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The scrub typhus in mainland China: spatiotemporal expansion and risk prediction underpinned by complex factors.

Yao H, Wang Y, Mi X, Sun Y, Liu K, Li X, Ren X, Geng M, Yang Y, Wang L, Liu W, Fang L.

Emerg Microbes Infect. 2019;8(1):909-919. doi: 10.1080/22221751.2019.1631719.


Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer.

Jin N, Bi A, Lan X, Xu J, Wang X, Liu Y, Wang T, Tang S, Zeng H, Chen Z, Tan M, Ai J, Xie H, Zhang T, Liu D, Huang R, Song Y, Leung EL, Yao X, Ding J, Geng M, Lin SH, Huang M.

Nat Commun. 2019 Jun 20;10(1):2701. doi: 10.1038/s41467-019-10427-2.


PI3Kα inhibitors sensitize esophageal squamous cell carcinoma to radiation by abrogating survival signals in tumor cells and tumor microenvironment.

Shi JJ, Xing H, Wang YX, Zhang X, Zhan QM, Geng MY, Ding J, Meng LH.

Cancer Lett. 2019 Jun 4;459:145-155. doi: 10.1016/j.canlet.2019.05.040. [Epub ahead of print]


Differential expression of the Hsf family in cassava under biotic and abiotic stresses.

Yu XY, Yao Y, Hong YH, Hou PY, Li CX, Xia ZQ, Geng MT, Chen YH.

Genome. 2019 Jun 3:1-7. doi: 10.1139/gen-2018-0163. [Epub ahead of print]


Design and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia.

Guo Z, Zhang Z, Yang H, Cao D, Xu X, Zheng X, Chen D, Wang Q, Li Y, Li J, Du Z, Wang X, Chen L, Ding J, Shen J, Geng M, Huang X, Xiong B.

J Med Chem. 2019 Jun 13;62(11):5414-5433. doi: 10.1021/acs.jmedchem.9b00297. Epub 2019 Jun 4.


Structural and molecular basis of angiotensin-converting enzyme by computational modeling: Insights into the mechanisms of different inhibitors.

Fang L, Geng M, Liu C, Wang J, Min W, Liu J.

PLoS One. 2019 Apr 18;14(4):e0215609. doi: 10.1371/journal.pone.0215609. eCollection 2019.


Discovery of a series of dimethoxybenzene FGFR inhibitors with 5H-pyrrolo[2,3-b]pyrazine scaffold: structure-activity relationship, crystal structural characterization and in vivo study.

Wei P, Liu B, Wang R, Gao Y, Li L, Ma Y, Qian Z, Chen Y, Cheng M, Geng M, Shen J, Zhao D, Ai J, Xiong B.

Acta Pharm Sin B. 2019 Mar;9(2):351-368. doi: 10.1016/j.apsb.2018.12.008. Epub 2018 Dec 26.


Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies.

Liang X, Zang J, Li X, Tang S, Huang M, Geng M, Chou CJ, Li C, Cao Y, Xu W, Liu H, Zhang Y.

J Med Chem. 2019 Apr 25;62(8):3898-3923. doi: 10.1021/acs.jmedchem.8b01597. Epub 2019 Apr 3.


Parallel Speciation of Wild Rice Associated with Habitat Shifts.

Cai Z, Zhou L, Ren NN, Xu X, Liu R, Huang L, Zheng XM, Meng QL, Du YS, Wang MX, Geng MF, Chen WL, Jing CY, Zou XH, Guo J, Chen CB, Zeng HZ, Liang YT, Wei XH, Guo YL, Zhou HF, Zhang FM, Ge S.

Mol Biol Evol. 2019 May 1;36(5):875-889. doi: 10.1093/molbev/msz029.


p53 β-hydroxybutyrylation attenuates p53 activity.

Liu K, Li F, Sun Q, Lin N, Han H, You K, Tian F, Mao Z, Li T, Tong T, Geng M, Zhao Y, Gu W, Zhao W.

Cell Death Dis. 2019 Mar 11;10(3):243. doi: 10.1038/s41419-019-1463-y.


