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Items: 1 to 50 of 52

1.

A heme-binding protein produced by Haemophilus haemolyticus inhibits non-typeable Haemophilus influenzae.

Latham RD, Torrado M, Atto B, Walshe JL, Wilson R, Guss JM, Mackay JP, Tristram S, Gell DA.

Mol Microbiol. 2019 Nov 19. doi: 10.1111/mmi.14426. [Epub ahead of print]

PMID:
31742788
2.

Structural properties of a haemophore facilitate targeted elimination of the pathogen Porphyromonas gingivalis.

Gao JL, Kwan AH, Yammine A, Zhou X, Trewhella J, Hugrass BM, Collins DAT, Horne J, Ye P, Harty D, Nguyen KA, Gell DA, Hunter N.

Nat Commun. 2018 Oct 5;9(1):4097. doi: 10.1038/s41467-018-06470-0.

3.

Towards complete identification of allergens in Jack Jumper (Myrmecia pilosula) ant venom and their clinical relevance: An immunoproteomic approach.

Wanandy T, Wilson R, Gell D, Rose HE, Gueven N, Davies NW, Brown SGA, Wiese MD.

Clin Exp Allergy. 2018 Sep;48(9):1222-1234. doi: 10.1111/cea.13224. Epub 2018 Aug 3.

PMID:
29975807
4.

Energetics underlying hemin extraction from human hemoglobin by Staphylococcus aureus.

Sjodt M, Macdonald R, Marshall JD, Clayton J, Olson JS, Phillips M, Gell DA, Wereszczynski J, Clubb RT.

J Biol Chem. 2018 May 4;293(18):6942-6957. doi: 10.1074/jbc.RA117.000803. Epub 2018 Mar 14.

5.

Structure and function of haemoglobins.

Gell DA.

Blood Cells Mol Dis. 2018 May;70:13-42. doi: 10.1016/j.bcmd.2017.10.006. Epub 2017 Oct 31. Review.

PMID:
29126700
6.

An isolate of Haemophilus haemolyticus produces a bacteriocin-like substance that inhibits the growth of nontypeable Haemophilus influenzae.

Latham RD, Gell DA, Fairbairn RL, Lyons AB, Shukla SD, Cho KY, Jones DA, Harkness NM, Tristram SG.

Int J Antimicrob Agents. 2017 Apr;49(4):503-506. doi: 10.1016/j.ijantimicag.2016.12.010. Epub 2017 Feb 24.

PMID:
28242259
7.

The Staphylococcus aureus Protein IsdH Inhibits Host Hemoglobin Scavenging to Promote Heme Acquisition by the Pathogen.

Sæderup KL, Stødkilde K, Graversen JH, Dickson CF, Etzerodt A, Hansen SW, Fago A, Gell D, Andersen CB, Moestrup SK.

J Biol Chem. 2016 Nov 11;291(46):23989-23998. Epub 2016 Sep 28.

8.

The NEAT Domain-Containing Proteins of Clostridium perfringens Bind Heme.

Choo JM, Cheung JK, Wisniewski JA, Steer DL, Bulach DM, Hiscox TJ, Chakravorty A, Smith AI, Gell DA, Rood JI, Awad MM.

PLoS One. 2016 Sep 16;11(9):e0162981. doi: 10.1371/journal.pone.0162981. eCollection 2016.

9.

An antagonist of the platelet-activating factor receptor inhibits adherence of both nontypeable Haemophilus influenzae and Streptococcus pneumoniae to cultured human bronchial epithelial cells exposed to cigarette smoke.

Shukla SD, Fairbairn RL, Gell DA, Latham RD, Sohal SS, Walters EH, O'Toole RF.

Int J Chron Obstruct Pulmon Dis. 2016 Jul 25;11:1647-55. doi: 10.2147/COPD.S108698. eCollection 2016.

10.

The structure of haemoglobin bound to the haemoglobin receptor IsdH from Staphylococcus aureus shows disruption of the native α-globin haem pocket.

Dickson CF, Jacques DA, Clubb RT, Guss JM, Gell DA.

Acta Crystallogr D Biol Crystallogr. 2015 Jun;71(Pt 6):1295-306. doi: 10.1107/S1399004715005817. Epub 2015 May 14.

PMID:
26057669
11.

The PRE-Derived NMR Model of the 38.8-kDa Tri-Domain IsdH Protein from Staphylococcus aureus Suggests That It Adaptively Recognizes Human Hemoglobin.

