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Foam Cells: One Size Doesn't Fit All.

Guerrini V, Gennaro ML.

Trends Immunol. 2019 Dec;40(12):1163-1179. doi: 10.1016/ Epub 2019 Nov 12. Review.


Adjunctive host-directed therapy with statins improves tuberculosis-related outcomes in mice.

Dutta NK, Bruiners N, Zimmerman MD, Tan S, Dartois V, Gennaro ML, Karakousis PC.

J Infect Dis. 2019 Oct 12. pii: jiz517. doi: 10.1093/infdis/jiz517. [Epub ahead of print]


Active Tuberculosis Is Characterized by Highly Differentiated Effector Memory Th1 Cells.

Arrigucci R, Lakehal K, Vir P, Handler D, Davidow AL, Herrera R, Estrada-Guzmán JD, Bushkin Y, Tyagi S, Lardizabal AA, Gennaro ML.

Front Immunol. 2018 Sep 19;9:2127. doi: 10.3389/fimmu.2018.02127. eCollection 2018.


Storage lipid studies in tuberculosis reveal that foam cell biogenesis is disease-specific.

Guerrini V, Prideaux B, Blanc L, Bruiners N, Arrigucci R, Singh S, Ho-Liang HP, Salamon H, Chen PY, Lakehal K, Subbian S, O'Brien P, Via LE, Barry CE 3rd, Dartois V, Gennaro ML.

PLoS Pathog. 2018 Aug 30;14(8):e1007223. doi: 10.1371/journal.ppat.1007223. eCollection 2018 Aug.


Characterization of the Antigenic Heterogeneity of Lipoarabinomannan, the Major Surface Glycolipid of Mycobacterium tuberculosis, and Complexity of Antibody Specificities toward This Antigen.

Choudhary A, Patel D, Honnen W, Lai Z, Prattipati RS, Zheng RB, Hsueh YC, Gennaro ML, Lardizabal A, Restrepo BI, Garcia-Viveros M, Joe M, Bai Y, Shen K, Sahloul K, Spencer JS, Chatterjee D, Broger T, Lowary TL, Pinter A.

J Immunol. 2018 May 1;200(9):3053-3066. doi: 10.4049/jimmunol.1701673. Epub 2018 Apr 2.


Variations on a theme: evolution of the phage-shock-protein system in Actinobacteria.

Ravi J, Anantharaman V, Aravind L, Gennaro ML.

Antonie Van Leeuwenhoek. 2018 May;111(5):753-760. doi: 10.1007/s10482-018-1053-5. Epub 2018 Feb 27.


Tuberculosis State Is Associated with Expression of Toll-Like Receptor 2 in Sputum Macrophages.

Lakehal K, Levine D, Kerr KF, Vir P, Bruiners N, Lardizabal A, Gennaro ML, Pine R.

mSphere. 2017 Nov 1;2(6). pii: e00475-17. doi: 10.1128/mSphere.00475-17. eCollection 2017 Nov-Dec.


FISH-Flow, a protocol for the concurrent detection of mRNA and protein in single cells using fluorescence in situ hybridization and flow cytometry.

Arrigucci R, Bushkin Y, Radford F, Lakehal K, Vir P, Pine R, Martin D, Sugarman J, Zhao Y, Yap GS, Lardizabal AA, Tyagi S, Gennaro ML.

Nat Protoc. 2017 Jun;12(6):1245-1260. doi: 10.1038/nprot.2017.039. Epub 2017 May 18.


Diagnostic Performance of Tuberculosis-Specific IgG Antibody Profiles in Patients with Presumptive Tuberculosis from Two Continents.

Broger T, Basu Roy R, Filomena A, Greef CH, Rimmele S, Havumaki J, Danks D, Schneiderhan-Marra N, Gray CM, Singh M, Rosenkrands I, Andersen P, Husar GM, Joos TO, Gennaro ML, Lochhead MJ, Denkinger CM, Perkins MD.

Clin Infect Dis. 2017 Apr 1;64(7):947-955. doi: 10.1093/cid/cix023.


Experimental Evolution of Mycobacterium tuberculosis in Human Macrophages Results in Low-Frequency Mutations Not Associated with Selective Advantage.

Guerrini V, Subbian S, Santucci P, Canaan S, Gennaro ML, Pozzi G.

PLoS One. 2016 Dec 13;11(12):e0167989. doi: 10.1371/journal.pone.0167989. eCollection 2016.


