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Structure of the cytochrome aa 3 -600 heme-copper menaquinol oxidase bound to inhibitor HQNO shows TM0 is part of the quinol binding site.

Xu J, Ding Z, Liu B, Yi SM, Li J, Zhang Z, Liu Y, Li J, Liu L, Zhou A, Gennis RB, Zhu J.

Proc Natl Acad Sci U S A. 2020 Jan 14;117(2):872-876. doi: 10.1073/pnas.1915013117. Epub 2019 Dec 30.


The oligomeric state of the Caldivirga maquilingensis type III sulfide:Quinone Oxidoreductase is required for membrane binding.

Lencina AM, Gennis RB, Schurig-Briccio LA.

Biochim Biophys Acta Bioenerg. 2020 Feb 1;1861(2):148132. doi: 10.1016/j.bbabio.2019.148132. Epub 2019 Dec 6.


The Ubiquinol Binding Site of Cytochrome bo3 from Escherichia coli Accommodates Menaquinone and Stabilizes a Functional Menasemiquinone.

Ding Z, Sun C, Yi SM, Gennis RB, Dikanov SA.

Biochemistry. 2019 Nov 12;58(45):4559-4569. doi: 10.1021/acs.biochem.9b00750. Epub 2019 Nov 4.


Active site rearrangement and structural divergence in prokaryotic respiratory oxidases.

Safarian S, Hahn A, Mills DJ, Radloff M, Eisinger ML, Nikolaev A, Meier-Credo J, Melin F, Miyoshi H, Gennis RB, Sakamoto J, Langer JD, Hellwig P, Kühlbrandt W, Michel H.

Science. 2019 Oct 4;366(6461):100-104. doi: 10.1126/science.aay0967.


Characterization and X-ray structure of the NADH-dependent coenzyme A disulfide reductase from Thermus thermophilus.

Lencina AM, Koepke J, Preu J, Muenke C, Gennis RB, Michel H, Schurig-Briccio LA.

Biochim Biophys Acta Bioenerg. 2019 Nov 1;1860(11):148080. doi: 10.1016/j.bbabio.2019.148080. Epub 2019 Sep 11.


Single-particle cryo-EM studies of transmembrane proteins in SMA copolymer nanodiscs.

Sun C, Gennis RB.

Chem Phys Lipids. 2019 Jul;221:114-119. doi: 10.1016/j.chemphyslip.2019.03.007. Epub 2019 Mar 30. Review.


Microcin J25 inhibits ubiquinol oxidase activity of purified cytochrome bd-I from Escherichia coli.

Galván AE, Chalón MC, Ríos Colombo NS, Schurig-Briccio LA, Sosa-Padilla B, Gennis RB, Bellomio A.

Biochimie. 2019 May;160:141-147. doi: 10.1016/j.biochi.2019.02.007. Epub 2019 Feb 19.


Role of the tightly bound quinone for the oxygen reaction of cytochrome bo3 oxidase from Escherichia coli.

Melin F, Sabuncu S, Choi SK, Leprince A, Gennis RB, Hellwig P.

FEBS Lett. 2018 Oct;592(20):3380-3387. doi: 10.1002/1873-3468.13263. Epub 2018 Oct 19.


Mechanism of proton transfer through the KC proton pathway in the Vibrio cholerae cbb3 terminal oxidase.

Ahn YO, Albertsson I, Gennis RB, Ädelroth P.

Biochim Biophys Acta Bioenerg. 2018 Nov;1859(11):1191-1198. doi: 10.1016/j.bbabio.2018.08.002. Epub 2018 Aug 22.


Type 2 NADH Dehydrogenase Is the Only Point of Entry for Electrons into the Streptococcus agalactiae Respiratory Chain and Is a Potential Drug Target.

Lencina AM, Franza T, Sullivan MJ, Ulett GC, Ipe DS, Gaudu P, Gennis RB, Schurig-Briccio LA.

mBio. 2018 Jul 3;9(4). pii: e01034-18. doi: 10.1128/mBio.01034-18.


