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Items: 1 to 50 of 92


Glucose Drives Growth Factor-Independent Esophageal Cancer Proliferation via Phosphohistidine-Focal Adhesion Kinase Signaling.

Zhang J, Gelman IH, Katsuta E, Liang Y, Wang X, Li J, Qu J, Yan L, Takabe K, Hochwald SN.

Cell Mol Gastroenterol Hepatol. 2019;8(1):37-60. doi: 10.1016/j.jcmgh.2019.02.009. Epub 2019 Mar 2.


Identification of Genes Regulating Breast Cancer Dormancy in 3D Bone Endosteal Niche Cultures.

McGrath J, Panzica L, Ransom R, Withers HG, Gelman IH.

Mol Cancer Res. 2019 Apr;17(4):860-869. doi: 10.1158/1541-7786.MCR-18-0956. Epub 2019 Jan 16.


A-kinase anchoring protein 12 is downregulated in human hepatocellular carcinoma and its deficiency in mice aggravates thioacetamide-induced liver injury.

Lee HS, Choi J, Son T, Lee EJ, Kim JG, Ryu SH, Lee D, Jang MK, Yu E, Chung YH, Gelman IH, Kim KW.

Oncol Lett. 2018 Nov;16(5):5907-5915. doi: 10.3892/ol.2018.9396. Epub 2018 Sep 4.


A methyl-sensitive element induces bidirectional transcription in TATA-less CpG island-associated promoters.

Mahpour A, Scruggs BS, Smiraglia D, Ouchi T, Gelman IH.

PLoS One. 2018 Oct 17;13(10):e0205608. doi: 10.1371/journal.pone.0205608. eCollection 2018.


SSeCKS/Akap12 suppresses metastatic melanoma lung colonization by attenuating Src-mediated pre-metastatic niche crosstalk.

Muramatsu M, Akakura S, Gao L, Peresie J, Balderman B, Gelman IH.

Oncotarget. 2018 Sep 11;9(71):33515-33527. doi: 10.18632/oncotarget.26067. eCollection 2018 Sep 11.


Discovery of Novel Dual Mechanism of Action Src Signaling and Tubulin Polymerization Inhibitors (KX2-391 and KX2-361).

Smolinski MP, Bu Y, Clements J, Gelman IH, Hegab T, Cutler DL, Fang JWS, Fetterly G, Kwan R, Barnett A, Lau JYN, Hangauer DG.

J Med Chem. 2018 Jun 14;61(11):4704-4719. doi: 10.1021/acs.jmedchem.8b00164. Epub 2018 Apr 17.


A-Kinase Anchor Protein 12 Is Required for Oligodendrocyte Differentiation in Adult White Matter.

Maki T, Choi YK, Miyamoto N, Shindo A, Liang AC, Ahn BJ, Mandeville ET, Kaji S, Itoh K, Seo JH, Gelman IH, Lok J, Takahashi R, Kim KW, Lo EH, Arai K.

Stem Cells. 2018 May;36(5):751-760. doi: 10.1002/stem.2771. Epub 2018 Jan 22.


SSeCKS/AKAP12 scaffolding functions suppress B16F10-induced peritoneal metastasis by attenuating CXCL9/10 secretion by resident fibroblasts.

Muramatsu M, Gao L, Peresie J, Balderman B, Akakura S, Gelman IH.

Oncotarget. 2017 Aug 9;8(41):70281-70298. doi: 10.18632/oncotarget.20092. eCollection 2017 Sep 19.


VGLL4 Selectively Represses YAP-Dependent Gene Induction and Tumorigenic Phenotypes in Breast Cancer.

Zhang Y, Shen H, Withers HG, Yang N, Denson KE, Mussell AL, Truskinovsky A, Fan Q, Gelman IH, Frangou C, Zhang J.

Sci Rep. 2017 Jul 21;7(1):6190. doi: 10.1038/s41598-017-06227-7.