Protecting from Envelope Stress: Variations on the Phage-Shock-Protein Theme: (Trends in Microbiology 25, 205-216; 2017).

Manganelli R, Gennaro ML.

Trends Microbiol. 2017 Mar;25(3):242. doi: 10.1016/j.tim.2016.11.010. Epub 2016 Dec 4. No abstract available.


Protecting from Envelope Stress: Variations on the Phage-Shock-Protein Theme.

Manganelli R, Gennaro ML.

Trends Microbiol. 2017 Mar;25(3):205-216. doi: 10.1016/j.tim.2016.10.001. Epub 2016 Nov 16. Review. Erratum in: Trends Microbiol. 2017 Mar;25(3):242.


Role of Alanine Dehydrogenase of Mycobacterium tuberculosis during Recovery from Hypoxic Nonreplicating Persistence.

Giffin MM, Shi L, Gennaro ML, Sohaskey CD.

PLoS One. 2016 May 20;11(5):e0155522. doi: 10.1371/journal.pone.0155522. eCollection 2016.


Reconstruction and topological characterization of the sigma factor regulatory network of Mycobacterium tuberculosis.

Chauhan R, Ravi J, Datta P, Chen T, Schnappinger D, Bassler KE, Balázsi G, Gennaro ML.

Nat Commun. 2016 Mar 31;7:11062. doi: 10.1038/ncomms11062.


Carbon flux rerouting during Mycobacterium tuberculosis growth arrest.

Shi L, Sohaskey CD, Pheiffer C, Datta P, Parks M, McFadden J, North RJ, Gennaro ML.

Mol Microbiol. 2016 Mar;99(6):1179. doi: 10.1111/mmi.13350. No abstract available.


Statin adjunctive therapy shortens the duration of TB treatment in mice.

Dutta NK, Bruiners N, Pinn ML, Zimmerman MD, Prideaux B, Dartois V, Gennaro ML, Karakousis PC.

J Antimicrob Chemother. 2016 Jun;71(6):1570-7. doi: 10.1093/jac/dkw014. Epub 2016 Feb 21.


Non-monotonic Response to Monotonic Stimulus: Regulation of Glyoxylate Shunt Gene-Expression Dynamics in Mycobacterium tuberculosis.

Ascensao JA, Datta P, Hancioglu B, Sontag E, Gennaro ML, Igoshin OA.

PLoS Comput Biol. 2016 Feb 22;12(2):e1004741. doi: 10.1371/journal.pcbi.1004741. eCollection 2016 Feb.


Flow Cytometric Characterization of Antigen-Specific T Cells Based on RNA and Its Advantages in Detecting Infections and Immunological Disorders.

Radford F, Tyagi S, Gennaro ML, Pine R, Bushkin Y.

Crit Rev Immunol. 2016;36(5):359-378. doi: 10.1615/CritRevImmunol.2017018316.


Infection with Mycobacterium tuberculosis induces the Warburg effect in mouse lungs.

Shi L, Salamon H, Eugenin EA, Pine R, Cooper A, Gennaro ML.

Sci Rep. 2015 Dec 10;5:18176. doi: 10.1038/srep18176.


Single-Cell Cytokine Gene Expression in Peripheral Blood Cells Correlates with Latent Tuberculosis Status.

Vir P, Arrigucci R, Lakehal K, Davidow AL, Pine R, Tyagi S, Bushkin Y, Lardizabal A, Gennaro ML.

PLoS One. 2015 Dec 14;10(12):e0144904. doi: 10.1371/journal.pone.0144904. eCollection 2015.


The Psp system of Mycobacterium tuberculosis integrates envelope stress-sensing and envelope-preserving functions.

Datta P, Ravi J, Guerrini V, Chauhan R, Neiditch MB, Shell SS, Fortune SM, Hancioglu B, Igoshin OA, Gennaro ML.

Mol Microbiol. 2015 Aug;97(3):408-22. doi: 10.1111/mmi.13037. Epub 2015 May 26.


Profiling T cell activation using single-molecule fluorescence in situ hybridization and flow cytometry.

Bushkin Y, Radford F, Pine R, Lardizabal A, Mangura BT, Gennaro ML, Tyagi S.

J Immunol. 2015 Jan 15;194(2):836-41. doi: 10.4049/jimmunol.1401515. Epub 2014 Dec 12.


Cutting edge: Vitamin D regulates lipid metabolism in Mycobacterium tuberculosis infection.

Salamon H, Bruiners N, Lakehal K, Shi L, Ravi J, Yamaguchi KD, Pine R, Gennaro ML.

