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Items: 30


Bait Correlation Improves Interactor Identification by Tandem Mass Tag-Affinity Purification-Mass Spectrometry.

Mei L, Montoya MR, Quanrud GM, Tran M, Villa-Sharma A, Huang M, Genereux JC.

J Proteome Res. 2020 Apr 3;19(4):1565-1573. doi: 10.1021/acs.jproteome.9b00825. Epub 2020 Mar 25.


Mass spectrometric approaches for profiling protein folding and stability.

Genereux JC.

Adv Protein Chem Struct Biol. 2019;118:111-144. doi: 10.1016/bs.apcsb.2019.09.006. Epub 2019 Nov 26. Review.


Protein profiling and pseudo-parallel reaction monitoring to monitor a fusion-associated conformational change in hemagglutinin.

Nguyen KK, Thurmond S, Hai R, Genereux JC.

Anal Bioanal Chem. 2019 Jul;411(19):4987-4998. doi: 10.1007/s00216-019-01921-z. Epub 2019 Jun 28.


Quantitative Interactome Proteomics Reveals a Molecular Basis for ATF6-Dependent Regulation of a Destabilized Amyloidogenic Protein.

Plate L, Rius B, Nguyen B, Genereux JC, Kelly JW, Wiseman RL.

Cell Chem Biol. 2019 Jul 18;26(7):913-925.e4. doi: 10.1016/j.chembiol.2019.04.001. Epub 2019 May 16.


XBP1s activation can globally remodel N-glycan structure distribution patterns.

Wong MY, Chen K, Antonopoulos A, Kasper BT, Dewal MB, Taylor RJ, Whittaker CA, Hein PP, Dell A, Genereux JC, Haslam SM, Mahal LK, Shoulders MD.

Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10089-E10098. doi: 10.1073/pnas.1805425115. Epub 2018 Oct 10.


Mapping wild-type and R345W fibulin-3 intracellular interactomes.

Hulleman JD, Genereux JC, Nguyen A.

Exp Eye Res. 2016 Dec;153:165-169. doi: 10.1016/j.exer.2016.10.017. Epub 2016 Oct 21. Review.


Endoplasmic Reticulum Proteostasis Influences the Oligomeric State of an Amyloidogenic Protein Secreted from Mammalian Cells.

Chen JJ, Genereux JC, Suh EH, Vartabedian VF, Rius B, Qu S, Dendle MTA, Kelly JW, Wiseman RL.

Cell Chem Biol. 2016 Oct 20;23(10):1282-1293. doi: 10.1016/j.chembiol.2016.09.001. Epub 2016 Oct 6.


Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation.

Plate L, Cooley CB, Chen JJ, Paxman RJ, Gallagher CM, Madoux F, Genereux JC, Dobbs W, Garza D, Spicer TP, Scampavia L, Brown SJ, Rosen H, Powers ET, Walter P, Hodder P, Wiseman RL, Kelly JW.

Elife. 2016 Jul 20;5. pii: e15550. doi: 10.7554/eLife.15550.


A fluorogenic aryl fluorosulfate for intraorganellar transthyretin imaging in living cells and in Caenorhabditis elegans.

Baranczak A, Liu Y, Connelly S, Du WG, Greiner ER, Genereux JC, Wiseman RL, Eisele YS, Bradbury NC, Dong J, Noodleman L, Sharpless KB, Wilson IA, Encalada SE, Kelly JW.

J Am Chem Soc. 2015 Jun 17;137(23):7404-14. doi: 10.1021/jacs.5b03042. Epub 2015 Jun 8.


Endoplasmic reticulum quality control and systemic amyloid disease: Impacting protein stability from the inside out.

Chen JJ, Genereux JC, Wiseman RL.

IUBMB Life. 2015 Jun;67(6):404-13. doi: 10.1002/iub.1386. Epub 2015 May 26. Review.


Regulating extracellular proteostasis capacity through the unfolded protein response.

Genereux JC, Wiseman RL.

Prion. 2015;9(1):10-21. doi: 10.1080/19336896.2015.1011887.


ATF6 activation reduces the secretion and extracellular aggregation of destabilized variants of an amyloidogenic protein.

Chen JJ, Genereux JC, Qu S, Hulleman JD, Shoulders MD, Wiseman RL.

Chem Biol. 2014 Nov 20;21(11):1564-74. doi: 10.1016/j.chembiol.2014.09.009. Epub 2014 Oct 23.


Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis.

Genereux JC, Qu S, Zhou M, Ryno LM, Wang S, Shoulders MD, Kaufman RJ, Lasm├ęzas CI, Kelly JW, Wiseman RL.

EMBO J. 2015 Jan 2;34(1):4-19. doi: 10.15252/embj.201488896. Epub 2014 Oct 31.