Sjodt M, Macdonald R, Spirig T, Chan AH, Dickson CF, Fabian M, Olson JS, Gell DA, Clubb RT.

J Mol Biol. 2016 Mar 27;428(6):1107-1129. doi: 10.1016/j.jmb.2015.02.008. Epub 2015 Feb 14.

12.

The structure of α-haemoglobin in complex with a haemoglobin-binding domain from Staphylococcus aureus reveals the elusive α-haemoglobin dimerization interface.

Kumar KK, Jacques DA, Guss JM, Gell DA.

Acta Crystallogr F Struct Biol Commun. 2014 Aug;70(Pt 8):1032-7. doi: 10.1107/S2053230X14012175. Epub 2014 Jul 23.

13.

Structure of the hemoglobin-IsdH complex reveals the molecular basis of iron capture by Staphylococcus aureus.

Dickson CF, Kumar KK, Jacques DA, Malmirchegini GR, Spirig T, Mackay JP, Clubb RT, Guss JM, Gell DA.

J Biol Chem. 2014 Mar 7;289(10):6728-38. doi: 10.1074/jbc.M113.545566. Epub 2014 Jan 14.

14.

IsdB-dependent hemoglobin binding is required for acquisition of heme by Staphylococcus aureus.

Pishchany G, Sheldon JR, Dickson CF, Alam MT, Read TD, Gell DA, Heinrichs DE, Skaar EP.

J Infect Dis. 2014 Jun 1;209(11):1764-72. doi: 10.1093/infdis/jit817. Epub 2013 Dec 13.

15.

α-Hemoglobin-stabilizing protein (AHSP) perturbs the proximal heme pocket of oxy-α-hemoglobin and weakens the iron-oxygen bond.

Dickson CF, Rich AM, D'Avigdor WM, Collins DA, Lowry JA, Mollan TL, Khandros E, Olson JS, Weiss MJ, Mackay JP, Lay PA, Gell DA.

J Biol Chem. 2013 Jul 5;288(27):19986-20001. doi: 10.1074/jbc.M112.437509. Epub 2013 May 21.

16.

Effects of calcium binding and the hypertrophic cardiomyopathy A8V mutation on the dynamic equilibrium between closed and open conformations of the regulatory N-domain of isolated cardiac troponin C.

Cordina NM, Liew CK, Gell DA, Fajer PG, Mackay JP, Brown LJ.

Biochemistry. 2013 Mar 19;52(11):1950-62. doi: 10.1021/bi4000172. Epub 2013 Mar 6.

PMID:
23425245
17.

Hemoglobin variants: biochemical properties and clinical correlates.

Thom CS, Dickson CF, Gell DA, Weiss MJ.

Cold Spring Harb Perspect Med. 2013 Mar 1;3(3):a011858. doi: 10.1101/cshperspect.a011858. Review.

18.

Staphylococcus aureus uses a novel multidomain receptor to break apart human hemoglobin and steal its heme.

Spirig T, Malmirchegini GR, Zhang J, Robson SA, Sjodt M, Liu M, Krishna Kumar K, Dickson CF, Gell DA, Lei B, Loo JA, Clubb RT.

J Biol Chem. 2013 Jan 11;288(2):1065-78. doi: 10.1074/jbc.M112.419119. Epub 2012 Nov 6.

19.

The detection and quantitation of protein oligomerization.

Gell DA, Grant RP, Mackay JP.

Adv Exp Med Biol. 2012;747:19-41. doi: 10.1007/978-1-4614-3229-6_2. Review.

PMID:
22949109
20.

Interdomain orientation of cardiac troponin C characterized by paramagnetic relaxation enhancement NMR reveals a compact state.

Cordina NM, Liew CK, Gell DA, Fajer PG, Mackay JP, Brown LJ.

Protein Sci. 2012 Sep;21(9):1376-87. doi: 10.1002/pro.2124.

21.

Metallothionein (MT) -I and MT-II expression are induced and cause zinc sequestration in the liver after brain injury.

Pankhurst MW, Gell DA, Butler CW, Kirkcaldie MT, West AK, Chung RS.

PLoS One. 2012;7(2):e31185. doi: 10.1371/journal.pone.0031185. Epub 2012 Feb 17.

22.

Insights into hemoglobin assembly through in vivo mutagenesis of α-hemoglobin stabilizing protein.

Khandros E, Mollan TL, Yu X, Wang X, Yao Y, D'Souza J, Gell DA, Olson JS, Weiss MJ.

J Biol Chem. 2012 Mar 30;287(14):11325-37. doi: 10.1074/jbc.M111.313205. Epub 2012 Jan 27.