J Immunol. 2014 Jul 1;193(1):30-34. doi: 10.4049/jimmunol.1400736. Epub 2014 Jun 4.


Simvastatin increases the in vivo activity of the first-line tuberculosis regimen.

Skerry C, Pinn ML, Bruiners N, Pine R, Gennaro ML, Karakousis PC.

J Antimicrob Chemother. 2014 Sep;69(9):2453-7. doi: 10.1093/jac/dku166. Epub 2014 May 22.


Evidence for postinitiation regulation of mRNA biogenesis in tuberculosis.

Salamon H, Qiao Y, Cheng JC, Yamaguchi KD, Soteropoulos P, Weiden M, Gennaro ML, Pine R.

J Immunol. 2013 Mar 15;190(6):2747-55. doi: 10.4049/jimmunol.1202185. Epub 2013 Feb 1.


Genome-wide discovery of small RNAs in Mycobacterium tuberculosis.

Miotto P, Forti F, Ambrosi A, Pellin D, Veiga DF, Balazsi G, Gennaro ML, Di Serio C, Ghisotti D, Cirillo DM.

PLoS One. 2012;7(12):e51950. doi: 10.1371/journal.pone.0051950. Epub 2012 Dec 19.


Proteome-scale antibody responses and outcome of Mycobacterium tuberculosis infection in nonhuman primates and in tuberculosis patients.

Kunnath-Velayudhan S, Davidow AL, Wang HY, Molina DM, Huynh VT, Salamon H, Pine R, Michel G, Perkins MD, Xiaowu L, Felgner PL, Flynn JL, Catanzaro A, Gennaro ML.

J Infect Dis. 2012 Sep 1;206(5):697-705. doi: 10.1093/infdis/jis421. Epub 2012 Jun 25.


Immunodiagnosis of tuberculosis: a dynamic view of biomarker discovery.

Kunnath-Velayudhan S, Gennaro ML.

Clin Microbiol Rev. 2011 Oct;24(4):792-805. doi: 10.1128/CMR.00014-11. Review.


Regulation of central metabolism genes of Mycobacterium tuberculosis by parallel feed-forward loops controlled by sigma factor E (σ(E)).

Datta P, Shi L, Bibi N, Balázsi G, Gennaro ML.

J Bacteriol. 2011 Mar;193(5):1154-60. doi: 10.1128/JB.00459-10. Epub 2010 Dec 30.


Immunodiagnosis of Tuberculosis: New Questions, New Tools Virginia, VA, USA. 21-23 September 2008. Abstracts.

Gennaro ML, Doherty TM.

BMC Proc. 2010;4 Suppl 3:I1. doi: 10.1186/1753-6561-4-S3-I1. Epub 2010 Dec 17. No abstract available.


Carbon flux rerouting during Mycobacterium tuberculosis growth arrest.

Shi L, Sohaskey CD, Pheiffer C, Datta P, Parks M, McFadden J, North RJ, Gennaro ML.

Mol Microbiol. 2010 Dec;78(5):1199-215. doi: 10.1111/j.1365-2958.2010.07399.x. Epub 2010 Oct 6. Erratum in: Mol Microbiol. 2016 Mar;99(6):1179. Pfeiffer, Carmen [Corrected to Pheiffer, Carmen].


The interplay of multiple feedback loops with post-translational kinetics results in bistability of mycobacterial stress response.

Tiwari A, Balázsi G, Gennaro ML, Igoshin OA.

Phys Biol. 2010 Aug 23;7(3):036005. doi: 10.1088/1478-3975/7/3/036005.


Dynamic antibody responses to the Mycobacterium tuberculosis proteome.

Kunnath-Velayudhan S, Salamon H, Wang HY, Davidow AL, Molina DM, Huynh VT, Cirillo DM, Michel G, Talbot EA, Perkins MD, Felgner PL, Liang X, Gennaro ML.

Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14703-8. doi: 10.1073/pnas.1009080107. Epub 2010 Jul 28.


The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest.

Balázsi G, Heath AP, Shi L, Gennaro ML.

Mol Syst Biol. 2008;4:225. doi: 10.1038/msb.2008.63. Epub 2008 Nov 4.


In vitro model of mycobacterial growth arrest using nitric oxide with limited air.

Hussain S, Malik M, Shi L, Gennaro ML, Drlica K.

Antimicrob Agents Chemother. 2009 Jan;53(1):157-61. doi: 10.1128/AAC.00442-08. Epub 2008 Oct 27.


