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Items: 1 to 50 of 63

1.

Identification of reference genes for RT-qPCR data normalisation in aging studies.

González-Bermúdez L, Anglada T, Genescà A, Martín M, Terradas M.

Sci Rep. 2019 Sep 27;9(1):13970. doi: 10.1038/s41598-019-50035-0.

2.

Delayed γH2AX foci disappearance in mammary epithelial cells from aged women reveals an age-associated DNA repair defect.

Anglada T, Repullés J, Espinal A, LaBarge MA, Stampfer MR, Genescà A, Martín M.

Aging (Albany NY). 2019 Mar 14;11(5):1510-1523. doi: 10.18632/aging.101849.

3.

Radiation-Induced Malignant Transformation of Preneoplastic and Normal Breast Primary Epithelial Cells.

Repullés J, Anglada T, Soler D, Ramírez JC, Genescà A, Terradas M.

Mol Cancer Res. 2019 Apr;17(4):937-948. doi: 10.1158/1541-7786.MCR-18-0938. Epub 2019 Jan 16.

PMID:
30651374
4.

Detection of Impaired DNA Replication and Repair in Micronuclei as Indicators of Genomic Instability and Chromothripsis.

Terradas M, Martín M, Genescà A.

Methods Mol Biol. 2018;1769:197-208. doi: 10.1007/978-1-4939-7780-2_13.

PMID:
29564826
5.

Distinct Sets of lncRNAs are Differentially Modulated after Exposure to High and Low Doses of X Rays.

Terradas M, Martín M, Repullès J, Huarte M, Genescà A.

Radiat Res. 2016 Dec;186(6):549-558. doi: 10.1667/RR14377.1. Epub 2016 Nov 14.

PMID:
27841703
6.

Impaired nuclear functions in micronuclei results in genome instability and chromothripsis.

Terradas M, Martín M, Genescà A.

Arch Toxicol. 2016 Nov;90(11):2657-2667. Epub 2016 Aug 19. Review.

PMID:
27542123
7.

Analysis of Residual DSBs in Ataxia-Telangiectasia Lymphoblast Cells Initiating Apoptosis.

Anglada T, Terradas M, Hernández L, Genescà A, Martín M.

Biomed Res Int. 2016;2016:8279560. doi: 10.1155/2016/8279560. Epub 2016 Jan 6.

8.

Chromosome Bridges Maintain Kinetochore-Microtubule Attachment throughout Mitosis and Rarely Break during Anaphase.

Pampalona J, Roscioli E, Silkworth WT, Bowden B, Genescà A, Tusell L, Cimini D.

PLoS One. 2016 Jan 19;11(1):e0147420. doi: 10.1371/journal.pone.0147420. eCollection 2016.

9.

Breast primary epithelial cells that escape p16-dependent stasis enter a telomere-driven crisis state.

Feijoo P, Terradas M, Soler D, Domínguez D, Tusell L, Genescà A.

Breast Cancer Res. 2016 Jan 13;18(1):7. doi: 10.1186/s13058-015-0667-z.

10.

Centrosome aberrations in human mammary epithelial cells driven by cooperative interactions between p16INK4a deficiency and telomere-dependent genotoxic stress.

Domínguez D, Feijoo P, Bernal A, Ercilla A, Agell N, Genescà A, Tusell L.

Oncotarget. 2015 Sep 29;6(29):28238-56. doi: 10.18632/oncotarget.4958.

11.

Genomic instability: Crossing pathways at the origin of structural and numerical chromosome changes.

Russo A, Pacchierotti F, Cimini D, Ganem NJ, Genescà A, Natarajan AT, Pavanello S, Valle G, Degrassi F.

Environ Mol Mutagen. 2015 Aug;56(7):563-80. doi: 10.1002/em.21945. Epub 2015 Mar 18. Review.

PMID:
25784636
12.

Aging and radiation: bad companions.

Hernández L, Terradas M, Camps J, Martín M, Tusell L, Genescà A.

Aging Cell. 2015 Apr;14(2):153-61. doi: 10.1111/acel.12306. Epub 2015 Feb 2. Review.

13.

γH2AX foci on apparently intact mitotic chromosomes: not signatures of misrejoining events but signals of unresolved DNA damage.

Martín M, Terradas M, Hernández L, Genescà A.

Cell Cycle. 2014;13(19):3026-36. doi: 10.4161/15384101.2014.947786.

14.

Telomere-dependent genomic integrity: evolution of the fusion-bridge-breakage cycle concept.

Feijoo P, Dominguez D, Tusell L, Genesca A.

Curr Pharm Des. 2014;20(41):6375-85. Review.

PMID:
24975612
15.

Highly sensitive automated method for DNA damage assessment: gamma-H2AX foci counting and cell cycle sorting.

Hernández L, Terradas M, Martín M, Tusell L, Genescà A.

Int J Mol Sci. 2013 Jul 30;14(8):15810-26. doi: 10.3390/ijms140815810.

16.

Increased mammogram-induced DNA damage in mammary epithelial cells aged in vitro.