Structural environment built by AKAP12+ colon mesenchymal cells drives M2 macrophages during inflammation recovery.

Yang JM, Lee HS, Seo JH, Park JH, Gelman IH, Lo EH, Kim KW.

Sci Rep. 2017 Feb 16;7:42723. doi: 10.1038/srep42723.


Src promotes castration-recurrent prostate cancer through androgen receptor-dependent canonical and non-canonical transcriptional signatures.

Chattopadhyay I, Wang J, Qin M, Gao L, Holtz R, Vessella RL, Leach RW, Gelman IH.

Oncotarget. 2017 Feb 7;8(6):10324-10347. doi: 10.18632/oncotarget.14401.


How the TRAMP Model Revolutionized the Study of Prostate Cancer Progression.

Gelman IH.

Cancer Res. 2016 Nov 1;76(21):6137-6139. No abstract available.


GRM1 is An Androgen-Regulated Gene and its Expression Correlates with Prostate Cancer Progression in Pre-Clinical Models.

Shourideh M, Azabdaftari G, Attwood K, DePriest A, Wadosky KM, Gillard BM, Karasik E, Heemers H, Kyprianou N, Gelman IH, Corey E, Vessella RL, Mohler JL, Koochekpour S.

Clin Cancer Res. 2016 Jul 25. pii: clincanres.0137.2016. doi: 10.1158/1078-0432.CCR-16-0137. [Epub ahead of print] Retraction in: Clin Cancer Res. 2017 Jul 15;23 (14 ):3973.


Identification of novel focal adhesion kinase substrates: role for FAK in NFκB signaling.

Dwyer SF, Gao L, Gelman IH.

Int J Biol Sci. 2015 Feb 17;11(4):404-10. doi: 10.7150/ijbs.10273. eCollection 2015.


Suppression of chemotaxis by SSeCKS via scaffolding of phosphoinositol phosphates and the recruitment of the Cdc42 GEF, Frabin, to the leading edge.

Ko HK, Guo LW, Su B, Gao L, Gelman IH.

PLoS One. 2014 Oct 30;9(10):e111534. doi: 10.1371/journal.pone.0111534. eCollection 2014.


Prompt meningeal reconstruction mediated by oxygen-sensitive AKAP12 scaffolding protein after central nervous system injury.

Cha JH, Wee HJ, Seo JH, Ahn BJ, Park JH, Yang JM, Lee SW, Lee OH, Lee HJ, Gelman IH, Arai K, Lo EH, Kim KW.

Nat Commun. 2014 Sep 17;5:4952. doi: 10.1038/ncomms5952.


Differential requirement for Src family tyrosine kinases in the initiation, progression, and metastasis of prostate cancer.

Gelman IH, Peresie J, Eng KH, Foster BA.

Mol Cancer Res. 2014 Oct;12(10):1470-9. doi: 10.1158/1541-7786.MCR-13-0490-T. Epub 2014 Jul 22.


A genome-wide RNAi screen identifies FOXO4 as a metastasis-suppressor through counteracting PI3K/AKT signal pathway in prostate cancer.

Su B, Gao L, Baranowski C, Gillard B, Wang J, Ransom R, Ko HK, Gelman IH.

PLoS One. 2014 Jul 1;9(7):e101411. doi: 10.1371/journal.pone.0101411. eCollection 2014.


Androgen receptor activation in castration-recurrent prostate cancer: the role of Src-family and Ack1 tyrosine kinases.

Gelman IH.

Int J Biol Sci. 2014 Jun 5;10(6):620-6. doi: 10.7150/ijbs.8264. eCollection 2014. Review.


AKAP12 mediates barrier functions of fibrotic scars during CNS repair.

Cha JH, Wee HJ, Seo JH, Ahn BJ, Park JH, Yang JM, Lee SW, Kim EH, Lee OH, Heo JH, Lee HJ, Gelman IH, Arai K, Lo EH, Kim KW.

