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Items: 1 to 50 of 389

1.
2.

Triazolopyrimidines and Imidazopyridines: Structure-Activity Relationships and in Vivo Efficacy for Trypanosomiasis.

Nagendar P, Gillespie JR, Herbst ZM, Ranade RM, Molasky NMR, Faghih O, Turner RM, Gelb MH, Buckner FS.

ACS Med Chem Lett. 2018 Dec 4;10(1):105-110. doi: 10.1021/acsmedchemlett.8b00498. eCollection 2019 Jan 10.

PMID:
30655955
3.

Function of secreted phospholipase A2 group-X in asthma and allergic disease.

Nolin JD, Murphy RC, Gelb MH, Altemeier WA, Henderson WR Jr, Hallstrand TS.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Dec 5. pii: S1388-1981(18)30365-2. doi: 10.1016/j.bbalip.2018.11.009. [Epub ahead of print] Review.

PMID:
30529275
4.

Taiwan National Newborn Screening Program by Tandem Mass Spectrometry for Mucopolysaccharidoses Types I, II, and VI.

Chan MJ, Liao HC, Gelb MH, Chuang CK, Liu MY, Chen HJ, Kao SM, Lin HY, Huang YH, Kumar AB, Chennamaneni NK, Pendem N, Lin SP, Chiang CC.

J Pediatr. 2019 Feb;205:176-182. doi: 10.1016/j.jpeds.2018.09.063. Epub 2018 Nov 6.

PMID:
30409495
5.

Detection of Infantile Batten Disease by Tandem Mass Spectrometry Assay of PPT1 Enzyme Activity in Dried Blood Spots.

Khaledi H, Liu Y, Masi S, Gelb MH.

Anal Chem. 2018 Oct 16;90(20):12168-12171. doi: 10.1021/acs.analchem.8b03188. Epub 2018 Sep 24.

PMID:
30204428
6.

One-step synthesis of carbon-13-labeled globotriaosylsphingosine (lyso-Gb3), an internal standard for biomarker analysis of Fabry disease.

Hong X, Gelb MH.

Mol Genet Metab. 2018 Nov;125(3):292-294. doi: 10.1016/j.ymgme.2018.08.001. Epub 2018 Aug 10.

PMID:
30126819
7.

Absolute Amounts of Analytes: When Gravimetric Methods Are Insufficient.

Gelb MH.

Clin Chem. 2018 Oct;64(10):1430-1432. doi: 10.1373/clinchem.2018.290486. Epub 2018 Jul 27. No abstract available.

PMID:
30054339
8.

Detection of mucopolysaccharidosis III-A (Sanfilippo Syndrome-A) in dried blood spots (DBS) by tandem mass spectrometry.

Yi F, Hong X, Kumar AB, Zong C, Boons GJ, Scott CR, Turecek F, Robinson BH, Gelb MH.

Mol Genet Metab. 2018 Sep;125(1-2):59-63. doi: 10.1016/j.ymgme.2018.05.005. Epub 2018 May 23.

PMID:
30006231
9.

Multiplex tandem mass spectrometry assay for newborn screening of X-linked adrenoleukodystrophy, biotinidase deficiency, and galactosemia with flexibility to assay other enzyme assays and biomarkers.

Hong X, Kumar AB, Ronald Scott C, Gelb MH.

Mol Genet Metab. 2018 Jun;124(2):101-108. doi: 10.1016/j.ymgme.2018.03.012. Epub 2018 Mar 29.

PMID:
29680633
10.

An Inexpensive, In-House-Made, Microdialysis Device for Measuring Drug-Protein Binding.

Herbst ZM, Shibata S, Fan E, Gelb MH.

ACS Med Chem Lett. 2017 Sep 28;9(3):279-282. doi: 10.1021/acsmedchemlett.7b00316. eCollection 2018 Mar 8.

11.

Consensus guidelines for newborn screening, diagnosis and treatment of infantile Krabbe disease.

Kwon JM, Matern D, Kurtzberg J, Wrabetz L, Gelb MH, Wenger DA, Ficicioglu C, Waldman AT, Burton BK, Hopkins PV, Orsini JJ.

