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Items: 46

1.

Insulin-like peptide 5 fails to improve metabolism or body weight in obese mice.

Zaykov AN, Gelfanov VM, Perez-Tilve D, Finan B, DiMarchi RD.

Peptides. 2019 Oct;120:170116. doi: 10.1016/j.peptides.2019.170116. Epub 2019 Jul 23.

PMID:
31348991
2.

A Disulfide Scan of Insulin by [3 + 1] Methodology Exhibits Site-Specific Influence on Bioactivity.

Brunel FM, Mayer JP, Gelfanov VM, Zaykov AN, Finan B, Perez-Tilve D, DiMarchi RD.

ACS Chem Biol. 2019 Aug 16;14(8):1829-1835. doi: 10.1021/acschembio.9b00420. Epub 2019 Aug 6.

PMID:
31343157
3.

The islet-expressed Lhx1 transcription factor interacts with Islet-1 and contributes to glucose homeostasis.

Bethea M, Liu Y, Wade AK, Mullen R, Gupta R, Gelfanov V, DiMarchi R, Bhatnagar S, Behringer R, Habegger KM, Hunter CS.

Am J Physiol Endocrinol Metab. 2019 Mar 1;316(3):E397-E409. doi: 10.1152/ajpendo.00235.2018. Epub 2019 Jan 8.

PMID:
30620636
4.

Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism.

Mroz PA, Finan B, Gelfanov V, Yang B, Tschöp MH, DiMarchi RD, Perez-Tilve D.

Mol Metab. 2019 Feb;20:51-62. doi: 10.1016/j.molmet.2018.12.001. Epub 2018 Dec 5.

5.

Structurally Constrained Insulin Analogs by Directed Stepwise Crosslinking.

Zhang F, Mayer JP, Gelfanov V, Liu F, DiMarchi RD.

Protein Pept Lett. 2018;25(12):1149-1154. doi: 10.2174/0929866525666181101103500.

PMID:
30381053
6.

High-Yield Synthesis of Human Insulin-Like Peptide 5 Employing a Nonconventional Strategy.

Zaykov AN, Gelfanov VM, Liu F, DiMarchi RD.

Org Lett. 2018 Jun 15;20(12):3695-3699. doi: 10.1021/acs.orglett.8b01501. Epub 2018 Jun 6.

PMID:
29874090
7.

Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host-microbe interactions.

Altindis E, Cai W, Sakaguchi M, Zhang F, GuoXiao W, Liu F, De Meyts P, Gelfanov V, Pan H, DiMarchi R, Kahn CR.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2461-2466. doi: 10.1073/pnas.1721117115. Epub 2018 Feb 21.

8.

Synthesis and Characterization of the R27S Genetic Variant of Insulin-like Peptide 5.

Zaykov AN, Gelfanov VM, Liu F, DiMarchi RD.

ChemMedChem. 2018 Apr 23;13(8):852-859. doi: 10.1002/cmdc.201800057. Epub 2018 Mar 23.

PMID:
29466617
9.

Controlled intramolecular antagonism as a regulator of insulin receptor maximal activity.

Brandt SJ, Mayer JP, Ford J, Gelfanov VM, DiMarchi RD.

Peptides. 2018 Feb;100:18-23. doi: 10.1016/j.peptides.2017.11.022.

PMID:
29412818
10.

Max Bergmann award lecture:Macromolecular medicinal chemistry as applied to metabolic diseases.

DiMarchi RD, Mayer JP, Gelfanov VM, Tschöp M.

J Pept Sci. 2018 Jan;24(1). doi: 10.1002/psc.3056. Review.

PMID:
29322647
11.

Optimization of peptide-based polyagonists for treatment of diabetes and obesity.

Knerr PJ, Finan B, Gelfanov V, Perez-Tilve D, Tschöp MH, DiMarchi RD.

Bioorg Med Chem. 2018 Jun 1;26(10):2873-2881. doi: 10.1016/j.bmc.2017.10.047. Epub 2017 Nov 2. Review. No abstract available.

PMID:
29153547
12.

Synthetic Advances in Insulin-like Peptides Enable Novel Bioactivity.

Liu F, Li P, Gelfanov V, Mayer J, DiMarchi R.

Acc Chem Res. 2017 Aug 15;50(8):1855-1865. doi: 10.1021/acs.accounts.7b00227. Epub 2017 Aug 3.

PMID:
28771323
13.

Synthesis of relaxin-2 and insulin-like peptide 5 enabled by novel tethering and traceless chemical excision.

