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Items: 1 to 50 of 82

1.

Expression, purification, and characterization of a human complement component C3 analog that lacks the C-terminal C345c domain.

Ramyar KX, Xu X, White NM, Keightley A, Geisbrecht BV.

J Immunol Methods. 2019 Oct;473:112633. doi: 10.1016/j.jim.2019.07.005. Epub 2019 Jul 15.

PMID:
31319063
2.

Backbone resonance assignments of innate immune evasion protein EapH2 from the S. aureus.

Herrera AI, Dubey A, Geisbrecht BV, Arthanari H, Prakash O.

Biomol NMR Assign. 2019 Apr;13(1):219-222. doi: 10.1007/s12104-019-09880-3. Epub 2019 Feb 7.

PMID:
30729401
3.

Investigation of Human Neutrophil Elastase Inhibition by Staphylococcus aureus EapH1: The Key Role Played by Arginine 89.

Herdendorf TJ, Geisbrecht BV.

Biochemistry. 2018 Dec 18;57(50):6888-6896. doi: 10.1021/acs.biochem.8b01134. Epub 2018 Nov 30.

4.

The Staphylococcus aureus Extracellular Adherence Protein Eap Is a DNA Binding Protein Capable of Blocking Neutrophil Extracellular Trap Formation.

Eisenbeis J, Saffarzadeh M, Peisker H, Jung P, Thewes N, Preissner KT, Herrmann M, Molle V, Geisbrecht BV, Jacobs K, Bischoff M.

Front Cell Infect Microbiol. 2018 Jul 9;8:235. doi: 10.3389/fcimb.2018.00235. eCollection 2018.

5.

Using disruptive insertional mutagenesis to identify the in situ structure-function landscape of the Shigella translocator protein IpaB.

Barta ML, Tachiyama S, Muthuramalingam M, Arizmendi O, Villanueva CE, Ramyar KX, Geisbrecht BV, Lovell S, Battaile KP, Picking WL, Picking WD.

Protein Sci. 2018 Aug;27(8):1392-1406. doi: 10.1002/pro.3428. Epub 2018 May 3.

6.

Identification and structural characterization of a novel myeloperoxidase inhibitor from Staphylococcus delphini.

Ploscariu NT, de Jong NWM, van Kessel KPM, van Strijp JAG, Geisbrecht BV.

Arch Biochem Biophys. 2018 May 1;645:1-11. doi: 10.1016/j.abb.2018.03.007. Epub 2018 Mar 7.

7.

Quantitative monitoring of two simultaneously binding species using Label-Enhanced surface plasmon resonance.

Eng L, Garcia BL, Geisbrecht BV, Hanning A.

Biochem Biophys Res Commun. 2018 Feb 26;497(1):133-138. doi: 10.1016/j.bbrc.2018.02.040. Epub 2018 Feb 7.

8.

Identification of a staphylococcal complement inhibitor with broad host specificity in equid Staphylococcus aureus strains.

de Jong NWM, Vrieling M, Garcia BL, Koop G, Brettmann M, Aerts PC, Ruyken M, van Strijp JAG, Holmes M, Harrison EM, Geisbrecht BV, Rooijakkers SHM.

J Biol Chem. 2018 Mar 23;293(12):4468-4477. doi: 10.1074/jbc.RA117.000599. Epub 2018 Feb 5.

9.

1H, 15N, and 13C resonance assignments of the third domain from the S. aureus innate immune evasion protein Eap.

Herrera AI, Ploscariu NT, Geisbrecht BV, Prakash O.

Biomol NMR Assign. 2018 Apr;12(1):175-178. doi: 10.1007/s12104-018-9804-9. Epub 2018 Jan 25.

10.

Mechanistic Insights into Dye-Decolorizing Peroxidase Revealed by Solvent Isotope and Viscosity Effects.

Shrestha R, Huang G, Meekins DA, Geisbrecht BV, Li P.

ACS Catal. 2017 Sep 1;7(9):6352-6364. doi: 10.1021/acscatal.7b01861. Epub 2017 Aug 9.