PLoS One. 2014 Apr 23;9(4):e94695. doi: 10.1371/journal.pone.0094695. eCollection 2014.


A transgenic mouse model for early prostate metastasis to lymph nodes.

Ko HK, Akakura S, Peresie J, Goodrich DW, Foster BA, Gelman IH.

Cancer Res. 2014 Feb 1;74(3):945-53. doi: 10.1158/0008-5472.CAN-13-1157. Erratum in: Cancer Res. 2014 Apr 15;74(8):2374.


Src controls castration recurrence of CWR22 prostate cancer xenografts.

Su B, Gillard B, Gao L, Eng KH, Gelman IH.

Cancer Med. 2013 Dec;2(6):784-92. doi: 10.1002/cam4.144. Epub 2013 Oct 11.


Origin of parietal podocytes in atubular glomeruli mapped by lineage tracing.

Schulte K, Berger K, Boor P, Jirak P, Gelman IH, Arkill KP, Neal CR, Kriz W, Floege J, Smeets B, Moeller MJ.

J Am Soc Nephrol. 2014 Jan;25(1):129-41. doi: 10.1681/ASN.2013040376. Epub 2013 Sep 26.


Gravin orchestrates protein kinase A and β2-adrenergic receptor signaling critical for synaptic plasticity and memory.

Havekes R, Canton DA, Park AJ, Huang T, Nie T, Day JP, Guercio LA, Grimes Q, Luczak V, Gelman IH, Baillie GS, Scott JD, Abel T.

J Neurosci. 2012 Dec 12;32(50):18137-49. doi: 10.1523/JNEUROSCI.3612-12.2012.


Proximal tubular cells contain a phenotypically distinct, scattered cell population involved in tubular regeneration.

Smeets B, Boor P, Dijkman H, Sharma SV, Jirak P, Mooren F, Berger K, Bornemann J, Gelman IH, Floege J, van der Vlag J, Wetzels JF, Moeller MJ.

J Pathol. 2013 Apr;229(5):645-59. doi: 10.1002/path.4125.


Adhesion-mediated cytoskeletal remodeling is controlled by the direct scaffolding of Src from FAK complexes to lipid rafts by SSeCKS/AKAP12.

Su B, Gao L, Meng F, Guo LW, Rothschild J, Gelman IH.

Oncogene. 2013 Apr 18;32(16):2016-26. doi: 10.1038/onc.2012.218. Epub 2012 Jun 18.


Suppression of tumor and metastasis progression through the scaffolding functions of SSeCKS/Gravin/AKAP12.

Gelman IH.

Cancer Metastasis Rev. 2012 Dec;31(3-4):493-500. doi: 10.1007/s10555-012-9360-1. Review.


PTPN14 interacts with and negatively regulates the oncogenic function of YAP.

Liu X, Yang N, Figel SA, Wilson KE, Morrison CD, Gelman IH, Zhang J.

Oncogene. 2013 Mar 7;32(10):1266-73. doi: 10.1038/onc.2012.147. Epub 2012 Apr 23.


A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl)-3, 5, 7-triaza-1-azoniatricyclo [,7)]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonogenicity and tumor growth in vivo.

Golubovskaya VM, Figel S, Ho BT, Johnson CP, Yemma M, Huang G, Zheng M, Nyberg C, Magis A, Ostrov DA, Gelman IH, Cance WG.

Carcinogenesis. 2012 May;33(5):1004-13. doi: 10.1093/carcin/bgs120. Epub 2012 Mar 7.


SSeCKS sequesters cyclin D1 in glomerular parietal epithelial cells and influences proliferative injury in the glomerulus.

Burnworth B, Pippin J, Karna P, Akakura S, Krofft R, Zhang G, Hudkins K, Alpers CE, Smith K, Shankland SJ, Gelman IH, Nelson PJ.

Lab Invest. 2012 Apr;92(4):499-510. doi: 10.1038/labinvest.2011.199. Epub 2012 Jan 16.


