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BRCA-1 depletion impairs pro-inflammatory polarization and activation of RAW 264.7 macrophages in a NF-κB-dependent mechanism.

Morrone MDS, Somensi N, Franz L, Ramos VM, Gasparotto J, da Rosa HT, Sartori M, Figueiró F, Gelain DP, Zanotto-Filho A, Moreira JCF.

Mol Cell Biochem. 2019 Aug 24. doi: 10.1007/s11010-019-03605-9. [Epub ahead of print]


Obesity associated with coal ash inhalation triggers systemic inflammation and oxidative damage in the hippocampus of rats.

Gasparotto J, Chaves PR, da Boit Martinello K, Silva Oliveira LF, Gelain DP, Fonseca Moreira JC.

Food Chem Toxicol. 2019 Nov;133:110766. doi: 10.1016/j.fct.2019.110766. Epub 2019 Aug 17.


Carvacrol suppresses LPS-induced pro-inflammatory activation in RAW 264.7 macrophages through ERK1/2 and NF-kB pathway.

Somensi N, Rabelo TK, Guimarães AG, Quintans-Junior LJ, de Souza Araújo AA, Moreira JCF, Gelain DP.

Int Immunopharmacol. 2019 Oct;75:105743. doi: 10.1016/j.intimp.2019.105743. Epub 2019 Jul 26.


Subcellular distribution of human tyrosine hydroxylase isoforms 1 and 4 in SH-SY5Y cells.

Kunzler A, Garcia Sobrinho P, Smith T, Gelain DP, Moreira JCF, Dunkley PR, Dickson PW.

J Cell Biochem. 2019 Dec;120(12):19730-19737. doi: 10.1002/jcb.29279. Epub 2019 Jul 11.


Retinoic acid downregulates thiol antioxidant defences and homologous recombination while promotes A549 cells sensitization to cisplatin.

de Miranda Ramos V, Gasparotto J, Figueiró F, de Fraga Dias A, Rostirolla DC, Somensi N, da Rosa HT, Grun LK, Barbé-Tuana FM, Gelain DP, Moreira JCF.

Cell Signal. 2019 Oct;62:109356. doi: 10.1016/j.cellsig.2019.109356. Epub 2019 Jul 6.


Activated peripheral blood mononuclear cell mediators trigger astrocyte reactivity.

Bellaver B, Rocha AS, Souza DG, Leffa DT, De Bastiani MA, Schu G, Lukasewicz Ferreira PC, Venturin GT, Greggio S, Ribeiro CT, da Costa JC, Moreira JCF, Gelain DP, Torres ILDS, Klamt F, Zimmer ER.

Brain Behav Immun. 2019 Aug;80:879-888. doi: 10.1016/j.bbi.2019.05.041. Epub 2019 Jun 5.


Anti-NMDA Receptor Autoantibody Is an Independent Predictor of Hospital Mortality but Not Brain Dysfunction in Septic Patients.

Malfussi H, Santana IV, Gasparotto J, Righy C, Tomasi CD, Gelain DP, Bozza FA, Walz R, Dal-Pizzol F, Ritter C.

Front Neurol. 2019 Mar 15;10:221. doi: 10.3389/fneur.2019.00221. eCollection 2019.


Guarana supplementation attenuated obesity, insulin resistance, and adipokines dysregulation induced by a standardized human Western diet via brown adipose tissue activation.

Bortolin RC, Vargas AR, de Miranda Ramos V, Gasparotto J, Chaves PR, Schnorr CE, da Boit Martinello K, Silveira AK, Gomes HM, Rabelo TK, Grunwald MS, Ligabue-Braun R, Gelain DP, Moreira JCF.

Phytother Res. 2019 May;33(5):1394-1403. doi: 10.1002/ptr.6330. Epub 2019 Mar 13.


Oral administration of carvacrol/β-cyclodextrin complex protects against 6-hydroxydopamine-induced dopaminergic denervation.

Tiefensee Ribeiro C, Gasparotto J, Petiz LL, Brum PO, Peixoto DO, Kunzler A, da Rosa Silva HT, Bortolin RC, Almeida RF, Quintans-Junior LJ, Araújo AA, Moreira JCF, Gelain DP.