Orphanet J Rare Dis. 2018 Feb 1;13(1):30. doi: 10.1186/s13023-018-0766-x. Review.

12.

Specific Substrate for the Assay of Lysosomal Acid Lipase.

Masi S, Chennamaneni N, Turecek F, Scott CR, Gelb MH.

Clin Chem. 2018 Apr;64(4):690-696. doi: 10.1373/clinchem.2017.282251. Epub 2018 Jan 16.

PMID:
29339442
13.

Secreted PLA2 group X orchestrates innate and adaptive immune responses to inhaled allergen.

Nolin JD, Lai Y, Ogden HL, Manicone AM, Murphy RC, An D, Frevert CW, Ghomashchi F, Naika GS, Gelb MH, Gauvreau GM, Piliponsky AM, Altemeier WA, Hallstrand TS.

JCI Insight. 2017 Nov 2;2(21). pii: 94929. doi: 10.1172/jci.insight.94929.

14.

1-Benzyl-3-aryl-2-thiohydantoin Derivatives as New Anti-Trypanosoma brucei Agents: SAR and in Vivo Efficacy.

Buchynskyy A, Gillespie JR, Herbst ZM, Ranade RM, Buckner FS, Gelb MH.

ACS Med Chem Lett. 2017 Jul 10;8(8):886-891. doi: 10.1021/acsmedchemlett.7b00230. eCollection 2017 Aug 10.

15.

New Class of Antitrypanosomal Agents Based on Imidazopyridines.

Silva DG, Gillespie JR, Ranade RM, Herbst ZM, Nguyen UTT, Buckner FS, Montanari CA, Gelb MH.

ACS Med Chem Lett. 2017 Jun 27;8(7):766-770. doi: 10.1021/acsmedchemlett.7b00202. eCollection 2017 Jul 13.

16.

Newborn Screening for Lysosomal Storage Diseases: A Concise Review of the Literature on Screening Methods, Therapeutic Possibilities and Regional Programs.

Schielen PCJI, Kemper EA, Gelb MH.

Int J Neonatal Screen. 2017 Jun;3(2). pii: 6. doi: 10.3390/ijns3020006. Epub 2017 Mar 29.

17.

Regulation of calcium release from the endoplasmic reticulum by the serine hydrolase ABHD2.

Yun B, Lee H, Powell R, Reisdorph N, Ewing H, Gelb MH, Hsu KL, Cravatt BF, Leslie CC.

Biochem Biophys Res Commun. 2017 Sep 2;490(4):1226-1231. doi: 10.1016/j.bbrc.2017.06.195. Epub 2017 Jul 3.

18.

Comparison of tandem mass spectrometry to fluorimetry for newborn screening of LSDs.

Gelb MH, Ronald Scott C, Turecek F, Liao HC.

Mol Genet Metab Rep. 2017 Jun 12;12:80-81. doi: 10.1016/j.ymgmr.2017.05.004. eCollection 2017 Sep. No abstract available.

19.

Lymphocyte Galactocerebrosidase Activity by LC-MS/MS for Post-Newborn Screening Evaluation of Krabbe Disease.

Liao HC, Spacil Z, Ghomashchi F, Escolar ML, Kurtzberg J, Orsini JJ, Turecek F, Scott CR, Gelb MH.

Clin Chem. 2017 Aug;63(8):1363-1369. doi: 10.1373/clinchem.2016.264952. Epub 2017 Jun 7.

20.

Psychosine, a marker of Krabbe phenotype and treatment effect.

Escolar ML, Kiely BT, Shawgo E, Hong X, Gelb MH, Orsini JJ, Matern D, Poe MD.

Mol Genet Metab. 2017 Jul;121(3):271-278. doi: 10.1016/j.ymgme.2017.05.015. Epub 2017 May 22.

21.

Mass Spectrometry but Not Fluorimetry Distinguishes Affected and Pseudodeficiency Patients in Newborn Screening for Pompe Disease.

Liao HC, Chan MJ, Yang CF, Chiang CC, Niu DM, Huang CK, Gelb MH.