11.

Identification of Surface-Exposed Protein Radicals and A Substrate Oxidation Site in A-Class Dye-Decolorizing Peroxidase from Thermomonospora curvata.

Shrestha R, Chen X, Ramyar KX, Hayati Z, Carlson EA, Bossmann SH, Song L, Geisbrecht BV, Li P.

ACS Catal. 2016 Dec 2;6(12):8036-8047. doi: 10.1021/acscatal.6b01952. Epub 2016 Oct 12.

12.

A structurally dynamic N-terminal region drives function of the staphylococcal peroxidase inhibitor (SPIN).

de Jong NWM, Ploscariu NT, Ramyar KX, Garcia BL, Herrera AI, Prakash O, Katz BB, Leidal KG, Nauseef WM, van Kessel KPM, van Strijp JAG, Geisbrecht BV.

J Biol Chem. 2018 Feb 16;293(7):2260-2271. doi: 10.1074/jbc.RA117.000134. Epub 2018 Jan 5.

13.

Evidence for multiple modes of neutrophil serine protease recognition by the EAP family of Staphylococcal innate immune evasion proteins.

Stapels DAC, Woehl JL, Milder FJ, Tromp AT, van Batenburg AA, de Graaf WC, Broll SC, White NM, Rooijakkers SHM, Geisbrecht BV.

Protein Sci. 2018 Feb;27(2):509-522. doi: 10.1002/pro.3342. Epub 2017 Nov 21.

14.

Backbone and side-chain 1H, 15N, and 13C resonance assignments of a novel Staphylococcal inhibitor of myeloperoxidase.

Ploscariu NT, Herrera AI, Jayanthi S, Suresh Kumar TK, Geisbrecht BV, Prakash O.

Biomol NMR Assign. 2017 Oct;11(2):285-288. doi: 10.1007/s12104-017-9764-5. Epub 2017 Aug 16.

15.

Immune evasion by a staphylococcal inhibitor of myeloperoxidase.

de Jong NWM, Ramyar KX, Guerra FE, Nijland R, Fevre C, Voyich JM, McCarthy AJ, Garcia BL, van Kessel KPM, van Strijp JAG, Geisbrecht BV, Haas PA.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):9439-9444. doi: 10.1073/pnas.1707032114. Epub 2017 Aug 14.

16.

Enterotoxigenic Escherichia coli Flagellin Inhibits TNF-Induced NF-κB Activation in Intestinal Epithelial Cells.

Wang G, Geisbrecht BV, Rueter C, Hardwidge PR.

Pathogens. 2017 May 17;6(2). pii: E18. doi: 10.3390/pathogens6020018.

17.

The structural basis for inhibition of the classical and lectin complement pathways by S. aureus extracellular adherence protein.

Woehl JL, Ramyar KX, Katz BB, Walker JK, Geisbrecht BV.

Protein Sci. 2017 Aug;26(8):1595-1608. doi: 10.1002/pro.3195. Epub 2017 May 31.

18.

Enantioselective Synthesis of Dilignol Model Compounds and Their Stereodiscrimination Study with a Dye-Decolorizing Peroxidase.

Huang G, Shrestha R, Jia K, Geisbrecht BV, Li P.

Org Lett. 2017 Apr 7;19(7):1820-1823. doi: 10.1021/acs.orglett.7b00587. Epub 2017 Mar 22.

19.

Identification of C3b-Binding Small-Molecule Complement Inhibitors Using Cheminformatics.

Garcia BL, Skaff DA, Chatterjee A, Hanning A, Walker JK, Wyckoff GJ, Geisbrecht BV.

J Immunol. 2017 May 1;198(9):3705-3718. doi: 10.4049/jimmunol.1601932. Epub 2017 Mar 15.

20.

Structural Implications for the Formation and Function of the Complement Effector Protein iC3b.

Papanastasiou M, Koutsogiannaki S, Sarigiannis Y, Geisbrecht BV, Ricklin D, Lambris JD.