Neurochem Int. 2019 Jun;126:27-35. doi: 10.1016/j.neuint.2019.02.021. Epub 2019 Mar 5.


The effects of retinol oral supplementation in 6-hydroxydopamine dopaminergic denervation model in Wistar rats.

Kunzler A, Ribeiro CT, Gasparotto J, Petiz LL, da Rosa Silva HT, da Silva JD Jr, Bortolin R, de Souza PO, Barreto F, Espitia-Perez P, Schnorr CE, Somensi N, Moreira JCF, Gelain DP.

Neurochem Int. 2019 May;125:25-34. doi: 10.1016/j.neuint.2019.02.002. Epub 2019 Feb 7.


Nuclear RXRα and RXRβ receptors exert distinct and opposite effects on RA-mediated neuroblastoma differentiation.

Girardi CS, Rostirolla DC, Lini FJM, Brum PO, Delgado J, Ribeiro CT, Teixeira AA, Peixoto DO, Heimfarth L, Kunzler A, Moreira JCF, Gelain DP.

Biochim Biophys Acta Mol Cell Res. 2019 Mar;1866(3):317-328. doi: 10.1016/j.bbamcr.2018.11.014. Epub 2018 Dec 7.


Neurobehavioral and oxidative stress alterations following methylmercury and retinyl palmitate co-administration in pregnant and lactating rats and their offspring.

Espitia-Pérez P, Albino SM, Espitia-Pérez L, Brango H, da Rosa H, Kleber Silveira A, Moraes DP, Cerveira C, Mingori M, Tiefensee Ribeiro C, Gelain DP, Schnorr CE, Fonseca Moreira JC.

Neurotoxicology. 2018 Dec;69:164-180. doi: 10.1016/j.neuro.2018.10.004. Epub 2018 Oct 11.


Bioactive compounds and protective effect of red and black rice brans extracts in human neuron-like cells (SH-SY5Y).

Vargas CG, da Silva Junior JD, Rabelo TK, Moreira JCF, Gelain DP, Rodrigues E, Augusti PR, Rios AO, Flôres SH.

Food Res Int. 2018 Nov;113:57-64. doi: 10.1016/j.foodres.2018.06.069. Epub 2018 Jun 30.


Obese rats are more vulnerable to inflammation, genotoxicity and oxidative stress induced by coal dust inhalation than non-obese rats.

Gasparotto J, Chaves PR, da Boit Martinello K, da Rosa-Siva HT, Bortolin RC, Silva LFO, Rabelo TK, da Silva J, da Silva FR, Nordin AP, Soares K, Borges MS, Gelain DP, Moreira JCF.

Ecotoxicol Environ Saf. 2018 Dec 15;165:44-51. doi: 10.1016/j.ecoenv.2018.08.097. Epub 2018 Sep 1.


Systemic Inflammation Changes the Site of RAGE Expression from Endothelial Cells to Neurons in Different Brain Areas.

Gasparotto J, Ribeiro CT, da Rosa-Silva HT, Bortolin RC, Rabelo TK, Peixoto DO, Moreira JCF, Gelain DP.

Mol Neurobiol. 2019 May;56(5):3079-3089. doi: 10.1007/s12035-018-1291-6. Epub 2018 Aug 9.


Effects of methylmercury and retinol palmitate co-administration in rats during pregnancy and breastfeeding: Metabolic and redox parameters in dams and their offspring.

Espitia-Pérez P, Albino SM, da Rosa HT, Silveira AK, Espitia-Pérez L, Brango H, Moraes DP, Hermann PRS, Mingori M, Barreto F, Kunzler A, Gelain DP, Schnorr CE, Moreira JCF.

Ecotoxicol Environ Saf. 2018 Oct 30;162:603-615. doi: 10.1016/j.ecoenv.2018.06.093.


Effects of Achyrocline satureioides Inflorescence Extracts against Pathogenic Intestinal Bacteria: Chemical Characterization, In Vitro Tests, and In Vivo Evaluation.

