Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 421

1.

Broad-spectrum antivirals.

Edagwa BJ, Gendelman HE.

Nat Mater. 2018 Feb;17(2):114-116. doi: 10.1038/nmat5064. No abstract available.

PMID:
31745273
2.

Synthesis and Characterization of Long Acting Darunavir Prodrugs.

Banoub MG, Bade AN, Lin Z, Cobb D, Gautam N, Dyavar Shetty BL, Wojtkiewicz M, Alnouti Y, McMillan J, Gendelman HE, Edagwa B.

Mol Pharm. 2019 Nov 19. doi: 10.1021/acs.molpharmaceut.9b00871. [Epub ahead of print]

PMID:
31742407
3.

Predictive biomarkers for cognitive decline during progressive HIV infection.

Gendelman HE.

EBioMedicine. 2019 Nov 14. pii: S2352-3964(19)30741-8. doi: 10.1016/j.ebiom.2019.10.064. [Epub ahead of print] No abstract available.

4.

A Synthetic Agonist to Vasoactive Intestinal Peptide Receptor-2 Induces Regulatory T Cell Neuroprotective Activities in Models of Parkinson's Disease.

Mosley RL, Lu Y, Olson KE, Machhi J, Yan W, Namminga KL, Smith JR, Shandler SJ, Gendelman HE.

Front Cell Neurosci. 2019 Sep 18;13:421. doi: 10.3389/fncel.2019.00421. eCollection 2019.

5.

A long acting nanoformulated lamivudine ProTide.

Smith N, Bade AN, Soni D, Gautam N, Alnouti Y, Herskovitz J, Ibrahim IM, Wojtkiewicz MS, Dyavar Shetty BL, McMillan J, Gendelman HE, Edagwa B.

Biomaterials. 2019 Dec;223:119476. doi: 10.1016/j.biomaterials.2019.119476. Epub 2019 Sep 5.

PMID:
31525692
6.

Synthesis and characterization of a long-acting emtricitabine prodrug nanoformulation.

Ibrahim IM, Bade AN, Lin Z, Soni D, Wojtkiewicz M, Dyavar Shetty BL, Gautam N, McMillan JM, Alnouti Y, Edagwa BJ, Gendelman HE.

Int J Nanomedicine. 2019 Aug 7;14:6231-6247. doi: 10.2147/IJN.S215447. eCollection 2019.

7.

Creation of a long-acting rilpivirine prodrug nanoformulation.

Hilaire JR, Bade AN, Sillman B, Gautam N, Herskovitz J, Dyavar Shetty BL, Wojtkiewicz MS, Szlachetka A, Lamberty BG, Sravanam S, Fox HS, Alnouti Y, Dash PK, McMillan JM, Edagwa BJ, Gendelman HE.

J Control Release. 2019 Sep 3;311-312:201-211. doi: 10.1016/j.jconrel.2019.09.001. [Epub ahead of print]

PMID:
31491432
8.

Synthesis of a long acting nanoformulated emtricitabine ProTide.

Soni D, Bade AN, Gautam N, Herskovitz J, Ibrahim IM, Smith N, Wojtkiewicz MS, Dyavar Shetty BL, Alnouti Y, McMillan J, Gendelman HE, Edagwa BJ.

Biomaterials. 2019 Nov;222:119441. doi: 10.1016/j.biomaterials.2019.119441. Epub 2019 Aug 20.

PMID:
31472458
9.

Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice.

Dash PK, Kaminski R, Bella R, Su H, Mathews S, Ahooyi TM, Chen C, Mancuso P, Sariyer R, Ferrante P, Donadoni M, Robinson JA, Sillman B, Lin Z, Hilaire JR, Banoub M, Elango M, Gautam N, Mosley RL, Poluektova LY, McMillan J, Bade AN, Gorantla S, Sariyer IK, Burdo TH, Young WB, Amini S, Gordon J, Jacobson JM, Edagwa B, Khalili K, Gendelman HE.

Nat Commun. 2019 Jul 2;10(1):2753. doi: 10.1038/s41467-019-10366-y.

10.

The Promise of Long-Acting Antiretroviral Therapies: From Need to Manufacture.

