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Osmanicin, a Polyketide Alkaloid Isolated from Streptomyces osmaniensis CA-244599 Inhibits Elastase in Human Fibroblasts.

Samy MN, Le Goff G, Lopes P, Georgousaki K, Gumeni S, Almeida C, González I, Genilloud O, Trougakos I, Fokialakis N, Ouazzani J.

Molecules. 2019 Jun 15;24(12). pii: E2239. doi: 10.3390/molecules24122239.


Cercospora sp. as a source of anti-aging polyketides targeting 26S proteasome and scale-up production in submerged bioreactor.

Georgousaki K, Tsafantakis N, Gumeni S, González-Menéndez V, de Pedro N, Tormo JR, Almeida C, Lambert C, Genilloud O, Trougakos IP, Fokialakis N.

J Biotechnol. 2019 Aug 10;301:88-96. doi: 10.1016/j.jbiotec.2019.05.015. Epub 2019 May 29.


Comparative Metabolomics between Mycobacterium tuberculosis and the MTBVAC Vaccine Candidate.

Díaz C, Pérez Del Palacio J, Valero-Guillén PL, Mena García P, Pérez I, Vicente F, Martín C, Genilloud O, Sánchez Pozo A, Gonzalo-Asensio J.

ACS Infect Dis. 2019 Aug 9;5(8):1317-1326. doi: 10.1021/acsinfecdis.9b00008. Epub 2019 May 30.


Terrestrial Microorganisms: Cell Factories of Bioactive Molecules with Skin Protecting Applications.

Peyrat LA, Tsafantakis N, Georgousaki K, Ouazzani J, Genilloud O, Trougakos IP, Fokialakis N.

Molecules. 2019 May 13;24(9). pii: E1836. doi: 10.3390/molecules24091836. Review.


Caniferolide A, a Macrolide from Streptomyces caniferus, Attenuates Neuroinflammation, Oxidative Stress, Amyloid-Beta, and Tau Pathology in Vitro.

Alvariño R, Alonso E, Lacret R, Oves-Costales D, Genilloud O, Reyes F, Alfonso A, Botana LM.

Mol Pharm. 2019 Apr 1;16(4):1456-1466. doi: 10.1021/acs.molpharmaceut.8b01090. Epub 2019 Mar 11.


Structure elucidation and biosynthetic gene cluster analysis of caniferolides A-D, new bioactive 36-membered macrolides from the marine-derived Streptomyces caniferus CA-271066.

Pérez-Victoria I, Oves-Costales D, Lacret R, Martín J, Sánchez-Hidalgo M, Díaz C, Cautain B, Vicente F, Genilloud O, Reyes F.

Org Biomol Chem. 2019 Mar 13;17(11):2954-2971. doi: 10.1039/c8ob03115k.


EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology.

Brennecke P, Rasina D, Aubi O, Herzog K, Landskron J, Cautain B, Vicente F, Quintana J, Mestres J, Stechmann B, Ellinger B, Brea J, Kolanowski JL, Pilarski R, Orzaez M, Pineda-Lucena A, Laraia L, Nami F, Zielenkiewicz P, Paruch K, Hansen E, von Kries JP, Neuenschwander M, Specker E, Bartunek P, Simova S, Leśnikowski Z, Krauss S, Lehtiö L, Bilitewski U, Brönstrup M, Taskén K, Jirgensons A, Lickert H, Clausen MH, Andersen JH, Vicent MJ, Genilloud O, Martinez A, Nazaré M, Fecke W, Gribbon P.

SLAS Discov. 2019 Mar;24(3):398-413. doi: 10.1177/2472555218816276. Epub 2019 Jan 7.


The XRE-DUF397 Protein Pair, Scr1 and Scr2, Acts as a Strong Positive Regulator of Antibiotic Production in Streptomyces.

Santamaría RI, Sevillano L, Martín J, Genilloud O, González I, Díaz M.

Front Microbiol. 2018 Nov 16;9:2791. doi: 10.3389/fmicb.2018.02791. eCollection 2018.


Ultraviolet (IUV) and mass spectrometry (IMS) imaging for the deconvolution of microbial interactions.

González-Menéndez V, Martínez G, Serrano R, Muñoz F, Martín J, Genilloud O, Tormo JR.

BMC Syst Biol. 2018 Nov 20;12(Suppl 5):99. doi: 10.1186/s12918-018-0617-3.


