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Items: 29

1.

The innate immune DNA sensor cGAS: A membrane, cytosolic, or nuclear protein?

Gekara NO, Jiang H.

Sci Signal. 2019 May 14;12(581). pii: eaax3521. doi: 10.1126/scisignal.aax3521. Review.

PMID:
31088977
2.

The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex.

Panda S, Gekara NO.

Nat Commun. 2018 Nov 7;9(1):4654. doi: 10.1038/s41467-018-07016-0.

3.

Loss of the DNA Damage Repair Kinase ATM Impairs Inflammasome-Dependent Anti-Bacterial Innate Immunity.

Erttmann SF, Härtlova A, Sloniecka M, Raffi FAM, Hosseinzadeh A, Edgren T, Rofougaran R, Resch U, Fällman M, Ek T, Gekara NO.

Immunity. 2017 Dec 19;47(6):1210-1211. doi: 10.1016/j.immuni.2017.11.014. No abstract available.

4.

DNA damage-induced immune response: Micronuclei provide key platform.

Gekara NO.

J Cell Biol. 2017 Oct 2;216(10):2999-3001. doi: 10.1083/jcb.201708069. Epub 2017 Aug 31.

5.

Subversion of innate immune responses by Francisella involves the disruption of TRAF3 and TRAF6 signalling complexes.

Putzova D, Panda S, Härtlova A, Stulík J, Gekara NO.

Cell Microbiol. 2017 Nov;19(11). doi: 10.1111/cmi.12769. Epub 2017 Aug 16.

PMID:
28745813
6.

Detection of a microbial metabolite by STING regulates inflammasome activation in response to Chlamydia trachomatis infection.

Webster SJ, Brode S, Ellis L, Fitzmaurice TJ, Elder MJ, Gekara NO, Tourlomousis P, Bryant C, Clare S, Chee R, Gaston HJS, Goodall JC.

PLoS Pathog. 2017 Jun 1;13(6):e1006383. doi: 10.1371/journal.ppat.1006383. eCollection 2017 Jun.

7.

Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects.

Lindqvist R, Mundt F, Gilthorpe JD, Wölfel S, Gekara NO, Kröger A, Överby AK.

J Neuroinflammation. 2016 Oct 24;13(1):277.

8.

Loss of the DNA Damage Repair Kinase ATM Impairs Inflammasome-Dependent Anti-Bacterial Innate Immunity.

Erttmann SF, Härtlova A, Sloniecka M, Raffi FA, Hosseinzadeh A, Edgren T, Rofougaran R, Resch U, Fällman M, Ek T, Gekara NO.

Immunity. 2016 Jul 19;45(1):106-18. doi: 10.1016/j.immuni.2016.06.018. Epub 2016 Jul 12. Erratum in: Immunity. 2017 Dec 19;47(6):1210-1211.

9.

Type I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1.

Kurhade C, Zegenhagen L, Weber E, Nair S, Michaelsen-Preusse K, Spanier J, Gekara NO, Kröger A, Överby AK.

J Neuroinflammation. 2016 Jan 27;13:22. doi: 10.1186/s12974-016-0487-9.

10.

Deubiquitinase MYSM1 Regulates Innate Immunity through Inactivation of TRAF3 and TRAF6 Complexes.

Panda S, Nilsson JA, Gekara NO.

Immunity. 2015 Oct 20;43(4):647-59. doi: 10.1016/j.immuni.2015.09.010.

11.

DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity.

Härtlova A, Erttmann SF, Raffi FA, Schmalz AM, Resch U, Anugula S, Lienenklaus S, Nilsson LM, Kröger A, Nilsson JA, Ek T, Weiss S, Gekara NO.

Immunity. 2015 Feb 17;42(2):332-343. doi: 10.1016/j.immuni.2015.01.012.

12.

Type I interferon protects mice from fatal neurotropic infection with Langat virus by systemic and local antiviral responses.

Weber E, Finsterbusch K, Lindquist R, Nair S, Lienenklaus S, Gekara NO, Janik D, Weiss S, Kalinke U, Överby AK, Kröger A.

J Virol. 2014 Nov;88(21):12202-12. doi: 10.1128/JVI.01215-14. Epub 2014 Aug 13.

13.

Bacteria induce prolonged PMN survival via a phosphatidylcholine-specific phospholipase C- and protein kinase C-dependent mechanism.

Erttmann SF, Gekara NO, Fällman M.

PLoS One. 2014 Jan 31;9(1):e87859. doi: 10.1371/journal.pone.0087859. eCollection 2014.

14.

Quantitative proteomics analysis of macrophage-derived lipid rafts reveals induction of autophagy pathway at the early time of Francisella tularensis LVS infection.

Härtlova A, Link M, Balounova J, Benesova M, Resch U, Straskova A, Sobol M, Philimonenko A, Hozak P, Krocova Z, Gekara N, Filipp D, Stulik J.

J Proteome Res. 2014 Feb 7;13(2):796-804. doi: 10.1021/pr4008656. Epub 2014 Jan 7.

