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Items: 1 to 50 of 515

1.

UGCG influences glutamine metabolism of breast cancer cells.

Schömel N, Hancock SE, Gruber L, Olzomer EM, Byrne FL, Shah D, Hoehn KL, Turner N, Grösch S, Geisslinger G, Wegner MS.

Sci Rep. 2019 Oct 30;9(1):15665. doi: 10.1038/s41598-019-52169-7.

2.

Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis.

Queck A, Thomas D, Jansen C, Schreiber Y, Rüschenbaum S, Praktiknjo M, Schwarzkopf KM, Mücke MM, Schierwagen R, Uschner FE, Meyer C, Clària J, Zeuzem S, Geisslinger G, Trebicka J, Lange CM.

PLoS One. 2019 Oct 23;14(10):e0222840. doi: 10.1371/journal.pone.0222840. eCollection 2019.

3.

A data science approach to the selection of most informative readouts of the human intradermal capsaicin pain model to assess pregabalin effects.

Lötsch J, Walter C, Zunftmeister M, Zinn S, Wolters M, Ferreiros N, Rossmanith T, Oertel BG, Geisslinger G.

Basic Clin Pharmacol Toxicol. 2019 Oct 14. doi: 10.1111/bcpt.13337. [Epub ahead of print]

PMID:
31608551
4.

Inhibitors of Oxidative Phosphorylation Modulate Astrocyte Inflammatory Responses through AMPK-Dependent Ptgs2 mRNA Stabilization.

Astakhova A, Chistyakov D, Thomas D, Geisslinger G, Brüne B, Sergeeva M, Namgaladze D.

Cells. 2019 Oct 1;8(10). pii: E1185. doi: 10.3390/cells8101185.

5.

4 Ds in health research-working together toward rapid precision medicine.

Niederberger E, Parnham MJ, Maas J, Geisslinger G.

EMBO Mol Med. 2019 Nov 7;11(11):e10917. doi: 10.15252/emmm.201910917. Epub 2019 Sep 18.

6.

[Generating knowledge from complex data sets in human experimental pain research].

Lötsch J, Geisslinger G, Walter C.

Schmerz. 2019 Sep 2. doi: 10.1007/s00482-019-00412-5. [Epub ahead of print] Review. German.

PMID:
31478142
7.

Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML.

Oellerich T, Schneider C, Thomas D, Knecht KM, Buzovetsky O, Kaderali L, Schliemann C, Bohnenberger H, Angenendt L, Hartmann W, Wardelmann E, Rothenburger T, Mohr S, Scheich S, Comoglio F, Wilke A, Ströbel P, Serve H, Michaelis M, Ferreirós N, Geisslinger G, Xiong Y, Keppler OT, Cinatl J Jr.

Nat Commun. 2019 Aug 2;10(1):3475. doi: 10.1038/s41467-019-11413-4.

8.

Determination of endocannabinoids and endocannabinoid-like substances in human K3EDTA plasma - LC-MS/MS method validation and pre-analytical characteristics.

Gurke R, Thomas D, Schreiber Y, Schäfer SMG, Fleck SC, Geisslinger G, Ferreirós N.

Talanta. 2019 Nov 1;204:386-394. doi: 10.1016/j.talanta.2019.06.004. Epub 2019 Jun 3.

PMID:
31357310
9.

The Lipid Status in Patients with Ulcerative Colitis: Sphingolipids are Disease-Dependent Regulated.

Bazarganipour S, Hausmann J, Oertel S, El-Hindi K, Brachtendorf S, Blumenstein I, Kubesch A, Sprinzl K, Birod K, Hahnefeld L, Trautmann S, Thomas D, Herrmann E, Geisslinger G, Schiffmann S, Grösch S.

J Clin Med. 2019 Jul 4;8(7). pii: E971. doi: 10.3390/jcm8070971.

10.

5-Amino-1-β-D-Ribofuranosyl-Imidazole-4-Carboxamide (AICAR) Reduces Peripheral Inflammation by Macrophage Phenotype Shift.

Martin LM, Möller M, Weiss U, Russe OQ, Scholich K, Pierre S, Geisslinger G, Niederberger E.

Int J Mol Sci. 2019 Jul 2;20(13). pii: E3255. doi: 10.3390/ijms20133255.

11.

A validated LC-MS/MS method for the determination of homocysteic acid in biological samples.

Gurke R, Schmidt D, Thomas D, Fleck SC, Geisslinger G, Ferreirós N.