Control of protein kinase C activity, phorbol ester-induced cytoskeletal remodeling, and cell survival signals by the scaffolding protein SSeCKS/GRAVIN/AKAP12.

Guo LW, Gao L, Rothschild J, Su B, Gelman IH.

J Biol Chem. 2011 Nov 4;286(44):38356-66. doi: 10.1074/jbc.M111.258830. Epub 2011 Sep 7.


Introduction: hanafusa memorial issue, part 2.

Gelman IH, Sudol M.

Genes Cancer. 2010 Dec;1(12):1163. doi: 10.1177/1947601911407630. No abstract available.


Introduction: hanafusa memorial issue.

Gelman IH, Sudol M.

Genes Cancer. 2010 Nov;1(11):1088. doi: 10.1177/1947601911401912. No abstract available.


Src-family tyrosine kinases as therapeutic targets in advanced cancer.

Gelman IH.

Front Biosci (Elite Ed). 2011 Jun 1;3:801-7. Review.


Retinoid-induced expression and activity of an immediate early tumor suppressor gene in vascular smooth muscle cells.

Streb JW, Long X, Lee TH, Sun Q, Kitchen CM, Georger MA, Slivano OJ, Blaner WS, Carr DW, Gelman IH, Miano JM.

PLoS One. 2011 Apr 5;6(4):e18538. doi: 10.1371/journal.pone.0018538.


Focal adhesion kinase controls prostate cancer progression via intrinsic kinase and scaffolding functions.

Figel S, Gelman IH.

Anticancer Agents Med Chem. 2011 Sep;11(7):607-16. Review.


Carcinogen-induced squamous papillomas and oncogenic progression in the absence of the SSeCKS/AKAP12 metastasis suppressor correlate with FAK upregulation.

Akakura S, Bouchard R, Bshara W, Morrison C, Gelman IH.

Int J Cancer. 2011 Oct 15;129(8):2025-31. doi: 10.1002/ijc.25828. Epub 2011 Apr 1.


Rb-dependent cellular senescence, multinucleation and susceptibility to oncogenic transformation through PKC scaffolding by SSeCKS/AKAP12.

Akakura S, Nochajski P, Gao L, Sotomayor P, Matsui S, Gelman IH.

Cell Cycle. 2010 Dec 1;9(23):4656-65. Epub 2010 Dec 1.


Role for transcription factor TFII-I in the suppression of SSeCKS/Gravin/Akap12 transcription by Src.

Bu Y, Gao L, Gelman IH.

Int J Cancer. 2011 Apr 15;128(8):1836-42. doi: 10.1002/ijc.25524.


SSeCKS/Gravin/AKAP12 inhibits cancer cell invasiveness and chemotaxis by suppressing a protein kinase C- Raf/MEK/ERK pathway.

Su B, Bu Y, Engelberg D, Gelman IH.

J Biol Chem. 2010 Feb 12;285(7):4578-86. doi: 10.1074/jbc.M109.073494. Epub 2009 Dec 15.


Expression of Src and FAK in hepatocellular carcinoma and the effect of Src inhibitors on hepatocellular carcinoma in vitro.

Lau GM, Lau GM, Yu GL, Gelman IH, Gutowski A, Hangauer D, Fang JW.

Dig Dis Sci. 2009 Jul;54(7):1465-74. doi: 10.1007/s10620-008-0519-0. Epub 2008 Nov 1.


Reovirus infection of cancer cells is not due to activated Ras pathway.

Song L, Ohnuma T, Gelman IH, Holland JF.

Cancer Gene Ther. 2009 Apr;16(4):382. doi: 10.1038/cgt.2008.84. Epub 2008 Oct 24. No abstract available.


Loss of the SSeCKS/Gravin/AKAP12 gene results in prostatic hyperplasia.

Akakura S, Huang C, Nelson PJ, Foster B, Gelman IH.

Cancer Res. 2008 Jul 1;68(13):5096-103. doi: 10.1158/0008-5472.CAN-07-5619.


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