PMID:
24364512
15.

IFN-γ production by CD27⁺ NK cells exacerbates Listeria monocytogenes infection in mice by inhibiting granulocyte mobilization.

Viegas N, Andzinski L, Wu CF, Komoll RM, Gekara N, Dittmar KE, Weiss S, Jablonska J.

Eur J Immunol. 2013 Oct;43(10):2626-37. doi: 10.1002/eji.201242937. Epub 2013 Jul 25.

16.

SIGN-R1+MHC II+ cells of the splenic marginal zone--a novel type of resident dendritic cells.

Łyszkiewicz M, Zietara N, Rohde M, Gekara NO, Jabłońska J, Dittmar KE, Weiss S.

J Leukoc Biol. 2011 Apr;89(4):607-15. doi: 10.1189/jlb.0610368. Epub 2011 Jan 4.

PMID:
21208895
17.

Listeria monocytogenes induces T cell receptor unresponsiveness through pore-forming toxin listeriolysin O.

Gekara NO, Zietara N, Geffers R, Weiss S.

J Infect Dis. 2010 Dec 1;202(11):1698-707. doi: 10.1086/657145. Epub 2010 Oct 20.

PMID:
20961225
18.

Murine toll-like receptor 2 activation induces type I interferon responses from endolysosomal compartments.

Dietrich N, Lienenklaus S, Weiss S, Gekara NO.

PLoS One. 2010 Apr 20;5(4):e10250. doi: 10.1371/journal.pone.0010250.

19.

Mast cells elicit proinflammatory but not type I interferon responses upon activation of TLRs by bacteria.

Dietrich N, Rohde M, Geffers R, Kröger A, Hauser H, Weiss S, Gekara NO.

Proc Natl Acad Sci U S A. 2010 May 11;107(19):8748-53. doi: 10.1073/pnas.0912551107. Epub 2010 Apr 26.

20.

Tumor invasion of Salmonella enterica serovar Typhimurium is accompanied by strong hemorrhage promoted by TNF-alpha.

Leschner S, Westphal K, Dietrich N, Viegas N, Jablonska J, Lyszkiewicz M, Lienenklaus S, Falk W, Gekara N, Loessner H, Weiss S.

PLoS One. 2009 Aug 20;4(8):e6692. doi: 10.1371/journal.pone.0006692.

21.

Novel reporter mouse reveals constitutive and inflammatory expression of IFN-beta in vivo.

Lienenklaus S, Cornitescu M, Zietara N, Łyszkiewicz M, Gekara N, Jabłónska J, Edenhofer F, Rajewsky K, Bruder D, Hafner M, Staeheli P, Weiss S.

J Immunol. 2009 Sep 1;183(5):3229-36. doi: 10.4049/jimmunol.0804277. Epub 2009 Aug 10.

22.

Absence of IFN-beta impairs antigen presentation capacity of splenic dendritic cells via down-regulation of heat shock protein 70.

Zietara N, Łyszkiewicz M, Gekara N, Puchałka J, Dos Santos VA, Hunt CR, Pandita TK, Lienenklaus S, Weiss S.

J Immunol. 2009 Jul 15;183(2):1099-109. doi: 10.4049/jimmunol.0803214.

23.

Signals triggered by a bacterial pore-forming toxin contribute to toll-like receptor redundancy in gram-positive bacterial recognition.

Gekara NO, Dietrich N, Lyszkiewicz M, Lienenklaus S, Weiss S.

J Infect Dis. 2009 Jan 1;199(1):124-33. doi: 10.1086/595562.

PMID:
19032107
24.
25.

Mast cells initiate early anti-Listeria host defences.

Gekara NO, Weiss S.

Cell Microbiol. 2008 Jan;10(1):225-36. Epub 2007 Aug 20.

PMID:
17714516
26.

The multiple mechanisms of Ca2+ signalling by listeriolysin O, the cholesterol-dependent cytolysin of Listeria monocytogenes.

Gekara NO, Westphal K, Ma B, Rohde M, Groebe L, Weiss S.

Cell Microbiol. 2007 Aug;9(8):2008-21. Epub 2007 Apr 5.

PMID:
17419718
27.

Sterol and pH interdependence in the binding, oligomerization, and pore formation of Listeriolysin O.

Bavdek A, Gekara NO, Priselac D, Gutiérrez Aguirre I, Darji A, Chakraborty T, Macek P, Lakey JH, Weiss S, Anderluh G.

Biochemistry. 2007 Apr 10;46(14):4425-37. Epub 2007 Mar 15.

PMID:
17358050
28.

The cholesterol-dependent cytolysin listeriolysin O aggregates rafts via oligomerization.

Gekara NO, Jacobs T, Chakraborty T, Weiss S.

Cell Microbiol. 2005 Sep;7(9):1345-56.

PMID:
16098221
29.

Lipid rafts clustering and signalling by listeriolysin O.

Gekara NO, Weiss S.

Biochem Soc Trans. 2004 Nov;32(Pt 5):712-4. Review.

PMID:
15493995

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