Mining Actinomycetes for Novel Antibiotics in the Omics Era: Are We Ready to Exploit This New Paradigm?

Genilloud O.

Antibiotics (Basel). 2018 Sep 25;7(4). pii: E85. doi: 10.3390/antibiotics7040085. Review.


Streptocyclinones A and B ameliorate Alzheimer's disease pathological processes in vitro.

Alvariño R, Alonso E, Lacret R, Oves-Costales D, Genilloud O, Reyes F, Alfonso A, Botana LM.

Neuropharmacology. 2018 Oct;141:283-295. doi: 10.1016/j.neuropharm.2018.09.008. Epub 2018 Sep 8.


Fungal endophytes from arid areas of Andalusia: high potential sources for antifungal and antitumoral agents.

González-Menéndez V, Crespo G, de Pedro N, Diaz C, Martín J, Serrano R, Mackenzie TA, Justicia C, González-Tejero MR, Casares M, Vicente F, Reyes F, Tormo JR, Genilloud O.

Sci Rep. 2018 Jun 27;8(1):9729. doi: 10.1038/s41598-018-28192-5.


MDN-0185, an Antiplasmodial Polycyclic Xanthone Isolated from Micromonospora sp. CA-256353.

Annang F, Pérez-Victoria I, Pérez-Moreno G, Domingo E, González I, Tormo JR, Martín J, Ruiz-Pérez LM, Genilloud O, González-Pacanowska D, Vicente F, Reyes F.

J Nat Prod. 2018 Jul 27;81(7):1687-1691. doi: 10.1021/acs.jnatprod.8b00323. Epub 2018 Jun 20.


Unveiling Concealed Functions of Endosymbiotic Bacteria Harbored in the Ascomycete Stachylidium bicolor.

Almeida C, Silva Pereira C, Gonzalez-Menendez V, Bills G, Pascual J, Sánchez-Hidalgo M, Kehraus S, Genilloud O.

Appl Environ Microbiol. 2018 Jul 17;84(15). pii: e00660-18. doi: 10.1128/AEM.00660-18. Print 2018 Aug 1.


Non-geminal Aliphatic Dihalogenation Pattern in Dichlorinated Diaporthins from Hamigera fusca NRRL 35721.

Almeida C, Pérez-Victoria I, González-Menéndez V, de Pedro N, Martín J, Crespo G, Mackenzie T, Cautain B, Reyes F, Vicente F, Genilloud O.

J Nat Prod. 2018 Jun 22;81(6):1488-1492. doi: 10.1021/acs.jnatprod.8b00041. Epub 2018 May 24.


Antiprotozoan sesterterpenes and triterpenes isolated from two Ghanaian mushrooms.

Annang F, Pérez-Victoria I, Appiah T, Pérez-Moreno G, Domingo E, Martín J, Mackenzie T, Ruiz-Pérez L, González-Pacanowska D, Genilloud O, Vicente F, Agyare C, Reyes F.

Fitoterapia. 2018 Jun;127:341-348. doi: 10.1016/j.fitote.2018.03.016. Epub 2018 Apr 3.


Comparative Genomics and Biosynthetic Potential Analysis of Two Lichen-Isolated Amycolatopsis Strains.

Sánchez-Hidalgo M, González I, Díaz-Muñoz C, Martínez G, Genilloud O.

Front Microbiol. 2018 Mar 13;9:369. doi: 10.3389/fmicb.2018.00369. eCollection 2018.


Phocoenamicins B and C, New Antibacterial Spirotetronates Isolated from a Marine Micromonospora sp.

Pérez-Bonilla M, Oves-Costales D, de la Cruz M, Kokkini M, Martín J, Vicente F, Genilloud O, Reyes F.

Mar Drugs. 2018 Mar 16;16(3). pii: E95. doi: 10.3390/md16030095.


MDN-0171, a new medermycin analogue from Streptomyces albolongus CA-186053.

Lacret R, Oves-Costales D, Pérez-Victoria I, de la Cruz M, Díaz C, Vicente F, Genilloud O, Reyes F.

Nat Prod Res. 2019 Jan;33(1):66-73. doi: 10.1080/14786419.2018.1434636. Epub 2018 Feb 7.


Editorial overview: Antimicrobials.

Mueller R, Genilloud O.

