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1.

Is There a Role for CD8+ Tc2 Cells in Steroid Resistant Asthma?

Gelfand EW, Hinks TSC.

J Allergy Clin Immunol. 2019 Jul 31. pii: S0091-6749(19)30971-6. doi: 10.1016/j.jaci.2019.07.022. [Epub ahead of print] No abstract available.

PMID:
31376407
2.

Outcomes and Treatment Strategies for Autoimmunity and Hyperinflammation in Patients with RAG Deficiency.

Farmer JR, Foldvari Z, Ujhazi B, De Ravin SS, Chen K, Bleesing JJH, Schuetz C, Al-Herz W, Abraham RS, Joshi AY, Costa-Carvalho BT, Buchbinder D, Booth C, Reiff A, Ferguson PJ, Aghamohammadi A, Abolhassani H, Puck JM, Adeli M, Cancrini C, Palma P, Bertaina A, Locatelli F, Di Matteo G, Geha RS, Kanariou MG, Lycopoulou L, Tzanoudaki M, Sleasman JW, Parikh S, Pinero G, Fischer BM, Dbaibo G, Unal E, Patiroglu T, Karakukcu M, Al-Saad KK, Dilley MA, Pai SY, Dutmer CM, Gelfand EW, Geier CB, Eibl MM, Wolf HM, Henderson LA, Hazen MM, Bonfim C, Wolska-Kuśnierz B, Butte MJ, Hernandez JD, Nicholas SK, Stepensky P, Chandrakasan S, Miano M, Westermann-Clark E, Goda V, Kriván G, Holland SM, Fadugba O, Henrickson SE, Ozen A, Karakoc-Aydiner E, Baris S, Kiykim A, Bredius R, Hoeger B, Boztug K, Pashchenko O, Neven B, Moshous D, Villartay JP, Bousfiha AA, Hill HR, Notarangelo LD, Walter JE.

J Allergy Clin Immunol Pract. 2019 Jul - Aug;7(6):1970-1985.e4. doi: 10.1016/j.jaip.2019.02.038. Epub 2019 Mar 12.

3.

Hypoxia enhances CD8+ TC2 cell-dependent airway hyperresponsiveness and inflammation through hypoxia-inducible factor 1α.

Ning F, Takeda K, Schedel M, Domenico J, Joetham A, Gelfand EW.

J Allergy Clin Immunol. 2019 Jun;143(6):2026-2037.e7. doi: 10.1016/j.jaci.2018.11.049. Epub 2019 Jan 17.

PMID:
30660639
4.

A novel ATM mutation associated with elevated atypical lymphocyte populations, hyper-IgM, and cutaneous granulomas.

Minto H, Mensah KA, Reynolds PR, Meffre E, Rubtsova K, Gelfand EW.

Clin Immunol. 2019 Mar;200:55-63. doi: 10.1016/j.clim.2019.01.002. Epub 2019 Jan 9.

PMID:
30639167
5.

Confronting the Challenges of Severe Asthma.

Gelfand EW, Wechsler ME.

J Fam Pract. 2018 Oct;67(10 Suppl):S19-S26. No abstract available.

PMID:
30423007
6.

Ever-evolving Concepts in the Asthma Management Landscape in the United States.

Gelfand EW, Kaplan AG, Hayden ML, Bender BG.

J Fam Pract. 2018 Oct;67(10 Suppl):S4-S11. No abstract available.

PMID:
30423005
7.

Biallelic mutations in DNA ligase 1 underlie a spectrum of immune deficiencies.

Maffucci P, Chavez J, Jurkiw TJ, O'Brien PJ, Abbott JK, Reynolds PR, Worth A, Notarangelo LD, Felgentreff K, Cortes P, Boisson B, Radigan L, Cobat A, Dinakar C, Ehlayel M, Ben-Omran T, Gelfand EW, Casanova JL, Cunningham-Rundles C.

J Clin Invest. 2018 Dec 3;128(12):5489-5504. doi: 10.1172/JCI99629. Epub 2018 Nov 5.

8.

Molecular Endotypes Contribute to the Heterogeneity of Asthma.

Gelfand EW, Schedel M.

Immunol Allergy Clin North Am. 2018 Nov;38(4):655-665. doi: 10.1016/j.iac.2018.06.008. Epub 2018 Sep 21. Review.