Profiling antibodies to Mycobacterium tuberculosis by multiplex microbead suspension arrays for serodiagnosis of tuberculosis.

Khan IH, Ravindran R, Yee J, Ziman M, Lewinsohn DM, Gennaro ML, Flynn JL, Goulding CW, DeRiemer K, Lerche NW, Luciw PA.

Clin Vaccine Immunol. 2008 Mar;15(3):433-8. Epub 2007 Dec 12.


Transcriptional characterization of the antioxidant response of Mycobacterium tuberculosis in vivo and during adaptation to hypoxia in vitro.

Shi L, Sohaskey CD, North RJ, Gennaro ML.

Tuberculosis (Edinb). 2008 Jan;88(1):1-6. Epub 2007 Oct 24.


Antibody markers of incident tuberculosis among HIV-infected adults in the USA: a historical prospective study.

Gennaro ML, Affouf M, Kanaujia GV, Brusasca PN, Mangura B, Reichman L.

Int J Tuberc Lung Dis. 2007 Jun;11(6):624-31.


Serological markers of pulmonary tuberculosis and of response to anti-tuberculosis treatment in a patient population in Guinea.

Azzurri A, Kanaujia GV, Sow OY, Bah B, Diallo A, Del Prete G, Gennaro ML.

Int J Immunopathol Pharmacol. 2006 Jan-Mar;19(1):199-208.


Integration of microscopy and serodiagnostic tests to screen for active tuberculosis.

Kanaujia GV, Lam PK, Perry S, Brusasca PN, Catanzaro A, Gennaro ML.

Int J Tuberc Lung Dis. 2005 Oct;9(10):1120-6.


Changes in energy metabolism of Mycobacterium tuberculosis in mouse lung and under in vitro conditions affecting aerobic respiration.

Shi L, Sohaskey CD, Kana BD, Dawes S, North RJ, Mizrahi V, Gennaro ML.

Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15629-34. Epub 2005 Oct 14.


Antibody profiles characteristic of Mycobacterium tuberculosis infection state.

Davidow A, Kanaujia GV, Shi L, Kaviar J, Guo X, Sung N, Kaplan G, Menzies D, Gennaro ML.

Infect Immun. 2005 Oct;73(10):6846-51.


Analyzing Mycobacterium tuberculosis proteomes for candidate vaccine epitopes.

McMurry J, Sbai H, Gennaro ML, Carter EJ, Martin W, De Groot AS.

Tuberculosis (Edinb). 2005 Jan-Mar;85(1-2):95-105. Epub 2004 Dec 25.


Immunological characterization of novel secreted antigens of Mycobacterium tuberculosis.

Ben Amor Y, Shashkina E, Johnson S, Bifani PJ, Kurepina N, Kreiswirth B, Bhattacharya S, Spencer J, Rendon A, Catanzaro A, Gennaro ML.

Scand J Immunol. 2005 Feb;61(2):139-46. Erratum in: Scand J Immunol. 2005 Mar;61(3):298. Amor, YB [corrected to Ben Amor, Y].


Comparative analysis of B- and T-cell epitopes of Mycobacterium leprae and Mycobacterium tuberculosis culture filtrate protein 10.

Spencer JS, Kim HJ, Marques AM, Gonzalez-Juarerro M, Lima MC, Vissa VD, Truman RW, Gennaro ML, Cho SN, Cole ST, Brennan PJ.

Infect Immun. 2004 Jun;72(6):3161-70.


Tuberculosis immunology in children: diagnostic and therapeutic challenges and opportunities.

Lewinsohn DA, Gennaro ML, Scholvinck L, Lewinsohn DM.

Int J Tuberc Lung Dis. 2004 May;8(5):658-74. Review.


Detection of early secretory antigenic target-6 antibody for diagnosis of tuberculosis in non-human primates.

Kanaujia GV, Garcia MA, Bouley DM, Peters R, Gennaro ML.

Comp Med. 2003 Dec;53(6):602-6.


Recognition of ESAT-6 sequences by antibodies in sera of tuberculous nonhuman primates.

Kanaujia GV, Motzel S, Garcia MA, Andersen P, Gennaro ML.

Clin Diagn Lab Immunol. 2004 Jan;11(1):222-6.


Antigen recognition by serum antibodies in non-human primates experimentally infected with Mycobacterium tuberculosis.

Brusasca PN, Peters RL, Motzel SL, Klein HJ, Gennaro ML.

Comp Med. 2003 Apr;53(2):165-72.


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