Utility of sonographic assessment of the position of the third part of the duodenum using water instillation in intestinal malrotation: a single-center retrospective audit.

Hennessey I, John R, Gent R, Goh DW.

Pediatr Radiol. 2014 Apr;44(4):387-91. doi: 10.1007/s00247-013-2839-2. Epub 2013 Dec 4.

PMID:
24306735
35.

Barrow-in-Furness: a large community legionellosis outbreak in the UK.

Bennett E, Ashton M, Calvert N, Chaloner J, Cheesbrough J, Egan J, Farrell I, Hall I, Harrison TG, Naik FC, Partridge S, Syed Q, Gent RN.

Epidemiol Infect. 2014 Aug;142(8):1763-77. doi: 10.1017/S0950268813002483. Epub 2013 Oct 11.

PMID:
24112310
36.

Does metformin improve vascular health in children with type 1 diabetes? Protocol for a one year, double blind, randomised, placebo controlled trial.

Anderson J, Peña AS, Sullivan T, Gent R, D'Arcy B, Olds T, Coppin B, Couper J.

BMC Pediatr. 2013 Jul 16;13:108. doi: 10.1186/1471-2431-13-108.

37.

Vascular function and glucose variability improve transiently following initiation of continuous subcutaneous insulin infusion in children with type 1 diabetes.

Harrington J, Peña AS, Wilson L, Gent R, Dowling K, Baghurst P, Couper J.

Pediatr Diabetes. 2013 Nov;14(7):504-11. doi: 10.1111/pedi.12050. Epub 2013 May 9.

PMID:
23659762
38.

Value of an automatic external defibrillator printout as a diagnostic tool after successful AED use on a child.

van Sambeeck SJ, van Gent R, Schroër C, Halbertsma FJ.

BMJ Case Rep. 2013 Apr 22;2013. pii: bcr2012007532. doi: 10.1136/bcr-2012-007532.

39.

Patients treated with high-dose intravenous immunoglobulin show selective activation of regulatory T cells.

Tjon AS, Tha-In T, Metselaar HJ, van Gent R, van der Laan LJ, Groothuismink ZM, te Boekhorst PA, van Hagen PM, Kwekkeboom J.

Clin Exp Immunol. 2013 Aug;173(2):259-67. doi: 10.1111/cei.12102.

40.

Randomized trial using ultrasound to assess intramuscular vaccination at a 60° or 90° needle angle.

Marshall HS, Clarke MF, Evans S, Piotto L, Gent RJ.

Vaccine. 2013 May 28;31(23):2647-52. doi: 10.1016/j.vaccine.2013.03.037. Epub 2013 Apr 6.

PMID:
23566948
41.

Folate fortification and supplementation do not provide vascular health benefits in type 1 diabetes.

Peña AS, Maftei O, Dowling K, Gent R, Wiltshire E, MacKenzie K, Couper J.

J Pediatr. 2013 Jul;163(1):255-60. doi: 10.1016/j.jpeds.2012.12.055. Epub 2013 Jan 30.

PMID:
23374677
42.

Four of a kind: asthma control, FEV1, FeNO, and psychosocial problems in adolescents.

Tibosch M, de Ridder J, Landstra A, Hugen C, Brouwer M, Gerrits P, van Gent R, Roukema J, Verhaak C, Merkus P.

Pediatr Pulmonol. 2012 Oct;47(10):933-40. doi: 10.1002/ppul.22514. Epub 2012 Feb 10.

PMID:
22328345
43.

Hypoglycemia, but not glucose variability, relates to vascular function in children with type 1 diabetes.

Peña AS, Couper JJ, Harrington J, Gent R, Fairchild J, Tham E, Baghurst P.

Diabetes Technol Ther. 2012 Jun;14(6):457-62. doi: 10.1089/dia.2011.0229. Epub 2012 Feb 7.

44.

Adolescents with congenital adrenal hyperplasia because of 21-hydroxylase deficiency have vascular dysfunction.

Harrington J, Peña AS, Gent R, Hirte C, Couper J.

Clin Endocrinol (Oxf). 2012 Jun;76(6):837-42. doi: 10.1111/j.1365-2265.2011.04309.x.

PMID:
22145701
45.

How to deploy online guidance during a major incident.

Balasegaram S, Kar-Purkayastha I, Bussell ME, Burns T, Hough N, Sheridan P, Gent RN, Barker RM.

J Bus Contin Emer Plan. 2011 Oct;5(3):257-66.

PMID:
22130344
46.

First global consensus for evidence-based management of the hematopoietic syndrome resulting from exposure to ionizing radiation.

Dainiak N, Gent RN, Carr Z, Schneider R, Bader J, Buglova E, Chao N, Coleman CN, Ganser A, Gorin C, Hauer-Jensen M, Huff LA, Lillis-Hearne P, Maekawa K, Nemhauser J, Powles R, Schünemann H, Shapiro A, Stenke L, Valverde N, Weinstock D, White D, Albanese J, Meineke V.

Disaster Med Public Health Prep. 2011 Oct;5(3):202-12. doi: 10.1001/dmp.2011.68. Epub 2011 Oct 10. Review.

47.

Literature review and global consensus on management of acute radiation syndrome affecting nonhematopoietic organ systems.

Dainiak N, Gent RN, Carr Z, Schneider R, Bader J, Buglova E, Chao N, Coleman CN, Ganser A, Gorin C, Hauer-Jensen M, Huff LA, Lillis-Hearne P, Maekawa K, Nemhauser J, Powles R, Schünemann H, Shapiro A, Stenke L, Valverde N, Weinstock D, White D, Albanese J, Meineke V.

Disaster Med Public Health Prep. 2011 Oct;5(3):183-201. doi: 10.1001/dmp.2011.73. Epub 2011 Oct 10. Review.

48.

Nocturnal apnea in Chiari type I malformation.

Aarts LA, Willemsen MA, Vandenbussche NL, van Gent R.

Eur J Pediatr. 2011 Oct;170(10):1349-52. doi: 10.1007/s00431-011-1500-z. Epub 2011 Jun 4.

PMID:
21643652
49.

Long-term restoration of the human T-cell compartment after thymectomy during infancy: a role for thymic regeneration?

van Gent R, Schadenberg AW, Otto SA, Nievelstein RA, Sieswerda GT, Haas F, Miedema F, Tesselaar K, Jansen NJ, Borghans JA.

Blood. 2011 Jul 21;118(3):627-34. doi: 10.1182/blood-2011-03-341396. Epub 2011 May 31.

50.

Immune reconstitution in children following chemotherapy for haematological malignancies: a long-term follow-up.

van Tilburg CM, van Gent R, Bierings MB, Otto SA, Sanders EA, Nibbelke EE, Gaiser JF, Janssens-Korpela PL, Wolfs TF, Bloem AC, Borghans JA, Tesselaar K.

Br J Haematol. 2011 Jan;152(2):201-10. doi: 10.1111/j.1365-2141.2010.08478.x. Epub 2010 Nov 28.

PMID:
21114483

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