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Items: 1 to 50 of 102

1.

Autophagy promotes visceral aging in wild-type C. elegans.

Benedetto A, Gems D.

Autophagy. 2019 Jan 30:1-2. doi: 10.1080/15548627.2019.1569919. [Epub ahead of print]

PMID:
30700231
2.

Does senescence promote fitness in Caenorhabditis elegans by causing death?

Lohr JN, Galimov ER, Gems D.

Ageing Res Rev. 2019 Jan 9;50:58-71. doi: 10.1016/j.arr.2019.01.008. [Epub ahead of print] Review.

3.

C. elegans Eats Its Own Intestine to Make Yolk Leading to Multiple Senescent Pathologies.

Ezcurra M, Benedetto A, Sornda T, Gilliat AF, Au C, Zhang Q, van Schelt S, Petrache AL, Wang H, Guardia Y, Bar-Nun S, Tyler E, Wakelam MJ, Gems D.

Curr Biol. 2018 Oct 22;28(20):3352. doi: 10.1016/j.cub.2018.10.003. No abstract available.

4.

C. elegans Eats Its Own Intestine to Make Yolk Leading to Multiple Senescent Pathologies.

Ezcurra M, Benedetto A, Sornda T, Gilliat AF, Au C, Zhang Q, van Schelt S, Petrache AL, Wang H, de la Guardia Y, Bar-Nun S, Tyler E, Wakelam MJ, Gems D.

Curr Biol. 2018 Aug 20;28(16):2544-2556.e5. doi: 10.1016/j.cub.2018.06.035. Epub 2018 Aug 9. Erratum in: Curr Biol. 2018 Oct 22;28(20):3352.

5.

A parthenogenetic quasi-program causes teratoma-like tumors during aging in wild-type C. elegans.

Wang H, Zhao Y, Ezcurra M, Benedetto A, Gilliat AF, Hellberg J, Ren Z, Galimov ER, Athigapanich T, Girstmair J, Telford MJ, Dolphin CT, Zhang Z, Gems D.

NPJ Aging Mech Dis. 2018 Jun 13;4:6. doi: 10.1038/s41514-018-0025-3. eCollection 2018.

6.

Monsters in the uterus: teratoma-like tumors in senescent C. elegans result from a parthenogenetic quasi-program.

Wang H, Zhang Z, Gems D.

Aging (Albany NY). 2018 Jun 19;10(6):1188-1189. doi: 10.18632/aging.101486. No abstract available.

7.

Coupling of Rigor Mortis and Intestinal Necrosis during C. elegans Organismal Death.

Galimov ER, Pryor RE, Poole SE, Benedetto A, Pincus Z, Gems D.

Cell Rep. 2018 Mar 6;22(10):2730-2741. doi: 10.1016/j.celrep.2018.02.050.

8.

The SKN-1/Nrf2 transcription factor can protect against oxidative stress and increase lifespan in C. elegans by distinct mechanisms.

Tullet JMA, Green JW, Au C, Benedetto A, Thompson MA, Clark E, Gilliat AF, Young A, Schmeisser K, Gems D.

Aging Cell. 2017 Oct;16(5):1191-1194. doi: 10.1111/acel.12627. Epub 2017 Jun 14.

9.

Two forms of death in ageing Caenorhabditis elegans.

Zhao Y, Gilliat AF, Ziehm M, Turmaine M, Wang H, Ezcurra M, Yang C, Phillips G, McBay D, Zhang WB, Partridge L, Pincus Z, Gems D.

Nat Commun. 2017 May 23;8:15458. doi: 10.1038/ncomms15458.

10.

Nutritional Programming of Lifespan by FOXO Inhibition on Sugar-Rich Diets.

Dobson AJ, Ezcurra M, Flanagan CE, Summerfield AC, Piper MDW, Gems D, Alic N.

Cell Rep. 2017 Jan 10;18(2):299-306. doi: 10.1016/j.celrep.2016.12.029.

11.

Run-on of germline apoptosis promotes gonad senescence in C. elegans.

de la Guardia Y, Gilliat AF, Hellberg J, Rennert P, Cabreiro F, Gems D.

Oncotarget. 2016 Jun 28;7(26):39082-39096. doi: 10.18632/oncotarget.9681.

12.

