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Items: 1 to 50 of 102


Perfect timing: circadian rhythms, sleep, and immunity - an NIH workshop summary.

Haspel JA, Anafi R, Brown MK, Cermakian N, Depner C, Desplats P, Gelman AE, Haack M, Jelic S, Kim BS, Laposky AD, Lee YC, Mongodin E, Prather AA, Prendergast B, Reardon C, Shaw AC, Sengupta S, Szentirmai É, Thakkar M, Walker WE, Solt LA.

JCI Insight. 2020 Jan 16;5(1). pii: 131487. doi: 10.1172/jci.insight.131487. Review.


IL-22 is required for the induction of bronchus-associated lymphoid tissue in tolerant lung allografts.

Tanaka S, Gauthier JM, Fuchs A, Li W, Tong AY, Harrison MS, Higashikubo R, Terada Y, Hachem RR, Ruiz-Perez D, Ritter JH, Cella M, Colonna M, Turnbull IR, Krupnick AS, Gelman AE, Kreisel D.

Am J Transplant. 2019 Nov 13. doi: 10.1111/ajt.15701. [Epub ahead of print]


Pseudomonas aeruginosa and acute rejection independently increase the risk of donor-specific antibodies after lung transplantation.

Kulkarni HS, Tsui K, Sunder S, Ganninger A, Tague LK, Witt CA, Byers DE, Trulock EP, Nava R, Puri V, Kreisel D, Mohanakumar T, Gelman AE, Hachem RR.

Am J Transplant. 2019 Nov 2. doi: 10.1111/ajt.15687. [Epub ahead of print]


Deciphering the role of eosinophils in solid organ transplantation.

Onyema OO, Guo Y, Hata A, Kreisel D, Gelman AE, Jacobsen EA, Krupnick AS.

Am J Transplant. 2019 Oct 24. doi: 10.1111/ajt.15660. [Epub ahead of print] Review.


The emerging role of regulatory T cells following lung transplantation.

Gauthier JM, Harrison MS, Krupnick AS, Gelman AE, Kreisel D.

Immunol Rev. 2019 Nov;292(1):194-208. doi: 10.1111/imr.12801. Epub 2019 Sep 19. Review.


Lung transplant outcomes are influenced by severity of neutropenia and granulocyte colony-stimulating factor treatment.

Tague LK, Scozzi D, Wallendorf M, Gage BF, Krupnick AS, Kreisel D, Byers D, Hachem RR, Gelman AE.

Am J Transplant. 2020 Jan;20(1):250-261. doi: 10.1111/ajt.15581. Epub 2019 Sep 26.


Vendor-specific microbiome controls both acute and chronic murine lung allograft rejection by altering CD4+ Foxp3+ regulatory T cell levels.

Guo Y, Wang Q, Li D, Onyema OO, Mei Z, Manafi A, Banerjee A, Mahgoub B, Stoler MH, Barker TH, Wilkes DS, Gelman AE, Kreisel D, Krupnick AS.

Am J Transplant. 2019 Oct;19(10):2705-2718. doi: 10.1111/ajt.15523. Epub 2019 Aug 2.


Eosinophils downregulate lung alloimmunity by decreasing TCR signal transduction.

Onyema OO, Guo Y, Mahgoub B, Wang Q, Manafi A, Mei Z, Banerjee A, Li D, Stoler MH, Zaidi MT, Schrum AG, Kreisel D, Gelman AE, Jacobsen EA, Krupnick AS.

JCI Insight. 2019 Jun 6;4(11). pii: 128241. doi: 10.1172/jci.insight.128241. eCollection 2019 Jun 6.


An obligatory role for club cells in preventing obliterative bronchiolitis in lung transplants.

Liu Z, Liao F, Scozzi D, Furuya Y, Pugh KN, Hachem R, Chen DL, Cano M, Green JM, Krupnick AS, Kreisel D, Perl AKT, Huang HJ, Brody SL, Gelman AE.

JCI Insight. 2019 Apr 16;5. pii: 124732. doi: 10.1172/jci.insight.124732.


Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation.

Li W, Feng G, Gauthier JM, Lokshina I, Higashikubo R, Evans S, Liu X, Hassan A, Tanaka S, Cicka M, Hsiao HM, Ruiz-Perez D, Bredemeyer A, Gross RW, Mann DL, Tyurina YY, Gelman AE, Kagan VE, Linkermann A, Lavine KJ, Kreisel D.