Thalluri K, Kou B, Yang X, Zaykov AN, Mayer JP, Gelfanov VM, Liu F, DiMarchi RD.

J Pept Sci. 2017 Jun;23(6):455-465. doi: 10.1002/psc.3010. Epub 2017 May 3.

PMID:
28466571
14.

Synthesis of Four-Disulfide Insulin Analogs via Sequential Disulfide Bond Formation.

Wu F, Mayer JP, Gelfanov VM, Liu F, DiMarchi RD.

J Org Chem. 2017 Apr 7;82(7):3506-3512. doi: 10.1021/acs.joc.6b03078. Epub 2017 Mar 27.

PMID:
28319665
15.

Biomimetic Synthesis of Insulin Enabled by Oxime Ligation and Traceless "C-Peptide" Chemical Excision.

Thalluri K, Kou B, Gelfanov V, Mayer JP, Liu F, DiMarchi RD.

Org Lett. 2017 Feb 3;19(3):706-709. doi: 10.1021/acs.orglett.6b03876. Epub 2017 Jan 26.

PMID:
28124920
16.

Synthetic Route to Human Relaxin-2 via Iodine-Free Sequential Disulfide Bond Formation.

Yang X, Gelfanov V, Liu F, DiMarchi R.

Org Lett. 2016 Nov 4;18(21):5516-5519. Epub 2016 Oct 18.

PMID:
27754694
17.

Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease.

Finan B, Clemmensen C, Zhu Z, Stemmer K, Gauthier K, Müller L, De Angelis M, Moreth K, Neff F, Perez-Tilve D, Fischer K, Lutter D, Sánchez-Garrido MA, Liu P, Tuckermann J, Malehmir M, Healy ME, Weber A, Heikenwalder M, Jastroch M, Kleinert M, Jall S, Brandt S, Flamant F, Schramm KW, Biebermann H, Döring Y, Weber C, Habegger KM, Keuper M, Gelfanov V, Liu F, Köhrle J, Rozman J, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Hofmann SM, Yang B, Tschöp MH, DiMarchi R, Müller TD.

Cell. 2016 Oct 20;167(3):843-857.e14. doi: 10.1016/j.cell.2016.09.014. Epub 2016 Oct 6.

18.

Pyridyl-alanine as a Hydrophilic, Aromatic Element in Peptide Structural Optimization.

Mroz PA, Perez-Tilve D, Liu F, Gelfanov V, DiMarchi RD, Mayer JP.

J Med Chem. 2016 Sep 8;59(17):8061-7. doi: 10.1021/acs.jmedchem.6b00840. Epub 2016 Aug 25.

PMID:
27509198
19.

Unimolecular Polypharmacy for Treatment of Diabetes and Obesity.

Tschöp MH, Finan B, Clemmensen C, Gelfanov V, Perez-Tilve D, Müller TD, DiMarchi RD.

Cell Metab. 2016 Jul 12;24(1):51-62. doi: 10.1016/j.cmet.2016.06.021. Review.

20.

Three-chain insulin analogs demonstrate the importance of insulin secondary structure to bioactivity.

Wu F, Chabenne JR, Gelfanov VM, Mayer JP, DiMarchi RD.

J Pept Sci. 2015 Mar;21(3):223-30. doi: 10.1002/psc.2744. Epub 2015 Feb 9.

PMID:
25665061
21.

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents.

Finan B, Yang B, Ottaway N, Smiley DL, Ma T, Clemmensen C, Chabenne J, Zhang L, Habegger KM, Fischer K, Campbell JE, Sandoval D, Seeley RJ, Bleicher K, Uhles S, Riboulet W, Funk J, Hertel C, Belli S, Sebokova E, Conde-Knape K, Konkar A, Drucker DJ, Gelfanov V, Pfluger PT, Müller TD, Perez-Tilve D, DiMarchi RD, Tschöp MH.

Nat Med. 2015 Jan;21(1):27-36. doi: 10.1038/nm.3761. Epub 2014 Dec 8.

PMID:
25485909
22.

A glucagon analog chemically stabilized for immediate treatment of life-threatening hypoglycemia.

Chabenne J, Chabenne MD, Zhao Y, Levy J, Smiley D, Gelfanov V, Dimarchi R.

Mol Metab. 2014 Jan 22;3(3):293-300. doi: 10.1016/j.molmet.2014.01.006. eCollection 2014 Jun.

23.

Chemical synthesis of insulin analogs through a novel precursor.

Zaykov AN, Mayer JP, Gelfanov VM, DiMarchi RD.

