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Structural geology data and 3-D subsurface models of the Budgell Harbour Stock and associated dykes, Newfoundland, Canada.

Peace AL, Welford JK, Geng M, Sandeman H, Gaetz BD, Ryan SS.

Data Brief. 2018 Oct 25;21:1690-1696. doi: 10.1016/j.dib.2018.10.072. eCollection 2018 Dec.


[The associations between nighttime sleep duration, bedtime and preschool children's obesity].

Jiang L, Yan SQ, Geng ML, Gu CL, Huang K, Cao H, Wu XY, Tao FB.

Zhonghua Yu Fang Yi Xue Za Zhi. 2018 Nov 6;52(11):1146-1151. doi: 10.3760/cma.j.issn.0253-9624.2018.11.010. Chinese.


Discovery and structure-activity-relationship study of novel imidazole cyclopropyl amine analogues for mutant isocitric dehydrogenase 1 (IDH1) inhibitors.

Zheng Q, Chen Z, Wan H, Tang S, Ye Y, Xu Y, Jiang L, Ding J, Geng M, Huang M, Huang Y.

Bioorg Med Chem Lett. 2018 Jul 4. pii: S0960-894X(18)30552-3. doi: 10.1016/j.bmcl.2018.07.002. [Epub ahead of print]


A new amphiphilic pillar[5]arene: synthesis and controllable self-assembly in water and application in white-light-emitting systems.

Sun S, Geng M, Huang L, Chen Y, Cen M, Lu D, Wang A, Wang Y, Shi Y, Yao Y.

Chem Commun (Camb). 2018 Nov 15;54(92):13006-13009. doi: 10.1039/c8cc07658h.


Correction to Discovery of Potent Irreversible Pan-Fibroblast Growth Factor Receptor (FGFR) Inhibitors.

Wang Y, Li L, Fan J, Dai Y, Jiang A, Geng M, Ai J, Duan W.

J Med Chem. 2018 Oct 25;61(20):9393. doi: 10.1021/acs.jmedchem.8b01414. Epub 2018 Oct 12. No abstract available.


A Novel Actin Binding Drug with In Vivo Efficacy.

Ravichandran A, Geng M, Hull KG, Li J, Romo D, Lu SE, Albee A, Nutter C, Gordon DM, Ghannoum MA, Lockless SW, Smith L.

Antimicrob Agents Chemother. 2018 Oct 15. pii: AAC.01585-18. doi: 10.1128/AAC.01585-18. [Epub ahead of print]


Identification and expression analysis of MinD gene involved in plastid division in cassava.

Ke L, Cao LJ, Geng MT, Wang CC, Yao Y, Xiao Y, Huang W, Li RM, Min Y, Guo JC.

Biosci Biotechnol Biochem. 2018 Oct 5:1-11. doi: 10.1080/09168451.2018.1520075. [Epub ahead of print]


Efficacious Analogs of the Lantibiotic Mutacin 1140 against a Systemic Methicillin-Resistant Staphylococcus aureus Infection.

Geng M, Ravichandran A, Escano J, Smith L.

Antimicrob Agents Chemother. 2018 Nov 26;62(12). pii: e01626-18. doi: 10.1128/AAC.01626-18. Print 2018 Dec.


Overexpression of MinE gene affects the plastid division in cassava.

Wang CC, Ke L, Cao LJ, Yao Y, Geng MT, Wang Y, Xiao Y, Huang W, Liu XH, Cao P, Guo JC, Min Y.

Biosci Biotechnol Biochem. 2018 Sep 27:1-11. doi: 10.1080/09168451.2018.1518703. [Epub ahead of print]


Cancer mortality attributable to cigarette smoking in 2005, 2010 and 2015 in Qingdao, China.

Xu Z, Qi F, Wang Y, Jia X, Lin P, Geng M, Wang R, Li S.

PLoS One. 2018 Sep 20;13(9):e0204221. doi: 10.1371/journal.pone.0204221. eCollection 2018.


CUDC-907 displays potent antitumor activity against human pancreatic adenocarcinoma in vitro and in vivo through inhibition of HDAC6 to downregulate c-Myc expression.