J Clin Invest. 2019 Feb 26;129(6):2293-2304. doi: 10.1172/JCI126428.


Mitochondrial damage-associated molecular patterns released by lung transplants are associated with primary graft dysfunction.

Scozzi D, Ibrahim M, Liao F, Lin X, Hsiao HM, Hachem R, Tague LK, Ricci A, Kulkarni HS, Huang HJ, Sugimoto S, Krupnick AS, Kreisel D, Gelman AE.

Am J Transplant. 2019 May;19(5):1464-1477. doi: 10.1111/ajt.15232. Epub 2019 Jan 25.


Bronchus-associated lymphoid tissue-resident Foxp3+ T lymphocytes prevent antibody-mediated lung rejection.

Li W, Gauthier JM, Higashikubo R, Hsiao HM, Tanaka S, Vuong L, Ritter JH, Tong AY, Wong BW, Hachem RR, Puri V, Bharat A, Krupnick AS, Hsieh CS, Baldwin WM 3rd, Kelly FL, Palmer SM, Gelman AE, Kreisel D.

J Clin Invest. 2019 Feb 1;129(2):556-568. doi: 10.1172/JCI122083. Epub 2018 Dec 18.


Neutrophil extracellular trap fragments stimulate innate immune responses that prevent lung transplant tolerance.

Scozzi D, Wang X, Liao F, Liu Z, Zhu J, Pugh K, Ibrahim M, Hsiao HM, Miller MJ, Yizhan G, Mohanakumar T, Krupnick AS, Kreisel D, Gelman AE.

Am J Transplant. 2019 Apr;19(4):1011-1023. doi: 10.1111/ajt.15163. Epub 2018 Dec 13.


Spleen-derived classical monocytes mediate lung ischemia-reperfusion injury through IL-1β.

Hsiao HM, Fernandez R, Tanaka S, Li W, Spahn JH, Chiu S, Akbarpour M, Ruiz-Perez D, Wu Q, Turam C, Scozzi D, Takahashi T, Luehmann HP, Puri V, Budinger GRS, Krupnick AS, Misharin AV, Lavine KJ, Liu Y, Gelman AE, Bharat A, Kreisel D.

J Clin Invest. 2018 Jul 2;128(7):2833-2847. doi: 10.1172/JCI98436. Epub 2018 May 21.


Diagnosis, Pathophysiology and Experimental Models of Chronic Lung Allograft Rejection.

Gauthier JM, Ruiz-Pérez D, Li W, Hachem RR, Puri V, Gelman AE, Kreisel D.

Transplantation. 2018 Sep;102(9):1459-1466. doi: 10.1097/TP.0000000000002250. Review.


Visualization of Monocytic Cells in Regressing Atherosclerotic Plaques by Intravital 2-Photon and Positron Emission Tomography-Based Imaging-Brief Report.

Li W, Luehmann HP, Hsiao HM, Tanaka S, Higashikubo R, Gauthier JM, Sultan D, Lavine KJ, Brody SL, Gelman AE, Gropler RJ, Liu Y, Kreisel D.

Arterioscler Thromb Vasc Biol. 2018 May;38(5):1030-1036. doi: 10.1161/ATVBAHA.117.310517. Epub 2018 Mar 22.


Eosinophils promote inducible NOS-mediated lung allograft acceptance.

Onyema OO, Guo Y, Wang Q, Stoler MH, Lau C, Li K, Nazaroff CD, Wang X, Li W, Kreisel D, Gelman AE, Lee JJ, Jacobsen EA, Krupnick AS.

JCI Insight. 2017 Dec 21;2(24). pii: 96455. doi: 10.1172/jci.insight.96455.


Naive CD4+ T Cells Carrying a TLR2 Agonist Overcome TGF-β-Mediated Tumor Immune Evasion.

Ibrahim M, Scozzi D, Toth KA, Ponti D, Kreisel D, Menna C, De Falco E, D'Andrilli A, Rendina EA, Calogero A, Krupnick AS, Gelman AE.

J Immunol. 2018 Jan 15;200(2):847-856. doi: 10.4049/jimmunol.1700396. Epub 2017 Dec 6.


Mechanisms of Graft Rejection and Immune Regulation after Lung Transplant.

Gauthier JM, Li W, Hsiao HM, Takahashi T, Arefanian S, Krupnick AS, Gelman AE, Kreisel D.