Clin Chem. 2017 Jul;63(7):1271-1277. doi: 10.1373/clinchem.2016.269027. Epub 2017 Apr 27.

22.

Multiplex Tandem Mass Spectrometry Enzymatic Activity Assay for Newborn Screening of the Mucopolysaccharidoses and Type 2 Neuronal Ceroid Lipofuscinosis.

Liu Y, Yi F, Kumar AB, Kumar Chennamaneni N, Hong X, Scott CR, Gelb MH, Turecek F.

Clin Chem. 2017 Jun;63(6):1118-1126. doi: 10.1373/clinchem.2016.269167. Epub 2017 Apr 20.

23.

Liquid Chromatography-Tandem Mass Spectrometry Assay of Leukocyte Acid α-Glucosidase for Post-Newborn Screening Evaluation of Pompe Disease.

Lin N, Huang J, Violante S, Orsini JJ, Caggana M, Hughes EE, Stevens C, DiAntonio L, Chieh Liao H, Hong X, Ghomashchi F, Babu Kumar A, Zhou H, Kornreich R, Wasserstein M, Gelb MH, Yu C.

Clin Chem. 2017 Apr;63(4):842-851. doi: 10.1373/clinchem.2016.259036. Epub 2017 Feb 14.

24.

Discovery of N-(2-aminoethyl)-N-benzyloxyphenyl benzamides: New potent Trypanosoma brucei inhibitors.

Buchynskyy A, Gillespie JR, Hulverson MA, McQueen J, Creason SA, Ranade RM, Duster NA, Gelb MH, Buckner FS.

Bioorg Med Chem. 2017 Mar 1;25(5):1571-1584. doi: 10.1016/j.bmc.2016.11.019. Epub 2016 Nov 12.

25.

Preface.

Gelb MH.

Methods Enzymol. 2017;584:xv-xix. doi: 10.1016/S0076-6879(16)30469-4. No abstract available.

PMID:
28065275
26.

Preface.

Gelb MH.

Methods Enzymol. 2017;583:xv-xix. doi: 10.1016/S0076-6879(16)30456-6. No abstract available.

PMID:
28063501
27.

Preparation of the Full Set of Recombinant Mouse- and Human-Secreted Phospholipases A2.

Ghomashchi F, Brglez V, Payré C, Jeammet L, Bezzine S, Gelb MH, Lambeau G.

Methods Enzymol. 2017;583:35-69. doi: 10.1016/bs.mie.2016.10.034. Epub 2016 Dec 23.

PMID:
28063498
28.

Urea Derivatives of 2-Aryl-benzothiazol-5-amines: A New Class of Potential Drugs for Human African Trypanosomiasis.

Patrick DA, Gillespie JR, McQueen J, Hulverson MA, Ranade RM, Creason SA, Herbst ZM, Gelb MH, Buckner FS, Tidwell RR.

J Med Chem. 2017 Feb 9;60(3):957-971. doi: 10.1021/acs.jmedchem.6b01163. Epub 2016 Dec 19.

29.

Newborn Screening for Lysosomal Storage Disorders: Quo Vadis?

Peake RW, Marsden DL, Bodamer OA, Gelb MH, Millington DS, Wijburg F.

Clin Chem. 2016 Nov;62(11):1430-1438. Epub 2016 Sep 14. No abstract available.

30.

Newborn screening for Krabbe's disease.

Orsini JJ, Saavedra-Matiz CA, Gelb MH, Caggana M.

J Neurosci Res. 2016 Nov;94(11):1063-75. doi: 10.1002/jnr.23781. Review.

31.

5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors.

Zhang Z, Koh CY, Ranade RM, Shibata S, Gillespie JR, Hulverson MA, Huang W, Nguyen J, Pendem N, Gelb MH, Verlinde CL, Hol WG, Buckner FS, Fan E.

ACS Infect Dis. 2016 Jun 10;2(6):399-404. doi: 10.1021/acsinfecdis.6b00036. Epub 2016 Apr 11.

32.

Off-target effect of the cPLA2α inhibitor pyrrophenone: Inhibition of calcium release from the endoplasmic reticulum.