Moresco KS, Silveira AK, Zeidán-Chuliá F, Correa APF, Oliveria RR, Borges AG, Grun L, Barbé-Tuana F, Zmozinski A, Brandelli A, Vale MGR, Gelain DP, Bassani VL, Moreira JCF.

Evid Based Complement Alternat Med. 2017 Sep 7;2017:4874865. doi: 10.1155/2017/4874865. eCollection 2017.


Anticancer activity of flavonoids isolated from Achyrocline satureioides in gliomas cell lines.

Souza PO, Bianchi SE, Figueiró F, Heimfarth L, Moresco KS, Gonçalves RM, Hoppe JB, Klein CP, Salbego CG, Gelain DP, Bassani VL, Zanotto Filho A, Moreira JCF.

Toxicol In Vitro. 2018 Sep;51:23-33. doi: 10.1016/j.tiv.2018.04.013. Epub 2018 May 4.


Aminochrome decreases NGF, GDNF and induces neuroinflammation in organotypic midbrain slice cultures.

de Araújo FM, Ferreira RS, Souza CS, Dos Santos CC, Rodrigues TLRS, E Silva JHC, Gasparotto J, Gelain DP, El-Bachá RS, D Costa MF, Fonseca JCM, Segura-Aguilar J, Costa SL, Silva VDA.

Neurotoxicology. 2018 May;66:98-106. doi: 10.1016/j.neuro.2018.03.009. Epub 2018 Mar 26.


Immune neutralization of the receptor for advanced glycation end products reduce liver oxidative damage induced by an acute systemic injection of lipopolysaccharide.

Tiefensee Ribeiro C, Gasparotto J, Teixeira AA, Portela LVC, Flores VNL, Moreira JCF, Gelain DP.

J Biochem. 2018 Jun 1;163(6):515-523. doi: 10.1093/jb/mvy013.


Delayed neurochemical effects of prenatal exposure to MeHg in the cerebellum of developing rats.

Heimfarth L, Delgado J, Mingori MR, Moresco KS, Pureur RP, Gelain DP, Moreira JCF.

Toxicol Lett. 2018 Mar 1;284:161-169. doi: 10.1016/j.toxlet.2017.12.006. Epub 2017 Dec 16.


Receptor for advanced glycation end products mediates sepsis-triggered amyloid-β accumulation, Tau phosphorylation, and cognitive impairment.

Gasparotto J, Girardi CS, Somensi N, Ribeiro CT, Moreira JCF, Michels M, Sonai B, Rocha M, Steckert AV, Barichello T, Quevedo J, Dal-Pizzol F, Gelain DP.

J Biol Chem. 2018 Jan 5;293(1):226-244. doi: 10.1074/jbc.M117.786756. Epub 2017 Nov 10.


Supplementation with Achyrocline satureioides Inflorescence Extracts to Pregnant and Breastfeeding Rats Induces Tissue-Specific Changes in Enzymatic Activity and Lower Neonatal Survival.

Moresco KS, Silveira AK, Schnorr CE, Zeidán-Chuliá F, Bortolin RC, Bittencourt LDS, Mingori M, Heimfarth L, Rabelo TK, Morrone MDS, Carini JP, Gelain DP, Bassani VL, Moreira JCF.

Biomedicines. 2017 Aug 29;5(3). pii: E53. doi: 10.3390/biomedicines5030053.


Antioxidant and Anti-Inflammatory Properties of Anacardium occidentale Leaf Extract.

Souza NC, de Oliveira JM, Morrone MDS, Albanus RD, Amarante MDSM, Camillo CDS, Langassner SMZ, Gelain DP, Moreira JCF, Dalmolin RJS, Pasquali MAB.

Evid Based Complement Alternat Med. 2017;2017:2787308. doi: 10.1155/2017/2787308. Epub 2017 Aug 17.


A new animal diet based on human Western diet is a robust diet-induced obesity model: comparison to high-fat and cafeteria diets in term of metabolic and gut microbiota disruption.

Bortolin RC, Vargas AR, Gasparotto J, Chaves PR, Schnorr CE, Martinello KB, Silveira AK, Rabelo TK, Gelain DP, Moreira JCF.