Ann Am Thorac Soc. 2017 Sep;14(Supplement_3):S216-S219. doi: 10.1513/AnnalsATS.201607-576MG.


Endotracheal tube-induced sore throat pain and inflammation is coupled to the release of mitochondrial DNA.

Puyo CA, Peruzzi D, Earhart A, Roller E, Karanikolas M, Kollef MH, Krupnick AS, Kreisel D, Ibrahim M, Gelman AE.

Mol Pain. 2017 Jan-Dec;13:1744806917731696. doi: 10.1177/1744806917731696.


Report of the ISHLT Working Group on Primary Lung Graft Dysfunction Part III: Mechanisms: A 2016 Consensus Group Statement of the International Society for Heart and Lung Transplantation.

Gelman AE, Fisher AJ, Huang HJ, Baz MA, Shaver CM, Egan TM, Mulligan MS.

J Heart Lung Transplant. 2017 Oct;36(10):1114-1120. doi: 10.1016/j.healun.2017.07.014. Epub 2017 Jul 24. Review. No abstract available.


PD-1 expression on CD8+ T cells regulates their differentiation within lung allografts and is critical for tolerance induction.

Takahashi T, Hsiao HM, Tanaka S, Li W, Higashikubo R, Scozzi D, Bharat A, Ritter JH, Krupnick AS, Gelman AE, Kreisel D.

Am J Transplant. 2018 Jan;18(1):216-225. doi: 10.1111/ajt.14437. Epub 2017 Aug 23.


Zbtb7a induction in alveolar macrophages is implicated in anti-HLA-mediated lung allograft rejection.

Nayak DK, Zhou F, Xu M, Huang J, Tsuji M, Yu J, Hachem R, Gelman AE, Bremner RM, Smith MA, Mohanakumar T.

Sci Transl Med. 2017 Jul 12;9(398). pii: eaal1243. doi: 10.1126/scitranslmed.aal1243.


Models of Lung Transplant Research: a consensus statement from the National Heart, Lung, and Blood Institute workshop.

Lama VN, Belperio JA, Christie JD, El-Chemaly S, Fishbein MC, Gelman AE, Hancock WW, Keshavjee S, Kreisel D, Laubach VE, Looney MR, McDyer JF, Mohanakumar T, Shilling RA, Panoskaltsis-Mortari A, Wilkes DS, Eu JP, Nicolls MR.

JCI Insight. 2017 May 4;2(9). pii: 93121. doi: 10.1172/jci.insight.93121. eCollection 2017 May 4. Review.


Deficiency of the adaptor protein SLy1 results in a natural killer cell ribosomopathy affecting tumor clearance.

Arefanian S, Schäll D, Chang S, Ghasemi R, Higashikubo R, Zheleznyak A, Guo Y, Yu J, Asgharian H, Li W, Gelman AE, Kreisel D, French AR, Zaher H, Plougastel-Douglas B, Maggi L, Yokoyama W, Beer-Hammer S, Krupnick AS.

Oncoimmunology. 2016 Sep 27;5(12):e1238543. doi: 10.1080/2162402X.2016.1238543. eCollection 2016.


CD36 deficiency impairs the small intestinal barrier and induces subclinical inflammation in mice.

Cifarelli V, Ivanov S, Xie Y, Son NH, Saunders BT, Pietka TA, Shew TM, Yoshino J, Sundaresan S, Davidson NO, Goldberg IJ, Gelman AE, Zinselmeyer BH, Randolph GJ, Abumrad NA.

Cell Mol Gastroenterol Hepatol. 2017 Jan;3(1):82-98. doi: 10.1016/j.jcmgh.2016.09.001.


Selective targeting of IL-2 to NKG2D bearing cells for improved immunotherapy.

Ghasemi R, Lazear E, Wang X, Arefanian S, Zheleznyak A, Carreno BM, Higashikubo R, Gelman AE, Kreisel D, Fremont DH, Krupnick AS.

Nat Commun. 2016 Sep 21;7:12878. doi: 10.1038/ncomms12878.


Heart-resident CCR2+ macrophages promote neutrophil extravasation through TLR9/MyD88/CXCL5 signaling.

Li W, Hsiao HM, Higashikubo R, Saunders BT, Bharat A, Goldstein DR, Krupnick AS, Gelman AE, Lavine KJ, Kreisel D.

