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Global Network Analysis of Neisseria gonorrhoeae Identifies Coordination between Pathways, Processes, and Regulators Expressed during Human Infection.

McClure R, Sunkavalli A, Balzano PM, Massari P, Cho C, Nauseef WM, Apicella MA, Genco CA.

mSystems. 2020 Feb 4;5(1). pii: e00729-19. doi: 10.1128/mSystems.00729-19.


Tribute: Edward 'Ned' Lally.

Shenker BJ, Boesze-Battaglia K, Genco CA, Progulske-Fox A.

Mol Oral Microbiol. 2019 Dec;34(6):235-236. doi: 10.1111/omi.12269. Epub 2019 Oct 21. No abstract available.


The Distinct Immune-Stimulatory Capacities of Porphyromonas gingivalis Strains 381 and ATCC 33277 Are Determined by the fimB Allele and Gingipain Activity.

Coats SR, Kantrong N, To TT, Jain S, Genco CA, McLean JS, Darveau RP.

Infect Immun. 2019 Nov 18;87(12). pii: e00319-19. doi: 10.1128/IAI.00319-19. Print 2019 Dec.


Strategies for Global RNA Sequencing of the Human Pathogen Neisseria gonorrhoeae.

McClure R, Genco CA.

Methods Mol Biol. 2019;1997:163-183. doi: 10.1007/978-1-4939-9496-0_11.


Increased virulence of the oral microbiome in oral squamous cell carcinoma revealed by metatranscriptome analyses.

Yost S, Stashenko P, Choi Y, Kukuruzinska M, Genco CA, Salama A, Weinberg EO, Kramer CD, Frias-Lopez J.

Int J Oral Sci. 2018 Nov 12;10(4):32. doi: 10.1038/s41368-018-0037-7.


Transcriptome Analysis of Neisseria gonorrhoeae during Natural Infection Reveals Differential Expression of Antibiotic Resistance Determinants between Men and Women.

Nudel K, McClure R, Moreau M, Briars E, Abrams AJ, Tjaden B, Su XH, Trees D, Rice PA, Massari P, Genco CA.

mSphere. 2018 Jun 27;3(3). pii: e00312-18. doi: 10.1128/mSphereDirect.00312-18. Print 2018 Aug 29.


Neisseria gonorrhoeae-Induced Inflammatory Pyroptosis in Human Macrophages is Dependent on Intracellular Gonococci and Lipooligosaccharide.

Ritter JL, Genco CA.

J Cell Death. 2018 Jan 3;11:1179066017750902. doi: 10.1177/1179066017750902. eCollection 2018.


Distinct roles for dietary lipids and Porphyromonas gingivalis infection on atherosclerosis progression and the gut microbiota.

Kramer CD, Simas AM, He X, Ingalls RR, Weinberg EO, Genco CA.

Anaerobe. 2017 Jun;45:19-30. doi: 10.1016/j.anaerobe.2017.04.011. Epub 2017 Apr 23.


Microbiota, Immune Subversion, and Chronic Inflammation.

Kramer CD, Genco CA.

Front Immunol. 2017 Mar 13;8:255. doi: 10.3389/fimmu.2017.00255. eCollection 2017. Review.


Characterization of the Neisseria gonorrhoeae Iron and Fur Regulatory Network.

Yu C, McClure R, Nudel K, Daou N, Genco CA.

J Bacteriol. 2016 Jul 28;198(16):2180-91. doi: 10.1128/JB.00166-16. Print 2016 Aug 15.


Role for the Aryl Hydrocarbon Receptor and Diverse Ligands in Oral Squamous Cell Carcinoma Migration and Tumorigenesis.

Stanford EA, Ramirez-Cardenas A, Wang Z, Novikov O, Alamoud K, Koutrakis P, Mizgerd JP, Genco CA, Kukuruzinska M, Monti S, Bais MV, Sherr DH.

Mol Cancer Res. 2016 Aug;14(8):696-706. doi: 10.1158/1541-7786.MCR-16-0069. Epub 2016 Apr 29.


Periodontal disease and risk of all cancers among male never smokers: an updated analysis of the Health Professionals Follow-up Study.