Int J Obes (Lond). 2018 Mar;42(3):525-534. doi: 10.1038/ijo.2017.225. Epub 2017 Sep 12.


Developmental neurotoxicity of the hippocampus following in utero exposure to methylmercury: impairment in cell signaling.

Heimfarth L, Delgado J, Mignori MR, Gelain DP, Moreira JCF, Pessoa-Pureur R.

Arch Toxicol. 2018 Jan;92(1):513-527. doi: 10.1007/s00204-017-2042-6. Epub 2017 Aug 18.


Targeted inhibition of RAGE in substantia nigra of rats blocks 6-OHDA-induced dopaminergic denervation.

Gasparotto J, Ribeiro CT, Bortolin RC, Somensi N, Rabelo TK, Kunzler A, Souza NC, Pasquali MAB, Moreira JCF, Gelain DP.

Sci Rep. 2017 Aug 18;7(1):8795. doi: 10.1038/s41598-017-09257-3.


Role of vitamin A oral supplementation on oxidative stress and inflammatory response in the liver of trained rats.

Petiz LL, Kunzler A, Bortolin RC, Gasparotto J, Matté C, Moreira JCF, Gelain DP.

Appl Physiol Nutr Metab. 2017 Nov;42(11):1192-1200. doi: 10.1139/apnm-2017-0193. Epub 2017 Jun 28.


A longitudinal study of neurotrophic, oxidative, and inflammatory markers in first-onset depression in midlife women.

Pasquali MA, Harlow BL, Soares CN, Otto MW, Cohen LS, Minuzzi L, Gelain DP, Moreira JCF, Frey BN.

Eur Arch Psychiatry Clin Neurosci. 2018 Dec;268(8):771-781. doi: 10.1007/s00406-017-0812-z. Epub 2017 May 26.


Retinol (Vitamin A) Increases α-Synuclein, β-Amyloid Peptide, Tau Phosphorylation and RAGE Content in Human SH-SY5Y Neuronal Cell Line.

Kunzler A, Kolling EA, da Silva JD Jr, Gasparotto J, de Bittencourt Pasquali MA, Moreira JCF, Gelain DP.

Neurochem Res. 2017 Oct;42(10):2788-2797. doi: 10.1007/s11064-017-2292-y. Epub 2017 May 11.


Vitamin A Oral Supplementation Induces Oxidative Stress and Suppresses IL-10 and HSP70 in Skeletal Muscle of Trained Rats.

Petiz LL, Girardi CS, Bortolin RC, Kunzler A, Gasparotto J, Rabelo TK, Matté C, Moreira JC, Gelain DP.

Nutrients. 2017 Apr 2;9(4). pii: E353. doi: 10.3390/nu9040353.


Effect of Paullinia cupana Mart. Commercial Extract During the Aging of Middle Age Wistar Rats: Differential Effects on the Hippocampus and Striatum.

Mingori MR, Heimfarth L, Ferreira CF, Gomes HM, Moresco KS, Delgado J, Roncato S, Zeidán-Chuliá F, Gelain DP, Moreira JCF.

Neurochem Res. 2017 Aug;42(8):2257-2273. doi: 10.1007/s11064-017-2238-4. Epub 2017 Mar 27.


Sperm quality and oxidative status as affected by homogenization of liquid-stored boar semen diluted in short- and long-term extenders.

Menegat MB, Mellagi AP, Bortolin RC, Menezes TA, Vargas AR, Bernardi ML, Wentz I, Gelain DP, Moreira JC, Bortolozzo FP.

Anim Reprod Sci. 2017 Apr;179:67-79. doi: 10.1016/j.anireprosci.2017.02.003. Epub 2017 Feb 12.


N-acetyl-cysteine inhibits liver oxidative stress markers in BALB/c mice infected with Leishmania amazonensis.

Gasparotto J, Kunzler A, Senger MR, Souza CD, Simone SG, Bortolin RC, Somensi N, Dal-Pizzol F, Moreira JC, Abreu-Silva AL, Calabrese KD, Silva FP Jr, Gelain DP.