JCI Insight. 2016 Aug 4;1(12). pii: 87315. doi: 10.1172/jci.insight.87315.


The Role of Neutrophils in Transplanted Organs.

Scozzi D, Ibrahim M, Menna C, Krupnick AS, Kreisel D, Gelman AE.

Am J Transplant. 2017 Feb;17(2):328-335. doi: 10.1111/ajt.13940. Epub 2016 Jul 25. Review.


Noninvasive Imaging of CCR2+ Cells in Ischemia-Reperfusion Injury After Lung Transplantation.

Liu Y, Li W, Luehmann HP, Zhao Y, Detering L, Sultan DH, Hsiao HM, Krupnick AS, Gelman AE, Combadiere C, Gropler RJ, Brody SL, Kreisel D.

Am J Transplant. 2016 Oct;16(10):3016-3023. doi: 10.1111/ajt.13907. Epub 2016 Jul 14.


The Role of Lymphoid Neogenesis in Allografts.

Hsiao HM, Li W, Gelman AE, Krupnick AS, Kreisel D.

Am J Transplant. 2016 Apr;16(4):1079-85. doi: 10.1111/ajt.13645. Epub 2016 Feb 15. Review.


De novo-developed antibodies to donor MHC antigens lead to dysregulation of microRNAs and induction of MHC class II.

Xu Z, Nayak DK, Benshoff N, Hachem R, Gelman AE, Mohanakumar T.

J Immunol. 2015 Jun 15;194(12):6133-43. doi: 10.4049/jimmunol.1401848. Epub 2015 May 4.


Disseminated Ureaplasma infection as a cause of fatal hyperammonemia in humans.

Bharat A, Cunningham SA, Scott Budinger GR, Kreisel D, DeWet CJ, Gelman AE, Waites K, Crabb D, Xiao L, Bhorade S, Ambalavanan N, Dilling DF, Lowery EM, Astor T, Hachem R, Krupnick AS, DeCamp MM, Ison MG, Patel R.

Sci Transl Med. 2015 Apr 22;7(284):284re3. doi: 10.1126/scitranslmed.aaa8419.


DAP12 expression in lung macrophages mediates ischemia/reperfusion injury by promoting neutrophil extravasation.

Spahn JH, Li W, Bribriesco AC, Liu J, Shen H, Ibricevic A, Pan JH, Zinselmeyer BH, Brody SL, Goldstein DR, Krupnick AS, Gelman AE, Miller MJ, Kreisel D.

J Immunol. 2015 Apr 15;194(8):4039-48. doi: 10.4049/jimmunol.1401415. Epub 2015 Mar 11.


Human recombinant apyrase therapy protects against canine pulmonary ischemia-reperfusion injury.

Ibrahim M, Wang X, Puyo CA, Montecalvo A, Huang HJ, Hachem RR, Andreetti C, Menna C, Chen R, Krupnick AS, Kreisel D, Rendina EA, Gelman AE.

J Heart Lung Transplant. 2015 Feb;34(2):247-53. doi: 10.1016/j.healun.2014.09.034. Epub 2014 Oct 2.


Lung transplant immunosuppression - time for a new approach?

Witt CA, Puri V, Gelman AE, Krupnick AS, Kreisel D.

Expert Rev Clin Immunol. 2014 Nov;10(11):1419-21. doi: 10.1586/1744666X.2014.959499. Epub 2014 Sep 14. Review.


Immune response to tissue-restricted self-antigens induces airway inflammation and fibrosis following murine lung transplantation.

Subramanian V, Ramachandran S, Banan B, Bharat A, Wang X, Benshoff N, Kreisel D, Gelman AE, Mohanakumar T.

Am J Transplant. 2014 Oct;14(10):2359-66. doi: 10.1111/ajt.12908. Epub 2014 Sep 12.


Imaging mouse lung allograft rejection with (1)H MRI.

Guo J, Huang HJ, Wang X, Wang W, Ellison H, Thomen RP, Gelman AE, Woods JC.

Magn Reson Med. 2015 May;73(5):1970-8. doi: 10.1002/mrm.25313. Epub 2014 Jun 20.


The role of neutrophil myeloperoxidase in models of lung tumor development.

Rymaszewski AL, Tate E, Yimbesalu JP, Gelman AE, Jarzembowski JA, Zhang H, Pritchard KA Jr, Vikis HG.

Cancers (Basel). 2014 May 9;6(2):1111-27. doi: 10.3390/cancers6021111.