Ionophoric effects of the antitubercular drug bedaquiline.

Hards K, McMillan DGG, Schurig-Briccio LA, Gennis RB, Lill H, Bald D, Cook GM.

Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):7326-7331. doi: 10.1073/pnas.1803723115. Epub 2018 Jun 25.


Bacterial denitrifying nitric oxide reductases and aerobic respiratory terminal oxidases use similar delivery pathways for their molecular substrates.

Mahinthichaichan P, Gennis RB, Tajkhorshid E.

Biochim Biophys Acta Bioenerg. 2018 Sep;1859(9):712-724. doi: 10.1016/j.bbabio.2018.06.002. Epub 2018 Jun 5.


The electron distribution in the "activated" state of cytochrome c oxidase.

Vilhjálmsdóttir J, Gennis RB, Brzezinski P.

Sci Rep. 2018 May 14;8(1):7502. doi: 10.1038/s41598-018-25779-w.


Functional importance of Glutamate-445 and Glutamate-99 in proton-coupled electron transfer during oxygen reduction by cytochrome bd from Escherichia coli.

Murali R, Gennis RB.

Biochim Biophys Acta Bioenerg. 2018 Aug;1859(8):577-590. doi: 10.1016/j.bbabio.2018.04.012. Epub 2018 Apr 30.


Structure of the alternative complex III in a supercomplex with cytochrome oxidase.

Sun C, Benlekbir S, Venkatakrishnan P, Wang Y, Hong S, Hosler J, Tajkhorshid E, Rubinstein JL, Gennis RB.

Nature. 2018 May;557(7703):123-126. doi: 10.1038/s41586-018-0061-y. Epub 2018 Apr 25.


Cytochrome aa3 Oxygen Reductase Utilizes the Tunnel Observed in the Crystal Structures To Deliver O2 for Catalysis.

Mahinthichaichan P, Gennis RB, Tajkhorshid E.

Biochemistry. 2018 Apr 10;57(14):2150-2161. doi: 10.1021/acs.biochem.7b01194. Epub 2018 Mar 29.


X-ray transparent microfluidic platforms for membrane protein crystallization with microseeds.

Schieferstein JM, Pawate AS, Varel MJ, Guha S, Astrauskaite I, Gennis RB, Kenis PJA.

Lab Chip. 2018 Mar 13;18(6):944-954. doi: 10.1039/c7lc01141e.


WITHDRAWN: Characterization of the supercomplex formed by the alternative complex III and the terminal aa3 oxidase from Flavobacterium johnsoniae isolated in styrene:maleic acid copolymer nanodiscs.

Venkatakrishnan P, Benlekbir S, Sun C, Hong S, Hosler J, Rubinstein J, Gennis RB.

Biochim Biophys Acta Bioenerg. 2018 Feb 12. pii: S0005-2728(18)30013-6. doi: 10.1016/j.bbabio.2018.01.007. [Epub ahead of print]


Unpaired Electron Spin Density Distribution across Reduced [2Fe-2S] Cluster Ligands by 13Cβ-Cysteine Labeling.

Taguchi AT, Miyajima-Nakano Y, Fukazawa R, Lin MT, Baldansuren A, Gennis RB, Hasegawa K, Kumasaka T, Dikanov SA, Iwasaki T.

Inorg Chem. 2018 Jan 16;57(2):741-746. doi: 10.1021/acs.inorgchem.7b02676. Epub 2017 Dec 26.


Cytochromes bd-I and bo3 are essential for the bactericidal effect of microcin J25 on Escherichia coli cells.

Galván AE, Chalón MC, Schurig-Briccio LA, Salomón RA, Minahk CJ, Gennis RB, Bellomio A.

Biochim Biophys Acta Bioenerg. 2018 Feb;1859(2):110-118. doi: 10.1016/j.bbabio.2017.10.006. Epub 2017 Oct 28.


Critical Role of Water Molecules in Proton Translocation by the Membrane-Bound Transhydrogenase.