Mem Inst Oswaldo Cruz. 2017 Feb;112(2):146-154. doi: 10.1590/0074-02760160403.


Anti-RAGE antibody selectively blocks acute systemic inflammatory responses to LPS in serum, liver, CSF and striatum.

Gasparotto J, Ribeiro CT, Bortolin RC, Somensi N, Fernandes HS, Teixeira AA, Guasselli MOR, Agani CAJO, Souza NC, Grings M, Leipnitz G, Gomes HM, de Bittencourt Pasquali MA, Dunkley PR, Dickson PW, Moreira JCF, Gelain DP.

Brain Behav Immun. 2017 May;62:124-136. doi: 10.1016/j.bbi.2017.01.008. Epub 2017 Jan 11.


Glycine Administration Alters MAPK Signaling Pathways and Causes Neuronal Damage in Rat Brain: Putative Mechanisms Involved in the Neurological Dysfunction in Nonketotic Hyperglycinemia.

Moura AP, Parmeggiani B, Gasparotto J, Grings M, Fernandez Cardoso GM, Seminotti B, Moreira JCF, Gelain DP, Wajner M, Leipnitz G.

Mol Neurobiol. 2018 Jan;55(1):741-750. doi: 10.1007/s12035-016-0319-z. Epub 2017 Jan 3.


Hydroethanolic extracts from different genotypes of açaí (Euterpe oleracea) presented antioxidant potential and protected human neuron-like cells (SH-SY5Y).

Torma PD, Brasil AV, Carvalho AV, Jablonski A, Rabelo TK, Moreira JC, Gelain DP, Flôres SH, Augusti PR, Rios AO.

Food Chem. 2017 May 1;222:94-104. doi: 10.1016/j.foodchem.2016.12.006. Epub 2016 Dec 7.


Inflammatory landscape of human brain tumors reveals an NFκB dependent cytokine pathway associated with mesenchymal glioblastoma.

Zanotto-Filho A, Gonçalves RM, Klafke K, de Souza PO, Dillenburg FC, Carro L, Gelain DP, Moreira JC.

Cancer Lett. 2017 Apr 1;390:176-187. doi: 10.1016/j.canlet.2016.12.015. Epub 2016 Dec 20.


A statistical method to calculate blood contamination in the measurement of salivary hormones in healthy women.

Behr GA, Patel JP, Coote M, Moreira JCF, Gelain DP, Steiner M, Frey BN.

Clin Biochem. 2017 May;50(7-8):436-439. doi: 10.1016/j.clinbiochem.2016.12.005. Epub 2016 Dec 16.


Putative model for heat shock protein 70 complexation with receptor of advanced glycation end products through fluorescence proximity assays and normal mode analyses.

Grunwald MS, Ligabue-Braun R, Souza CS, Heimfarth L, Verli H, Gelain DP, Moreira JC.

Cell Stress Chaperones. 2017 Jan;22(1):99-111. doi: 10.1007/s12192-016-0746-9. Epub 2016 Nov 17.


NRF2 Mediates Neuroblastoma Proliferation and Resistance to Retinoic Acid Cytotoxicity in a Model of In Vitro Neuronal Differentiation.

de Miranda Ramos V, Zanotto-Filho A, de Bittencourt Pasquali MA, Klafke K, Gasparotto J, Dunkley P, Gelain DP, Moreira JCF.

Mol Neurobiol. 2016 Nov;53(9):6124-6135. doi: 10.1007/s12035-015-9506-6. Epub 2015 Nov 5.


Changes in Cell Cycle and Up-Regulation of Neuronal Markers During SH-SY5Y Neurodifferentiation by Retinoic Acid are Mediated by Reactive Species Production and Oxidative Stress.

Kunzler A, Zeidán-Chuliá F, Gasparotto J, Girardi CS, Klafke K, Petiz LL, Bortolin RC, Rostirolla DC, Zanotto-Filho A, de Bittencourt Pasquali MA, Dickson P, Dunkley P, Moreira JCF, Gelain DP.