ERdj3 is an endoplasmic reticulum degradation factor for mutant glucocerebrosidase variants linked to Gaucher's disease.

Tan YL, Genereux JC, Pankow S, Aerts JM, Yates JR 3rd, Kelly JW.

Chem Biol. 2014 Aug 14;21(8):967-76. doi: 10.1016/j.chembiol.2014.06.008.


Heat-shock response transcriptional program enables high-yield and high-quality recombinant protein production in Escherichia coli.

Zhang X, Liu Y, Genereux JC, Nolan C, Singh M, Kelly JW.

ACS Chem Biol. 2014 Sep 19;9(9):1945-9. doi: 10.1021/cb5004477. Epub 2014 Aug 2.


Characterizing the altered cellular proteome induced by the stress-independent activation of heat shock factor 1.

Ryno LM, Genereux JC, Naito T, Morimoto RI, Powers ET, Shoulders MD, Wiseman RL.

ACS Chem Biol. 2014 Jun 20;9(6):1273-83. doi: 10.1021/cb500062n. Epub 2014 Apr 16.


Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts.

Liu Y, Tan YL, Zhang X, Bhabha G, Ekiert DC, Genereux JC, Cho Y, Kipnis Y, Bjelic S, Baker D, Kelly JW.

Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4449-54. doi: 10.1073/pnas.1323268111. Epub 2014 Mar 3.


Stress-regulated translational attenuation adapts mitochondrial protein import through Tim17A degradation.

Rainbolt TK, Atanassova N, Genereux JC, Wiseman RL.

Cell Metab. 2013 Dec 3;18(6):908-19. doi: 10.1016/j.cmet.2013.11.006.


Induced pluripotent stem cell modeling of multisystemic, hereditary transthyretin amyloidosis.

Leung A, Nah SK, Reid W, Ebata A, Koch CM, Monti S, Genereux JC, Wiseman RL, Wolozin B, Connors LH, Berk JL, Seldin DC, Mostoslavsky G, Kotton DN, Murphy GJ.

Stem Cell Reports. 2013 Oct 31;1(5):451-63. doi: 10.1016/j.stemcr.2013.10.003. eCollection 2013.


Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis.

Suh EH, Liu Y, Connelly S, Genereux JC, Wilson IA, Kelly JW.

J Am Chem Soc. 2013 Nov 27;135(47):17869-80. doi: 10.1021/ja408230k. Epub 2013 Nov 18.


Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments.

Shoulders MD, Ryno LM, Genereux JC, Moresco JJ, Tu PG, Wu C, Yates JR 3rd, Su AI, Kelly JW, Wiseman RL.

Cell Rep. 2013 Apr 25;3(4):1279-92. doi: 10.1016/j.celrep.2013.03.024. Epub 2013 Apr 11.


Single-step charge transport through DNA over long distances.

Genereux JC, Wuerth SM, Barton JK.

J Am Chem Soc. 2011 Mar 23;133(11):3863-8. doi: 10.1021/ja107033v. Epub 2011 Feb 24.


Chemically targeting the emergent properties of a chaperone complex.

Genereux JC, Wiseman RL.

Chem Biol. 2011 Feb 25;18(2):144-5. doi: 10.1016/j.chembiol.2011.02.002.


Mechanisms for DNA charge transport.

Genereux JC, Barton JK.

Chem Rev. 2010 Mar 10;110(3):1642-62. doi: 10.1021/cr900228f. Review. No abstract available.


DNA-mediated charge transport in redox sensing and signaling.

Genereux JC, Boal AK, Barton JK.

J Am Chem Soc. 2010 Jan 27;132(3):891-905. doi: 10.1021/ja907669c.


Redox signaling between DNA repair proteins for efficient lesion detection.

Boal AK, Genereux JC, Sontz PA, Gralnick JA, Newman DK, Barton JK.

Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15237-42. doi: 10.1073/pnas.0908059106. Epub 2009 Aug 31.


Molecular electronics: DNA charges ahead.

Genereux JC, Barton JK.

Nat Chem. 2009 May;1(2):106-7. doi: 10.1038/nchem.188. No abstract available.


Ping-pong electron transfer through DNA.

Elias B, Genereux JC, Barton JK.

Angew Chem Int Ed Engl. 2008;47(47):9067-70. doi: 10.1002/anie.200803556. No abstract available.


Back-electron transfer suppresses the periodic length dependence of DNA-mediated charge transport across adenine tracts.

Genereux JC, Augustyn KE, Davis ML, Shao F, Barton JK.

J Am Chem Soc. 2008 Nov 12;130(45):15150-6. doi: 10.1021/ja8052738. Epub 2008 Oct 15.


Distance-independent DNA charge transport across an adenine tract.

Augustyn KE, Genereux JC, Barton JK.

Angew Chem Int Ed Engl. 2007;46(30):5731-3. No abstract available.


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