Central memory CD8+ T lymphocytes mediate lung allograft acceptance.

Krupnick AS, Lin X, Li W, Higashikubo R, Zinselmeyer BH, Hartzler H, Toth K, Ritter JH, Berezin MY, Wang ST, Miller MJ, Gelman AE, Kreisel D.

J Clin Invest. 2014 Mar;124(3):1130-43. doi: 10.1172/JCI71359. Epub 2014 Feb 24.


Hyaluronan contributes to bronchiolitis obliterans syndrome and stimulates lung allograft rejection through activation of innate immunity.

Todd JL, Wang X, Sugimoto S, Kennedy VE, Zhang HL, Pavlisko EN, Kelly FL, Huang H, Kreisel D, Palmer SM, Gelman AE.

Am J Respir Crit Care Med. 2014 Mar 1;189(5):556-66. doi: 10.1164/rccm.201308-1481OC.


Activating killers by stimulating RAGE.

Gelman AE, Scozzi D.

Am J Transplant. 2013 Sep;13(9):2237-8. doi: 10.1111/ajt.12367. No abstract available.


Increased T cell glucose uptake reflects acute rejection in lung grafts.

Chen DL, Wang X, Yamamoto S, Carpenter D, Engle JT, Li W, Lin X, Kreisel D, Krupnick AS, Huang HJ, Gelman AE.

Am J Transplant. 2013 Oct;13(10):2540-9. doi: 10.1111/ajt.12389. Epub 2013 Aug 8.


Surgical technique for lung retransplantation in the mouse.

Li W, Goldstein DR, Bribriesco AC, Nava RG, Spahn JH, Wang X, Gelman AE, Krupnick AS, Kreisel D.

J Thorac Dis. 2013 Jun;5(3):321-5. doi: 10.3978/j.issn.2072-1439.2013.04.15.


Unique pulmonary antigen presentation may call for an alternative approach toward lung cancer immunotherapy.

Chang S, Lin X, Higashikubo R, Toth K, Gelman AE, Kreisel D, Krupnick AS.

Oncoimmunology. 2013 Mar 1;2(3):e23563.


Cutting edge: Pseudomonas aeruginosa abolishes established lung transplant tolerance by stimulating B7 expression on neutrophils.

Yamamoto S, Nava RG, Zhu J, Huang HJ, Ibrahim M, Mohanakumar T, Miller MJ, Krupnick AS, Kreisel D, Gelman AE.

J Immunol. 2012 Nov 1;189(9):4221-5. doi: 10.4049/jimmunol.1201683. Epub 2012 Sep 26.


Complement activation is not required for obliterative airway disease induced by antibodies to major histocompatibility complex class I: Implications for chronic lung rejection.

Takenaka M, Subramanian V, Tiriveedhi V, Phelan D, Hachem R, Trulock E, Gelman AE, Patterson GA, Hoshinaga K, Mohanakumar T.

J Heart Lung Transplant. 2012 Nov;31(11):1214-22. doi: 10.1016/j.healun.2012.08.011. Epub 2012 Sep 11.


T regulatory cells play a significant role in modulating MHC class I antibody-induced obliterative airway disease.

Tiriveedhi V, Takenaka M, Ramachandran S, Gelman AE, Subramanian V, Patterson GA, Mohanakumar T.

Am J Transplant. 2012 Oct;12(10):2663-74. doi: 10.1111/j.1600-6143.2012.04191.x. Epub 2012 Jul 23.


Five-year update on the mouse model of orthotopic lung transplantation: Scientific uses, tricks of the trade, and tips for success.

Lin X, Li W, Lai J, Okazaki M, Sugimoto S, Yamamoto S, Wang X, Gelman AE, Kreisel D, Krupnick AS.

J Thorac Dis. 2012 Jun 1;4(3):247-58. doi: 10.3978/j.issn.2072-1439.2012.06.02.


Strain-specific variation in murine natural killer gene complex contributes to differences in immunosurveillance for urethane-induced lung cancer.

Kreisel D, Gelman AE, Higashikubo R, Lin X, Vikis HG, White JM, Toth KA, Deshpande C, Carreno BM, You M, Taffner SM, Yokoyama WM, Bui JD, Schreiber RD, Krupnick AS.

Cancer Res. 2012 Sep 1;72(17):4311-7. Epub 2012 Jun 29.

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