Hernández L, Terradas M, Martín M, Feijoo P, Soler D, Tusell L, Genescà A.

PLoS One. 2013 May 7;8(5):e63052. doi: 10.1371/journal.pone.0063052. Print 2013.

17.

Is DNA damage response ready for action anywhere?

Terradas M, Martín M, Hernández L, Tusell L, Genescà A.

Int J Mol Sci. 2012;13(9):11569-83. doi: 10.3390/ijms130911569. Epub 2012 Sep 14. Review.

18.

Telomere dysfunction and genome instability.

Frias C, Pampalona J, Genesca A, Tusell L.

Front Biosci (Landmark Ed). 2012 Jun 1;17:2181-96. Review.

PMID:
22652771
19.

Progressive telomere dysfunction causes cytokinesis failure and leads to the accumulation of polyploid cells.

Pampalona J, Frías C, Genescà A, Tusell L.

PLoS Genet. 2012;8(4):e1002679. doi: 10.1371/journal.pgen.1002679. Epub 2012 Apr 26.

20.

ATM and DNA-PKcs make a complementary couple in DNA double strand break repair.

Martín M, Terradas M, Tusell L, Genescà A.

Mutat Res Rev Mutat Res. 2012 Jul-Sep;751(1):29-35. doi: 10.1016/j.mrrev.2011.12.006. Epub 2012 Jan 2.

PMID:
22230547
21.

Nuclear envelope defects impede a proper response to micronuclear DNA lesions.

Terradas M, Martín M, Hernández L, Tusell L, Genescà A.

Mutat Res. 2012 Jan 3;729(1-2):35-40. doi: 10.1016/j.mrfmmm.2011.09.003. Epub 2011 Sep 16.

PMID:
21945242
22.

Role of telomere dysfunction in genetic intratumor diversity.

Genescà A, Pampalona J, Frías C, Domínguez D, Tusell L.

Adv Cancer Res. 2011;112:11-41. doi: 10.1016/B978-0-12-387688-1.00002-8. Review.

PMID:
21925300
23.

Different outcomes of telomere-dependent anaphase bridges.

Tusell L, Pampalona J, Soler D, Frías C, Genescà A.

Biochem Soc Trans. 2010 Dec;38(6):1698-703. doi: 10.1042/BST0381698.

PMID:
21118150
24.

Genetic activities in micronuclei: is the DNA entrapped in micronuclei lost for the cell?

Terradas M, Martín M, Tusell L, Genescà A.

Mutat Res. 2010 Jul-Sep;705(1):60-7. doi: 10.1016/j.mrrev.2010.03.004. Epub 2010 Mar 20. Review.

PMID:
20307686
25.

Whole chromosome loss is promoted by telomere dysfunction in primary cells.

Pampalona J, Soler D, Genescà A, Tusell L.

Genes Chromosomes Cancer. 2010 Apr;49(4):368-78. doi: 10.1002/gcc.20749.

PMID:
20088004
26.

Telomere dysfunction and chromosome structure modulate the contribution of individual chromosomes in abnormal nuclear morphologies.

Pampalona J, Soler D, Genescà A, Tusell L.

Mutat Res. 2010 Jan 5;683(1-2):16-22. doi: 10.1016/j.mrfmmm.2009.10.001.

PMID:
19822157
27.

DNA lesions sequestered in micronuclei induce a local defective-damage response.

Terradas M, Martín M, Tusell L, Genescà A.

DNA Repair (Amst). 2009 Oct 2;8(10):1225-34. doi: 10.1016/j.dnarep.2009.07.004. Epub 2009 Aug 14.

PMID:
19683478
28.

Radiation sensitivity increases with proliferation-associated telomere dysfunction in nontransformed human epithelial cells.

Soler D, Pampalona J, Tusell L, Genescà A.

Aging Cell. 2009 Aug;8(4):414-25. doi: 10.1111/j.1474-9726.2009.00488.x. Epub 2009 May 16.

29.

Breaks invisible to the DNA damage response machinery accumulate in ATM-deficient cells.

Martín M, Terradas M, Iliakis G, Tusell L, Genescà A.

Genes Chromosomes Cancer. 2009 Sep;48(9):745-59. doi: 10.1002/gcc.20679.

PMID:
19455703
30.

The number of dysfunctional telomeres in a cell: one amplifies; more than one translocate.

Tusell L, Soler D, Agostini M, Pampalona J, Genescà A.

Cytogenet Genome Res. 2008;122(3-4):315-25. doi: 10.1159/000167818. Epub 2009 Jan 30. Review.

PMID:
19188701
31.

Telomere dysfunction: a new player in radiation sensitivity.

Genescà A, Martín M, Latre L, Soler D, Pampalona J, Tusell L.

Bioessays. 2006 Dec;28(12):1172-80. Review.

PMID:
17120191
32.

Postreplicative joining of DNA double-strand breaks causes genomic instability in DNA-PKcs-deficient mouse embryonic fibroblasts.