The aging-disease false dichotomy: understanding senescence as pathology.

Gems D.

Front Genet. 2015 Jun 16;6:212. doi: 10.3389/fgene.2015.00212. eCollection 2015. Review.

13.

Interventions to Slow Aging in Humans: Are We Ready?

Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L.

Aging Cell. 2015 Aug;14(4):497-510. doi: 10.1111/acel.12338. Epub 2015 Apr 22. Review.

14.

The 'mitoflash' probe cpYFP does not respond to superoxide.

Schwarzländer M, Wagner S, Ermakova YG, Belousov VV, Radi R, Beckman JS, Buettner GR, Demaurex N, Duchen MR, Forman HJ, Fricker MD, Gems D, Halestrap AP, Halliwell B, Jakob U, Johnston IG, Jones NS, Logan DC, Morgan B, Müller FL, Nicholls DG, Remington SJ, Schumacker PT, Winterbourn CC, Sweetlove LJ, Meyer AJ, Dick TP, Murphy MP.

Nature. 2014 Oct 23;514(7523):E12-4. doi: 10.1038/nature13858. No abstract available.

15.

What is an anti-aging treatment?

Gems D.

Exp Gerontol. 2014 Oct;58:14-8. doi: 10.1016/j.exger.2014.07.003. Epub 2014 Jul 11.

PMID:
25017442
16.

Evolution of sexually dimorphic longevity in humans.

Gems D.

Aging (Albany NY). 2014 Feb;6(2):84-91. Review.

17.

MDL-1, a growth- and tumor-suppressor, slows aging and prevents germline hyperplasia and hypertrophy in C. elegans.

Riesen M, Feyst I, Rattanavirotkul N, Ezcurra M, Tullet JM, Papatheodorou I, Ziehm M, Au C, Gilliat AF, Hellberg J, Thornton JM, Gems D.

Aging (Albany NY). 2014 Feb;6(2):98-117.

18.

DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans.

Tullet JM, Araiz C, Sanders MJ, Au C, Benedetto A, Papatheodorou I, Clark E, Schmeisser K, Jones D, Schuster EF, Thornton JM, Gems D.

PLoS Genet. 2014 Feb 6;10(2):e1004109. doi: 10.1371/journal.pgen.1004109. eCollection 2014 Feb.

19.

Cell-nonautonomous effects of dFOXO/DAF-16 in aging.

Alic N, Tullet JM, Niccoli T, Broughton S, Hoddinott MP, Slack C, Gems D, Partridge L.

Cell Rep. 2014 Feb 27;6(4):608-16. doi: 10.1016/j.celrep.2014.01.015. Epub 2014 Feb 6.

20.

The neurodegenerative effects of selenium are inhibited by FOXO and PINK1/PTEN regulation of insulin/insulin-like growth factor signaling in Caenorhabditis elegans.

Estevez AO, Morgan KL, Szewczyk NJ, Gems D, Estevez M.

Neurotoxicology. 2014 Mar;41:28-43. doi: 10.1016/j.neuro.2013.12.012. Epub 2014 Jan 6.

21.

The mysterious case of the C. elegans gut granule: death fluorescence, anthranilic acid and the kynurenine pathway.

Coburn C, Gems D.

Front Genet. 2013 Aug 7;4:151. doi: 10.3389/fgene.2013.00151. eCollection 2013.

22.

Anthranilate fluorescence marks a calcium-propagated necrotic wave that promotes organismal death in C. elegans.

Coburn C, Allman E, Mahanti P, Benedetto A, Cabreiro F, Pincus Z, Matthijssens F, Araiz C, Mandel A, Vlachos M, Edwards SA, Fischer G, Davidson A, Pryor RE, Stevens A, Slack FJ, Tavernarakis N, Braeckman BP, Schroeder FC, Nehrke K, Gems D.

PLoS Biol. 2013 Jul;11(7):e1001613. doi: 10.1371/journal.pbio.1001613. Epub 2013 Jul 23.

23.

Worms need microbes too: microbiota, health and aging in Caenorhabditis elegans.

Cabreiro F, Gems D.

EMBO Mol Med. 2013 Sep;5(9):1300-10. doi: 10.1002/emmm.201100972. Epub 2013 Aug 1. Review.

24.

Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.

Cabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D.