Michaud DS, Kelsey KT, Papathanasiou E, Genco CA, Giovannucci E.

Ann Oncol. 2016 May;27(5):941-7. doi: 10.1093/annonc/mdw028. Epub 2016 Jan 24.


Immune dysregulation mediated by the oral microbiome: potential link to chronic inflammation and atherosclerosis.

Slocum C, Kramer C, Genco CA.

J Intern Med. 2016 Jul;280(1):114-28. doi: 10.1111/joim.12476. Epub 2016 Jan 21. Review.


The Gonococcal Transcriptome during Infection of the Lower Genital Tract in Women.

McClure R, Nudel K, Massari P, Tjaden B, Su X, Rice PA, Genco CA.

PLoS One. 2015 Aug 5;10(8):e0133982. doi: 10.1371/journal.pone.0133982. eCollection 2015.


Specific Inflammatory Stimuli Lead to Distinct Platelet Responses in Mice and Humans.

Beaulieu LM, Clancy L, Tanriverdi K, Benjamin EJ, Kramer CD, Weinberg EO, He X, Mekasha S, Mick E, Ingalls RR, Genco CA, Freedman JE.

PLoS One. 2015 Jul 6;10(7):e0131688. doi: 10.1371/journal.pone.0131688. eCollection 2015.


Neisseria gonorrhoeae Modulates Cell Death in Human Endocervical Epithelial Cells through Export of Exosome-Associated cIAP2.

Nudel K, Massari P, Genco CA.

Infect Immun. 2015 Sep;83(9):3410-7. doi: 10.1128/IAI.00732-15. Epub 2015 Jun 15.


Porphyromonas gingivalis evasion of autophagy and intracellular killing by human myeloid dendritic cells involves DC-SIGN-TLR2 crosstalk.

El-Awady AR, Miles B, Scisci E, Kurago ZB, Palani CD, Arce RM, Waller JL, Genco CA, Slocum C, Manning M, Schoenlein PV, Cutler CW.

PLoS Pathog. 2015 Feb 13;10(2):e1004647. doi: 10.1371/journal.ppat.1004647. eCollection 2015 Feb.


Distinct gene signatures in aortic tissue from ApoE-/- mice exposed to pathogens or Western diet.

Kramer CD, Weinberg EO, Gower AC, He X, Mekasha S, Slocum C, Beaulieu LM, Wetzler L, Alekseyev Y, Gibson FC 3rd, Freedman JE, Ingalls RR, Genco CA.

BMC Genomics. 2014 Dec 24;15:1176. doi: 10.1186/1471-2164-15-1176.


A mouse model for pathogen-induced chronic inflammation at local and systemic sites.

Papadopoulos G, Kramer CD, Slocum CS, Weinberg EO, Hua N, Gudino CV, Hamilton JA, Genco CA.

J Vis Exp. 2014 Aug 8;(90):e51556. doi: 10.3791/51556.


Distinct lipid a moieties contribute to pathogen-induced site-specific vascular inflammation.

Slocum C, Coats SR, Hua N, Kramer C, Papadopoulos G, Weinberg EO, Gudino CV, Hamilton JA, Darveau RP, Genco CA.

PLoS Pathog. 2014 Jul 10;10(7):e1004215. doi: 10.1371/journal.ppat.1004215. eCollection 2014 Jul.


Aging and contribution of MyD88 and TRIF to expression of TLR pathway-associated genes following stimulation with Porphyromonas gingivalis.

Shaik-Dasthagirisaheb YB, Huang N, Weinberg EO, Shen SS, Genco CA, Gibson FC 3rd.

J Periodontal Res. 2015 Feb;50(1):89-102. doi: 10.1111/jre.12185. Epub 2014 May 24.


A high-throughput method to examine protein-nucleotide interactions identifies targets of the bacterial transcriptional regulatory protein fur.

Yu C, Lopez CA, Hu H, Xia Y, Freedman DS, Reddington AP, Daaboul GG, Unlü MS, Genco CA.

PLoS One. 2014 May 8;9(5):e96832. doi: 10.1371/journal.pone.0096832. eCollection 2014.