23.

Structural basis for hemoglobin capture by Staphylococcus aureus cell-surface protein, IsdH.

Krishna Kumar K, Jacques DA, Pishchany G, Caradoc-Davies T, Spirig T, Malmirchegini GR, Langley DB, Dickson CF, Mackay JP, Clubb RT, Skaar EP, Guss JM, Gell DA.

J Biol Chem. 2011 Nov 4;286(44):38439-47. doi: 10.1074/jbc.M111.287300. Epub 2011 Sep 14.

24.

AHSP (α-haemoglobin-stabilizing protein) stabilizes apo-α-haemoglobin in a partially folded state.

Krishna Kumar K, Dickson CF, Weiss MJ, Mackay JP, Gell DA.

Biochem J. 2010 Dec 1;432(2):275-82. doi: 10.1042/BJ20100642.

25.

Two-state conformational equilibrium in the Par-4 leucine zipper domain.

Schwalbe M, Dutta K, Libich DS, Venugopal H, Claridge JK, Gell DA, Mackay JP, Edwards PJ, Pascal SM.

Proteins. 2010 Aug 15;78(11):2433-49. doi: 10.1002/prot.22752.

PMID:
20602362
26.

A cis-proline in alpha-hemoglobin stabilizing protein directs the structural reorganization of alpha-hemoglobin.

Gell DA, Feng L, Zhou S, Jeffrey PD, Bendak K, Gow A, Weiss MJ, Shi Y, Mackay JP.

J Biol Chem. 2009 Oct 23;284(43):29462-9. doi: 10.1074/jbc.M109.027045. Epub 2009 Aug 25.

27.

An erythroid chaperone that facilitates folding of alpha-globin subunits for hemoglobin synthesis.

Yu X, Kong Y, Dore LC, Abdulmalik O, Katein AM, Zhou S, Choi JK, Gell D, Mackay JP, Gow AJ, Weiss MJ.

J Clin Invest. 2007 Jul;117(7):1856-65.

28.

A novel haem-binding interface in the 22 kDa haem-binding protein p22HBP.

Gell DA, Westman BJ, Gorman D, Liew C, Welch JJ, Weiss MJ, Mackay JP.

J Mol Biol. 2006 Sep 15;362(2):287-97. Epub 2006 Aug 14.

PMID:
16905148
29.

Cassini ion and neutral mass spectrometer: Enceladus plume composition and structure.

Waite JH Jr, Combi MR, Ip WH, Cravens TE, McNutt RL Jr, Kasprzak W, Yelle R, Luhmann J, Niemann H, Gell D, Magee B, Fletcher G, Lunine J, Tseng WL.

Science. 2006 Mar 10;311(5766):1419-22.

30.

Role of alpha-hemoglobin-stabilizing protein in normal erythropoiesis and beta-thalassemia.

Weiss MJ, Zhou S, Feng L, Gell DA, Mackay JP, Shi Y, Gow AJ.

Ann N Y Acad Sci. 2005;1054:103-17. Review.

PMID:
16339656
31.

Structure of oxidized alpha-haemoglobin bound to AHSP reveals a protective mechanism for haem.

Feng L, Zhou S, Gu L, Gell DA, Mackay JP, Weiss MJ, Gow AJ, Shi Y.

Nature. 2005 Jun 2;435(7042):697-701.

PMID:
15931225
32.

Ion neutral mass spectrometer results from the first flyby of Titan.

Waite JH Jr, Niemann H, Yelle RV, Kasprzak WT, Cravens TE, Luhmann JG, McNutt RL, Ip WH, Gell D, De La Haye V, Müller-Wordag I, Magee B, Borggren N, Ledvina S, Fletcher G, Walter E, Miller R, Scherer S, Thorpe R, Xu J, Block B, Arnett K.

Science. 2005 May 13;308(5724):982-6.

33.

Molecular mechanism of AHSP-mediated stabilization of alpha-hemoglobin.

Feng L, Gell DA, Zhou S, Gu L, Kong Y, Li J, Hu M, Yan N, Lee C, Rich AM, Armstrong RS, Lay PA, Gow AJ, Weiss MJ, Mackay JP, Shi Y.

Cell. 2004 Nov 24;119(5):629-40.

34.

Loss of alpha-hemoglobin-stabilizing protein impairs erythropoiesis and exacerbates beta-thalassemia.

Kong Y, Zhou S, Kihm AJ, Katein AM, Yu X, Gell DA, Mackay JP, Adachi K, Foster-Brown L, Louden CS, Gow AJ, Weiss MJ.