Curr Opin Microbiol. 2017 Oct;39:v-vii. doi: 10.1016/j.mib.2017.11.025. No abstract available.


Draft Genome Sequence of Burkholderia contaminans 293K04B, an Endosymbiont of the Sponge-Derived Fungus Stachylidium bicolor.

Fisch KM, Silva Pereira C, Genilloud O, Almeida C, Schäberle TF.

Genome Announc. 2017 Nov 9;5(45). pii: e01142-17. doi: 10.1128/genomeA.01142-17.


Correction for Bertoni-Mann et al., "Draft Genome Sequence of Phytopathogenic Fungus Fusarium proliferatum CF-295141, Isolated from Pinus sylvestris".

Bertoni-Mann M, Sánchez-Hidalgo M, González-Menéndez V, Genilloud O.

Genome Announc. 2017 Oct 26;5(43). pii: e01116-17. doi: 10.1128/genomeA.01116-17. No abstract available.


Luteolibacter gellanilyticus sp. nov., a gellan-gum-degrading bacterium of the phylum Verrucomicrobia isolated from miniaturized diffusion chambers.

Pascual J, García-López M, González I, Genilloud O.

Int J Syst Evol Microbiol. 2017 Oct;67(10):3951-3959. doi: 10.1099/ijsem.0.002227. Epub 2017 Sep 14.


Actinomycetes: still a source of novel antibiotics.

Genilloud O.

Nat Prod Rep. 2017 Oct 18;34(10):1203-1232. doi: 10.1039/c7np00026j. Review.


Co-culturing of Fungal Strains Against Botrytis cinerea as a Model for the Induction of Chemical Diversity and Therapeutic Agents.

Serrano R, González-Menéndez V, Rodríguez L, Martín J, Tormo JR, Genilloud O.

Front Microbiol. 2017 Apr 19;8:649. doi: 10.3389/fmicb.2017.00649. eCollection 2017.


Exploring the Role of CYP3A4 Mediated Drug Metabolism in the Pharmacological Modulation of Nitric Oxide Production.

Pérez-Del Palacio J, Díaz C, Vergara N, Algieri F, Rodríguez-Nogales A, de Pedro N, Rodríguez-Cabezas ME, Genilloud O, Gálvez J, Vicente F.

Front Pharmacol. 2017 Apr 12;8:202. doi: 10.3389/fphar.2017.00202. eCollection 2017.


Production of Ramoplanin and Ramoplanin Analogs by Actinomycetes.

de la Cruz M, González I, Parish CA, Onishi R, Tormo JR, Martín J, Peláez F, Zink D, El Aouad N, Reyes F, Genilloud O, Vicente F.

Front Microbiol. 2017 Mar 6;8:343. doi: 10.3389/fmicb.2017.00343. eCollection 2017.


A High-Throughput Screening Platform of Microbial Natural Products for the Discovery of Molecules with Antibiofilm Properties against Salmonella.

Paytubi S, de La Cruz M, Tormo JR, Martín J, González I, González-Menendez V, Genilloud O, Reyes F, Vicente F, Madrid C, Balsalobre C.

Front Microbiol. 2017 Mar 2;8:326. doi: 10.3389/fmicb.2017.00326. eCollection 2017.


Hormonemate Derivatives from Dothiora sp., an Endophytic Fungus.

Pérez-Bonilla M, González-Menéndez V, Pérez-Victoria I, de Pedro N, Martín J, Molero-Mesa J, Casares-Porcel M, González-Tejero MR, Vicente F, Genilloud O, Tormo JR, Reyes F.

J Nat Prod. 2017 Apr 28;80(4):845-853. doi: 10.1021/acs.jnatprod.6b00680. Epub 2017 Mar 9.


Draft Genome Sequence of Phytopathogenic Fungus Fusarium proliferatum [corrected] CF-295141, Isolated from Pinus sylvestris.

Bertoni-Mann M, Sánchez-Hidalgo M, González-Menéndez V, Genilloud O.

Genome Announc. 2016 Oct 20;4(5). pii: e01164-16. doi: 10.1128/genomeA.01164-16. Erratum in: Genome Announc. 2017 Oct 26;5(43):.


MDN-0170, a New Napyradiomycin from Streptomyces sp. Strain CA-271078.