Yun B, Lee H, Ewing H, Gelb MH, Leslie CC.

Biochem Biophys Res Commun. 2016 Oct 7;479(1):61-6. doi: 10.1016/j.bbrc.2016.09.033. Epub 2016 Sep 9.

33.

Dataset and standard operating procedure for newborn screening of six lysosomal storage diseases: By tandem mass spectrometry.

Elliott S, Buroker N, Cournoyer JJ, Potier AM, Trometer JD, Elbin C, Schermer MJ, Kantola J, Boyce A, Turecek F, Gelb MH, Scott CR.

Data Brief. 2016 Jul 5;8:915-24. doi: 10.1016/j.dib.2016.06.052. eCollection 2016 Sep.

34.

Identification of Epithelial Phospholipase A2 Receptor 1 as a Potential Target in Asthma.

Nolin JD, Ogden HL, Lai Y, Altemeier WA, Frevert CW, Bollinger JG, Naika GS, Kicic A, Stick SM, Lambeau G, Henderson WR Jr, Gelb MH, Hallstrand TS.

Am J Respir Cell Mol Biol. 2016 Dec;55(6):825-836.

35.

Pilot study of newborn screening for six lysosomal storage diseases using Tandem Mass Spectrometry.

Elliott S, Buroker N, Cournoyer JJ, Potier AM, Trometer JD, Elbin C, Schermer MJ, Kantola J, Boyce A, Turecek F, Gelb MH, Scott CR.

Mol Genet Metab. 2016 Aug;118(4):304-9. doi: 10.1016/j.ymgme.2016.05.015. Epub 2016 May 20.

36.

Expression and Function of Group IIE Phospholipase A2 in Mouse Skin.

Yamamoto K, Miki Y, Sato H, Nishito Y, Gelb MH, Taketomi Y, Murakami M.

J Biol Chem. 2016 Jul 22;291(30):15602-13. doi: 10.1074/jbc.M116.734657. Epub 2016 May 23.

37.

Dual Roles of Group IID Phospholipase A2 in Inflammation and Cancer.

Miki Y, Kidoguchi Y, Sato M, Taketomi Y, Taya C, Muramatsu K, Gelb MH, Yamamoto K, Murakami M.

J Biol Chem. 2016 Jul 22;291(30):15588-601. doi: 10.1074/jbc.M116.734624. Epub 2016 May 21.

38.

Fluorometric High-Throughput Screening Assay for Secreted Phospholipases A2 Using Phospholipid Vesicles.

Ewing H, Fernández-Vega V, Spicer TP, Chase P, Brown S, Scampavia L, Roush WR, Riley S, Rosen H, Hodder P, Lambeau G, Gelb MH.

J Biomol Screen. 2016 Aug;21(7):713-21. doi: 10.1177/1087057116646742. Epub 2016 May 4.

PMID:
27146384
39.

Repurposing strategies for tropical disease drug discovery.

Klug DM, Gelb MH, Pollastri MP.

Bioorg Med Chem Lett. 2016 Jun 1;26(11):2569-76. doi: 10.1016/j.bmcl.2016.03.103. Epub 2016 Mar 30. Review.

40.

Development of a potent 2-oxoamide inhibitor of secreted phospholipase A2 guided by molecular docking calculations and molecular dynamics simulations.

Vasilakaki S, Barbayianni E, Leonis G, Papadopoulos MG, Mavromoustakos T, Gelb MH, Kokotos G.

Bioorg Med Chem. 2016 Apr 15;24(8):1683-95. doi: 10.1016/j.bmc.2016.02.040. Epub 2016 Mar 2.

41.

Sulfatide Analysis by Mass Spectrometry for Screening of Metachromatic Leukodystrophy in Dried Blood and Urine Samples.

Spacil Z, Babu Kumar A, Liao HC, Auray-Blais C, Stark S, Suhr TR, Scott CR, Turecek F, Gelb MH.

Clin Chem. 2016 Jan;62(1):279-86. doi: 10.1373/clinchem.2015.245159. Epub 2015 Nov 19.

42.

The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia.