[Clinical analysis of 54 patients with non-syndromic enlarged vestibular aqueduct].

Wang LL, Song YT, Geng MY, Mi YF, Guo XY, Wang L, Tang JF, Li Z, Li WC.

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Mar;33(3):255-258. doi: 10.13201/j.issn.1001-1781.2019.03.017. Chinese.


Sensor Fusion-Based Cooperative Trail Following for Autonomous Multi-Robot System.

Geng M, Liu S, Wu Z.

Sensors (Basel). 2019 Feb 17;19(4). pii: E823. doi: 10.3390/s19040823.


Draft Genome Sequence of the Lantibiotic-Producing Strain Streptococcus salivarius HS0302.

Geng M, Deng P, Mire T, Austin F, Smith L.

Microbiol Resour Announc. 2019 Jan 3;8(1). pii: e01410-18. doi: 10.1128/MRA.01410-18. eCollection 2019 Jan.


Effect of post-silking drought stress on the expression profiles of genes involved in carbon and nitrogen metabolism during leaf senescence in maize (Zea mays L.).

Yang M, Geng M, Shen P, Chen X, Li Y, Wen X.

Plant Physiol Biochem. 2019 Feb;135:304-309. doi: 10.1016/j.plaphy.2018.12.025. Epub 2018 Dec 25.


[Surveillance data on notifiable infectious diseases among students aged 6-22 years in China, 2011-2016].

Sun J, Yang WW, Zeng LJ, Geng MJ, Dong YH, Xing Y, Ma J, Li ZJ, Wang LP.

Zhonghua Liu Xing Bing Xue Za Zhi. 2018 Dec 10;39(12):1589-1595. doi: 10.3760/cma.j.issn.0254-6450.2018.12.010. Chinese.


Discovery and optimization of a series of 3-substituted indazole derivatives as multi-target kinase inhibitors for the treatment of lung squamous cell carcinoma.

Wang Q, Dai Y, Ji Y, Shi H, Guo Z, Chen D, Chen Y, Peng X, Gao Y, Wang X, Chen L, Jiang Y, Geng M, Shen J, Ai J, Xiong B.

Eur J Med Chem. 2019 Feb 1;163:671-689. doi: 10.1016/j.ejmech.2018.12.015. Epub 2018 Dec 7.


Fragment-based drug discovery of triazole inhibitors to block PDEδ-RAS protein-protein interaction.

Chen D, Chen Y, Lian F, Chen L, Li Y, Cao D, Wang X, Chen L, Li J, Meng T, Huang M, Geng M, Shen J, Zhang N, Xiong B.

Eur J Med Chem. 2019 Feb 1;163:597-609. doi: 10.1016/j.ejmech.2018.12.018. Epub 2018 Dec 11.


Density functional theory calculations and thermodynamic analysis of bridgmanite surface structure.

Geng M, Jónsson H.

Phys Chem Chem Phys. 2019 Jan 21;21(3):1009-1013. doi: 10.1039/c8cp06702c. Epub 2018 Dec 7.


The Secretome Engages STAT3 to Favor a Cytokine-rich Microenvironment in Mediating Acquired Resistance to FGFR Inhibitors.

Wang X, Ai J, Liu H, Peng X, Chen H, Chen Y, Su Y, Shen A, Huang X, Ding J, Geng M.

Mol Cancer Ther. 2019 Mar;18(3):667-679. doi: 10.1158/1535-7163.MCT-18-0179. Epub 2018 Dec 6.


Structural geology data and 3-D subsurface models of the Budgell Harbour Stock and associated dykes, Newfoundland, Canada.

Peace AL, Welford JK, Geng M, Sandeman H, Gaetz BD, Ryan SS.

Data Brief. 2018 Oct 25;21:1690-1696. doi: 10.1016/j.dib.2018.10.072. eCollection 2018 Dec.


[The associations between nighttime sleep duration, bedtime and preschool children's obesity].

Jiang L, Yan SQ, Geng ML, Gu CL, Huang K, Cao H, Wu XY, Tao FB.