ACS Chem Biol. 2014 Mar 21;9(3):683-91. doi: 10.1021/cb400792s. Epub 2014 Jan 2.

PMID:
24328449
24.

Peptide lipidation stabilizes structure to enhance biological function.

Ward BP, Ottaway NL, Perez-Tilve D, Ma D, Gelfanov VM, Tschöp MH, Dimarchi RD.

Mol Metab. 2013 Sep 5;2(4):468-79. doi: 10.1016/j.molmet.2013.08.008. eCollection 2013.

25.

A hydrophobic site on the GLP-1 receptor extracellular domain orients the peptide ligand for signal transduction.

Patterson JT, Li P, Day JW, Gelfanov VM, Dimarchi RD.

Mol Metab. 2013 Jan 16;2(2):86-91. doi: 10.1016/j.molmet.2013.01.003. eCollection 2013.

26.

Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans.

Finan B, Ma T, Ottaway N, Müller TD, Habegger KM, Heppner KM, Kirchner H, Holland J, Hembree J, Raver C, Lockie SH, Smiley DL, Gelfanov V, Yang B, Hofmann S, Bruemmer D, Drucker DJ, Pfluger PT, Perez-Tilve D, Gidda J, Vignati L, Zhang L, Hauptman JB, Lau M, Brecheisen M, Uhles S, Riboulet W, Hainaut E, Sebokova E, Conde-Knape K, Konkar A, DiMarchi RD, Tschöp MH.

Sci Transl Med. 2013 Oct 30;5(209):209ra151. doi: 10.1126/scitranslmed.3007218.

27.

Discovery of high potency, single-chain insulin analogs with a shortened B-chain and nonpeptide linker.

Kaur ZP, Ochman AR, Mayer JP, Gelfanov VM, DiMarchi RD.

ACS Chem Biol. 2013 Aug 16;8(8):1822-9. doi: 10.1021/cb4002624. Epub 2013 Jun 18.

PMID:
23730814
28.

Fibroblast growth factor 21 mediates specific glucagon actions.

Habegger KM, Stemmer K, Cheng C, Müller TD, Heppner KM, Ottaway N, Holland J, Hembree JL, Smiley D, Gelfanov V, Krishna R, Arafat AM, Konkar A, Belli S, Kapps M, Woods SC, Hofmann SM, D'Alessio D, Pfluger PT, Perez-Tilve D, Seeley RJ, Konishi M, Itoh N, Kharitonenkov A, Spranger J, DiMarchi RD, Tschöp MH.

Diabetes. 2013 May;62(5):1453-63. doi: 10.2337/db12-1116. Epub 2013 Jan 10.

29.

Optimization of co-agonism at GLP-1 and glucagon receptors to safely maximize weight reduction in DIO-rodents.

Day JW, Gelfanov V, Smiley D, Carrington PE, Eiermann G, Chicchi G, Erion MD, Gidda J, Thornberry NA, Tschöp MH, Marsh DJ, SinhaRoy R, DiMarchi R, Pocai A.

Biopolymers. 2012;98(5):443-50. doi: 10.1002/bip.22072.

PMID:
23203689
30.

Targeted estrogen delivery reverses the metabolic syndrome.

Finan B, Yang B, Ottaway N, Stemmer K, Müller TD, Yi CX, Habegger K, Schriever SC, García-Cáceres C, Kabra DG, Hembree J, Holland J, Raver C, Seeley RJ, Hans W, Irmler M, Beckers J, de Angelis MH, Tiano JP, Mauvais-Jarvis F, Perez-Tilve D, Pfluger P, Zhang L, Gelfanov V, DiMarchi RD, Tschöp MH.

Nat Med. 2012 Dec;18(12):1847-56. doi: 10.1038/nm.3009. Epub 2012 Nov 11.

31.

Functional association of the N-terminal residues with the central region in glucagon-related peptides.

Patterson JT, Day JW, Gelfanov VM, DiMarchi RD.

J Pept Sci. 2011 Oct;17(10):659-66. doi: 10.1002/psc.1385. Epub 2011 Jun 10.

PMID:
21661079
32.

Charge inversion at position 68 of the glucagon and glucagon-like peptide-1 receptors supports selectivity in hormone action.

Day JW, Li P, Patterson JT, Chabenne J, Chabenne MD, Gelfanov VM, Dimarchi RD.

J Pept Sci. 2011 Mar;17(3):218-25. doi: 10.1002/psc.1317. Epub 2010 Nov 30.