Fu XH, Zhang X, Yang H, Xu XW, Hu ZL, Yan J, Zheng XL, Wei RR, Zhang ZQ, Tang SR, Geng MY, Huang X.

Acta Pharmacol Sin. 2018 Sep 17. doi: 10.1038/s41401-018-0108-5. [Epub ahead of print]


Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors.

Huang X, Yan J, Zhang M, Wang Y, Chen Y, Fu X, Wei R, Zheng XL, Liu Z, Zhang X, Yang H, Hao B, Shen YY, Su Y, Cong X, Huang M, Tan M, Ding J, Geng M.

Cell. 2018 Sep 20;175(1):186-199.e19. doi: 10.1016/j.cell.2018.08.058. Epub 2018 Sep 13.


Targeting ERK, an Achilles' Heel of the MAPK pathway, in cancer therapy.

Liu F, Yang X, Geng M, Huang M.

Acta Pharm Sin B. 2018 Jul;8(4):552-562. doi: 10.1016/j.apsb.2018.01.008. Epub 2018 Feb 16. Review.


Localization of Glucose Transporter 10 to Hair Cells' Cuticular Plate in the Mouse Inner Ear.

Chen B, Wang Y, Geng M, Lin X, Tang W.

Biomed Res Int. 2018 Jun 14;2018:7817453. doi: 10.1155/2018/7817453. eCollection 2018.


The diagnostic role and dynamic changes in cerebrospinal fluid neopterin during treatment of patients with primary central nervous system lymphoma.

Geng M, Xiao H, Liu J, Song Y, Fu P, Cheng X, Zhang J, Wang G.

Cancer Med. 2018 Aug;7(8):3889-3898. doi: 10.1002/cam4.1581. Epub 2018 Jul 7.


Identification of compound D2923 as a novel anti-tumor agent targeting CSF1R.

Liu YQ, Wang YN, Lu XY, Tong LJ, Li Y, Zhang T, Xun QJ, Feng F, Chen YZ, Su Y, Shen YY, Chen Y, Geng MY, Ding K, Li YL, Xie H, Ding J.

Acta Pharmacol Sin. 2018 Nov;39(11):1768-1776. doi: 10.1038/s41401-018-0056-0. Epub 2018 Jul 3.


A tightly controlled Src-YAP signaling axis determines therapeutic response to dasatinib in renal cell carcinoma.

Sun J, Wang X, Tang B, Liu H, Zhang M, Wang Y, Ping F, Ding J, Shen A, Geng M.

Theranostics. 2018 May 11;8(12):3256-3267. doi: 10.7150/thno.23964. eCollection 2018.


Selection of an anti-solvent for efficient and stable cesium-containing triple cation planar perovskite solar cells.

Xiao M, Zhao L, Geng M, Li Y, Dong B, Xu Z, Wan L, Li W, Wang S.

Nanoscale. 2018 Jul 5;10(25):12141-12148. doi: 10.1039/c8nr03580f.


Effects of gas reservoir configuration and pore radius on shale gas nanoflow: A molecular dynamics study.

Tian H, Guo GJ, Geng M, Zhang Z, Zhang M, Gao K.

J Chem Phys. 2018 May 28;148(20):204703. doi: 10.1063/1.5021139.


Piribedil disrupts the MLL1-WDR5 interaction and sensitizes MLL-rearranged acute myeloid leukemia (AML) to doxorubicin-induced apoptosis.

Zhang X, Zheng X, Yang H, Yan J, Fu X, Wei R, Xu X, Zhang Z, Yu A, Zhou K, Ding J, Geng M, Huang X.

Cancer Lett. 2018 Sep 1;431:150-160. doi: 10.1016/j.canlet.2018.05.034. Epub 2018 May 30.


Modifying the Lantibiotic Mutacin 1140 for Increased Yield, Activity, and Stability.

Geng M, Smith L.

Appl Environ Microbiol. 2018 Jul 17;84(15). pii: e00830-18. doi: 10.1128/AEM.00830-18. Print 2018 Aug 1.


Design, synthesis and biological evaluation of a series of novel 2-benzamide-4-(6-oxy-N-methyl-1-naphthamide)-pyridine derivatives as potent fibroblast growth factor receptor (FGFR) inhibitors.