Zhonghua Yu Fang Yi Xue Za Zhi. 2018 Nov 6;52(11):1146-1151. doi: 10.3760/cma.j.issn.0253-9624.2018.11.010. Chinese.


Discovery and structure-activity-relationship study of novel imidazole cyclopropyl amine analogues for mutant isocitric dehydrogenase 1 (IDH1) inhibitors.

Zheng Q, Chen Z, Wan H, Tang S, Ye Y, Xu Y, Jiang L, Ding J, Geng M, Huang M, Huang Y.

Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3808-3812. doi: 10.1016/j.bmcl.2018.07.002. Epub 2018 Jul 4.


A new amphiphilic pillar[5]arene: synthesis and controllable self-assembly in water and application in white-light-emitting systems.

Sun S, Geng M, Huang L, Chen Y, Cen M, Lu D, Wang A, Wang Y, Shi Y, Yao Y.

Chem Commun (Camb). 2018 Nov 15;54(92):13006-13009. doi: 10.1039/c8cc07658h.


Correction to Discovery of Potent Irreversible Pan-Fibroblast Growth Factor Receptor (FGFR) Inhibitors.

Wang Y, Li L, Fan J, Dai Y, Jiang A, Geng M, Ai J, Duan W.

J Med Chem. 2018 Oct 25;61(20):9393. doi: 10.1021/acs.jmedchem.8b01414. Epub 2018 Oct 12. No abstract available.


A Novel Actin Binding Drug with In Vivo Efficacy.

Ravichandran A, Geng M, Hull KG, Li J, Romo D, Lu SE, Albee A, Nutter C, Gordon DM, Ghannoum MA, Lockless SW, Smith L.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01585-18. doi: 10.1128/AAC.01585-18. Print 2019 Jan.


Identification and expression analysis of MinD gene involved in plastid division in cassava.

Ke L, Cao LJ, Geng MT, Wang CC, Yao Y, Xiao Y, Huang W, Li RM, Min Y, Guo JC.

Biosci Biotechnol Biochem. 2019 Jan;83(1):76-86. doi: 10.1080/09168451.2018.1520075. Epub 2018 Oct 5.


Efficacious Analogs of the Lantibiotic Mutacin 1140 against a Systemic Methicillin-Resistant Staphylococcus aureus Infection.

Geng M, Ravichandran A, Escano J, Smith L.

Antimicrob Agents Chemother. 2018 Nov 26;62(12). pii: e01626-18. doi: 10.1128/AAC.01626-18. Print 2018 Dec.


Overexpression of MinE gene affects the plastid division in cassava.

Wang CC, Ke L, Cao LJ, Yao Y, Geng MT, Wang Y, Xiao Y, Huang W, Liu XH, Cao P, Guo JC, Min Y.

Biosci Biotechnol Biochem. 2018 Sep 27:1-11. doi: 10.1080/09168451.2018.1518703. [Epub ahead of print]


Cancer mortality attributable to cigarette smoking in 2005, 2010 and 2015 in Qingdao, China.

Xu Z, Qi F, Wang Y, Jia X, Lin P, Geng M, Wang R, Li S.

PLoS One. 2018 Sep 20;13(9):e0204221. doi: 10.1371/journal.pone.0204221. eCollection 2018.


CUDC-907 displays potent antitumor activity against human pancreatic adenocarcinoma in vitro and in vivo through inhibition of HDAC6 to downregulate c-Myc expression.

Fu XH, Zhang X, Yang H, Xu XW, Hu ZL, Yan J, Zheng XL, Wei RR, Zhang ZQ, Tang SR, Geng MY, Huang X.

Acta Pharmacol Sin. 2019 May;40(5):677-688. doi: 10.1038/s41401-018-0108-5. Epub 2018 Sep 17.


Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors.

Huang X, Yan J, Zhang M, Wang Y, Chen Y, Fu X, Wei R, Zheng XL, Liu Z, Zhang X, Yang H, Hao B, Shen YY, Su Y, Cong X, Huang M, Tan M, Ding J, Geng M.

Cell. 2018 Sep 20;175(1):186-199.e19. doi: 10.1016/j.cell.2018.08.058. Epub 2018 Sep 13.