PMID:
30342586
9.

Pulmonary Manifestations of Common Variable Immunodeficiency.

Bang TJ, Richards JC, Olson AL, Groshong SD, Gelfand EW, Lynch DA.

J Thorac Imaging. 2018 Nov;33(6):377-383. doi: 10.1097/RTI.0000000000000350. Review.

PMID:
30067570
10.

Activation of p70S6 Kinase-1 in Mesenchymal Stem Cells Is Essential to Lung Tissue Repair.

Takeda K, Ning F, Domenico J, Okamoto M, Ashino S, Kim SH, Jeong YY, Shiraishi Y, Terada N, Sutherland ER, Gelfand EW.

Stem Cells Transl Med. 2018 Jul;7(7):551-558. doi: 10.1002/sctm.17-0200. Epub 2018 May 5.

11.

Mesenchymal Stem Cells Recruit CCR2+ Monocytes To Suppress Allergic Airway Inflammation.

Takeda K, Webb TL, Ning F, Shiraishi Y, Regan DP, Chow L, Smith MJ, Ashino S, Guth AM, Hopkins S, Gelfand EW, Dow S.

J Immunol. 2018 Feb 15;200(4):1261-1269. doi: 10.4049/jimmunol.1700562. Epub 2018 Jan 19.

12.

Role of toll-like receptors in inflammatory bowel disease.

Kordjazy N, Haj-Mirzaian A, Haj-Mirzaian A, Rohani MM, Gelfand EW, Rezaei N, Abdolghaffari AH.

Pharmacol Res. 2018 Mar;129:204-215. doi: 10.1016/j.phrs.2017.11.017. Epub 2017 Nov 16. Review.

PMID:
29155256
13.

Dominant-negative loss of function arises from a second, more frequent variant within the SAND domain of autoimmune regulator (AIRE).

Abbott JK, Huoh YS, Reynolds PR, Yu L, Rewers M, Reddy M, Anderson MS, Hur S, Gelfand EW.

J Autoimmun. 2018 Mar;88:114-120. doi: 10.1016/j.jaut.2017.10.010. Epub 2017 Nov 10.

14.

Corrigendum: Germline hypomorphic CARD11 mutations in severe atopic disease.

Ma CA, Stinson JR, Zhang Y, Abbott JK, Weinreich MA, Hauk PJ, Reynolds PR, Lyons JJ, Nelson CG, Ruffo E, Dorjbal B, Glauzy S, Yamakawa N, Arjunaraja S, Voss K, Stoddard J, Niemela J, Zhang Y, Rosenzweig SD, McElwee JJ, DiMaggio T, Matthews HF, Jones N, Stone KD, Palma A, Oleastro M, Prieto E, Bernasconi AR, Dubra G, Danielian S, Zaiat J, Marti MA, Kim B, Cooper MA, Romberg ND, Meffre E, Gelfand EW, Snow AL, Milner JD.

Nat Genet. 2017 Oct 27;49(11):1661. doi: 10.1038/ng1117-1661b.

PMID:
29074947
15.

Importance of the leukotriene B4-BLT1 and LTB4-BLT2 pathways in asthma.

Gelfand EW.

Semin Immunol. 2017 Oct;33:44-51. doi: 10.1016/j.smim.2017.08.005. Review.

16.

Hematopoietic stem cell transplantation in 29 patients hemizygous for hypomorphic IKBKG/NEMO mutations.

Miot C, Imai K, Imai C, Mancini AJ, Kucuk ZY, Kawai T, Nishikomori R, Ito E, Pellier I, Dupuis Girod S, Rosain J, Sasaki S, Chandrakasan S, Pachlopnik Schmid J, Okano T, Colin E, Olaya-Vargas A, Yamazaki-Nakashimada M, Qasim W, Espinosa Padilla S, Jones A, Krol A, Cole N, Jolles S, Bleesing J, Vraetz T, Gennery AR, Abinun M, Güngör T, Costa-Carvalho B, Condino-Neto A, Veys P, Holland SM, Uzel G, Moshous D, Neven B, Blanche S, Ehl S, Döffinger R, Patel SY, Puel A, Bustamante J, Gelfand EW, Casanova JL, Orange JS, Picard C.