Interleukin 1 receptor 1 and interleukin 1β regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans.

Beaulieu LM, Lin E, Mick E, Koupenova M, Weinberg EO, Kramer CD, Genco CA, Tanriverdi K, Larson MG, Benjamin EJ, Freedman JE.

Arterioscler Thromb Vasc Biol. 2014 Mar;34(3):552-64. doi: 10.1161/ATVBAHA.113.302700. Epub 2014 Jan 23.


Neisseria prophage repressor implicated in gonococcal pathogenesis.

Daou N, Yu C, McClure R, Gudino C, Reed GW, Genco CA.

Infect Immun. 2013 Oct;81(10):3652-61. doi: 10.1128/IAI.00298-13. Epub 2013 Jul 22.


Noncanonical dendritic cell differentiation and survival driven by a bacteremic pathogen.

Miles B, Scisci E, Carrion J, Sabino GJ, Genco CA, Cutler CW.

J Leukoc Biol. 2013 Aug;94(2):281-9. doi: 10.1189/jlb.0213108. Epub 2013 May 31.


Computational analysis of bacterial RNA-Seq data.

McClure R, Balasubramanian D, Sun Y, Bobrovskyy M, Sumby P, Genco CA, Vanderpool CK, Tjaden B.

Nucleic Acids Res. 2013 Aug;41(14):e140. doi: 10.1093/nar/gkt444. Epub 2013 May 28.


Macrophage-specific TLR2 signaling mediates pathogen-induced TNF-dependent inflammatory oral bone loss.

Papadopoulos G, Weinberg EO, Massari P, Gibson FC 3rd, Wetzler LM, Morgan EF, Genco CA.

J Immunol. 2013 Feb 1;190(3):1148-57. doi: 10.4049/jimmunol.1202511. Epub 2012 Dec 21.


Disruption of immune regulation by microbial pathogens and resulting chronic inflammation.

Barth K, Remick DG, Genco CA.

J Cell Physiol. 2013 Jul;228(7):1413-22. doi: 10.1002/jcp.24299. Review.


Directing TRAF-ic: cell-specific TRAF6 signaling in chronic inflammation and atherosclerosis.

Weinberg EO, Genco CA.

Circulation. 2012 Oct 2;126(14):1678-80. doi: 10.1161/CIRCULATIONAHA.112.134379. No abstract available.


Protective role for TLR4 signaling in atherosclerosis progression as revealed by infection with a common oral pathogen.

Hayashi C, Papadopoulos G, Gudino CV, Weinberg EO, Barth KR, Madrigal AG, Chen Y, Ning H, LaValley M, Gibson FC 3rd, Hamilton JA, Genco CA.

J Immunol. 2012 Oct 1;189(7):3681-8. Epub 2012 Sep 5.


Microbial carriage state of peripheral blood dendritic cells (DCs) in chronic periodontitis influences DC differentiation, atherogenic potential.

Carrion J, Scisci E, Miles B, Sabino GJ, Zeituni AE, Gu Y, Bear A, Genco CA, Brown DL, Cutler CW.

J Immunol. 2012 Sep 15;189(6):3178-87. doi: 10.4049/jimmunol.1201053. Epub 2012 Aug 13.


Fur-mediated global regulatory circuits in pathogenic Neisseria species.

Yu C, Genco CA.

J Bacteriol. 2012 Dec;194(23):6372-81. doi: 10.1128/JB.00262-12. Epub 2012 Aug 10. Review.


Pathogen-mediated proteolysis of the cell death regulator RIPK1 and the host defense modulator RIPK2 in human aortic endothelial cells.

Madrigal AG, Barth K, Papadopoulos G, Genco CA.

PLoS Pathog. 2012;8(6):e1002723. doi: 10.1371/journal.ppat.1002723. Epub 2012 Jun 7.


Fur-mediated activation of gene transcription in the human pathogen Neisseria gonorrhoeae.

Yu C, Genco CA.

J Bacteriol. 2012 Apr;194(7):1730-42. doi: 10.1128/JB.06176-11. Epub 2012 Jan 27.


