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Molecular Imaging of Sirtuin1 Expression-Activity in Rat Brain Using Positron-Emission Tomography-Magnetic-Resonance Imaging with [18F]-2-Fluorobenzoylaminohexanoicanilide.

Bonomi R, Popov V, Laws MT, Gelovani D, Majhi A, Shavrin A, Lu X, Muzik O, Turkman N, Liu R, Mangner T, Gelovani JG.

J Med Chem. 2018 Aug 23;61(16):7116-7130. doi: 10.1021/acs.jmedchem.8b00253. Epub 2018 Aug 13.


In Vivo 6-([18F]Fluoroacetamido)-1-hexanoicanilide PET Imaging of Altered Histone Deacetylase Activity in Chemotherapy-Induced Neurotoxicity.

Fukumitsu N, Yeh SH, Flores Ii LG, Mukhopadhyay U, Young D, Ogawa K, Jeong HJ, Tong W, Gelovani JG.

Contrast Media Mol Imaging. 2018 Mar 20;2018:3612027. doi: 10.1155/2018/3612027. eCollection 2018.


Neonatal brain resting-state functional connectivity imaging modalities.

Mohammadi-Nejad AR, Mahmoudzadeh M, Hassanpour MS, Wallois F, Muzik O, Papadelis C, Hansen A, Soltanian-Zadeh H, Gelovani J, Nasiriavanaki M.

Photoacoustics. 2018 Feb 2;10:1-19. doi: 10.1016/j.pacs.2018.01.003. eCollection 2018 Jun. Review.


MLH1-rheMac hereditary nonpolyposis colorectal cancer syndrome in rhesus macaques.

Brammer DW, Gillespie PJ, Tian M, Young D, Raveendran M, Williams LE, Gagea M, Benavides FJ, Perez CJ, Broaddus RR, Bernacky BJ, Barnhart KF, Alauddin MM, Bhutani MS, Gibbs RA, Sidman RL, Pasqualini R, Arap W, Rogers J, Abee CR, Gelovani JG.

Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2806-2811. doi: 10.1073/pnas.1722106115. Epub 2018 Feb 28.


A Novel Substrate Radiotracer for Molecular Imaging of SIRT2 Expression and Activity with Positron Emission Tomography.

Bonomi RE, Laws M, Popov V, Kamal S, Potukutchi S, Shavrin A, Lu X, Turkman N, Liu RS, Mangner T, Gelovani JG.

Mol Imaging Biol. 2018 Aug;20(4):594-604. doi: 10.1007/s11307-017-1149-8.


Implementation of [18F]-labeled amyloid brain PET imaging biomarker in the diagnosis of Alzheimer's disease: first-hand experience in Thailand.

Thientunyakit T, Sethanandha C, Muangpaisan W, Chawalparit O, Arunrungvichian K, Siriprapa T, Thongpraparn T, Chanachai R, Gelovani J.

Nucl Med Commun. 2018 Feb;39(2):186-192. doi: 10.1097/MNM.0000000000000787. No abstract available.


A numerical analysis of a semi-dry coupling configuration in photoacoustic computed tomography for infant brain imaging.

Meimani N, Abani N, Gelovani J, Avanaki MRN.

Photoacoustics. 2017 Jun 21;7:27-35. doi: 10.1016/j.pacs.2017.06.001. eCollection 2017 Sep.


Intracellular targeting of annexin A2 inhibits tumor cell adhesion, migration, and in vivo grafting.

Staquicini DI, Rangel R, Guzman-Rojas L, Staquicini FI, Dobroff AS, Tarleton CA, Ozbun MA, Kolonin MG, Gelovani JG, Marchiò S, Sidman RL, Hajjar KA, Arap W, Pasqualini R.

Sci Rep. 2017 Jun 26;7(1):4243. doi: 10.1038/s41598-017-03470-w.


Investigating carbohydrate based ligands for galectin-3 with docking and molecular dynamics studies.

Walker AR, Bonomi R, Popov V, Gelovani JG, Andrés Cisneros G.

J Mol Graph Model. 2017 Jan;71:211-217. doi: 10.1016/j.jmgm.2016.10.018. Epub 2016 Nov 25.


Imaging of Sleeping Beauty-Modified CD19-Specific T Cells Expressing HSV1-Thymidine Kinase by Positron Emission Tomography.

Najjar AM, Manuri PR, Olivares S, Flores L 2nd, Mi T, Huls H, Shpall EJ, Champlin RE, Turkman N, Paolillo V, Roszik J, Rabinovich B, Lee DA, Alauddin M, Gelovani J, Cooper LJ.