Wei M, Peng X, Xing L, Dai Y, Huang R, Geng M, Zhang A, Ai J, Song Z.

Eur J Med Chem. 2018 Jun 25;154:9-28. doi: 10.1016/j.ejmech.2018.05.005. Epub 2018 May 16.


Coordinated effects of lead toxicity and nutrient deprivation on growth, oxidative status, and elemental composition of primed and non-primed rice seedlings.

Khan F, Hussain S, Tanveer M, Khan S, Hussain HA, Iqbal B, Geng M.

Environ Sci Pollut Res Int. 2018 Jul;25(21):21185-21194. doi: 10.1007/s11356-018-2262-1. Epub 2018 May 17.


Modified citrus pectin inhibited bladder tumor growth through downregulation of galectin-3.

Fang T, Liu DD, Ning HM, Dan Liu, Sun JY, Huang XJ, Dong Y, Geng MY, Yun SF, Yan J, Huang RM.

Acta Pharmacol Sin. 2018 Dec;39(12):1885-1893. doi: 10.1038/s41401-018-0004-z. Epub 2018 May 16.


Corrigendum: (-)-Epigallocatechin-3-Gallate Ameliorates Atherosclerosis and Modulates Hepatic Lipid Metabolic Gene Expression in Apolipoprotein E Knockout Mice: Involvement of TTC39B.

Wang W, Zhang ZZ, Wu Y, Wang RQ, Chen JW, Chen J, Zhang Y, Chen YJ, Geng M, Xu ZD, Dai M, Li JH, Pan LL.

Front Pharmacol. 2018 May 1;9:459. doi: 10.3389/fphar.2018.00459. eCollection 2018.


Discovery of 4,7-Diamino-5-(4-phenoxyphenyl)-6-methylene-pyrimido[5,4- b]pyrrolizines as Novel Bruton's Tyrosine Kinase Inhibitors.

Xue Y, Song P, Song Z, Wang A, Tong L, Geng M, Ding J, Liu Q, Sun L, Xie H, Zhang A.

J Med Chem. 2018 May 24;61(10):4608-4627. doi: 10.1021/acs.jmedchem.8b00441. Epub 2018 May 9.


Design, synthesis and pharmacological evaluation of ALK and Hsp90 dual inhibitors bearing resorcinol and 2,4-diaminopyrimidine motifs.

Geng K, Liu H, Song Z, Zhang C, Zhang M, Yang H, Cao J, Geng M, Shen A, Zhang A.

Eur J Med Chem. 2018 May 25;152:76-86. doi: 10.1016/j.ejmech.2018.04.019. Epub 2018 Apr 11.


Total synthesis of (±)-tanshinol B, tanshinone I, and (±)-tanshindiol B and C.

Wang F, Yang H, Yu S, Xue Y, Fan Z, Liang G, Geng M, Zhang A, Ding C.

Org Biomol Chem. 2018 May 9;16(18):3376-3381. doi: 10.1039/c8ob00567b.


(-)-Epigallocatechin-3-Gallate Ameliorates Atherosclerosis and Modulates Hepatic Lipid Metabolic Gene Expression in Apolipoprotein E Knockout Mice: Involvement of TTC39B.

Pan LL, Wu Y, Wang RQ, Chen JW, Chen J, Zhang Y, Chen YJ, Geng M, Xu ZD, Dai M, Li JH, Wang W, Zhang ZZ.

Front Pharmacol. 2018 Mar 9;9:195. doi: 10.3389/fphar.2018.00195. eCollection 2018. Erratum in: Front Pharmacol. 2018 May 01;9:459.


Prevalence of and risk factors for tuberculosis among healthcare workers in Chinese tuberculosis facilities.

Wang XN, He TL, Geng MJ, Song YD, Wang JC, Liu M, Hoosdally SJ, Cruz ALG, Zhao F, Pang Y, Zhao YL, He GX.

Infect Dis Poverty. 2018 Mar 24;7(1):26. doi: 10.1186/s40249-018-0407-6.


Discovery and Optimization of Phosphopantetheine Adenylyltransferase Inhibitors with Gram-Negative Antibacterial Activity.