PMID:
21308878
33.

Optimization of the native glucagon sequence for medicinal purposes.

Chabenne JR, DiMarchi MA, Gelfanov VM, DiMarchi RD.

J Diabetes Sci Technol. 2010 Nov 1;4(6):1322-31.

34.

A novel human-based receptor antagonist of sustained action reveals body weight control by endogenous GLP-1.

Patterson JT, Ottaway N, Gelfanov VM, Smiley DL, Perez-Tilve D, Pfluger PT, Tschöp MH, Dimarchi RD.

ACS Chem Biol. 2011 Feb 18;6(2):135-45. doi: 10.1021/cb1002015. Epub 2010 Nov 4.

PMID:
20939591
35.

Glucagon regulation of energy metabolism.

Heppner KM, Habegger KM, Day J, Pfluger PT, Perez-Tilve D, Ward B, Gelfanov V, Woods SC, DiMarchi R, Tschöp M.

Physiol Behav. 2010 Jul 14;100(5):545-8. doi: 10.1016/j.physbeh.2010.03.019. Epub 2010 Apr 8. Review.

PMID:
20381509
36.

A new glucagon and GLP-1 co-agonist eliminates obesity in rodents.

Day JW, Ottaway N, Patterson JT, Gelfanov V, Smiley D, Gidda J, Findeisen H, Bruemmer D, Drucker DJ, Chaudhary N, Holland J, Hembree J, Abplanalp W, Grant E, Ruehl J, Wilson H, Kirchner H, Lockie SH, Hofmann S, Woods SC, Nogueiras R, Pfluger PT, Perez-Tilve D, DiMarchi R, Tschöp MH.

Nat Chem Biol. 2009 Oct;5(10):749-57. doi: 10.1038/nchembio.209. Epub 2009 Jul 13.

PMID:
19597507
37.

Role for c-jun N-terminal kinase in treatment-refractory acute myeloid leukemia (AML): signaling to multidrug-efflux and hyperproliferation.

Cripe LD, Gelfanov VM, Smith EA, Spigel DR, Phillips CA, Gabig TG, Jung SH, Fyffe J, Hartman AD, Kneebone P, Mercola D, Burgess GS, Boswell HS.

Leukemia. 2002 May;16(5):799-812.

38.
39.

Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor and parthenolide.

Patel NM, Nozaki S, Shortle NH, Bhat-Nakshatri P, Newton TR, Rice S, Gelfanov V, Boswell SH, Goulet RJ Jr, Sledge GW Jr, Nakshatri H.

Oncogene. 2000 Aug 24;19(36):4159-69.

40.

IL-15 promotes survival but not effector function differentiation of CD8+ TCRalphabeta+ intestinal intraepithelial lymphocytes.

Lai YG, Gelfanov V, Gelfanova V, Kulik L, Chu CL, Jeng SW, Liao NS.

J Immunol. 1999 Dec 1;163(11):5843-50.

41.

Modulation of cytokine responses of murine CD8+ alphabeta intestinal intraepithelial lymphocytes by IL-4 and IL-12.

Gelfanova V, Lai Y, Gelfanov V, Tzou S, Tu Y, Liao N.

J Biomed Sci. 1999 Jul-Aug;6(4):269-76.

PMID:
10420084
42.

Distinct actions of interleukin-9 and interleukin-4 on a hematopoietic stem cell line, EMLC1.

Wang XY, Gelfanov V, Sun HB, Tsai S, Yang YC.

Exp Hematol. 1999 Jan;27(1):139-46.

PMID:
9923452
44.

Differential requirement of CD28 costimulation for activation of murine CD8+ intestinal intraepithelial lymphocyte subsets and lymph node cells.

Gelfanov V, Lai YG, Gelfanova V, Dong JY, Su JP, Liao NS.

J Immunol. 1995 Jul 1;155(1):76-82.

PMID:
7602124
45.

New virus-specific T-helper epitopes of foot-and-mouth disease viral VP1 protein.

Volpina OM, Gelfanov VM, Yarov AV, Surovoy AY, Chepurkin AV, Ivanov VT.

FEBS Lett. 1994 Jan 17;337(3):315. No abstract available.

46.

New virus-specific T-helper epitopes of foot-and-mouth disease viral VP1 protein.

Volpina OM, Gelfanov VM, Yarov AV, Surovoy AYu, Chepurkin AV, Ivanov VT.

FEBS Lett. 1993 Oct 25;333(1-2):175-8. Erratum in: FEBS Lett. 1994 Jan 17;337(3):315.

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