Cell. 2013 Mar 28;153(1):228-39. doi: 10.1016/j.cell.2013.02.035.

25.

Genetics of longevity in model organisms: debates and paradigm shifts.

Gems D, Partridge L.

Annu Rev Physiol. 2013;75:621-44. doi: 10.1146/annurev-physiol-030212-183712. Epub 2012 Nov 26. Review.

PMID:
23190075
26.

Alternative Perspectives on Aging in Caenorhabditis elegans: Reactive Oxygen Species or Hyperfunction?

Gems D, de la Guardia Y.

Antioxid Redox Signal. 2013 Jul 20;19(3):321-9. doi: 10.1089/ars.2012.4840. Epub 2012 Sep 24. Review.

27.

Excessive folate synthesis limits lifespan in the C. elegans: E. coli aging model.

Virk B, Correia G, Dixon DP, Feyst I, Jia J, Oberleitner N, Briggs Z, Hodge E, Edwards R, Ward J, Gems D, Weinkove D.

BMC Biol. 2012 Jul 31;10:67. doi: 10.1186/1741-7007-10-67.

28.

The second international conference "genetics of aging and longevity".

Anisimov VN, Bartke A, Barzilai N, Batin MA, Blagosklonny MV, Brown-Borg H, Budovskaya Y, Campisi J, Friguet B, Fraifeld V, Franceschi C, Gems D, Gladyshev V, Gorbunova V, Gudkov AV, Kennedy B, Konovalenko M, Kraemer B, Moskalev A, Petropoulos I, Pasyukova E, Rattan S, Rogina B, Seluanov A, Shaposhnikov M, Shmookler Reis R, Tavernarakis N, Vijg J, Yashin A, Zimniak P.

Aging (Albany NY). 2012 May;4(5):305-17. No abstract available.

29.

Manipulation of in vivo iron levels can alter resistance to oxidative stress without affecting ageing in the nematode C. elegans.

Valentini S, Cabreiro F, Ackerman D, Alam MM, Kunze MB, Kay CW, Gems D.

Mech Ageing Dev. 2012 May;133(5):282-90. doi: 10.1016/j.mad.2012.03.003. Epub 2012 Mar 16.

30.

Insulin/IGF-1 and hypoxia signaling act in concert to regulate iron homeostasis in Caenorhabditis elegans.

Ackerman D, Gems D.

PLoS Genet. 2012;8(3):e1002498. doi: 10.1371/journal.pgen.1002498. Epub 2012 Mar 1.

31.

The mystery of C. elegans aging: an emerging role for fat. Distant parallels between C. elegans aging and metabolic syndrome?

Ackerman D, Gems D.

Bioessays. 2012 Jun;34(6):466-71. doi: 10.1002/bies.201100189. Epub 2012 Feb 27. Review.

PMID:
22371137
32.

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila.

Burnett C, Valentini S, Cabreiro F, Goss M, Somogyvári M, Piper MD, Hoddinott M, Sutphin GL, Leko V, McElwee JJ, Vazquez-Manrique RP, Orfila AM, Ackerman D, Au C, Vinti G, Riesen M, Howard K, Neri C, Bedalov A, Kaeberlein M, Soti C, Partridge L, Gems D.

Nature. 2011 Sep 21;477(7365):482-5. doi: 10.1038/nature10296.

33.

Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage.

Cabreiro F, Ackerman D, Doonan R, Araiz C, Back P, Papp D, Braeckman BP, Gems D.

Free Radic Biol Med. 2011 Oct 15;51(8):1575-82. doi: 10.1016/j.freeradbiomed.2011.07.020. Epub 2011 Jul 31.

34.

Unraveling the biological roles of reactive oxygen species.

Murphy MP, Holmgren A, Larsson NG, Halliwell B, Chang CJ, Kalyanaraman B, Rhee SG, Thornalley PJ, Partridge L, Gems D, Nyström T, Belousov V, Schumacker PT, Winterbourn CC.

Cell Metab. 2011 Apr 6;13(4):361-366. doi: 10.1016/j.cmet.2011.03.010.

35.

Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix.

Cochemé HM, Quin C, McQuaker SJ, Cabreiro F, Logan A, Prime TA, Abakumova I, Patel JV, Fearnley IM, James AM, Porteous CM, Smith RA, Saeed S, Carré JE, Singer M, Gems D, Hartley RC, Partridge L, Murphy MP.