Lacret R, Pérez-Victoria I, Oves-Costales D, de la Cruz M, Domingo E, Martín J, Díaz C, Vicente F, Genilloud O, Reyes F.

Mar Drugs. 2016 Oct 18;14(10). pii: E188.


Antifungal Long-Chain Alkenyl Sulphates Isolated from Culture Broths of the Fungus Chaetopsina sp.

Crespo G, González-Menéndez V, de la Cruz M, Martín J, Cautain B, Sánchez P, Pérez-Victoria I, Vicente F, Genilloud O, Reyes F.

Planta Med. 2017 Apr;83(6):545-550. doi: 10.1055/s-0042-118190. Epub 2016 Oct 5.


Untargeted LC-HRMS-Based Metabolomics for Searching New Biomarkers of Pancreatic Ductal Adenocarcinoma: A Pilot Study.

Ríos Peces S, Díaz Navarro C, Márquez López C, Caba O, Jiménez-Luna C, Melguizo C, Prados JC, Genilloud O, Vicente Pérez F, Pérez Del Palacio J.

SLAS Discov. 2017 Apr;22(4):348-359. doi: 10.1177/1087057116671490. Epub 2016 Sep 27.


Antimicrobial Activities of Some Actinomycetes Isolated from Different Rhizospheric Soils in Tunisia.

Trabelsi I, Oves D, Manteca A, Genilloud O, Altalhi A, Nour M.

Curr Microbiol. 2016 Aug;73(2):220-7. doi: 10.1007/s00284-016-1053-5. Epub 2016 May 2.


High-Throughput Screening Platform for the Discovery of New Immunomodulator Molecules from Natural Product Extract Libraries.

Pérez Del Palacio J, Díaz C, de la Cruz M, Annang F, Martín J, Pérez-Victoria I, González-Menéndez V, de Pedro N, Tormo JR, Algieri F, Rodriguez-Nogales A, Rodríguez-Cabezas ME, Reyes F, Genilloud O, Vicente F, Gálvez J.

J Biomol Screen. 2016 Jul;21(6):567-78. doi: 10.1177/1087057116635517. Epub 2016 Mar 8.


Description of Kibdelosporangium banguiense sp. nov., a novel actinomycete isolated from soil of the forest of Pama, on the plateau of Bangui, Central African Republic.

Pascual J, González I, Estévez M, Benito P, Trujillo ME, Genilloud O.

Antonie Van Leeuwenhoek. 2016 May;109(5):685-95. doi: 10.1007/s10482-016-0669-6. Epub 2016 Mar 2.


Multicomponent Analysis of the Differential Induction of Secondary Metabolite Profiles in Fungal Endophytes.

González-Menéndez V, Pérez-Bonilla M, Pérez-Victoria I, Martín J, Muñoz F, Reyes F, Tormo JR, Genilloud O.

Molecules. 2016 Feb 18;21(2). pii: E234. doi: 10.3390/molecules21020234.


Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis.

Mann PA, McLellan CA, Koseoglu S, Si Q, Kuzmin E, Flattery A, Harris G, Sher X, Murgolo N, Wang H, Devito K, de Pedro N, Genilloud O, Kahn JN, Jiang B, Costanzo M, Boone C, Garlisi CG, Lindquist S, Roemer T.

ACS Infect Dis. 2015 Jan 9;1(1):59-72. doi: 10.1021/id5000212. Epub 2014 Dec 12.


Longimicrobium terrae gen. nov., sp. nov., an oligotrophic bacterium of the under-represented phylum Gemmatimonadetes isolated through a system of miniaturized diffusion chambers.

Pascual J, García-López M, Bills GF, Genilloud O.

Int J Syst Evol Microbiol. 2016 May;66(5):1976-85. doi: 10.1099/ijsem.0.000974. Epub 2016 Feb 12.


Assessing Bacterial Diversity in the Rhizosphere of Thymus zygis Growing in the Sierra Nevada National Park (Spain) through Culture-Dependent and Independent Approaches.

Pascual J, Blanco S, García-López M, García-Salamanca A, Bursakov SA, Genilloud O, Bills GF, Ramos JL, van Dillewijn P.

PLoS One. 2016 Jan 7;11(1):e0146558. doi: 10.1371/journal.pone.0146558. eCollection 2016.


Discovery of New Compounds Active against Plasmodium falciparum by High Throughput Screening of Microbial Natural Products.