Blood. 2017 Sep 21;130(12):1456-1467. doi: 10.1182/blood-2017-03-771600. Epub 2017 Jul 5.

17.

Spectrum of T-lymphocyte activities regulating allergic lung inflammation.

Gelfand EW, Joetham A, Wang M, Takeda K, Schedel M.

Immunol Rev. 2017 Jul;278(1):63-86. doi: 10.1111/imr.12561. Review.

18.

Mechanisms of genotype-phenotype correlation in autosomal dominant anhidrotic ectodermal dysplasia with immune deficiency.

Petersheim D, Massaad MJ, Lee S, Scarselli A, Cancrini C, Moriya K, Sasahara Y, Lankester AC, Dorsey M, Di Giovanni D, Bezrodnik L, Ohnishi H, Nishikomori R, Tanita K, Kanegane H, Morio T, Gelfand EW, Jain A, Secord E, Picard C, Casanova JL, Albert MH, Torgerson TR, Geha RS.

J Allergy Clin Immunol. 2018 Mar;141(3):1060-1073.e3. doi: 10.1016/j.jaci.2017.05.030. Epub 2017 Jun 17.

19.

Germline hypomorphic CARD11 mutations in severe atopic disease.

Ma CA, Stinson JR, Zhang Y, Abbott JK, Weinreich MA, Hauk PJ, Reynolds PR, Lyons JJ, Nelson CG, Ruffo E, Dorjbal B, Glauzy S, Yamakawa N, Arjunaraja S, Voss K, Stoddard J, Niemela J, Zhang Y, Rosenzweig SD, McElwee JJ, DiMaggio T, Matthews HF, Jones N, Stone KD, Palma A, Oleastro M, Prieto E, Bernasconi AR, Dubra G, Danielian S, Zaiat J, Marti MA, Kim B, Cooper MA, Romberg N, Meffre E, Gelfand EW, Snow AL, Milner JD.

Nat Genet. 2017 Aug;49(8):1192-1201. doi: 10.1038/ng.3898. Epub 2017 Jun 19. Erratum in: Nat Genet. 2017 Oct 27;49(11):1661.

20.

Recurrent rhinovirus infections in a child with inherited MDA5 deficiency.

Lamborn IT, Jing H, Zhang Y, Drutman SB, Abbott JK, Munir S, Bade S, Murdock HM, Santos CP, Brock LG, Masutani E, Fordjour EY, McElwee JJ, Hughes JD, Nichols DP, Belkadi A, Oler AJ, Happel CS, Matthews HF, Abel L, Collins PL, Subbarao K, Gelfand EW, Ciancanelli MJ, Casanova JL, Su HC.

J Exp Med. 2017 Jul 3;214(7):1949-1972. doi: 10.1084/jem.20161759. Epub 2017 Jun 12.

21.

Forkhead box protein 3 demethylation is associated with tolerance induction in peanut-induced intestinal allergy.

Wang M, Yang IV, Davidson EJ, Joetham A, Takeda K, O'Connor BP, Gelfand EW.

J Allergy Clin Immunol. 2018 Feb;141(2):659-670.e2. doi: 10.1016/j.jaci.2017.04.020. Epub 2017 May 4.

22.

Mitogen-activated protein kinases as therapeutic targets for asthma.

Khorasanizadeh M, Eskian M, Gelfand EW, Rezaei N.

Pharmacol Ther. 2017 Jun;174:112-126. doi: 10.1016/j.pharmthera.2017.02.024. Epub 2017 Feb 14. Review.

PMID:
28223227
23.

Dysregulation of metabolic pathways in a mouse model of allergic asthma.

Quinn KD, Schedel M, Nkrumah-Elie Y, Joetham A, Armstrong M, Cruickshank-Quinn C, Reisdorph R, Gelfand EW, Reisdorph N.

Allergy. 2017 Sep;72(9):1327-1337. doi: 10.1111/all.13144. Epub 2017 Mar 29.

PMID:
28213886
24.

IL-23 Is Essential for the Development of Elastase-Induced Pulmonary Inflammation and Emphysema.