J Immunol. 2017 Apr 15;198(8):3326-3335. doi: 10.4049/jimmunol.1601864. Epub 2017 Mar 3.

21.

Novel Evasion Mechanisms of the Classical Complement Pathway.

Garcia BL, Zwarthoff SA, Rooijakkers SH, Geisbrecht BV.

J Immunol. 2016 Sep 15;197(6):2051-60. doi: 10.4049/jimmunol.1600863. Review.

22.

(1)H, (15)N, and (13)C resonance assignments of Staphylococcus aureus extracellular adherence protein domain 4.

Woehl JL, Takahashi D, Herrera AI, Geisbrecht BV, Prakash O.

Biomol NMR Assign. 2016 Oct;10(2):301-5. doi: 10.1007/s12104-016-9688-5. Epub 2016 Jul 2.

23.

NlpC/P60 domain-containing proteins of Mycobacterium avium subspecies paratuberculosis that differentially bind and hydrolyze peptidoglycan.

Bannantine JP, Lingle CK, Adam PR, Ramyar KX, McWhorter WJ, Stabel JR, Picking WD, Geisbrecht BV.

Protein Sci. 2016 Apr;25(4):840-51. doi: 10.1002/pro.2884. Epub 2016 Feb 14.

24.

Attenuation of Staphylococcus aureus-Induced Bacteremia by Human Mini-Antibodies Targeting the Complement Inhibitory Protein Efb.

Georgoutsou-Spyridonos M, Ricklin D, Pratsinis H, Perivolioti E, Pirmettis I, Garcia BL, Geisbrecht BV, Foukas PG, Lambris JD, Mastellos DC, Sfyroera G.

J Immunol. 2015 Oct 15;195(8):3946-58. doi: 10.4049/jimmunol.1500966. Epub 2015 Sep 4.

25.

Characterization of Dye-decolorizing Peroxidase (DyP) from Thermomonospora curvata Reveals Unique Catalytic Properties of A-type DyPs.

Chen C, Shrestha R, Jia K, Gao PF, Geisbrecht BV, Bossmann SH, Shi J, Li P.

J Biol Chem. 2015 Sep 18;290(38):23447-63. doi: 10.1074/jbc.M115.658807. Epub 2015 Jul 23.

26.

Identification of peptidic inhibitors of the alternative complement pathway based on Staphylococcus aureus SCIN proteins.

Summers BJ, Garcia BL, Woehl JL, Ramyar KX, Yao X, Geisbrecht BV.

Mol Immunol. 2015 Oct;67(2 Pt B):193-205. doi: 10.1016/j.molimm.2015.05.012. Epub 2015 Jun 4.

27.

Inhibition of bacterial mevalonate diphosphate decarboxylase by eriochrome compounds.

Skaff DA, McWhorter WJ, Geisbrecht BV, Wyckoff GJ, Miziorko HM.

Arch Biochem Biophys. 2015 Jan 15;566:1-6. doi: 10.1016/j.abb.2014.12.002. Epub 2014 Dec 11.

28.

Neutrophil serine proteases in antibacterial defense.

Stapels DA, Geisbrecht BV, Rooijakkers SH.

Curr Opin Microbiol. 2015 Feb;23:42-8. doi: 10.1016/j.mib.2014.11.002. Epub 2014 Nov 18. Review.

29.

The extracellular adherence protein from Staphylococcus aureus inhibits the classical and lectin pathways of complement by blocking formation of the C3 proconvertase.

Woehl JL, Stapels DAC, Garcia BL, Ramyar KX, Keightley A, Ruyken M, Syriga M, Sfyroera G, Weber AB, Zolkiewski M, Ricklin D, Lambris JD, Rooijakkers SHM, Geisbrecht BV.

J Immunol. 2014 Dec 15;193(12):6161-6171. doi: 10.4049/jimmunol.1401600. Epub 2014 Nov 7.

30.

Staphylococcus aureus secretes a unique class of neutrophil serine protease inhibitors.

