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Items: 7

1.

Refining Liver Safety Risk Assessment: Application of Mechanistic Modeling and Serum Biomarkers to Cimaglermin Alfa (GGF2) Clinical Trials.

Longo DM, Generaux GT, Howell BA, Siler SQ, Antoine DJ, Button D, Caggiano A, Eisen A, Iaci J, Stanulis R, Parry T, Mosedale M, Watkins PB.

Clin Pharmacol Ther. 2017 Dec;102(6):961-969. doi: 10.1002/cpt.711. Epub 2017 May 27.

2.

Impact of physiologically based pharmacokinetic modeling and simulation in drug development.

Shardlow CE, Generaux GT, Patel AH, Tai G, Tran T, Bloomer JC.

Drug Metab Dispos. 2013 Dec;41(12):1994-2003. doi: 10.1124/dmd.113.052803. Epub 2013 Sep 5.

PMID:
24009310
3.

In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitor.

Reese MJ, Savina PM, Generaux GT, Tracey H, Humphreys JE, Kanaoka E, Webster LO, Harmon KA, Clarke JD, Polli JW.

Drug Metab Dispos. 2013 Feb;41(2):353-61. doi: 10.1124/dmd.112.048918. Epub 2012 Nov 6.

PMID:
23132334
4.

Utilizing drug-drug interaction prediction tools during drug development: enhanced decision making based on clinical risk.

Shardlow CE, Generaux GT, MacLauchlin CC, Pons N, Skordos KW, Bloomer JC.

Drug Metab Dispos. 2011 Nov;39(11):2076-84. doi: 10.1124/dmd.111.039214. Epub 2011 Aug 10.

PMID:
21832001
5.

Impact of SLCO1B1 (OATP1B1) and ABCG2 (BCRP) genetic polymorphisms and inhibition on LDL-C lowering and myopathy of statins.

Generaux GT, Bonomo FM, Johnson M, Doan KM.

Xenobiotica. 2011 Aug;41(8):639-51. doi: 10.3109/00498254.2011.562566. Epub 2011 Mar 22. Review.

PMID:
21425956
6.

Use of cassette dosing in sandwich-cultured rat and human hepatocytes to identify drugs that inhibit bile acid transport.

Wolf KK, Vora S, Webster LO, Generaux GT, Polli JW, Brouwer KL.

Toxicol In Vitro. 2010 Feb;24(1):297-309. doi: 10.1016/j.tiv.2009.08.009. Epub 2009 Aug 23.

7.

An in vitro mechanistic study to elucidate the desipramine/bupropion clinical drug-drug interaction.

Reese MJ, Wurm RM, Muir KT, Generaux GT, St John-Williams L, McConn DJ.

Drug Metab Dispos. 2008 Jul;36(7):1198-201. doi: 10.1124/dmd.107.020198. Epub 2008 Apr 17.

PMID:
18420781

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