Skepper CK, Moreau RJ, Appleton BA, Benton BM, Drumm JE 3rd, Feng BY, Geng M, Hu C, Li C, Lingel A, Lu Y, Mamo M, Mergo W, Mostafavi M, Rath CM, Steffek M, Takeoka KT, Uehara K, Wang L, Wei JR, Xie L, Xu W, Zhang Q, de Vicente J.

J Med Chem. 2018 Apr 26;61(8):3325-3349. doi: 10.1021/acs.jmedchem.7b01861. Epub 2018 Apr 13.


Down-regulation of miR-10a-5p promotes proliferation and restricts apoptosis via targeting T-box transcription factor 5 in inflamed synoviocytes.

Hussain N, Zhu W, Jiang C, Xu J, Geng M, Wu X, Hussain S, Wang B, Rajoka MSR, Li Y, Tian J, Meng L, Lu S.

Biosci Rep. 2018 Apr 13;38(2). pii: BSR20180003. doi: 10.1042/BSR20180003. Print 2018 Apr 27.


Economic fabrication of a novel hybrid planar Grating/Fresnel lens for miniature spectrometers.

Zhou Q, Li X, Geng M, Hu H, Ni K, Zhong L, Yan P, Wang X.

Opt Express. 2018 Mar 5;26(5):6079-6089. doi: 10.1364/OE.26.006079.


Discovery of Potent Irreversible Pan-Fibroblast Growth Factor Receptor (FGFR) Inhibitors.

Wang Y, Li L, Fan J, Dai Y, Jiang A, Geng M, Ai J, Duan W.

J Med Chem. 2018 Oct 25;61(20):9085-9104. doi: 10.1021/acs.jmedchem.7b01843. Epub 2018 Mar 16. Erratum in: J Med Chem. 2018 Oct 25;61(20):9393.


Quantitative Proteomics Identify the Possible Tumor Suppressive Role of Protease-Activated Receptor-4 in Esophageal Squamous Cell Carcinoma Cells.

Wang M, An S, Wang D, Ji H, Geng M, Guo X, Wang Z.

Pathol Oncol Res. 2018 Mar 4. doi: 10.1007/s12253-018-0395-7. [Epub ahead of print]


Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria.

Moreau RJ, Skepper CK, Appleton BA, Blechschmidt A, Balibar CJ, Benton BM, Drumm JE 3rd, Feng BY, Geng M, Li C, Lindvall MK, Lingel A, Lu Y, Mamo M, Mergo W, Polyakov V, Smith TM, Takeoka K, Uehara K, Wang L, Wei JR, Weiss AH, Xie L, Xu W, Zhang Q, de Vicente J.

J Med Chem. 2018 Apr 26;61(8):3309-3324. doi: 10.1021/acs.jmedchem.7b01691. Epub 2018 Apr 9.


Simultaneous Transfer of Leaf Rust and Powdery Mildew Resistance Genes from Hexaploid Triticale Cultivar Sorento into Bread Wheat.

Li F, Li Y, Cao L, Liu P, Geng M, Zhang Q, Qiu L, Sun Q, Xie C.

Front Plant Sci. 2018 Feb 5;9:85. doi: 10.3389/fpls.2018.00085. eCollection 2018.


Design, synthesis and biological evaluation of tetrahydronaphthyridine derivatives as bioavailable CDK4/6 inhibitors for cancer therapy.

Zha C, Deng W, Fu Y, Tang S, Lan X, Ye Y, Su Y, Jiang L, Chen Y, Huang Y, Ding J, Geng M, Huang M, Wan H.

Eur J Med Chem. 2018 Mar 25;148:140-153. doi: 10.1016/j.ejmech.2018.02.022. Epub 2018 Feb 12.


Alzheimer's disease hypothesis and related therapies.

Du X, Wang X, Geng M.

Transl Neurodegener. 2018 Jan 30;7:2. doi: 10.1186/s40035-018-0107-y. eCollection 2018. Review.


CTC clusters induced by heparanase enhance breast cancer metastasis.

Wei RR, Sun DN, Yang H, Yan J, Zhang X, Zheng XL, Fu XH, Geng MY, Huang X, Ding J.