Pérez-Moreno G, Cantizani J, Sánchez-Carrasco P, Ruiz-Pérez LM, Martín J, El Aouad N, Pérez-Victoria I, Tormo JR, González-Menendez V, González I, de Pedro N, Reyes F, Genilloud O, Vicente F, González-Pacanowska D.

PLoS One. 2016 Jan 6;11(1):e0145812. doi: 10.1371/journal.pone.0145812. eCollection 2016.


Metabolomic profile related to cardiovascular disease in patients with type 2 diabetes mellitus: A pilot study.

García-Fontana B, Morales-Santana S, Díaz Navarro C, Rozas-Moreno P, Genilloud O, Vicente Pérez F, Pérez del Palacio J, Muñoz-Torres M.

Talanta. 2016;148:135-43. doi: 10.1016/j.talanta.2015.10.070. Epub 2015 Oct 27.


Elucidation of DnaE as the Antibacterial Target of the Natural Product, Nargenicin.

Painter RE, Adam GC, Arocho M, DiNunzio E, Donald RG, Dorso K, Genilloud O, Gill C, Goetz M, Hairston NN, Murgolo N, Nare B, Olsen DB, Powles M, Racine F, Su J, Vicente F, Wisniewski D, Xiao L, Hammond M, Young K.

Chem Biol. 2015 Oct 22;22(10):1362-73. doi: 10.1016/j.chembiol.2015.08.015. Epub 2015 Oct 8.


Protective effects of isolecanoric acid on neurodegenerative in vitro models.

de Pedro N, Cantizani J, Ortiz-López FJ, González-Menéndez V, Cautain B, Rodríguez L, Bills GF, Reyes F, Genilloud O, Vicente F.

Neuropharmacology. 2016 Feb;101:538-48. doi: 10.1016/j.neuropharm.2015.09.029. Epub 2015 Oct 9.


Specialized Bioactive Microbial Metabolites: From Gene to Product.

Marinelli F, Genilloud O, Fedorenko V, Ron EZ.

Biomed Res Int. 2015;2015:276964. doi: 10.1155/2015/276964. Epub 2015 Aug 5. No abstract available.


Antibacterial Discovery and Development: From Gene to Product and Back.

Fedorenko V, Genilloud O, Horbal L, Marcone GL, Marinelli F, Paitan Y, Ron EZ.

Biomed Res Int. 2015;2015:591349. doi: 10.1155/2015/591349. Epub 2015 Aug 3. Review.


Hitting the caspofungin salvage pathway of human-pathogenic fungi with the novel lasso peptide humidimycin (MDN-0010).

Valiante V, Monteiro MC, Martín J, Altwasser R, El Aouad N, González I, Kniemeyer O, Mellado E, Palomo S, de Pedro N, Pérez-Victoria I, Tormo JR, Vicente F, Reyes F, Genilloud O, Brakhage AA.

Antimicrob Agents Chemother. 2015 Sep;59(9):5145-53. doi: 10.1128/AAC.00683-15. Epub 2015 Jun 8.


Identification of the Lipodepsipeptide MDN-0066, a Novel Inhibitor of VHL/HIF Pathway Produced by a New Pseudomonas Species.

Cautain B, de Pedro N, Schulz C, Pascual J, Sousa Tda S, Martin J, Pérez-Victoria I, Asensio F, González I, Bills GF, Reyes F, Genilloud O, Vicente F.

PLoS One. 2015 May 27;10(5):e0125221. doi: 10.1371/journal.pone.0125221. eCollection 2015.


Cyclic colisporifungin and linear cavinafungins, antifungal lipopeptides isolated from Colispora cavincola.

Ortíz-López FJ, Monteiro MC, González-Menéndez V, Tormo JR, Genilloud O, Bills GF, Vicente F, Zhang C, Roemer T, Singh SB, Reyes F.

J Nat Prod. 2015 Mar 27;78(3):468-75. doi: 10.1021/np500854j. Epub 2015 Jan 30.


New ikarugamycin derivatives with antifungal and antibacterial properties from Streptomyces zhaozhouensis.

Lacret R, Oves-Costales D, Gómez C, Díaz C, de la Cruz M, Pérez-Victoria I, Vicente F, Genilloud O, Reyes F.

Mar Drugs. 2014 Dec 29;13(1):128-40. doi: 10.3390/md13010128.

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