J Pharm Biomed Anal. 2019 Sep 10;174:578-587. doi: 10.1016/j.jpba.2019.06.008. Epub 2019 Jun 21.

PMID:
31261039
12.

Computer-Aided Selective Optimization of Side Activities of Talinolol.

Hiesinger K, Kramer JS, Achenbach J, Moser D, Weber J, Wittmann SK, Morisseau C, Angioni C, Geisslinger G, Kahnt AS, Kaiser A, Proschak A, Steinhilber D, Pogoryelov D, Wagner K, Hammock BD, Proschak E.

ACS Med Chem Lett. 2019 May 29;10(6):899-903. doi: 10.1021/acsmedchemlett.9b00075. eCollection 2019 Jun 13.

PMID:
31223445
13.

GPER1 influences cellular homeostasis and cytostatic drug resistance via influencing long chain ceramide synthesis in breast cancer cells.

Wegner MS, Gruber L, Schömel N, Trautmann S, Brachtendorf S, Fuhrmann D, Schreiber Y, Olesch C, Brüne B, Geisslinger G, Grösch S.

Int J Biochem Cell Biol. 2019 Jul;112:95-106. doi: 10.1016/j.biocel.2019.05.002. Epub 2019 May 11.

PMID:
31082617
14.

Novel Approaches to Persistent Pain Therapy.

Sisignano M, Parnham MJ, Geisslinger G.

Trends Pharmacol Sci. 2019 Jun;40(6):367-377. doi: 10.1016/j.tips.2019.04.003. Epub 2019 May 8. Review.

PMID:
31078322
15.

Targeted lipidomics reveal derangement of ceramides in major depression and bipolar disorder.

Brunkhorst-Kanaan N, Klatt-Schreiner K, Hackel J, Schröter K, Trautmann S, Hahnefeld L, Wicker S, Reif A, Thomas D, Geisslinger G, Kittel-Schneider S, Tegeder I.

Metabolism. 2019 Jun;95:65-76. doi: 10.1016/j.metabol.2019.04.002. Epub 2019 Apr 5.

PMID:
30954559
16.

Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor γ.

Göbel T, Diehl O, Heering J, Merk D, Angioni C, Wittmann SK, Buscato E, Kottke R, Weizel L, Schader T, Maier TJ, Geisslinger G, Schubert-Zsilavecz M, Steinhilber D, Proschak E, Kahnt AS.

Front Pharmacol. 2019 Mar 20;10:263. doi: 10.3389/fphar.2019.00263. eCollection 2019.

17.

Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase.

Schwiebs A, Herrero San Juan M, Schmidt KG, Wiercinska E, Anlauf M, Ottenlinger F, Thomas D, Elwakeel E, Weigert A, Farin HF, Bonig H, Scholich K, Geisslinger G, Pfeilschifter JM, Radeke HH.

Oncogene. 2019 Jun;38(24):4788-4803. doi: 10.1038/s41388-019-0758-x. Epub 2019 Feb 28.

PMID:
30816345
18.

A Data Science-Based Analysis Points at Distinct Patterns of Lipid Mediator Plasma Concentrations in Patients With Dementia.

Gurke R, Etyemez S, Prvulovic D, Thomas D, Fleck SC, Reif A, Geisslinger G, Lötsch J.

Front Psychiatry. 2019 Feb 11;10:41. doi: 10.3389/fpsyt.2019.00041. eCollection 2019.

19.

Potential biomarkers for persistent and neuropathic pain therapy.

Sisignano M, Lötsch J, Parnham MJ, Geisslinger G.

Pharmacol Ther. 2019 Jul;199:16-29. doi: 10.1016/j.pharmthera.2019.02.004. Epub 2019 Feb 10. Review.

PMID:
30759376
20.

Omega-3 and -6 fatty acid plasma levels are not associated with liver cirrhosis-associated systemic inflammation.

Schwarzkopf KM, Queck A, Thomas D, Angioni C, Cai C, Freygang Y, Rüschenbaum S, Geisslinger G, Zeuzem S, Welsch C, Lange CM.

PLoS One. 2019 Jan 31;14(1):e0211537. doi: 10.1371/journal.pone.0211537. eCollection 2019.

21.

Role of ceramide synthase 2 in G-CSF signaling and G-CSF-R translocation into detergent-resistant membranes.

Kurz J, Barthelmes J, Blum L, Ulshöfer T, Wegner MS, Ferreirós N, Roser L, Geisslinger G, Grösch S, Schiffmann S.