Targeting ERK, an Achilles' Heel of the MAPK pathway, in cancer therapy.

Liu F, Yang X, Geng M, Huang M.

Acta Pharm Sin B. 2018 Jul;8(4):552-562. doi: 10.1016/j.apsb.2018.01.008. Epub 2018 Feb 16. Review.


Localization of Glucose Transporter 10 to Hair Cells' Cuticular Plate in the Mouse Inner Ear.

Chen B, Wang Y, Geng M, Lin X, Tang W.

Biomed Res Int. 2018 Jun 14;2018:7817453. doi: 10.1155/2018/7817453. eCollection 2018.


The diagnostic role and dynamic changes in cerebrospinal fluid neopterin during treatment of patients with primary central nervous system lymphoma.

Geng M, Xiao H, Liu J, Song Y, Fu P, Cheng X, Zhang J, Wang G.

Cancer Med. 2018 Aug;7(8):3889-3898. doi: 10.1002/cam4.1581. Epub 2018 Jul 7.


Identification of compound D2923 as a novel anti-tumor agent targeting CSF1R.

Liu YQ, Wang YN, Lu XY, Tong LJ, Li Y, Zhang T, Xun QJ, Feng F, Chen YZ, Su Y, Shen YY, Chen Y, Geng MY, Ding K, Li YL, Xie H, Ding J.

Acta Pharmacol Sin. 2018 Nov;39(11):1768-1776. doi: 10.1038/s41401-018-0056-0. Epub 2018 Jul 3.


A tightly controlled Src-YAP signaling axis determines therapeutic response to dasatinib in renal cell carcinoma.

Sun J, Wang X, Tang B, Liu H, Zhang M, Wang Y, Ping F, Ding J, Shen A, Geng M.

Theranostics. 2018 May 11;8(12):3256-3267. doi: 10.7150/thno.23964. eCollection 2018.


Selection of an anti-solvent for efficient and stable cesium-containing triple cation planar perovskite solar cells.

Xiao M, Zhao L, Geng M, Li Y, Dong B, Xu Z, Wan L, Li W, Wang S.

Nanoscale. 2018 Jul 5;10(25):12141-12148. doi: 10.1039/c8nr03580f.


Effects of gas reservoir configuration and pore radius on shale gas nanoflow: A molecular dynamics study.

Tian H, Guo GJ, Geng M, Zhang Z, Zhang M, Gao K.

J Chem Phys. 2018 May 28;148(20):204703. doi: 10.1063/1.5021139.


Piribedil disrupts the MLL1-WDR5 interaction and sensitizes MLL-rearranged acute myeloid leukemia (AML) to doxorubicin-induced apoptosis.

Zhang X, Zheng X, Yang H, Yan J, Fu X, Wei R, Xu X, Zhang Z, Yu A, Zhou K, Ding J, Geng M, Huang X.

Cancer Lett. 2018 Sep 1;431:150-160. doi: 10.1016/j.canlet.2018.05.034. Epub 2018 May 30.


Modifying the Lantibiotic Mutacin 1140 for Increased Yield, Activity, and Stability.

Geng M, Smith L.

Appl Environ Microbiol. 2018 Jul 17;84(15). pii: e00830-18. doi: 10.1128/AEM.00830-18. Print 2018 Aug 1.


Design, synthesis and biological evaluation of a series of novel 2-benzamide-4-(6-oxy-N-methyl-1-naphthamide)-pyridine derivatives as potent fibroblast growth factor receptor (FGFR) inhibitors.

Wei M, Peng X, Xing L, Dai Y, Huang R, Geng M, Zhang A, Ai J, Song Z.

Eur J Med Chem. 2018 Jun 25;154:9-28. doi: 10.1016/j.ejmech.2018.05.005. Epub 2018 May 16.


Coordinated effects of lead toxicity and nutrient deprivation on growth, oxidative status, and elemental composition of primed and non-primed rice seedlings.

Khan F, Hussain S, Tanveer M, Khan S, Hussain HA, Iqbal B, Geng M.