Yamamoto K, Miki Y, Sato M, Taketomi Y, Nishito Y, Taya C, Muramatsu K, Ikeda K, Nakanishi H, Taguchi R, Kambe N, Kabashima K, Lambeau G, Gelb MH, Murakami M.

J Exp Med. 2015 Oct 19;212(11):1901-19. doi: 10.1084/jem.20141904. Epub 2015 Oct 5.

43.

Tandem Mass Spectrometry Has a Larger Analytical Range than Fluorescence Assays of Lysosomal Enzymes: Application to Newborn Screening and Diagnosis of Mucopolysaccharidoses Types II, IVA, and VI.

Kumar AB, Masi S, Ghomashchi F, Chennamaneni NK, Ito M, Scott CR, Turecek F, Gelb MH, Spacil Z.

Clin Chem. 2015 Nov;61(11):1363-71. doi: 10.1373/clinchem.2015.242560. Epub 2015 Sep 14.

44.

Fluorimetric assays for N-acetylgalactosamine-6-sulfatase and arylsulfatase B based on the natural substrates for confirmation of mucopolysaccharidoses types IVA and VI.

Kumar AB, Spacil Z, Ghomashchi F, Masi S, Sumida T, Ito M, Turecek F, Scott CR, Gelb MH.

Clin Chim Acta. 2015 Dec 7;451(Pt B):125-8. doi: 10.1016/j.cca.2015.08.010. Epub 2015 Aug 15.

45.

Endogenous secreted phospholipase A2 group X regulates cysteinyl leukotrienes synthesis by human eosinophils.

Hallstrand TS, Lai Y, Hooper KA, Oslund RC, Altemeier WA, Matute-Bello G, Gelb MH.

J Allergy Clin Immunol. 2016 Jan;137(1):268-277.e8. doi: 10.1016/j.jaci.2015.05.026. Epub 2015 Jun 30.

46.

Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA.

Duchez AC, Boudreau LH, Naika GS, Bollinger J, Belleannée C, Cloutier N, Laffont B, Mendoza-Villarroel RE, Lévesque T, Rollet-Labelle E, Rousseau M, Allaeys I, Tremblay JJ, Poubelle PE, Lambeau G, Pouliot M, Provost P, Soulet D, Gelb MH, Boilard E.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):E3564-73. doi: 10.1073/pnas.1507905112. Epub 2015 Jun 23. Erratum in: Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):E6825. Naika, Gajendra S [added].

47.

Study of the role of cytosolic phospholipase A2 alpha in eicosanoid generation and thymocyte maturation in the thymus.

Rousseau M, Naika GS, Perron J, Jacques F, Gelb MH, Boilard E.

PLoS One. 2015 May 13;10(5):e0126204. doi: 10.1371/journal.pone.0126204. eCollection 2015.

48.

In vitro anti-Plasmodium falciparum properties of the full set of human secreted phospholipases A2.

Guillaume C, Payré C, Jemel I, Jeammet L, Bezzine S, Naika GS, Bollinger J, Grellier P, Gelb MH, Schrével J, Lambeau G, Deregnaucourt C.

Infect Immun. 2015 Jun;83(6):2453-65. doi: 10.1128/IAI.02474-14. Epub 2015 Mar 30.

49.

Matrix metalloproteinase-2 negatively regulates cardiac secreted phospholipase A2 to modulate inflammation and fever.

Berry E, Hernandez-Anzaldo S, Ghomashchi F, Lehner R, Murakami M, Gelb MH, Kassiri Z, Wang X, Fernandez-Patron C.

J Am Heart Assoc. 2015 Mar 27;4(4). pii: e001868. doi: 10.1161/JAHA.115.001868.

50.

Computational protein design enables a novel one-carbon assimilation pathway.

Siegel JB, Smith AL, Poust S, Wargacki AJ, Bar-Even A, Louw C, Shen BW, Eiben CB, Tran HM, Noor E, Gallaher JL, Bale J, Yoshikuni Y, Gelb MH, Keasling JD, Stoddard BL, Lidstrom ME, Baker D.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3704-9. doi: 10.1073/pnas.1500545112. Epub 2015 Mar 9.

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