Sci Rep. 2019 Jan 24;9(1):747. doi: 10.1038/s41598-018-37342-8.

22.

Immunogenicity assay development and validation for biological therapy as exemplified by ustekinumab.

Mojtahed Poor S, Ulshöfer T, Gabriel LA, Henke M, Köhm M, Behrens F, Geisslinger G, Parnham MJ, Burkhardt H, Schiffmann S.

Clin Exp Immunol. 2019 May;196(2):259-275. doi: 10.1111/cei.13261. Epub 2019 Feb 3.

PMID:
30656642
23.

Thromboxane-Induced α-CGRP Release from Peripheral Neurons Is an Essential Positive Feedback Loop in Capsaicin-Induced Neurogenic Inflammation.

Tarighi N, Menger D, Pierre S, Kornstädt L, Thomas D, Ferreirós N, Nüsing RM, Geisslinger G, Scholich K.

J Invest Dermatol. 2019 Mar;139(3):656-664. doi: 10.1016/j.jid.2018.10.011. Epub 2018 Oct 26.

PMID:
30612974
24.

Correction: Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders.

Thalman C, Horta G, Qiao L, Endle H, Tegeder I, Cheng H, Laube G, Sigurdsson T, Hauser MJ, Tenzer S, Distler U, Aoki J, Morris AJ, Geisslinger G, Röper J, Kirischuk S, Luhmann HJ, Radyushkin K, Nitsch R, Vogt J.

Mol Psychiatry. 2019 Jan 2. doi: 10.1038/s41380-018-0320-1. [Epub ahead of print]

PMID:
30602735
25.

Cytokine-induced endogenous production of prostaglandin D2 is essential for human group 2 innate lymphoid cell activation.

Maric J, Ravindran A, Mazzurana L, Van Acker A, Rao A, Kokkinou E, Ekoff M, Thomas D, Fauland A, Nilsson G, Wheelock CE, Dahlén SE, Ferreirós N, Geisslinger G, Friberg D, Heinemann A, Konya V, Mjösberg J.

J Allergy Clin Immunol. 2019 Jun;143(6):2202-2214.e5. doi: 10.1016/j.jaci.2018.10.069. Epub 2018 Dec 19.

PMID:
30578872
26.

Inhibition of the protein kinase IKKepsilon attenuates neuropathic pain in mice.

Möser CV, Möller M, Fleck SC, Thomas D, Geisslinger G, Niederberger E.

Neuropharmacology. 2019 Mar 1;146:198-211. doi: 10.1016/j.neuropharm.2018.12.004. Epub 2018 Dec 6.

PMID:
30528326
27.

Ceramides as Novel Disease Biomarkers.

Kurz J, Parnham MJ, Geisslinger G, Schiffmann S.

Trends Mol Med. 2019 Jan;25(1):20-32. doi: 10.1016/j.molmed.2018.10.009. Epub 2018 Nov 23. Review.

PMID:
30477968
28.

Predictive PBPK modeling as a tool in the formulation of the drug candidate TMP-001.

Nothnagel L, Jung F, Rossmanith T, Thurn M, Ashtikar M, Geisslinger G, Parnham MJ, Wacker MG.

Eur J Pharm Biopharm. 2019 Jan;134:144-152. doi: 10.1016/j.ejpb.2018.11.012. Epub 2018 Nov 16.

PMID:
30453024
29.

Mast cell tetrahydrobiopterin contributes to itch in mice.

Zschiebsch K, Fischer C, Wilken-Schmitz A, Geisslinger G, Channon K, Watschinger K, Tegeder I.

J Cell Mol Med. 2019 Feb;23(2):985-1000. doi: 10.1111/jcmm.13999. Epub 2018 Nov 18.

30.

The G2A Receptor Controls Polarization of Macrophage by Determining Their Localization Within the Inflamed Tissue.

Kern K, Schäfer SMG, Cohnen J, Pierre S, Osthues T, Tarighi N, Hohmann S, Ferreiros N, Brüne B, Weigert A, Geisslinger G, Sisignano M, Scholich K.

Front Immunol. 2018 Oct 1;9:2261. doi: 10.3389/fimmu.2018.02261. eCollection 2018.

31.

The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1.

Knecht KM, Buzovetsky O, Schneider C, Thomas D, Srikanth V, Kaderali L, Tofoleanu F, Reiss K, Ferreirós N, Geisslinger G, Batista VS, Ji X, Cinatl J Jr, Keppler OT, Xiong Y.

Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10022-E10031. doi: 10.1073/pnas.1805593115. Epub 2018 Oct 10.