Gendelman HE, McMillan J, Bade AN, Edagwa B, Kevadiya BD.

Trends Microbiol. 2019 Jul;27(7):593-606. doi: 10.1016/j.tim.2019.02.009. Epub 2019 Apr 10. Review.

PMID:
30981593
11.

Immune Activations and Viral Tissue Compartmentalization During Progressive HIV-1 Infection of Humanized Mice.

Su H, Cheng Y, Sravanam S, Mathews S, Gorantla S, Poluektova LY, Dash PK, Gendelman HE.

Front Immunol. 2019 Feb 28;10:340. doi: 10.3389/fimmu.2019.00340. eCollection 2019.

12.

Human Interleukin-34 facilitates microglia-like cell differentiation and persistent HIV-1 infection in humanized mice.

Mathews S, Branch Woods A, Katano I, Makarov E, Thomas MB, Gendelman HE, Poluektova LY, Ito M, Gorantla S.

Mol Neurodegener. 2019 Mar 5;14(1):12. doi: 10.1186/s13024-019-0311-y.

13.

In Appreciation for a Job Well Done!

Gendelman HE, Taylor R.

J Neuroimmune Pharmacol. 2019 Mar;14(1):1. doi: 10.1007/s11481-019-09838-1. No abstract available.

PMID:
30734895
14.

Surface-engineered multimodal magnetic nanoparticles to manage CNS diseases.

Tomitaka A, Kaushik A, Kevadiya BD, Mukadam I, Gendelman HE, Khalili K, Liu G, Nair M.

Drug Discov Today. 2019 Mar;24(3):873-882. doi: 10.1016/j.drudis.2019.01.006. Epub 2019 Jan 17. Review.

PMID:
30660756
15.

Broad Spectrum Mixed Lineage Kinase Type 3 Inhibition and HIV-1 Persistence in Macrophages.

Saminathan P, Kevadiya BD, Marker DF, Gendelman HE, Gorantla S, Gelbard HA.

J Neuroimmune Pharmacol. 2019 Mar;14(1):44-51. doi: 10.1007/s11481-018-09829-8. Epub 2019 Jan 7. Review.

PMID:
30617749
16.

Neurotheranostics as personalized medicines.

Kevadiya BD, Ottemann BM, Thomas MB, Mukadam I, Nigam S, McMillan J, Gorantla S, Bronich TK, Edagwa B, Gendelman HE.

Adv Drug Deliv Rev. 2018 Oct 26. pii: S0169-409X(18)30261-8. doi: 10.1016/j.addr.2018.10.011. [Epub ahead of print] Review.

17.

Biodegradable polyanhydride-based nanomedicines for blood to brain drug delivery.

Brenza TM, Schlichtmann BW, Bhargavan B, Vela Ramirez JE, Nelson RD, Panthani MG, McMillan JM, Kalyanaraman B, Gendelman HE, Anantharam V, Kanthasamy AG, Mallapragada SK, Narasimhan B, Kanmogne GD.

J Biomed Mater Res A. 2018 Nov;106(11):2881-2890. doi: 10.1002/jbm.a.36477. Epub 2018 Oct 26.

18.

Moving toward Tuberculosis Elimination. Critical Issues for Research in Diagnostics and Therapeutics for Tuberculosis Infection.

Keshavjee S, Amanullah F, Cattamanchi A, Chaisson R, Dobos KM, Fox GJ, Gendelman HE, Gordon R, Hesseling A, Le Van H, Kampmann B, Kana B, Khuller G, Lewinsohn DM, Lewinsohn DA, Lin PL, Lu LL, Maartens G, Owen A, Protopopova M, Rengarajan J, Rubin E, Salgame P, Schurr E, Seddon JA, Swindells S, Tobin DM, Udwadia Z, Walzl G, Srinivasan S, Rustomjee R, Nahid P.

Am J Respir Crit Care Med. 2019 Mar 1;199(5):564-571. doi: 10.1164/rccm.201806-1053PP. No abstract available.

19.

Pharmacokinetic testing of a first-generation cabotegravir prodrug in rhesus macaques.

McMillan J, Szlachetka A, Zhou T, Morsey B, Lamberty B, Callen S, Gautam N, Alnouti Y, Edagwa B, Gendelman HE, Fox HS.