Padayatti PS, Leung JH, Mahinthichaichan P, Tajkhorshid E, Ishchenko A, Cherezov V, Soltis SM, Jackson JB, Stout CD, Gennis RB, Zhang Q.

Structure. 2017 Jul 5;25(7):1111-1119.e3. doi: 10.1016/j.str.2017.05.022. Epub 2017 Jun 22.


Location of the Substrate Binding Site of the Cytochrome bo3 Ubiquinol Oxidase from Escherichia coli.

Choi SK, Schurig-Briccio L, Ding Z, Hong S, Sun C, Gennis RB.

J Am Chem Soc. 2017 Jun 21;139(24):8346-8354. doi: 10.1021/jacs.7b03883. Epub 2017 Jun 6.


X-ray transparent microfluidic chips for high-throughput screening and optimization of in meso membrane protein crystallization.

Schieferstein JM, Pawate AS, Sun C, Wan F, Sheraden PN, Broecker J, Ernst OP, Gennis RB, Kenis PJA.

Biomicrofluidics. 2017 Apr 24;11(2):024118. doi: 10.1063/1.4981818. eCollection 2017 Mar.


Searching for the low affinity ubiquinone binding site in cytochrome bo3 from Escherichia coli.

Choi SK, Lin MT, Ouyang H, Gennis RB.

Biochim Biophys Acta Bioenerg. 2017 May;1858(5):366-370. doi: 10.1016/j.bbabio.2017.02.008. Epub 2017 Feb 21.


The unusual redox properties of C-type oxidases.

Melin F, Xie H, Meyer T, Ahn YO, Gennis RB, Michel H, Hellwig P.

Biochim Biophys Acta. 2016 Dec;1857(12):1892-1899. doi: 10.1016/j.bbabio.2016.09.009. Epub 2016 Sep 21.


Q-Band Electron-Nuclear Double Resonance Reveals Out-of-Plane Hydrogen Bonds Stabilize an Anionic Ubisemiquinone in Cytochrome bo3 from Escherichia coli.

Sun C, Taguchi AT, Vermaas JV, Beal NJ, O'Malley PJ, Tajkhorshid E, Gennis RB, Dikanov SA.

Biochemistry. 2016 Oct 11;55(40):5714-5725. Epub 2016 Sep 28.


CtaM Is Required for Menaquinol Oxidase aa3 Function in Staphylococcus aureus.

Hammer ND, Schurig-Briccio LA, Gerdes SY, Gennis RB, Skaar EP.

mBio. 2016 Jul 12;7(4). pii: e00823-16. doi: 10.1128/mBio.00823-16.


Proton Dynamics at the Membrane Surface.

Gennis RB.

Biophys J. 2016 May 10;110(9):1909-11. doi: 10.1016/j.bpj.2016.04.001. No abstract available.


A Purple Cupredoxin from Nitrosopumilus maritimus Containing a Mononuclear Type 1 Copper Center with an Open Binding Site.

Hosseinzadeh P, Tian S, Marshall NM, Hemp J, Mullen T, Nilges MJ, Gao YG, Robinson H, Stahl DA, Gennis RB, Lu Y.

J Am Chem Soc. 2016 May 25;138(20):6324-7. doi: 10.1021/jacs.5b13128. Epub 2016 May 12.


The CO Photodissociation and Recombination Dynamics of the W172Y/F282T Ligand Channel Mutant of Rhodobacter sphaeroides aa3 Cytochrome c Oxidase.

Cassano JA, Choi SK, McDonald W, Szundi I, Villa Gawboy TR, Gennis RB, Einarsdóttir Ó.

Photochem Photobiol. 2016 May;92(3):410-9. doi: 10.1111/php.12587. Epub 2016 Apr 21.


All the O2 Consumed by Thermus thermophilus Cytochrome ba3 Is Delivered to the Active Site through a Long, Open Hydrophobic Tunnel with Entrances within the Lipid Bilayer.

Mahinthichaichan P, Gennis RB, Tajkhorshid E.