32.

Machine-learning based lipid mediator serum concentration patterns allow identification of multiple sclerosis patients with high accuracy.

Lötsch J, Schiffmann S, Schmitz K, Brunkhorst R, Lerch F, Ferreiros N, Wicker S, Tegeder I, Geisslinger G, Ultsch A.

Sci Rep. 2018 Oct 5;8(1):14884. doi: 10.1038/s41598-018-33077-8.

33.

The relevance of ceramides and their synthesizing enzymes for multiple sclerosis.

Kurz J, Brunkhorst R, Foerch C, Blum L, Henke M, Gabriel L, Ulshöfer T, Ferreirós N, Parnham MJ, Geisslinger G, Schiffmann S.

Clin Sci (Lond). 2018 Aug 17;132(17):1963-1976. doi: 10.1042/CS20180506. Print 2018 Sep 14.

PMID:
30219773
34.

A Novel Function for 15-Lipoxygenases in Cholesterol Homeostasis and CCL17 Production in Human Macrophages.

Snodgrass RG, Zezina E, Namgaladze D, Gupta S, Angioni C, Geisslinger G, Lütjohann D, Brüne B.

Front Immunol. 2018 Aug 24;9:1906. doi: 10.3389/fimmu.2018.01906. eCollection 2018.

35.

Sphingosine-1-phosphate (S1P) induces potent anti-inflammatory effects in vitro and in vivo by S1P receptor 4-mediated suppression of 5-lipoxygenase activity.

Fettel J, Kühn B, Guillen NA, Sürün D, Peters M, Bauer R, Angioni C, Geisslinger G, Schnütgen F, Meyer Zu Heringdorf D, Werz O, Meybohm P, Zacharowski K, Steinhilber D, Roos J, Maier TJ.

FASEB J. 2019 Feb;33(2):1711-1726. doi: 10.1096/fj.201800221R. Epub 2018 Sep 6.

PMID:
30188757
36.

Dietary phytol reduces clinical symptoms in experimental autoimmune encephalomyelitis (EAE) at least partially by modulating NOX2 expression.

Blum L, Tafferner N, Spring I, Kurz J, deBruin N, Geisslinger G, Parnham MJ, Schiffmann S.

J Mol Med (Berl). 2018 Oct;96(10):1131-1144. doi: 10.1007/s00109-018-1689-7. Epub 2018 Aug 27.

PMID:
30151738
37.

Simultaneous determination of PUFA-derived pro-resolving metabolites and pathway markers using chiral chromatography and tandem mass spectrometry.

Toewe A, Balas L, Durand T, Geisslinger G, Ferreirós N.

Anal Chim Acta. 2018 Nov 15;1031:185-194. doi: 10.1016/j.aca.2018.05.020. Epub 2018 May 8.

PMID:
30119738
38.

The histone demethylase Jarid1b mediates angiotensin II-induced endothelial dysfunction by controlling the 3'UTR of soluble epoxide hydrolase.

Vasconez AE, Janetzko P, Oo JA, Pflüger-Müller B, Ratiu C, Gu L, Helin K, Geisslinger G, Fleming I, Schröder K, Fork C, Brandes RP, Leisegang MS.

Acta Physiol (Oxf). 2019 Jan;225(1):e13168. doi: 10.1111/apha.13168. Epub 2018 Aug 25.

PMID:
30076673
39.

Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy.

Brachtendorf S, Wanger RA, Birod K, Thomas D, Trautmann S, Wegner MS, Fuhrmann DC, Brüne B, Geisslinger G, Grösch S.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Oct;1863(10):1214-1227. doi: 10.1016/j.bbalip.2018.07.011. Epub 2018 Jul 27.

PMID:
30059758
40.

An in vitro test system for compounds that modulate human inflammatory macrophage polarization.

Shiratori H, Feinweber C, Luckhardt S, Wallner N, Geisslinger G, Weigert A, Parnham MJ.

Eur J Pharmacol. 2018 Aug 15;833:328-338. doi: 10.1016/j.ejphar.2018.06.017. Epub 2018 Jun 18.

PMID:
29920284
41.

Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells.

Hitzel J, Lee E, Zhang Y, Bibli SI, Li X, Zukunft S, Pflüger B, Hu J, Schürmann C, Vasconez AE, Oo JA, Kratzer A, Kumar S, Rezende F, Josipovic I, Thomas D, Giral H, Schreiber Y, Geisslinger G, Fork C, Yang X, Sigala F, Romanoski CE, Kroll J, Jo H, Landmesser U, Lusis AJ, Namgaladze D, Fleming I, Leisegang MS, Zhu J, Brandes RP.