Acta Pharmacol Sin. 2018 Aug;39(8):1326-1337. doi: 10.1038/aps.2017.189. Epub 2018 Feb 8.


Identification and therapeutic intervention of coactivated anaplastic lymphoma kinase, fibroblast growth factor receptor 2, and ephrin type-A receptor 5 kinases in hepatocellular carcinoma.

Wang X, Zhang M, Ping F, Liu H, Sun J, Wang Y, Shen A, Ding J, Geng M.

Hepatology. 2018 Jan 21. doi: 10.1002/hep.29792. [Epub ahead of print]


The predictive value of pre- and post-induction chemotherapy plasma EBV DNA level and tumor volume for the radiosensitivity of locally advanced nasopharyngeal carcinoma.

Song Y, Xiao H, Yang Z, Geng M, Ma J, Ren Y, Liu Y, Wang G.

EXCLI J. 2017 Nov 28;16:1268-1275. doi: 10.17179/excli2017-752. eCollection 2017.


Discovery of 2,4-diarylaminopyrimidines bearing a resorcinol motif as novel ALK inhibitors to overcome the G1202R resistant mutation.

Geng K, Xia Z, Ji Y, Zhang RR, Sun D, Ai J, Song Z, Geng M, Zhang A.

Eur J Med Chem. 2018 Jan 20;144:386-397. doi: 10.1016/j.ejmech.2017.12.060. Epub 2017 Dec 20.


Novel Small Molecule Inhibitors of Protein Kinase D Suppress NF-kappaB Activation and Attenuate the Severity of Rat Cerulein Pancreatitis.

Yuan J, Tan T, Geng M, Tan G, Chheda C, Pandol SJ.

Front Physiol. 2017 Dec 7;8:1014. doi: 10.3389/fphys.2017.01014. eCollection 2017.


Covalent Structure and Bioactivity of the Type AII Lantibiotic Salivaricin A2.

Geng M, Austin F, Shin R, Smith L.

Appl Environ Microbiol. 2018 Feb 14;84(5). pii: e02528-17. doi: 10.1128/AEM.02528-17. Print 2018 Mar 1.


Isolation and Characterization of Ftsz Genes in Cassava.

Geng MT, Min Y, Yao Y, Chen X, Fan J, Yuan S, Wang L, Sun C, Zhang F, Shang L, Wang YL, Li RM, Fu SP, Duan RJ, Liu J, Hu XW, Guo JC.

Genes (Basel). 2017 Dec 15;8(12). pii: E391. doi: 10.3390/genes8120391.


Optimization of CoaD Inhibitors against Gram-Negative Organisms through Targeted Metabolomics.

Rath CM, Benton BM, de Vicente J, Drumm JE, Geng M, Li C, Moreau RJ, Shen X, Skepper CK, Steffek M, Takeoka K, Wang L, Wei JR, Xu W, Zhang Q, Feng BY.

ACS Infect Dis. 2018 Mar 9;4(3):391-402. doi: 10.1021/acsinfecdis.7b00214. Epub 2017 Dec 22.


Preclinical Evaluation of SCC244 (Glumetinib), a Novel, Potent, and Highly Selective Inhibitor of c-Met in MET-dependent Cancer Models.

Ai J, Chen Y, Peng X, Ji Y, Xi Y, Shen Y, Yang X, Su Y, Sun Y, Gao Y, Ma Y, Xiong B, Shen J, Ding J, Geng M.

Mol Cancer Ther. 2018 Apr;17(4):751-762. doi: 10.1158/1535-7163.MCT-17-0368. Epub 2017 Dec 13.


Improving the attrition rate of Lanthipeptide discovery for commercial applications.

Geng M, Smith L.

Expert Opin Drug Discov. 2018 Feb;13(2):155-167. doi: 10.1080/17460441.2018.1410137. Epub 2017 Dec 1.


Distribution characteristics of poly- and perfluoroalkyl substances in the Yangtze River Delta.

Zheng B, Liu X, Guo R, Fu Q, Zhao X, Wang S, Chang S, Wang X, Geng M, Yang G.

J Environ Sci (China). 2017 Nov;61:97-109. doi: 10.1016/j.jes.2017.09.015. Epub 2017 Oct 6.


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