Mol Imaging Biol. 2016 Dec;18(6):838-848.


Targeted molecular-genetic imaging and ligand-directed therapy in aggressive variant prostate cancer.

Ferrara F, Staquicini DI, Driessen WHP, D'Angelo S, Dobroff AS, Barry M, Lomo LC, Staquicini FI, Cardó-Vila M, Soghomonyan S, Alauddin MM, Flores LG 2nd, Arap MA, Lauer RC, Mathew P, Efstathiou E, Aparicio AM, Troncoso P, Navone NM, Logothetis CJ, Marchiò S, Gelovani JG, Sidman RL, Pasqualini R, Arap W.

Proc Natl Acad Sci U S A. 2016 Nov 8;113(45):12786-12791. doi: 10.1073/pnas.1615400113. Epub 2016 Oct 24.


Towards a transcriptome-based theranostic platform for unfavorable breast cancer phenotypes.

Dobroff AS, D'Angelo S, Eckhardt BL, Ferrara F, Staquicini DI, Cardó-Vila M, Staquicini FI, Nunes DN, Kim K, Driessen WHP, Hajitou A, Lomo LC, Barry M, Krishnamurthy S, Sahin A, Woodward WA, Prossnitz ER, Anderson RL, Dias-Neto E, Brown-Glaberman UA, Royce ME, Ueno NT, Cristofanilli M, Hortobagyi GN, Marchiò S, Gelovani JG, Sidman RL, Arap W, Pasqualini R.

Proc Natl Acad Sci U S A. 2016 Nov 8;113(45):12780-12785. doi: 10.1073/pnas.1615288113. Epub 2016 Oct 24.


AAVP displaying octreotide for ligand-directed therapeutic transgene delivery in neuroendocrine tumors of the pancreas.

Smith TL, Yuan Z, Cardó-Vila M, Sanchez Claros C, Adem A, Cui MH, Branch CA, Gelovani JG, Libutti SK, Sidman RL, Pasqualini R, Arap W.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):2466-71. doi: 10.1073/pnas.1525709113. Epub 2016 Feb 16.


Integrated nanotechnology platform for tumor-targeted multimodal imaging and therapeutic cargo release.

Hosoya H, Dobroff AS, Driessen WH, Cristini V, Brinker LM, Staquicini FI, Cardó-Vila M, D'Angelo S, Ferrara F, Proneth B, Lin YS, Dunphy DR, Dogra P, Melancon MP, Stafford RJ, Miyazono K, Gelovani JG, Kataoka K, Brinker CJ, Sidman RL, Arap W, Pasqualini R.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1877-82. doi: 10.1073/pnas.1525796113. Epub 2016 Feb 2.


Ligand-targeted theranostic nanomedicines against cancer.

Yao VJ, D'Angelo S, Butler KS, Theron C, Smith TL, Marchiò S, Gelovani JG, Sidman RL, Dobroff AS, Brinker CJ, Bradbury ARM, Arap W, Pasqualini R.

J Control Release. 2016 Oct 28;240:267-286. doi: 10.1016/j.jconrel.2016.01.002. Epub 2016 Jan 6. Review.


Novel Histone Deacetylase Class IIa Selective Substrate Radiotracers for PET Imaging of Epigenetic Regulation in the Brain.

Bonomi R, Mukhopadhyay U, Shavrin A, Yeh HH, Majhi A, Dewage SW, Najjar A, Lu X, Cisneros GA, Tong WP, Alauddin MM, Liu RS, Mangner TJ, Turkman N, Gelovani JG.

PLoS One. 2015 Aug 5;10(8):e0133512. doi: 10.1371/journal.pone.0133512. eCollection 2015.


Development of a Bioluminescent Nitroreductase Probe for Preclinical Imaging.

Vorobyeva AG, Stanton M, Godinat A, Lund KB, Karateev GG, Francis KP, Allen E, Gelovani JG, McCormack E, Tangney M, Dubikovskaya EA.

PLoS One. 2015 Jun 25;10(6):e0131037. doi: 10.1371/journal.pone.0131037. eCollection 2015.


Enhancement of tumor initiation and expression of KCNMA1, MORF4L2 and ASPM genes in the adenocarcinoma of lung xenograft after vorinostat treatment.

Kuo WY, Wu CY, Hwu L, Lee JS, Tsai CH, Lin KP, Wang HE, Chou TY, Tsai CM, Gelovani J, Liu RS.

Oncotarget. 2015 Apr 20;6(11):8663-75.


Ligand-directed profiling of organelles with internalizing phage libraries.