Biochemistry. 2016 Mar 1;55(8):1265-78. doi: 10.1021/acs.biochem.5b01255. Epub 2016 Feb 18.


Antiinfectives targeting enzymes and the proton motive force.

Feng X, Zhu W, Schurig-Briccio LA, Lindert S, Shoen C, Hitchings R, Li J, Wang Y, Baig N, Zhou T, Kim BK, Crick DC, Cynamon M, McCammon JA, Gennis RB, Oldfield E.

Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):E7073-82. doi: 10.1073/pnas.1521988112. Epub 2015 Dec 7.


Correction to The Semiquinone at the Q(i) Site of the bc1 Complex Explored Using HYSCORE Spectroscopy and Specific Isotopic Labeling of Ubiquinone in Rhodobacter sphaeroides via (13)C Methionine and Construction of a Methionine Auxotroph.

Hong S, de Almeida WB, Taguchi AT, Samoilova RI, Gennis RB, O'Malley PJ, Dikanov SA, Crofts AR.

Biochemistry. 2015 Dec 15;54(49):7307. doi: 10.1021/acs.biochem.5b01251. Epub 2015 Dec 1. No abstract available.


Escherichia coli auxotroph host strains for amino acid-selective isotope labeling of recombinant proteins.

Lin MT, Fukazawa R, Miyajima-Nakano Y, Matsushita S, Choi SK, Iwasaki T, Gennis RB.

Methods Enzymol. 2015;565:45-66. doi: 10.1016/bs.mie.2015.05.012. Epub 2015 Jun 10.


Plasticity in the High Affinity Menaquinone Binding Site of the Cytochrome aa3-600 Menaquinol Oxidase from Bacillus subtilis.

Yi SM, Taguchi AT, Samoilova RI, O'Malley PJ, Gennis RB, Dikanov SA.

Biochemistry. 2015 Aug 18;54(32):5030-44. doi: 10.1021/acs.biochem.5b00528. Epub 2015 Aug 6.


Review and Hypothesis. New insights into the reaction mechanism of transhydrogenase: Swivelling the dIII component may gate the proton channel.

Jackson JB, Leung JH, Stout CD, Schurig-Briccio LA, Gennis RB.

FEBS Lett. 2015 Jul 22;589(16):2027-33. doi: 10.1016/j.febslet.2015.06.027. Epub 2015 Jul 2. Review.


The two transmembrane helices of CcoP are sufficient for assembly of the cbb3-type heme-copper oxygen reductase from Vibrio cholerae.

Ahn YO, Lee HJ, Kaluka D, Yeh SR, Rousseau DL, Ädelroth P, Gennis RB.

Biochim Biophys Acta. 2015 Oct;1847(10):1231-9. doi: 10.1016/j.bbabio.2015.06.013. Epub 2015 Jun 25.


Mutation of a single residue in the ba3 oxidase specifically impairs protonation of the pump site.

von Ballmoos C, Gonska N, Lachmann P, Gennis RB, Ädelroth P, Brzezinski P.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3397-402. doi: 10.1073/pnas.1422434112. Epub 2015 Mar 2.


Structural biology. Division of labor in transhydrogenase by alternating proton translocation and hydride transfer.

Leung JH, Schurig-Briccio LA, Yamaguchi M, Moeller A, Speir JA, Gennis RB, Stout CD.

Science. 2015 Jan 9;347(6218):178-81. doi: 10.1126/science.1260451.


Conformational coupling between the active site and residues within the K(C)-channel of the Vibrio cholerae cbb3-type (C-family) oxygen reductase.

Ahn YO, Mahinthichaichan P, Lee HJ, Ouyang H, Kaluka D, Yeh SR, Arjona D, Rousseau DL, Tajkhorshid E, Adelroth P, Gennis RB.

Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):E4419-28. doi: 10.1073/pnas.1411676111. Epub 2014 Oct 6.


The semiquinone at the Qi site of the bc1 complex explored using HYSCORE spectroscopy and specific isotopic labeling of ubiquinone in Rhodobacter sphaeroides via (13)C methionine and construction of a methionine auxotroph.