Fujii U, Miyahara N, Taniguchi A, Waseda K, Morichika D, Kurimoto E, Koga H, Kataoka M, Gelfand EW, Cua DJ, Yoshimura A, Tanimoto M, Kanehiro A.

Am J Respir Cell Mol Biol. 2016 Nov;55(5):697-707.

PMID:
27351934
25.

Inducible and naturally occurring regulatory T cells enhance lung allergic responses through divergent transcriptional pathways.

Joetham A, Schedel M, O'Connor BP, Kim S, Takeda K, Abbott J, Gelfand EW.

J Allergy Clin Immunol. 2017 Apr;139(4):1331-1342. doi: 10.1016/j.jaci.2016.06.051. Epub 2016 Aug 16.

26.

In Vivo Assessment of Airway Function in the Mouse Model.

Dakhama A, Gelfand EW.

Methods Mol Biol. 2016;1442:219-30. doi: 10.1007/978-1-4939-3687-8_16.

PMID:
27464698
27.

Immunomodulatory Effects of Ambroxol on Airway Hyperresponsiveness and Inflammation.

Takeda K, Miyahara N, Matsubara S, Taube C, Kitamura K, Hirano A, Tanimoto M, Gelfand EW.

Immune Netw. 2016 Jun;16(3):165-75. doi: 10.4110/in.2016.16.3.165. Epub 2016 Jun 17.

28.

Combined blockade of the histamine H1 and H4 receptor suppresses peanut-induced intestinal anaphylaxis by regulating dendritic cell function.

Wang M, Han J, Domenico J, Shin YS, Jia Y, Gelfand EW.

Allergy. 2016 Nov;71(11):1561-1574. doi: 10.1111/all.12904. Epub 2016 Aug 3.

29.

Loss of B Cells in Patients with Heterozygous Mutations in IKAROS.

Kuehn HS, Boisson B, Cunningham-Rundles C, Reichenbach J, Stray-Pedersen A, Gelfand EW, Maffucci P, Pierce KR, Abbott JK, Voelkerding KV, South ST, Augustine NH, Bush JS, Dolen WK, Wray BB, Itan Y, Cobat A, Sorte HS, Ganesan S, Prader S, Martins TB, Lawrence MG, Orange JS, Calvo KR, Niemela JE, Casanova JL, Fleisher TA, Hill HR, Kumánovics A, Conley ME, Rosenzweig SD.

N Engl J Med. 2016 Mar 17;374(11):1032-1043. doi: 10.1056/NEJMoa1512234.

30.

1,25D3 prevents CD8(+)Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter.

Schedel M, Jia Y, Michel S, Takeda K, Domenico J, Joetham A, Ning F, Strand M, Han J, Wang M, Lucas JJ, Vogelberg C, Kabesch M, O'Connor BP, Gelfand EW.

Nat Commun. 2016 Jan 11;7:10213. doi: 10.1038/ncomms10213.

31.

Late Onset Hypomorphic RAG2 Deficiency Presentation with Fatal Vaccine-Strain VZV Infection.

Dutmer CM, Asturias EJ, Smith C, Dishop MK, Schmid DS, Bellini WJ, Tirosh I, Lee YN, Notarangelo LD, Gelfand EW.

J Clin Immunol. 2015 Nov;35(8):754-60. doi: 10.1007/s10875-015-0207-8. Epub 2015 Oct 29.

32.

Contrasting roles for the receptor for advanced glycation end-products on structural cells in allergic airway inflammation vs. airway hyperresponsiveness.

Taniguchi A, Miyahara N, Waseda K, Kurimoto E, Fujii U, Tanimoto Y, Kataoka M, Yamamoto Y, Gelfand EW, Yamamoto H, Tanimoto M, Kanehiro A.

Am J Physiol Lung Cell Mol Physiol. 2015 Oct 15;309(8):L789-800. doi: 10.1152/ajplung.00087.2015. Epub 2015 Aug 21.

33.

Primary Immunodeficiency Masquerading as Allergic Disease.

Chan SK, Gelfand EW.

Immunol Allergy Clin North Am. 2015 Nov;35(4):767-78. doi: 10.1016/j.iac.2015.07.008. Epub 2015 Sep 4. Review.

PMID:
26454318
34.

Common Variable Immunodeficiency: Diagnosis, Management, and Treatment.

Abbott JK, Gelfand EW.