Cell Metab. 2011 Mar 2;13(3):340-50. doi: 10.1016/j.cmet.2011.02.003.

36.

Treating aging: progress toward dietary restriction mimetics.

Cabreiro F, Gems D.

F1000 Biol Rep. 2010 Oct 21;2:76. doi: 10.3410/B2-76.

37.

Tragedy and delight: the ethics of decelerated ageing.

Gems D.

Philos Trans R Soc Lond B Biol Sci. 2011 Jan 12;366(1561):108-12. doi: 10.1098/rstb.2010.0288. Review.

38.

DamID in C. elegans reveals longevity-associated targets of DAF-16/FoxO.

Schuster E, McElwee JJ, Tullet JM, Doonan R, Matthijssens F, Reece-Hoyes JS, Hope IA, Vanfleteren JR, Thornton JM, Gems D.

Mol Syst Biol. 2010 Aug 10;6:399. doi: 10.1038/msb.2010.54.

39.

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.

Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, Claret M, Al-Qassab H, Carmignac D, Ramadani F, Woods A, Robinson IC, Schuster E, Batterham RL, Kozma SC, Thomas G, Carling D, Okkenhaug K, Thornton JM, Partridge L, Gems D, Withers DJ.

Science. 2009 Oct 2;326(5949):140-4. doi: 10.1126/science.1177221. Erratum in: Science. 2011 Oct 7;334(6052):39.

40.

Longevity of Indy mutant Drosophila not attributable to Indy mutation.

Toivonen JM, Gems D, Partridge L.

Proc Natl Acad Sci U S A. 2009 May 26;106(21):E53; author reply E54. doi: 10.1073/pnas.0902462106. Epub 2009 May 12. No abstract available.

41.

Ageing and oxidants in the nematode Caenorhabditis elegans.

Gems D.

SEB Exp Biol Ser. 2009;62:31-56. No abstract available.

PMID:
19418991
42.

Antioxidant defense and aging in C. elegans: is the oxidative damage theory of aging wrong?

Gems D, Doonan R.

Cell Cycle. 2009 Jun 1;8(11):1681-7. Epub 2009 Jun 30. Review.

PMID:
19411855
43.

Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans.

Doonan R, McElwee JJ, Matthijssens F, Walker GA, Houthoofd K, Back P, Matscheski A, Vanfleteren JR, Gems D.

Genes Dev. 2008 Dec 1;22(23):3236-41. doi: 10.1101/gad.504808.

44.

Transcript profiles of long- and short-lived adults implicate protein synthesis in evolved differences in ageing in the nematode Strongyloides ratti.

Thompson FJ, Barker GL, Nolan T, Gems D, Viney ME.

Mech Ageing Dev. 2009 Mar;130(3):167-72. doi: 10.1016/j.mad.2008.11.001. Epub 2008 Nov 13.

PMID:
19056418
45.

Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis".

Selman C, Lingard S, Gems D, Partridge L, Withers DJ.

Science. 2008 May 23;320(5879):1012; author reply 1012. doi: 10.1126/science.1152366.

46.

Dietary restriction of Caenorhabditis elegans by axenic culture reflects nutritional requirement for constituents provided by metabolically active microbes.

Lenaerts I, Walker GA, Van Hoorebeke L, Gems D, Vanfleteren JR.

J Gerontol A Biol Sci Med Sci. 2008 Mar;63(3):242-52.

47.

Stress-response hormesis and aging: "that which does not kill us makes us stronger".

Gems D, Partridge L.

Cell Metab. 2008 Mar;7(3):200-3. doi: 10.1016/j.cmet.2008.01.001. Review.

48.

Clustering of genetically defined allele classes in the Caenorhabditis elegans DAF-2 insulin/IGF-1 receptor.

Patel DS, Garza-Garcia A, Nanji M, McElwee JJ, Ackerman D, Driscoll PC, Gems D.

Genetics. 2008 Feb;178(2):931-46. doi: 10.1534/genetics.107.070813. Epub 2008 Feb 1.

49.
50.

Benchmarks for ageing studies.

Partridge L, Gems D.

Nature. 2007 Nov 8;450(7167):165-7. No abstract available.

PMID:
17994065

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