AIDS. 2019 Mar 1;33(3):585-588. doi: 10.1097/QAD.0000000000002032.

PMID:
30289818
20.

Bioimaging predictors of rilpivirine biodistribution and antiretroviral activities.

Ottemann BM, Helmink AJ, Zhang W, Mukadam I, Woldstad C, Hilaire JR, Liu Y, McMillan JM, Edagwa BJ, Mosley RL, Garrison JC, Kevadiya BD, Gendelman HE.

Biomaterials. 2018 Dec;185:174-193. doi: 10.1016/j.biomaterials.2018.09.018. Epub 2018 Sep 14.

PMID:
30245386
21.

Modulating cellular autophagy for controlled antiretroviral drug release.

Thomas MB, Gnanadhas DP, Dash PK, Machhi J, Lin Z, McMillan J, Edagwa B, Gelbard H, Gendelman HE, Gorantla S.

Nanomedicine (Lond). 2018 Sep;13(17):2139-2154. doi: 10.2217/nnm-2018-0224. Epub 2018 Aug 21.

22.

Nanoformulated Antiretroviral Therapy Attenuates Brain Metabolic Oxidative Stress.

Montenegro-Burke JR, Woldstad CJ, Fang M, Bade AN, McMillan J, Edagwa B, Boska MD, Gendelman HE, Siuzdak G.

Mol Neurobiol. 2019 Apr;56(4):2896-2907. doi: 10.1007/s12035-018-1273-8. Epub 2018 Aug 1.

23.

ProTide generated long-acting abacavir nanoformulations.

Lin Z, Gautam N, Alnouti Y, McMillan J, Bade AN, Gendelman HE, Edagwa B.

Chem Commun (Camb). 2018 Jul 24;54(60):8371-8374. doi: 10.1039/c8cc04708a.

24.

EcoHIV infection of mice establishes latent viral reservoirs in T cells and active viral reservoirs in macrophages that are sufficient for induction of neurocognitive impairment.

Gu CJ, Borjabad A, Hadas E, Kelschenbach J, Kim BH, Chao W, Arancio O, Suh J, Polsky B, McMillan J, Edagwa B, Gendelman HE, Potash MJ, Volsky DJ.

PLoS Pathog. 2018 Jun 7;14(6):e1007061. doi: 10.1371/journal.ppat.1007061. eCollection 2018 Jun.

25.

Tolerogenic bone marrow-derived dendritic cells induce neuroprotective regulatory T cells in a model of Parkinson's disease.

Schutt CR, Gendelman HE, Mosley RL.

Mol Neurodegener. 2018 May 21;13(1):26. doi: 10.1186/s13024-018-0255-7.

26.

URMC-099 facilitates amyloid-β clearance in a murine model of Alzheimer's disease.

Kiyota T, Machhi J, Lu Y, Dyavarshetty B, Nemati M, Zhang G, Mosley RL, Gelbard HA, Gendelman HE.

J Neuroinflammation. 2018 May 5;15(1):137. doi: 10.1186/s12974-018-1172-y.

27.

Neuropathogenesis of human immunodeficiency virus infection.

Sillman B, Woldstad C, Mcmillan J, Gendelman HE.

Handb Clin Neurol. 2018;152:21-40. doi: 10.1016/B978-0-444-63849-6.00003-7. Review.

PMID:
29604978
28.

Persistent EcoHIV infection induces nigral degeneration in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxicated mice.

Olson KE, Bade AN, Namminga KL, Potash MJ, Mosley RL, Poluektova LY, Volsky DJ, Gendelman HE.

J Neurovirol. 2018 Aug;24(4):398-410. doi: 10.1007/s13365-018-0629-1. Epub 2018 Mar 28.

29.

Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer's disease mice.

Kiyota T, Machhi J, Lu Y, Dyavarshetty B, Nemati M, Yokoyama I, Mosley RL, Gendelman HE.

J Neuroimmunol. 2018 Jun 15;319:80-92. doi: 10.1016/j.jneuroim.2018.03.009. Epub 2018 Mar 17.

30.

HIV and the Macrophage: From Cell Reservoirs to Drug Delivery to Viral Eradication.