Immunol Allergy Clin North Am. 2015 Nov;35(4):637-58. doi: 10.1016/j.iac.2015.07.009. Epub 2015 Sep 4. Review.

PMID:
26454311
35.

A Toddler With Rash, Encephalopathy, and Hemolytic Anemia.

Smith C, Dutmer C, Schmid DS, Dishop MK, Bellini WJ, Gelfand EW, Asturias EJ.

J Pediatric Infect Dis Soc. 2015 Dec;4(4):376-80. doi: 10.1093/jpids/piv032. Epub 2015 May 28. No abstract available.

36.

Experimentally manipulated sleep duration in adolescents with asthma: Feasibility and preliminary findings.

Meltzer LJ, Faino A, Szefler SJ, Strand M, Gelfand EW, Beebe DW.

Pediatr Pulmonol. 2015 Dec;50(12):1360-7. doi: 10.1002/ppul.23179. Epub 2015 Apr 14.

37.

The other side of asthma: Steroid-refractory disease in the absence of TH2-mediated inflammation.

Gelfand EW, Alam R.

J Allergy Clin Immunol. 2015 May;135(5):1196-8. doi: 10.1016/j.jaci.2015.01.032. Epub 2015 Mar 13. No abstract available.

PMID:
25772592
38.

Eosinophils contribute to the resolution of lung-allergic responses following repeated allergen challenge.

Takeda K, Shiraishi Y, Ashino S, Han J, Jia Y, Wang M, Lee NA, Lee JJ, Gelfand EW.

J Allergy Clin Immunol. 2015 Feb;135(2):451-60. doi: 10.1016/j.jaci.2014.08.014. Epub 2014 Oct 11.

39.

Emphysema requires the receptor for advanced glycation end-products triggering on structural cells.

Waseda K, Miyahara N, Taniguchi A, Kurimoto E, Ikeda G, Koga H, Fujii U, Yamamoto Y, Gelfand EW, Yamamoto H, Tanimoto M, Kanehiro A.

Am J Respir Cell Mol Biol. 2015 Apr;52(4):482-91. doi: 10.1165/rcmb.2014-0027OC.

PMID:
25188021
40.

Newborn screening for severe combined immunodeficiency in 11 screening programs in the United States.

Kwan A, Abraham RS, Currier R, Brower A, Andruszewski K, Abbott JK, Baker M, Ballow M, Bartoshesky LE, Bonilla FA, Brokopp C, Brooks E, Caggana M, Celestin J, Church JA, Comeau AM, Connelly JA, Cowan MJ, Cunningham-Rundles C, Dasu T, Dave N, De La Morena MT, Duffner U, Fong CT, Forbes L, Freedenberg D, Gelfand EW, Hale JE, Hanson IC, Hay BN, Hu D, Infante A, Johnson D, Kapoor N, Kay DM, Kohn DB, Lee R, Lehman H, Lin Z, Lorey F, Abdel-Mageed A, Manning A, McGhee S, Moore TB, Naides SJ, Notarangelo LD, Orange JS, Pai SY, Porteus M, Rodriguez R, Romberg N, Routes J, Ruehle M, Rubenstein A, Saavedra-Matiz CA, Scott G, Scott PM, Secord E, Seroogy C, Shearer WT, Siegel S, Silvers SK, Stiehm ER, Sugerman RW, Sullivan JL, Tanksley S, Tierce ML 4th, Verbsky J, Vogel B, Walker R, Walkovich K, Walter JE, Wasserman RL, Watson MS, Weinberg GA, Weiner LB, Wood H, Yates AB, Puck JM, Bonagura VR.

JAMA. 2014 Aug 20;312(7):729-38. doi: 10.1001/jama.2014.9132. Erratum in: JAMA. 2014 Nov 26;312(20):2169. Bonagura, Vincent R [Added].

41.

JNK2 regulates the functional plasticity of naturally occurring T regulatory cells and the enhancement of lung allergic responses.

Joetham A, Schedel M, Takeda K, Jia Y, Ashino S, Dakhama A, Lluis A, Okamoto M, Gelfand EW.

J Immunol. 2014 Sep 1;193(5):2238-47. doi: 10.4049/jimmunol.1400604. Epub 2014 Jul 28.