Mol Neurobiol. 2017 Nov;54(9):6903-6916. doi: 10.1007/s12035-016-0189-4. Epub 2016 Oct 22.


Effects of Freeze-Thaw and Storage on Enzymatic Activities, Protein Oxidative Damage, and Immunocontent of the Blood, Liver, and Brain of Rats.

Bortolin RC, Gasparotto J, Vargas AR, da Silva Morrone M, Kunzler A, Henkin BS, Chaves PR, Roncato S, Gelain DP, Moreira JCF.

Biopreserv Biobank. 2017 Jun;15(3):182-190. doi: 10.1089/bio.2016.0023. Epub 2016 Sep 23.


Turnera subulata Anti-Inflammatory Properties in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages.

Souza NC, de Oliveira JM, Morrone MDS, Albanus RD, Amarante MDSM, Camillo CDS, Langassner SMZ, Gelain DP, Moreira JCF, Dalmolin RJS, de Bittencourt Pasquali MA.

J Med Food. 2016 Oct;19(10):922-930. doi: 10.1089/jmf.2016.0047. Epub 2016 Sep 7.


Apoptotic signaling pathways induced by acute administration of branched-chain amino acids in an animal model of maple syrup urine disease.

Vilela TC, Scaini G, Furlanetto CB, Pasquali MA, Santos JP, Gelain DP, Moreira JC, Schuck PF, Ferreira GC, Streck EL.

Metab Brain Dis. 2017 Feb;32(1):115-122. doi: 10.1007/s11011-016-9892-0. Epub 2016 Aug 11.


Shikimic acid inhibits LPS-induced cellular pro-inflammatory cytokines and attenuates mechanical hyperalgesia in mice.

Rabelo TK, Guimarães AG, Oliveira MA, Gasparotto J, Serafini MR, de Souza Araújo AA, Quintans-Júnior LJ, Moreira JCF, Gelain DP.

Int Immunopharmacol. 2016 Oct;39:97-105. doi: 10.1016/j.intimp.2016.07.016. Epub 2016 Jul 25.


Oral administration of curcumin relieves behavioral alterations and oxidative stress in the frontal cortex, hippocampus, and striatum of ovariectomized Wistar rats.

Da Silva Morrone M, Schnorr CE, Behr GA, Gasparotto J, Bortolin RC, Moresco KS, Bittencourt L, Zanotto-Filho A, Gelain DP, Moreira JC.

J Nutr Biochem. 2016 Jun;32:181-8. doi: 10.1016/j.jnutbio.2016.03.010. Epub 2016 Apr 1.


Chronic ozone exposure alters the secondary metabolite profile, antioxidant potential, anti-inflammatory property, and quality of red pepper fruit from Capsicum baccatum.

Bortolin RC, Caregnato FF, Divan Junior AM, Zanotto-Filho A, Moresco KS, Rios Ade O, Salvi Ade O, Ortmann CF, de Carvalho P, Reginatto FH, Gelain DP, Moreira JC.

Ecotoxicol Environ Saf. 2016 Jul;129:16-24. doi: 10.1016/j.ecoenv.2016.03.004. Epub 2016 Mar 10.


Curcumin Supplementation Decreases Intestinal Adiposity Accumulation, Serum Cholesterol Alterations, and Oxidative Stress in Ovariectomized Rats.

Morrone Mda S, Schnorr CE, Behr GA, Gasparotto J, Bortolin RC, da Boit Martinello K, Saldanha Henkin B, Rabello TK, Zanotto-Filho A, Gelain DP, Moreira JC.

Oxid Med Cell Longev. 2016;2016:5719291. doi: 10.1155/2016/5719291. Epub 2015 Nov 23.


Supplementation with vitamin A enhances oxidative stress in the lungs of rats submitted to aerobic exercise.

Gasparotto J, Petiz LL, Girardi CS, Bortolin RC, de Vargas AR, Henkin BS, Chaves PR, Roncato S, Matté C, Zanotto-Filho A, Moreira JC, Gelain DP.

Appl Physiol Nutr Metab. 2015 Dec;40(12):1253-61. doi: 10.1139/apnm-2015-0218. Epub 2015 Aug 17.


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