Herskovitz J, Gendelman HE.

J Neuroimmune Pharmacol. 2019 Mar;14(1):52-67. doi: 10.1007/s11481-018-9785-6. Epub 2018 Mar 23. Review.

PMID:
29572681
31.

Optimizing the preparation and stability of decorated antiretroviral drug nanocrystals.

Zhou T, Lin Z, Puligujja P, Palandri D, Hilaire J, Araínga M, Smith N, Gautam N, McMillan J, Alnouti Y, Liu X, Edagwa B, Gendelman HE.

Nanomedicine (Lond). 2018 Apr;13(8):871-885. doi: 10.2217/nnm-2017-0381. Epub 2018 Mar 19.

32.

Simultaneous quantification of intracellular lamivudine and abacavir triphosphate metabolites by LC-MS/MS.

Gautam N, Lin Z, Banoub MG, Smith NA, Maayah A, McMillan J, Gendelman HE, Alnouti Y.

J Pharm Biomed Anal. 2018 May 10;153:248-259. doi: 10.1016/j.jpba.2018.02.036. Epub 2018 Feb 20.

33.

Antiretroviral Drug Metabolism in Humanized PXR-CAR-CYP3A-NOG Mice.

McMillan JM, Cobb DA, Lin Z, Banoub MG, Dagur RS, Branch Woods AA, Wang W, Makarov E, Kocher T, Joshi PS, Quadros RM, Harms DW, Cohen SM, Gendelman HE, Gurumurthy CB, Gorantla S, Poluektova LY.

J Pharmacol Exp Ther. 2018 May;365(2):272-280. doi: 10.1124/jpet.117.247288. Epub 2018 Feb 23.

34.

Creation of a long-acting nanoformulated dolutegravir.

Sillman B, Bade AN, Dash PK, Bhargavan B, Kocher T, Mathews S, Su H, Kanmogne GD, Poluektova LY, Gorantla S, McMillan J, Gautam N, Alnouti Y, Edagwa B, Gendelman HE.

Nat Commun. 2018 Feb 6;9(1):443. doi: 10.1038/s41467-018-02885-x.

35.

Design of mannosylated oral amphotericin B nanoformulation: efficacy and safety in visceral leishmaniasis.

Sarwar HS, Sohail MF, Saljoughian N, Rehman AU, Akhtar S, Nadhman A, Yasinzai M, Gendelman HE, Satoskar AR, Shahnaz G.

Artif Cells Nanomed Biotechnol. 2018;46(sup1):521-531. doi: 10.1080/21691401.2018.1430699. Epub 2018 Jan 31.

PMID:
29385910
36.

Antimicrobials: Broad-spectrum antivirals.

Edagwa BJ, Gendelman HE.

Nat Mater. 2018 Jan 23;17(2):114-116. doi: 10.1038/nmat5064. No abstract available.

PMID:
29358769
37.

Multimodal Theranostic Nanoformulations Permit Magnetic Resonance Bioimaging of Antiretroviral Drug Particle Tissue-Cell Biodistribution.

Kevadiya BD, Woldstad C, Ottemann BM, Dash P, Sajja BR, Lamberty B, Morsey B, Kocher T, Dutta R, Bade AN, Liu Y, Callen SE, Fox HS, Byrareddy SN, McMillan JM, Bronich TK, Edagwa BJ, Boska MD, Gendelman HE.

Theranostics. 2018 Jan 1;8(1):256-276. doi: 10.7150/thno.22764. eCollection 2018.

38.

Thank You!

Gendelman HE.

J Neuroimmune Pharmacol. 2017 Dec;12(4):565. doi: 10.1007/s11481-017-9769-y. No abstract available.

39.

Systemic HIV-1 infection produces a unique glial footprint in humanized mouse brains.

Li W, Gorantla S, Gendelman HE, Poluektova LY.

Dis Model Mech. 2017 Dec 19;10(12):1489-1502. doi: 10.1242/dmm.031773.

40.

Pharmacokinetics of a Long-Acting Nanoformulated Dolutegravir Prodrug in Rhesus Macaques.