Dobroff AS, Rangel R, Guzman-Roja L, Salmeron CC, Gelovani JG, Sidman RL, Bologa CG, Oprea TI, Brinker CJ, Pasqualini R, Arap W.

Curr Protoc Protein Sci. 2015 Feb 2;79:30.4.1-30. doi: 10.1002/0471140864.ps3004s79.


Genetically encoded molecular biosensors to image histone methylation in living animals.

Sekar TV, Foygel K, Gelovani JG, Paulmurugan R.

Anal Chem. 2015 Jan 20;87(2):892-9. doi: 10.1021/ac502629r. Epub 2014 Dec 24.


FOXF1 mediates mesenchymal stem cell fusion-induced reprogramming of lung cancer cells.

Wei HJ, Nickoloff JA, Chen WH, Liu HY, Lo WC, Chang YT, Yang PC, Wu CW, Williams DF, Gelovani JG, Deng WP.

Oncotarget. 2014 Oct 15;5(19):9514-29.


Design and Synthesis of an Inositol Phosphate Analog Based on Computational Docking Studies.

Peng Z, Maxwell D, Sun D, Ying Y, Schuber PT Jr, Bhanu Prasad BA, Gelovani J, Yung WK, Bornmann WG.

Tetrahedron. 2014 Jan 28;70(4):984-990.


An improved synthesis of 1'-[18F]fluoroethyl-β-D-lactose ([18F]-FEL) for positron emission tomography imaging of pancreatic cancer.

Turkman N, Gelovani JG, Alauddin MM.

J Labelled Comp Radiopharm. 2013 Jun 15;56(7):351-5. doi: 10.1002/jlcr.3042. Epub 2013 Mar 22.


Imatinib analogs as potential agents for PET imaging of Bcr-Abl and c-KIT expression at a kinase level.

Peng Z, Maxwell DS, Sun D, Bhanu Prasad BA, Pal A, Wang S, Balatoni J, Ghosh P, Lim ST, Volgin A, Shavrin A, Alauddin MM, Gelovani JG, Bornmann WG.

Bioorg Med Chem. 2014 Jan 1;22(1):623-32. doi: 10.1016/j.bmc.2013.10.040. Epub 2013 Nov 6.


Targeting mammalian organelles with internalizing phage (iPhage) libraries.

Rangel R, Dobroff AS, Guzman-Rojas L, Salmeron CC, Gelovani JG, Sidman RL, Pasqualini R, Arap W.

Nat Protoc. 2013 Oct;8(10):1916-39. doi: 10.1038/nprot.2013.119. Epub 2013 Sep 12.


Molecular imaging of nonsmall cell lung carcinomas expressing active mutant EGFR kinase using PET with [(124)i]-morpholino-IPQA.

Yeh SH, Lin CF, Kong FL, Wang HE, Hsieh YJ, Gelovani JG, Liu RS.

Biomed Res Int. 2013;2013:549359. doi: 10.1155/2013/549359. Epub 2013 Jul 17.


Improved synthesis of 17β-hydroxy-16α-iodo-wortmannin, 17β-hydroxy-16α-iodoPX866, and the [(131)I] analogue as useful PET tracers for PI3-kinase.

Sun D, Bhanu Prasad BA, Schuber PT Jr, Peng Z, Maxwell DS, Martin DV, Guo L, Han D, Kurihara H, Yang DJ, Gelovani JG, Powis G, Bornmann WG.

Bioorg Med Chem. 2013 Sep 1;21(17):5182-7. doi: 10.1016/j.bmc.2013.06.036. Epub 2013 Jun 27.


Histone deacetylase class II and acetylated core histone immunohistochemistry in human brains with Huntington's disease.

Yeh HH, Young D, Gelovani JG, Robinson A, Davidson Y, Herholz K, Mann DM.

Brain Res. 2013 Apr 4;1504:16-24. doi: 10.1016/j.brainres.2013.02.012. Epub 2013 Feb 16.


Imaging epigenetic regulation by histone deacetylases in the brain using PET/MRI with ¹⁸F-FAHA.

Yeh HH, Tian M, Hinz R, Young D, Shavrin A, Mukhapadhyay U, Flores LG, Balatoni J, Soghomonyan S, Jeong HJ, Pal A, Uthamanthil R, Jackson JN, Nishii R, Mizuma H, Onoe H, Kagawa S, Higashi T, Fukumitsu N, Alauddin M, Tong W, Herholz K, Gelovani JG.

Neuroimage. 2013 Jan 1;64:630-9. doi: 10.1016/j.neuroimage.2012.09.019. Epub 2012 Sep 17.