Biomolecular detection employing the Interferometric Reflectance Imaging Sensor (IRIS).

Lopez CA, Daaboul GG, Ahn S, Reddington AP, Monroe MR, Zhang X, Irani RJ, Yu C, Genco CA, Cretich M, Chiari M, Goldberg BB, Connor JH, Ünlü MS.

J Vis Exp. 2011 May 3;(51). pii: 2694. doi: 10.3791/2694.


Porphyromonas gingivalis accelerates inflammatory atherosclerosis in the innominate artery of ApoE deficient mice.

Hayashi C, Viereck J, Hua N, Phinikaridou A, Madrigal AG, Gibson FC 3rd, Hamilton JA, Genco CA.

Atherosclerosis. 2011 Mar;215(1):52-9. doi: 10.1016/j.atherosclerosis.2010.12.009. Epub 2010 Dec 22.


Review: Pathogen-induced inflammation at sites distant from oral infection: bacterial persistence and induction of cell-specific innate immune inflammatory pathways.

Hayashi C, Gudino CV, Gibson FC 3rd, Genco CA.

Mol Oral Microbiol. 2010 Oct;25(5):305-16. doi: 10.1111/j.2041-1014.2010.00582.x. Review.


Pathogen-mediated inflammatory atherosclerosis is mediated in part via Toll-like receptor 2-induced inflammatory responses.

Hayashi C, Madrigal AG, Liu X, Ukai T, Goswami S, Gudino CV, Gibson FC 3rd, Genco CA.

J Innate Immun. 2010;2(4):334-43. doi: 10.1159/000314686. Epub 2010 May 10.


Neisseria gonorrhoeae infection protects human endocervical epithelial cells from apoptosis via expression of host antiapoptotic proteins.

Follows SA, Murlidharan J, Massari P, Wetzler LM, Genco CA.

Infect Immun. 2009 Sep;77(9):3602-10. doi: 10.1128/IAI.01366-08. Epub 2009 Jun 22.


Stimulation of Toll-like receptor 2 in human platelets induces a thromboinflammatory response through activation of phosphoinositide 3-kinase.

Blair P, Rex S, Vitseva O, Beaulieu L, Tanriverdi K, Chakrabarti S, Hayashi C, Genco CA, Iafrati M, Freedman JE.

Circ Res. 2009 Feb 13;104(3):346-54. doi: 10.1161/CIRCRESAHA.108.185785. Epub 2008 Dec 23.


Expression of the gonococcal global regulatory protein Fur and genes encompassing the Fur and iron regulon during in vitro and in vivo infection in women.

Agarwal S, Sebastian S, Szmigielski B, Rice PA, Genco CA.

J Bacteriol. 2008 May;190(9):3129-39. doi: 10.1128/JB.01830-07. Epub 2008 Feb 29.


Bacterial fimbriae stimulate proinflammatory activation in the endothelium through distinct TLRs.

Davey M, Liu X, Ukai T, Jain V, Gudino C, Gibson FC 3rd, Golenbock D, Visintin A, Genco CA.

J Immunol. 2008 Feb 15;180(4):2187-95.


cis- and trans-acting elements involved in regulation of norB (norZ), the gene encoding nitric oxide reductase in Neisseria gonorrhoeae.

Isabella V, Wright LF, Barth K, Spence JM, Grogan S, Genco CA, Clark VL.

Microbiology. 2008 Jan;154(Pt 1):226-239. doi: 10.1099/mic.0.2007/010470-0.


Toll-like receptor 2 plays a critical role in the progression of atherosclerosis that is independent of dietary lipids.

Liu X, Ukai T, Yumoto H, Davey M, Goswami S, Gibson FC 3rd, Genco CA.

Atherosclerosis. 2008 Jan;196(1):146-54. Epub 2007 Apr 26.


A novel fur- and iron-regulated small RNA, NrrF, is required for indirect fur-mediated regulation of the sdhA and sdhC genes in Neisseria meningitidis.

Mellin JR, Goswami S, Grogan S, Tjaden B, Genco CA.

J Bacteriol. 2007 May;189(10):3686-94. Epub 2007 Mar 9.

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