McMillan J, Szlachetka A, Slack L, Sillman B, Lamberty B, Morsey B, Callen S, Gautam N, Alnouti Y, Edagwa B, Gendelman HE, Fox HS.

Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01316-17. doi: 10.1128/AAC.01316-17. Print 2018 Jan.

41.

Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles.

Zhou T, Su H, Dash P, Lin Z, Dyavar Shetty BL, Kocher T, Szlachetka A, Lamberty B, Fox HS, Poluektova L, Gorantla S, McMillan J, Gautam N, Mosley RL, Alnouti Y, Edagwa B, Gendelman HE.

Biomaterials. 2018 Jan;151:53-65. doi: 10.1016/j.biomaterials.2017.10.023. Epub 2017 Oct 15.

42.

T cells and Parkinson's disease.

Mosley RL, Gendelman HE.

Lancet Neurol. 2017 Oct;16(10):769-771. doi: 10.1016/S1474-4422(17)30276-4. Epub 2017 Aug 11. No abstract available.

PMID:
28807669
43.

Evaluation of the safety and immunomodulatory effects of sargramostim in a randomized, double-blind phase 1 clinical Parkinson's disease trial.

Gendelman HE, Zhang Y, Santamaria P, Olson KE, Schutt CR, Bhatti D, Shetty BLD, Lu Y, Estes KA, Standaert DG, Heinrichs-Graham E, Larson L, Meza JL, Follett M, Forsberg E, Siuzdak G, Wilson TW, Peterson C, Mosley RL.

NPJ Parkinsons Dis. 2017 Mar 23;3:10. doi: 10.1038/s41531-017-0013-5. eCollection 2017.

44.

Proteomic analysis of mesenchymal to Schwann cell transdifferentiation.

Sharma AD, Wiederin J, Uz M, Ciborowski P, Mallapragada SK, Gendelman HE, Sakaguchi DS.

J Proteomics. 2017 Aug 8;165:93-101. doi: 10.1016/j.jprot.2017.06.011. Epub 2017 Jun 17.

PMID:
28629798
45.

MEMRI is a biomarker defining nicotine-specific neuronal responses in subregions of the rodent brain.

Bade AN, Gendelman HE, Boska MD, Liu Y.

Am J Transl Res. 2017 Feb 15;9(2):601-610. eCollection 2017.

46.

A mature macrophage is a principal HIV-1 cellular reservoir in humanized mice after treatment with long acting antiretroviral therapy.

Araínga M, Edagwa B, Mosley RL, Poluektova LY, Gorantla S, Gendelman HE.

Retrovirology. 2017 Mar 9;14(1):17. doi: 10.1186/s12977-017-0344-7.

47.

The cortical signature of symptom laterality in Parkinson's disease.

Heinrichs-Graham E, Santamaria PM, Gendelman HE, Wilson TW.

Neuroimage Clin. 2017 Feb 12;14:433-440. doi: 10.1016/j.nicl.2017.02.010. eCollection 2017.

48.

Autophagy facilitates macrophage depots of sustained-release nanoformulated antiretroviral drugs.

Gnanadhas DP, Dash PK, Sillman B, Bade AN, Lin Z, Palandri DL, Gautam N, Alnouti Y, Gelbard HA, McMillan J, Mosley RL, Edagwa B, Gendelman HE, Gorantla S.

J Clin Invest. 2017 Mar 1;127(3):857-873. doi: 10.1172/JCI90025. Epub 2017 Jan 30.

49.

Long-acting slow effective release antiretroviral therapy.

Edagwa B, McMillan J, Sillman B, Gendelman HE.

Expert Opin Drug Deliv. 2017 Nov;14(11):1281-1291. doi: 10.1080/17425247.2017.1288212. Epub 2017 Feb 6. Review.

50.

Cathepsin B Improves ß-Amyloidosis and Learning and Memory in Models of Alzheimer's Disease.

Embury CM, Dyavarshetty B, Lu Y, Wiederin JL, Ciborowski P, Gendelman HE, Kiyota T.

J Neuroimmune Pharmacol. 2017 Jun;12(2):340-352. doi: 10.1007/s11481-016-9721-6. Epub 2016 Dec 13.

Supplemental Content

Loading ...
Support Center