Environ Sci Pollut Res Int. 2018 Jul;25(21):21185-21194. doi: 10.1007/s11356-018-2262-1. Epub 2018 May 17.


Modified citrus pectin inhibited bladder tumor growth through downregulation of galectin-3.

Fang T, Liu DD, Ning HM, Dan Liu, Sun JY, Huang XJ, Dong Y, Geng MY, Yun SF, Yan J, Huang RM.

Acta Pharmacol Sin. 2018 Dec;39(12):1885-1893. doi: 10.1038/s41401-018-0004-z. Epub 2018 May 16.


Corrigendum: (-)-Epigallocatechin-3-Gallate Ameliorates Atherosclerosis and Modulates Hepatic Lipid Metabolic Gene Expression in Apolipoprotein E Knockout Mice: Involvement of TTC39B.

Wang W, Zhang ZZ, Wu Y, Wang RQ, Chen JW, Chen J, Zhang Y, Chen YJ, Geng M, Xu ZD, Dai M, Li JH, Pan LL.

Front Pharmacol. 2018 May 1;9:459. doi: 10.3389/fphar.2018.00459. eCollection 2018.


Discovery of 4,7-Diamino-5-(4-phenoxyphenyl)-6-methylene-pyrimido[5,4- b]pyrrolizines as Novel Bruton's Tyrosine Kinase Inhibitors.

Xue Y, Song P, Song Z, Wang A, Tong L, Geng M, Ding J, Liu Q, Sun L, Xie H, Zhang A.

J Med Chem. 2018 May 24;61(10):4608-4627. doi: 10.1021/acs.jmedchem.8b00441. Epub 2018 May 9.


Design, synthesis and pharmacological evaluation of ALK and Hsp90 dual inhibitors bearing resorcinol and 2,4-diaminopyrimidine motifs.

Geng K, Liu H, Song Z, Zhang C, Zhang M, Yang H, Cao J, Geng M, Shen A, Zhang A.

Eur J Med Chem. 2018 May 25;152:76-86. doi: 10.1016/j.ejmech.2018.04.019. Epub 2018 Apr 11.


Total synthesis of (±)-tanshinol B, tanshinone I, and (±)-tanshindiol B and C.

Wang F, Yang H, Yu S, Xue Y, Fan Z, Liang G, Geng M, Zhang A, Ding C.

Org Biomol Chem. 2018 May 9;16(18):3376-3381. doi: 10.1039/c8ob00567b.


(-)-Epigallocatechin-3-Gallate Ameliorates Atherosclerosis and Modulates Hepatic Lipid Metabolic Gene Expression in Apolipoprotein E Knockout Mice: Involvement of TTC39B.

Pan LL, Wu Y, Wang RQ, Chen JW, Chen J, Zhang Y, Chen YJ, Geng M, Xu ZD, Dai M, Li JH, Wang W, Zhang ZZ.

Front Pharmacol. 2018 Mar 9;9:195. doi: 10.3389/fphar.2018.00195. eCollection 2018. Erratum in: Front Pharmacol. 2018 May 01;9:459.


Prevalence of and risk factors for tuberculosis among healthcare workers in Chinese tuberculosis facilities.

Wang XN, He TL, Geng MJ, Song YD, Wang JC, Liu M, Hoosdally SJ, Cruz ALG, Zhao F, Pang Y, Zhao YL, He GX.

Infect Dis Poverty. 2018 Mar 24;7(1):26. doi: 10.1186/s40249-018-0407-6.


Discovery and Optimization of Phosphopantetheine Adenylyltransferase Inhibitors with Gram-Negative Antibacterial Activity.

Skepper CK, Moreau RJ, Appleton BA, Benton BM, Drumm JE 3rd, Feng BY, Geng M, Hu C, Li C, Lingel A, Lu Y, Mamo M, Mergo W, Mostafavi M, Rath CM, Steffek M, Takeoka KT, Uehara K, Wang L, Wei JR, Xie L, Xu W, Zhang Q, de Vicente J.

J Med Chem. 2018 Apr 26;61(8):3325-3349. doi: 10.1021/acs.jmedchem.7b01861. Epub 2018 Apr 13.


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