Nat Commun. 2018 Jun 12;9(1):2292. doi: 10.1038/s41467-018-04602-0.

42.

Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology.

Schierle S, Flauaus C, Heitel P, Willems S, Schmidt J, Kaiser A, Weizel L, Goebel T, Kahnt AS, Geisslinger G, Steinhilber D, Wurglics M, Rovati GE, Schmidtko A, Proschak E, Merk D.

J Med Chem. 2018 Jul 12;61(13):5758-5764. doi: 10.1021/acs.jmedchem.8b00458. Epub 2018 Jun 22.

PMID:
29878767
43.

The prostaglandin E2 receptor EP3 controls CC-chemokine ligand 2-mediated neuropathic pain induced by mechanical nerve damage.

Treutlein EM, Kern K, Weigert A, Tarighi N, Schuh CD, Nüsing RM, Schreiber Y, Ferreirós N, Brüne B, Geisslinger G, Pierre S, Scholich K.

J Biol Chem. 2018 Jun 22;293(25):9685-9695. doi: 10.1074/jbc.RA118.002492. Epub 2018 May 11.

44.

Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders.

Thalman C, Horta G, Qiao L, Endle H, Tegeder I, Cheng H, Laube G, Sigurdsson T, Hauser MJ, Tenzer S, Distler U, Aoki J, Morris AJ, Geisslinger G, Röper J, Kirischuk S, Luhmann HJ, Radyushkin K, Nitsch R, Vogt J.

Mol Psychiatry. 2018 Aug;23(8):1699-1710. doi: 10.1038/s41380-018-0053-1. Epub 2018 May 9. Erratum in: Mol Psychiatry. 2019 Jan 2;:.

45.

Non-invasive bioluminescence imaging as a standardized assessment measure in mouse models of dermal inflammation.

Hofmann MCJ, Schmidt M, Arne O, Geisslinger G, Parnham MJ, de Bruin NMWJ.

J Dermatol Sci. 2018 Apr 23. pii: S0923-1811(18)30187-7. doi: 10.1016/j.jdermsci.2018.04.013. [Epub ahead of print]

PMID:
29706245
46.

Bovine embryo elongation is altered due to maternal fatty acid supplementation.

Giller K, Drews B, Berard J, Kienberger H, Schmicke M, Frank J, Spanier B, Daniel H, Geisslinger G, Ulbrich SE.

Biol Reprod. 2018 Sep 1;99(3):600-610. doi: 10.1093/biolre/ioy084.

PMID:
29668864
47.

The oxidized linoleic acid metabolite 12,13-DiHOME mediates thermal hyperalgesia during inflammatory pain.

Zimmer B, Angioni C, Osthues T, Toewe A, Thomas D, Pierre SC, Geisslinger G, Scholich K, Sisignano M.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Jul;1863(7):669-678. doi: 10.1016/j.bbalip.2018.03.012. Epub 2018 Apr 4.

PMID:
29625231
48.

Machine-learned analysis of the association of next-generation sequencing-based human TRPV1 and TRPA1 genotypes with the sensitivity to heat stimuli and topically applied capsaicin.

Kringel D, Geisslinger G, Resch E, Oertel BG, Thrun MC, Heinemann S, Lötsch J.

Pain. 2018 Jul;159(7):1366-1381. doi: 10.1097/j.pain.0000000000001222.

49.

Activation of Adenylyl Cyclase Causes Stimulation of Adenosine Receptors.

Pleli T, Mondorf A, Ferreiros N, Thomas D, Dvorak K, Biondi RM, Heringdorf DMZ, Zeuzem S, Geisslinger G, Zimmermann H, Waidmann O, Piiper A.

Cell Physiol Biochem. 2018;45(6):2516-2528. doi: 10.1159/000488270. Epub 2018 Mar 27.

50.

UDP-glucose ceramide glucosyltransferase activates AKT, promoted proliferation, and doxorubicin resistance in breast cancer cells.

Wegner MS, Schömel N, Gruber L, Örtel SB, Kjellberg MA, Mattjus P, Kurz J, Trautmann S, Peng B, Wegner M, Kaulich M, Ahrends R, Geisslinger G, Grösch S.

Cell Mol Life Sci. 2018 Sep;75(18):3393-3410. doi: 10.1007/s00018-018-2799-7. Epub 2018 Mar 17.

PMID:
29549423

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