Monitoring therapy with MEK inhibitor U0126 in a novel Wilms tumor model in Wt1 knockout Igf2 transgenic mice using 18F-FDG PET with dual-contrast enhanced CT and MRI: early metabolic response without inhibition of tumor growth.

Flores LG 2nd, Yeh HH, Soghomonyan S, Young D, Bankson J, Hu Q, Alauddin M, Huff V, Gelovani JG.

Mol Imaging Biol. 2013 Apr;15(2):175-85. doi: 10.1007/s11307-012-0588-5.


Combinatorial targeting and discovery of ligand-receptors in organelles of mammalian cells.

Rangel R, Guzman-Rojas L, le Roux LG, Staquicini FI, Hosoya H, Barbu EM, Ozawa MG, Nie J, Dunner K Jr, Langley RR, Sage EH, Koivunen E, Gelovani JG, Lobb RR, Sidman RL, Pasqualini R, Arap W.

Nat Commun. 2012 Apr 17;3:788. doi: 10.1038/ncomms1773.


Synthesis and preliminary evaluation of [18F]-labeled 2-oxoquinoline derivatives for PET imaging of cannabinoid CB2 receptor.

Turkman N, Shavrin A, Paolillo V, Yeh HH, Flores L, Soghomonian S, Rabinovich B, Volgin A, Gelovani J, Alauddin M.

Nucl Med Biol. 2012 May;39(4):593-600. doi: 10.1016/j.nucmedbio.2011.10.019. Epub 2012 Jan 4.


Molecular imaging of mesenchymal stem cell: mechanistic insight into cardiac repair after experimental myocardial infarction.

Wang J, Najjar A, Zhang S, Rabinovich B, Willerson JT, Gelovani JG, Yeh ET.

Circ Cardiovasc Imaging. 2012 Jan;5(1):94-101. doi: 10.1161/CIRCIMAGING.111.966424. Epub 2011 Dec 1.


A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys.

Barnhart KF, Christianson DR, Hanley PW, Driessen WH, Bernacky BJ, Baze WB, Wen S, Tian M, Ma J, Kolonin MG, Saha PK, Do KA, Hulvat JF, Gelovani JG, Chan L, Arap W, Pasqualini R.

Sci Transl Med. 2011 Nov 9;3(108):108ra112. doi: 10.1126/scitranslmed.3002621.


Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets.

Kunnumakkara AB, Sung B, Ravindran J, Diagaradjane P, Deorukhkar A, Dey S, Koca C, Tong Z, Gelovani JG, Guha S, Krishnan S, Aggarwal BB.

Int J Cancer. 2012 Aug 1;131(3):E292-303. doi: 10.1002/ijc.26442. Epub 2011 Nov 9.


Imaging long-term fate of intramyocardially implanted mesenchymal stem cells in a porcine myocardial infarction model.

Perin EC, Tian M, Marini FC 3rd, Silva GV, Zheng Y, Baimbridge F, Quan X, Fernandes MR, Gahremanpour A, Young D, Paolillo V, Mukhopadhyay U, Borne AT, Uthamanthil R, Brammer D, Jackson J, Decker WK, Najjar AM, Thomas MW, Volgin A, Rabinovich B, Soghomonyan S, Jeong HJ, Rios JM, Steiner D, Robinson S, Mawlawi O, Pan T, Stafford J, Kundra V, Li C, Alauddin MM, Willerson JT, Shpall E, Gelovani JG.

PLoS One. 2011;6(9):e22949. doi: 10.1371/journal.pone.0022949. Epub 2011 Sep 1.


Fluorinated cannabinoid CB2 receptor ligands: synthesis and in vitro binding characteristics of 2-oxoquinoline derivatives.

Turkman N, Shavrin A, Ivanov RA, Rabinovich B, Volgin A, Gelovani JG, Alauddin MM.

Bioorg Med Chem. 2011 Sep 15;19(18):5698-707. doi: 10.1016/j.bmc.2011.07.062. Epub 2011 Aug 5.


Pharmacokinetics and magnetic resonance imaging of biodegradable macromolecular blood-pool contrast agent PG-Gd in non-human primates: a pilot study.

Tian M, Wen X, Jackson EF, Ng C, Uthamanthil R, Liang D, Gelovani JG, Li C.

Contrast Media Mol Imaging. 2011 Jul-Aug;6(4):289-97. doi: 10.1002/cmmi.431. Epub 2011 Jan 6.


Effects of photoacoustic imaging and photothermal ablation therapy mediated by targeted hollow gold nanospheres in an orthotopic mouse xenograft model of glioma.