Stapels DA, Ramyar KX, Bischoff M, von Köckritz-Blickwede M, Milder FJ, Ruyken M, Eisenbeis J, McWhorter WJ, Herrmann M, van Kessel KP, Geisbrecht BV, Rooijakkers SH.

Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13187-92. doi: 10.1073/pnas.1407616111. Epub 2014 Aug 26.

31.

Studies of the conformational stability of invasion plasmid antigen B from Shigella.

Choudhari SP, Kramer R, Barta ML, Greenwood JC 2nd, Geisbrecht BV, Joshi SB, Picking WD, Middaugh CR, Picking WL.

Protein Sci. 2013 May;22(5):666-70. doi: 10.1002/pro.2249. Epub 2013 Mar 26.

32.

A structurally dynamic N-terminal helix is a key functional determinant in staphylococcal complement inhibitor (SCIN) proteins.

Garcia BL, Summers BJ, Ramyar KX, Tzekou A, Lin Z, Ricklin D, Lambris JD, Laity JH, Geisbrecht BV.

J Biol Chem. 2013 Jan 25;288(4):2870-81. doi: 10.1074/jbc.M112.426858. Epub 2012 Dec 11.

33.

Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase.

Barta ML, McWhorter WJ, Miziorko HM, Geisbrecht BV.

Biochemistry. 2012 Jul 17;51(28):5611-21. Epub 2012 Jul 6.

34.

MAP1272c encodes an NlpC/P60 protein, an antigen detected in cattle with Johne's disease.

Bannantine JP, Lingle CK, Stabel JR, Ramyar KX, Garcia BL, Raeber AJ, Schacher P, Kapur V, Geisbrecht BV.

Clin Vaccine Immunol. 2012 Jul;19(7):1083-92. doi: 10.1128/CVI.00195-12. Epub 2012 May 16.

35.

Biochemical and structural basis for inhibition of Enterococcus faecalis hydroxymethylglutaryl-CoA synthase, mvaS, by hymeglusin.

Skaff DA, Ramyar KX, McWhorter WJ, Barta ML, Geisbrecht BV, Miziorko HM.

Biochemistry. 2012 Jun 12;51(23):4713-22. doi: 10.1021/bi300037k. Epub 2012 May 25.

36.

Binding affects the tertiary and quaternary structures of the Shigella translocator protein IpaB and its chaperone IpgC.

Adam PR, Patil MK, Dickenson NE, Choudhari S, Barta M, Geisbrecht BV, Picking WL, Picking WD.

Biochemistry. 2012 May 15;51(19):4062-71. doi: 10.1021/bi300243z. Epub 2012 May 1.

37.

Identification of the bile salt binding site on IpaD from Shigella flexneri and the influence of ligand binding on IpaD structure.

Barta ML, Guragain M, Adam P, Dickenson NE, Patil M, Geisbrecht BV, Picking WL, Picking WD.

Proteins. 2012 Mar;80(3):935-45.

38.

Host glycan recognition by a pore forming toxin.

Bouyain S, Geisbrecht BV.

Structure. 2012 Feb 8;20(2):197-8. doi: 10.1016/j.str.2012.01.013.

39.

The structures of coiled-coil domains from type III secretion system translocators reveal homology to pore-forming toxins.

Barta ML, Dickenson NE, Patil M, Keightley A, Wyckoff GJ, Picking WD, Picking WL, Geisbrecht BV.

J Mol Biol. 2012 Apr 13;417(5):395-405. doi: 10.1016/j.jmb.2012.01.026. Epub 2012 Feb 1.

40.

Diversity in the C3b [corrected] contact residues and tertiary structures of the staphylococcal complement inhibitor (SCIN) protein family.

Garcia BL, Summers BJ, Lin Z, Ramyar KX, Ricklin D, Kamath DV, Fu ZQ, Lambris JD, Geisbrecht BV.

J Biol Chem. 2012 Jan 2;287(1):628-40. doi: 10.1074/jbc.M111.298984. Epub 2011 Nov 15. Erratum in: J Biol Chem. 2012 Mar 16;287(12):9329.

