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Items: 21


A gain-of-function mutation in adenylate cyclase 3 protects mice from diet-induced obesity.

Pitman JL, Wheeler MC, Lloyd DJ, Walker JR, Glynne RJ, Gekakis N.

PLoS One. 2014 Oct 16;9(10):e110226. doi: 10.1371/journal.pone.0110226. eCollection 2014.


Hsp90 modulates PPARγ activity in a mouse model of nonalcoholic fatty liver disease.

Wheeler MC, Gekakis N.

J Lipid Res. 2014 Aug;55(8):1702-10. doi: 10.1194/jlr.M048918. Epub 2014 Jun 13.


Defective transport of the obesity mutant PC1/3 N222D contributes to loss of function.

Prabhu Y, Blanco EH, Liu M, Peinado JR, Wheeler MC, Gekakis N, Arvan P, Lindberg I.

Endocrinology. 2014 Jul;155(7):2391-401. doi: 10.1210/en.2013-1985. Epub 2014 May 14.


Defective ER associated degradation of a model luminal substrate in yeast carrying a mutation in the 4th ER luminal loop of Sec61p.

Wheeler MC, Gekakis N.

Biochem Biophys Res Commun. 2012 Nov 2;427(4):768-73. doi: 10.1016/j.bbrc.2012.09.136. Epub 2012 Oct 5.


Reduced cholesterol and triglycerides in mice with a mutation in Mia2, a liver protein that localizes to ER exit sites.

Pitman JL, Bonnet DJ, Curtiss LK, Gekakis N.

J Lipid Res. 2011 Oct;52(10):1775-86. doi: 10.1194/jlr.M017277. Epub 2011 Aug 1.


A point mutation in Sec61alpha1 leads to diabetes and hepatosteatosis in mice.

Lloyd DJ, Wheeler MC, Gekakis N.

Diabetes. 2010 Feb;59(2):460-70. doi: 10.2337/db08-1362. Epub 2009 Nov 23.


Negative regulators of insulin signaling revealed in a genome-wide functional screen.

Huang SM, Hancock MK, Pitman JL, Orth AP, Gekakis N.

PLoS One. 2009 Sep 3;4(9):e6871. doi: 10.1371/journal.pone.0006871.


Loss-of-function mutation in myostatin reduces tumor necrosis factor alpha production and protects liver against obesity-induced insulin resistance.

Wilkes JJ, Lloyd DJ, Gekakis N.

Diabetes. 2009 May;58(5):1133-43. doi: 10.2337/db08-0245. Epub 2009 Feb 10.


CIPC is a mammalian circadian clock protein without invertebrate homologues.

Zhao WN, Malinin N, Yang FC, Staknis D, Gekakis N, Maier B, Reischl S, Kramer A, Weitz CJ.

Nat Cell Biol. 2007 Mar;9(3):268-75. Epub 2007 Feb 18.


A role for Alström syndrome protein, alms1, in kidney ciliogenesis and cellular quiescence.

Li G, Vega R, Nelms K, Gekakis N, Goodnow C, McNamara P, Wu H, Hong NA, Glynne R.

PLoS Genet. 2007 Jan 5;3(1):e8. Epub 2006 Nov 30.


Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice.

Lloyd DJ, Bohan S, Gekakis N.

Hum Mol Genet. 2006 Jun 1;15(11):1884-93. Epub 2006 Apr 27. Erratum in: Hum Mol Genet. 2008 Nov 1;17(21):3435.


Diabetes insipidus in mice with a mutation in aquaporin-2.

Lloyd DJ, Hall FW, Tarantino LM, Gekakis N.

PLoS Genet. 2005 Aug;1(2):e20. Epub 2005 Aug 19.


Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription.

Sangoram AM, Saez L, Antoch MP, Gekakis N, Staknis D, Whiteley A, Fruechte EM, Vitaterna MH, Shimomura K, King DP, Young MW, Weitz CJ, Takahashi JS.

Neuron. 1998 Nov;21(5):1101-13.


Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim.

Darlington TK, Wager-Smith K, Ceriani MF, Staknis D, Gekakis N, Steeves TD, Weitz CJ, Takahashi JS, Kay SA.

Science. 1998 Jun 5;280(5369):1599-603.


Role of the CLOCK protein in the mammalian circadian mechanism.

Gekakis N, Staknis D, Nguyen HB, Davis FC, Wilsbacher LD, King DP, Takahashi JS, Weitz CJ.

Science. 1998 Jun 5;280(5369):1564-9.


Isolation of timeless by PER protein interaction: defective interaction between timeless protein and long-period mutant PERL.

Gekakis N, Saez L, Delahaye-Brown AM, Myers MP, Sehgal A, Young MW, Weitz CJ.

Science. 1995 Nov 3;270(5237):811-5.


Control of the murine phosphofructokinase-A gene during muscle differentiation.

Gekakis N, Sul HS.

Biochemistry. 1994 Feb 22;33(7):1771-7.


Structure, distribution, and functional expression of the phosphofructokinase C isozyme.

Gekakis N, Johnson RC, Jerkins A, Mains RE, Sul HS.

J Biol Chem. 1994 Feb 4;269(5):3348-55.


Phosphofructokinase isozyme expression during myoblast differentiation.

Gekakis N, Gehnrich SC, Sul HS.

J Biol Chem. 1989 Mar 5;264(7):3658-61.


Liver (B-type) phosphofructokinase mRNA. Cloning, structure, and expression.

Gehnrich SC, Gekakis N, Sul HS.

J Biol Chem. 1988 Aug 25;263(24):11755-9.

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