42.

Successful hematopoietic cell transplantation in patients with unique NF-κB essential modulator (NEMO) mutations.

Abbott JK, Quinones RR, de la Morena MT, Gelfand EW.

Bone Marrow Transplant. 2014 Nov;49(11):1446-7. doi: 10.1038/bmt.2014.157. Epub 2014 Jul 28. No abstract available.

PMID:
25068423
43.

Modulated expression of genes encoding estrogen metabolizing enzymes by G1-phase cyclin-dependent kinases 6 and 4 in human breast cancer cells.

Jia Y, Domenico J, Swasey C, Wang M, Gelfand EW, Lucas JJ.

PLoS One. 2014 May 21;9(5):e97448. doi: 10.1371/journal.pone.0097448. eCollection 2014.

44.

Is there a link between obesity and asthma?

Kim SH, Sutherland ER, Gelfand EW.

Allergy Asthma Immunol Res. 2014 May;6(3):189-95. doi: 10.4168/aair.2014.6.3.189. Epub 2014 Mar 7. Review.

45.

Somatic reversion in dedicator of cytokinesis 8 immunodeficiency modulates disease phenotype.

Jing H, Zhang Q, Zhang Y, Hill BJ, Dove CG, Gelfand EW, Atkinson TP, Uzel G, Matthews HF, Mustillo PJ, Lewis DB, Kavadas FD, Hanson IC, Kumar AR, Geha RS, Douek DC, Holland SM, Freeman AF, Su HC.

J Allergy Clin Immunol. 2014 Jun;133(6):1667-75. doi: 10.1016/j.jaci.2014.03.025. Epub 2014 May 3.

46.

Recommendations for live viral and bacterial vaccines in immunodeficient patients and their close contacts.

Medical Advisory Committee of the Immune Deficiency Foundation, Shearer WT, Fleisher TA, Buckley RH, Ballas Z, Ballow M, Blaese RM, Bonilla FA, Conley ME, Cunningham-Rundles C, Filipovich AH, Fuleihan R, Gelfand EW, Hernandez-Trujillo V, Holland SM, Hong R, Lederman HM, Malech HL, Miles S, Notarangelo LD, Ochs HD, Orange JS, Puck JM, Routes JM, Stiehm ER, Sullivan K, Torgerson T, Winkelstein J.

J Allergy Clin Immunol. 2014 Apr;133(4):961-6. doi: 10.1016/j.jaci.2013.11.043. Epub 2014 Feb 28. Review.

47.

Effects of anti-g and anti-f antibodies on airway function after respiratory syncytial virus infection.

Han J, Takeda K, Wang M, Zeng W, Jia Y, Shiraishi Y, Okamoto M, Dakhama A, Gelfand EW.

Am J Respir Cell Mol Biol. 2014 Jul;51(1):143-54. doi: 10.1165/rcmb.2013-0360OC.

48.

Role of prostaglandin D2 and CRTH2 blockade in early- and late-phase nasal responses.

Shiraishi Y, Takeda K, Domenico J, Gelfand EW.

Clin Exp Allergy. 2014 Aug;44(8):1076-82. doi: 10.1111/cea.12280.

PMID:
24456221
49.

Leukotriene B4 receptor 1 is differentially expressed on peripheral T cells of steroid-sensitive and -resistant asthmatics.

Chung EH, Jia Y, Ohnishi H, Takeda K, Leung DY, Sutherland ER, Dakhama A, Martin RJ, Gelfand EW.

Ann Allergy Asthma Immunol. 2014 Mar;112(3):211-216.e1. doi: 10.1016/j.anai.2013.12.006. Epub 2014 Jan 7.

50.

Vaccine strain varicella-zoster virus-induced central nervous system vasculopathy as the presenting feature of DOCK8 deficiency.

Sabry A, Hauk PJ, Jing H, Su HC, Stence NV, Mirsky DM, Nagel MA, Abbott JK, Dragone LL, Armstrong-Wells J, Curtis DJ, Cohrs R, Schmid DS, Gilden D, Gelfand EW.

J Allergy Clin Immunol. 2014 Apr;133(4):1225-1227. doi: 10.1016/j.jaci.2013.11.031. Epub 2014 Jan 11. No abstract available.

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