Martín M, Genescà A, Latre L, Jaco I, Taccioli GE, Egozcue J, Blasco MA, Iliakis G, Tusell L.

Cancer Res. 2005 Nov 15;65(22):10223-32.

33.

Telomere dysfunction drives chromosomal instability in human mammary epithelial cells.

Soler D, Genescà A, Arnedo G, Egozcue J, Tusell L.

Genes Chromosomes Cancer. 2005 Dec;44(4):339-50.

PMID:
16052508
34.

Capping of radiation-induced DNA breaks in mouse early embryos.

Tusell L, Latre L, Ponsa I, Miró R, Egozcue J, Genescà A.

J Radiat Res. 2004 Sep;45(3):415-22.

35.

Repair of DNA broken ends is similar in embryonic fibroblasts with and without telomerase.

Latre L, Genescà A, Martín M, Ribas M, Egozcue J, Blasco MA, Tusell L.

Radiat Res. 2004 Aug;162(2):136-42.

PMID:
15387140
36.

A keratin K5Cre transgenic line appropriate for tissue-specific or generalized Cre-mediated recombination.

Ramirez A, Page A, Gandarillas A, Zanet J, Pibre S, Vidal M, Tusell L, Genesca A, Whitaker DA, Melton DW, Jorcano JL.

Genesis. 2004 May;39(1):52-7.

PMID:
15124227
37.

Shortened telomeres join to DNA breaks interfering with their correct repair.

Latre L, Tusell L, Martin M, Miró R, Egozcue J, Blasco MA, Genescà A.

Exp Cell Res. 2003 Jul 15;287(2):282-8.

PMID:
12837284
38.

Radiation-induced chromosome breaks in ataxia-telangiectasia cells remain open.

Martín M, Genescà A, Latre L, Ribas M, Miró R, Egozcue J, Tusell L.

Int J Radiat Biol. 2003 Mar;79(3):203-10.

PMID:
12745885
39.

DBD-fish on neutral comets: simultaneous analysis of DNA single- and double-strand breaks in individual cells.

Fernández JL, Vázquez-Gundín F, Rivero MT, Genescá A, Gosálvez J, Goyanes V.

Exp Cell Res. 2001 Oct 15;270(1):102-9.

PMID:
11597132
40.
41.

Absence of chromosomal instability in spermatozoa of men affected by testicular cancer.

Alvarez R, Tusell L, Genescà A, Miró R, Garcia-del-Muro X, Egozcue J.

Hum Reprod. 1999 Jan;14(1):247-51.

PMID:
10374129
42.

A new assay to asses aneuploidy in human-hamster embryos.

Ponsa I, Tusell L, Alvarez R, Genescà A, Miró R, Egozcue J.

Adv Exp Med Biol. 1998;444:185-90.

PMID:
10026948
43.

Hamster origin of metaphases with multiple chromosome rearrangements in first cleavage human-hamster embryos.

Alvarez R, Tusell L, Genescà A, Miró R, Caballín MR, Benet J, Egozcue J.

Hum Reprod. 1997 Oct;12(10):2176-82.

PMID:
9402278
44.

Dose-response relationship for the induction of chromosomal abnormalities in gamma-irradiated human spermatozoa.

Alvarez R, Tusell L, Miró R, Genescà A, Caballín MR, Ribas M, Barquinero JF, Egozcue J.

Environ Mol Mutagen. 1997;29(4):357-66.

PMID:
9212786
45.

Chromosome aberrations in human spermatozoa treated with Ca2+ ionophore A23187.

Alvarez R, Tusell L, Genescà A, Miró R, Benet J, Caballín MR, Egozcue J.

Mol Hum Reprod. 1996 Jul;2(7):481-4.

PMID:
9239656
46.

Analysis of radiation-induced micronuclei in two-cell human-hamster embryos using telomeric and centromeric FISH probes.

Tusell L, Alvarez R, Genescà A, Caballín MR, Miró R, Egozcue J.

Cytogenet Cell Genet. 1996;74(1-2):102-6.

PMID:
8893812
47.

Induction of micronuclei in human sperm-hamster egg hybrids at the two-cell stage after in vitro gamma-irradiation of human spermatozoa.

Tusell L, Alvarez R, Caballín MR, Genescà A, Miró R, Ribas M, Egozcue J.

Environ Mol Mutagen. 1995;26(4):315-23.

PMID:
8575420
48.

Human origin of micronuclei in human x hamster two-cell embryos.

Tusell L, Alvarez R, Genescà A, Caballín MR, Miró R, Barrios L, Egozcue J.

Cytogenet Cell Genet. 1995;70(1-2):41-4.

PMID:
7736786
49.

Repair of human sperm chromosome aberrations in the hamster egg.

Genescà A, Caballín MR, Miró R, Benet J, Germà JR, Egozcue J.

Hum Genet. 1992 May;89(2):181-6.

PMID:
1587529
50.

Cytogenetic studies in motile sperm from normal men.

Benet J, Genescà A, Navarro J, Egozcue J, Templado C.

Hum Genet. 1992 May;89(2):176-80.

PMID:
1587528

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