Lu W, Melancon MP, Xiong C, Huang Q, Elliott A, Song S, Zhang R, Flores LG 2nd, Gelovani JG, Wang LV, Ku G, Stafford RJ, Li C.

Cancer Res. 2011 Oct 1;71(19):6116-21. doi: 10.1158/0008-5472.CAN-10-4557. Epub 2011 Aug 19.


The EIIAPA chimeric promoter for tumor specific gene therapy of hepatoma.

Hsieh YJ, Chen FD, Ke CC, Wang HE, Huang CJ, Hou MF, Lin KP, Gelovani JG, Liu RS.

Mol Imaging Biol. 2012 Aug;14(4):452-61. doi: 10.1007/s11307-011-0509-z.


A Preclinical Evaluation of Antrodia camphorata Alcohol Extracts in the Treatment of Non-Small Cell Lung Cancer Using Non-Invasive Molecular Imaging.

Chiou JF, Wu AT, Wang WT, Kuo TH, Gelovani JG, Lin IH, Wu CH, Chiu WT, Deng WP.

Evid Based Complement Alternat Med. 2011;2011:914561. doi: 10.1093/ecam/nep228. Epub 2011 Mar 13.


Improved detection and measurement of low levels of [18F]fluoride metabolized from [18F]-labeled pyrimidine nucleoside analogues in biological samples.

Paolillo V, Yeh HH, Mukhopadhyay U, Gelovani JG, Alauddin MM.

Nucl Med Biol. 2011 Nov;38(8):1129-34. doi: 10.1016/j.nucmedbio.2011.05.008. Epub 2011 Jul 8.


Boswellic acid inhibits growth and metastasis of human colorectal cancer in orthotopic mouse model by downregulating inflammatory, proliferative, invasive and angiogenic biomarkers.

Yadav VR, Prasad S, Sung B, Gelovani JG, Guha S, Krishnan S, Aggarwal BB.

Int J Cancer. 2012 May 1;130(9):2176-84. doi: 10.1002/ijc.26251. Epub 2011 Sep 12.


The use of nanoimprinted scaffolds as 3D culture models to facilitate spontaneous tumor cell migration and well-regulated spheroid formation.

Yoshii Y, Waki A, Yoshida K, Kakezuka A, Kobayashi M, Namiki H, Kuroda Y, Kiyono Y, Yoshii H, Furukawa T, Asai T, Okazawa H, Gelovani JG, Fujibayashi Y.

Biomaterials. 2011 Sep;32(26):6052-8. doi: 10.1016/j.biomaterials.2011.04.076. Epub 2011 Jun 2.


Whole-body biodistribution kinetics, metabolism, and radiation dosimetry estimates of 18F-PEG6-IPQA in nonhuman primates.

Tian M, Ogawa K, Wendt R, Mukhopadhyay U, Balatoni J, Fukumitsu N, Uthamanthil R, Borne A, Brammer D, Jackson J, Mawlawi O, Yang B, Alauddin MM, Gelovani JG.

J Nucl Med. 2011 Jun;52(6):934-41. doi: 10.2967/jnumed.110.086777. Epub 2011 May 13.


Pharmacokinetics, metabolism, biodistribution, radiation dosimetry, and toxicology of (18)F-fluoroacetate ((18)F-FACE) in non-human primates.

Nishii R, Tong W, Wendt R 3rd, Soghomonyan S, Mukhopadhyay U, Balatoni J, Mawlawi O, Bidaut L, Tinkey P, Borne A, Alauddin M, Gonzalez-Lepera C, Yang B, Gelovani JG.

Mol Imaging Biol. 2012 Apr;14(2):213-24. doi: 10.1007/s11307-011-0485-3.


Methodological and practical challenges for personalized cancer therapies.

Wistuba II, Gelovani JG, Jacoby JJ, Davis SE, Herbst RS.

Nat Rev Clin Oncol. 2011 Mar;8(3):135-41. doi: 10.1038/nrclinonc.2011.2. Review.


HIF-1-dependent stromal adaptation to ischemia mediates in vivo tumor radiation resistance.

Schwartz DL, Bankson J, Bidaut L, He Y, Williams R, Lemos R, Thitai AK, Oh J, Volgin A, Soghomonyan S, Yeh HH, Nishii R, Mukhopadhay U, Alauddin M, Mushkudiani I, Kuno N, Krishnan S, Bornman W, Lai SY, Powis G, Hazle J, Gelovani J.

Mol Cancer Res. 2011 Mar;9(3):259-70. doi: 10.1158/1541-7786.MCR-10-0469. Epub 2011 Mar 1.

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