41.

Advances in understanding the structure, function, and mechanism of the SCIN and Efb families of Staphylococcal immune evasion proteins.

Garcia BL, Ramyar KX, Ricklin D, Lambris JD, Geisbrecht BV.

Adv Exp Med Biol. 2012;946:113-33. doi: 10.1007/978-1-4614-0106-3_7. Review.

42.

Crystal structures of Staphylococcus epidermidis mevalonate diphosphate decarboxylase bound to inhibitory analogs reveal new insight into substrate binding and catalysis.

Barta ML, Skaff DA, McWhorter WJ, Herdendorf TJ, Miziorko HM, Geisbrecht BV.

J Biol Chem. 2011 Jul 8;286(27):23900-10. doi: 10.1074/jbc.M111.242016. Epub 2011 May 11.

43.

Surfactant protein A (SP-A)-mediated clearance of Staphylococcus aureus involves binding of SP-A to the staphylococcal adhesin eap and the macrophage receptors SP-A receptor 210 and scavenger receptor class A.

Sever-Chroneos Z, Krupa A, Davis J, Hasan M, Yang CH, Szeliga J, Herrmann M, Hussain M, Geisbrecht BV, Kobzik L, Chroneos ZC.

J Biol Chem. 2011 Feb 11;286(6):4854-70. doi: 10.1074/jbc.M110.125567. Epub 2010 Dec 1.

44.

Allosteric inhibition of complement function by a staphylococcal immune evasion protein.

Chen H, Ricklin D, Hammel M, Garcia BL, McWhorter WJ, Sfyroera G, Wu YQ, Tzekou A, Li S, Geisbrecht BV, Woods VL Jr, Lambris JD.

Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17621-6. doi: 10.1073/pnas.1003750107. Epub 2010 Sep 27.

45.

Molecular basis for complement recognition and inhibition determined by crystallographic studies of the staphylococcal complement inhibitor (SCIN) bound to C3c and C3b.

Garcia BL, Ramyar KX, Tzekou A, Ricklin D, McWhorter WJ, Lambris JD, Geisbrecht BV.

J Mol Biol. 2010 Sep 10;402(1):17-29. doi: 10.1016/j.jmb.2010.07.029. Epub 2010 Jul 21.

46.

Evidence for alternative quaternary structure in a bacterial Type III secretion system chaperone.

Barta ML, Zhang L, Picking WL, Geisbrecht BV.

BMC Struct Biol. 2010 Jul 15;10:21. doi: 10.1186/1472-6807-10-21.

47.

Characteristics of an extensive Mycobacterium avium subspecies paratuberculosis recombinant protein set.

Bannantine JP, Stabel JR, Bayles DO, Geisbrecht BV.

Protein Expr Purif. 2010 Aug;72(2):223-33. doi: 10.1016/j.pep.2010.03.019. Epub 2010 Mar 30.

PMID:
20359537
48.

Convertase inhibitory properties of Staphylococcal extracellular complement-binding protein.

Jongerius I, Garcia BL, Geisbrecht BV, van Strijp JA, Rooijakkers SH.

J Biol Chem. 2010 May 14;285(20):14973-9. doi: 10.1074/jbc.M109.091975. Epub 2010 Mar 19.

49.

Multi-scale characterization of the energy landscape of proteins with application to the C3D/Efb-C complex.

Haspel N, Geisbrecht BV, Lambris J, Kavraki L.

Proteins. 2010 Mar;78(4):1004-14. doi: 10.1002/prot.22624.

50.

A molecular insight into complement evasion by the staphylococcal complement inhibitor protein family.

Ricklin D, Tzekou A, Garcia BL, Hammel M, McWhorter WJ, Sfyroera G, Wu YQ, Holers VM, Herbert AP, Barlow PN, Geisbrecht BV, Lambris JD.

J Immunol. 2009 Aug 15;183(4):2565-74. doi: 10.4049/jimmunol.0901443. Epub 2009 Jul 22.

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