Hong S, de Almeida WB, Taguchi AT, Samoilova RI, Gennis RB, O'Malley PJ, Dikanov SA, Crofts AR.

Biochemistry. 2014 Sep 30;53(38):6022-31. doi: 10.1021/bi500654y. Epub 2014 Sep 17. Erratum in: Biochemistry. 2015 Dec 15;54(49):7307.


Kinetics and intermediates of the reaction of fully reduced Escherichia coli bo₃ ubiquinol oxidase with O₂.

Szundi I, Kittredge C, Choi SK, McDonald W, Ray J, Gennis RB, Einarsdóttir Ó.

Biochemistry. 2014 Aug 26;53(33):5393-404. doi: 10.1021/bi500567m. Epub 2014 Aug 15.


Evidence for distinct electron transfer processes in terminal oxidases from different origin by means of protein film voltammetry.

Meyer T, Melin F, Xie H, von der Hocht I, Choi SK, Noor MR, Michel H, Gennis RB, Soulimane T, Hellwig P.

J Am Chem Soc. 2014 Aug 6;136(31):10854-7. doi: 10.1021/ja505126v. Epub 2014 Jul 25.


Proton pumping by an inactive structural variant of cytochrome c oxidase.

Svahn E, Faxén K, Gennis RB, Brzezinski P.

J Inorg Biochem. 2014 Nov;140:6-11. doi: 10.1016/j.jinorgbio.2014.06.016. Epub 2014 Jul 1.


A third subunit in ancestral cytochrome c-dependent nitric oxide reductases.

Bricio C, Alvarez L, San Martin M, Schurig-Briccio LA, Gennis RB, Berenguer J.

Appl Environ Microbiol. 2014 Aug;80(16):4871-8. doi: 10.1128/AEM.00790-14. Epub 2014 Jun 6.


Characterization of the type 2 NADH:menaquinone oxidoreductases from Staphylococcus aureus and the bactericidal action of phenothiazines.

Schurig-Briccio LA, Yano T, Rubin H, Gennis RB.

Biochim Biophys Acta. 2014 Jul;1837(7):954-63. doi: 10.1016/j.bbabio.2014.03.017. Epub 2014 Apr 5.


Subunit CydX of Escherichia coli cytochrome bd ubiquinol oxidase is essential for assembly and stability of the di-heme active site.

Hoeser J, Hong S, Gehmann G, Gennis RB, Friedrich T.

FEBS Lett. 2014 May 2;588(9):1537-41. doi: 10.1016/j.febslet.2014.03.036. Epub 2014 Mar 26.


Multitarget drug discovery for tuberculosis and other infectious diseases.

Li K, Schurig-Briccio LA, Feng X, Upadhyay A, Pujari V, Lechartier B, Fontes FL, Yang H, Rao G, Zhu W, Gulati A, No JH, Cintra G, Bogue S, Liu YL, Molohon K, Orlean P, Mitchell DA, Freitas-Junior L, Ren F, Sun H, Jiang T, Li Y, Guo RT, Cole ST, Gennis RB, Crick DC, Oldfield E.

J Med Chem. 2014 Apr 10;57(7):3126-39. doi: 10.1021/jm500131s. Epub 2014 Apr 1.


The K(C) channel in the cbb3-type respiratory oxygen reductase from Rhodobacter capsulatus is required for both chemical and pumped protons.

Yıldız GG, Gennis RB, Daldal F, Öztürk M.

J Bacteriol. 2014 May;196(10):1825-32. doi: 10.1128/JB.00005-14. Epub 2014 Feb 21.


Single mutations that redirect internal proton transfer in the ba3 oxidase from Thermus thermophilus.

Smirnova I, Chang HY, von Ballmoos C, Ädelroth P, Gennis RB, Brzezinski P.

Biochemistry. 2013 Oct 8;52(40):7022-30. doi: 10.1021/bi4008726. Epub 2013 Sep 23.

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