J Clin Invest. 2004 Nov;114(10):1457-66.

35.

Engineering a protein scaffold from a PHD finger.

Kwan AH, Gell DA, Verger A, Crossley M, Matthews JM, Mackay JP.

Structure. 2003 Jul;11(7):803-13.

36.

Biophysical characterization of the alpha-globin binding protein alpha-hemoglobin stabilizing protein.

Gell D, Kong Y, Eaton SA, Weiss MJ, Mackay JP.

J Biol Chem. 2002 Oct 25;277(43):40602-9. Epub 2002 Aug 20.

37.

Ikaros: a key regulator of haematopoiesis.

Westman BJ, Mackay JP, Gell D.

Int J Biochem Cell Biol. 2002 Oct;34(10):1304-7. Review.

PMID:
12127581
38.

Characterization of the conserved interaction between GATA and FOG family proteins.

Kowalski K, Liew CK, Matthews JM, Gell DA, Crossley M, Mackay JP.

J Biol Chem. 2002 Sep 20;277(38):35720-9. Epub 2002 Jul 10.

39.

A new zinc binding fold underlines the versatility of zinc binding modules in protein evolution.

Sharpe BK, Matthews JM, Kwan AH, Newton A, Gell DA, Crossley M, Mackay JP.

Structure. 2002 May;10(5):639-48.

40.

Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression.

Herceg Z, Hulla W, Gell D, Cuenin C, Lleonart M, Jackson S, Wang ZQ.

Nat Genet. 2001 Oct;29(2):206-11.

PMID:
11544477
41.

A new X-ray sensitive CHO cell mutant of ionizing radiation group 7,XR-C2, that is defective in DSB repair but has only a mild defect in V(D)J recombination.

Errami A, Overkamp WJ, He DM, Friedl AA, Gell DA, Eckardt-Schupp F, Jackson SP, Hendrickson EA, Lohman PH, Zdzienicka MZ.

Mutat Res. 2000 Sep 15;461(1):59-69.

PMID:
10980412
42.

Mapping of protein-protein interactions within the DNA-dependent protein kinase complex.

Gell D, Jackson SP.

Nucleic Acids Res. 1999 Sep 1;27(17):3494-502.

43.

Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity.

Taccioli GE, Amatucci AG, Beamish HJ, Gell D, Xiang XH, Torres Arzayus MI, Priestley A, Jackson SP, Marshak Rothstein A, Jeggo PA, Herrera VL.

Immunity. 1998 Sep;9(3):355-66.

44.

Molecular and biochemical characterisation of DNA-dependent protein kinase-defective rodent mutant irs-20.

Priestley A, Beamish HJ, Gell D, Amatucci AG, Muhlmann-Diaz MC, Singleton BK, Smith GC, Blunt T, Schalkwyk LC, Bedford JS, Jackson SP, Jeggo PA, Taccioli GE.

Nucleic Acids Res. 1998 Apr 15;26(8):1965-73.

45.

A DNA double-strand break defective fibroblast cell line (180BR) derived from a radiosensitive patient represents a new mutant phenotype.

Badie C, Goodhardt M, Waugh A, Doyen N, Foray N, Calsou P, Singleton B, Gell D, Salles B, Jeggo P, Arlett CF, Malaise EP.

Cancer Res. 1997 Oct 15;57(20):4600-7.

46.

Modified mRNA rescue of maternal CK1/8 mRNA depletion in Xenopus oocytes.

Raats JM, Gell D, Vickers L, Heasman J, Wylie C.

Antisense Nucleic Acid Drug Dev. 1997 Aug;7(4):263-77.

PMID:
9303179
47.

Molecular and biochemical characterization of xrs mutants defective in Ku80.

Singleton BK, Priestley A, Steingrimsdottir H, Gell D, Blunt T, Jackson SP, Lehmann AR, Jeggo PA.

Mol Cell Biol. 1997 Mar;17(3):1264-73.

48.

Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse.

Blunt T, Gell D, Fox M, Taccioli GE, Lehmann AR, Jackson SP, Jeggo PA.

Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10285-90.

49.

Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus.

Miller RD, Hogg J, Ozaki JH, Gell D, Jackson SP, Riblet R.

Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10792-5.

50.

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product.

Hartley KO, Gell D, Smith GC, Zhang H, Divecha N, Connelly MA, Admon A, Lees-Miller SP, Anderson CW, Jackson SP.

Cell. 1995 Sep 8;82(5):849-56.

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