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Items: 50

1.

Hepatocyte-like cells generated by direct reprogramming from murine Somatic cells can repopulate decellularized livers.

Chen C, Pla-Palacín I, Baptista PM, Shang P, Oosterhoff LA, van Wolferen ME, Penning LC, Geijsen N, Spee B.

Biotechnol Bioeng. 2018 Jun 30. doi: 10.1002/bit.26784. [Epub ahead of print]

PMID:
29959867
2.

Genome editing by natural and engineered CRISPR-associated nucleases.

Wu WY, Lebbink JHG, Kanaar R, Geijsen N, van der Oost J.

Nat Chem Biol. 2018 Jul;14(7):642-651. doi: 10.1038/s41589-018-0080-x. Epub 2018 Jun 18. Review.

PMID:
29915237
3.

Bioengineered bile ducts recapitulate key cholangiocyte functions.

Chen C, Jochems PGM, Salz L, Schneeberger K, Penning LC, van de Graaf SFJ, Beuers U, Clevers H, Geijsen N, Masereeuw R, Spee B.

Biofabrication. 2018 Jun 12;10(3):034103. doi: 10.1088/1758-5090/aac8fd.

PMID:
29848792
4.

Blastocyst-like structures generated solely from stem cells.

Rivron NC, Frias-Aldeguer J, Vrij EJ, Boisset JC, Korving J, Vivié J, Truckenmüller RK, van Oudenaarden A, van Blitterswijk CA, Geijsen N.

Nature. 2018 May;557(7703):106-111. doi: 10.1038/s41586-018-0051-0. Epub 2018 May 2.

PMID:
29720634
5.

Circadian clocks: from stem cells to tissue homeostasis and regeneration.

Dierickx P, Van Laake LW, Geijsen N.

EMBO Rep. 2018 Jan;19(1):18-28. doi: 10.15252/embr.201745130. Epub 2017 Dec 19. Review.

6.

Neonatal rat cardiomyocytes as an in vitro model for circadian rhythms in the heart.

du Pré BC, Dierickx P, Crnko S, Doevendans PA, Vos MA, Geijsen N, Neutel D, van Veen TAB, van Laake LW.

J Mol Cell Cardiol. 2017 Nov;112:58-63. doi: 10.1016/j.yjmcc.2017.08.009. Epub 2017 Aug 18.

7.

Circadian networks in human embryonic stem cell-derived cardiomyocytes.

Dierickx P, Vermunt MW, Muraro MJ, Creyghton MP, Doevendans PA, van Oudenaarden A, Geijsen N, Van Laake LW.

EMBO Rep. 2017 Jul;18(7):1199-1212. doi: 10.15252/embr.201743897. Epub 2017 May 23.

8.

Knock-Out Serum Replacement and Melatonin Effects on Germ Cell Differentiation in Murine Testicular Explant Cultures.

Reda A, Albalushi H, Montalvo SC, Nurmio M, Sahin Z, Hou M, Geijsen N, Toppari J, Söder O, Stukenborg JB.

Ann Biomed Eng. 2017 Jul;45(7):1783-1794. doi: 10.1007/s10439-017-1847-z. Epub 2017 May 9.

9.

Long-Term Adult Feline Liver Organoid Cultures for Disease Modeling of Hepatic Steatosis.

Kruitwagen HS, Oosterhoff LA, Vernooij IGWH, Schrall IM, van Wolferen ME, Bannink F, Roesch C, van Uden L, Molenaar MR, Helms JB, Grinwis GCM, Verstegen MMA, van der Laan LJW, Huch M, Geijsen N, Vries RG, Clevers H, Rothuizen J, Schotanus BA, Penning LC, Spee B.

Stem Cell Reports. 2017 Apr 11;8(4):822-830. doi: 10.1016/j.stemcr.2017.02.015. Epub 2017 Mar 23.

10.

Rapid establishment of the European Bank for induced Pluripotent Stem Cells (EBiSC) - the Hot Start experience.

De Sousa PA, Steeg R, Wachter E, Bruce K, King J, Hoeve M, Khadun S, McConnachie G, Holder J, Kurtz A, Seltmann S, Dewender J, Reimann S, Stacey G, O'Shea O, Chapman C, Healy L, Zimmermann H, Bolton B, Rawat T, Atkin I, Veiga A, Kuebler B, Serano BM, Saric T, Hescheler J, Brüstle O, Peitz M, Thiele C, Geijsen N, Holst B, Clausen C, Lako M, Armstrong L, Gupta SK, Kvist AJ, Hicks R, Jonebring A, Brolén G, Ebneth A, Cabrera-Socorro A, Foerch P, Geraerts M, Stummann TC, Harmon S, George C, Streeter I, Clarke L, Parkinson H, Harrison PW, Faulconbridge A, Cherubin L, Burdett T, Trigueros C, Patel MJ, Lucas C, Hardy B, Predan R, Dokler J, Brajnik M, Keminer O, Pless O, Gribbon P, Claussen C, Ringwald A, Kreisel B, Courtney A, Allsopp TE.

Stem Cell Res. 2017 Apr;20:105-114. doi: 10.1016/j.scr.2017.03.002. Epub 2017 Mar 7.

11.

Cloning-free CRISPR.

Arbab M, Srinivasan S, Hashimoto T, Geijsen N, Sherwood RI.

Stem Cell Reports. 2015 Nov 10;5(5):908-917. doi: 10.1016/j.stemcr.2015.09.022. Epub 2015 Oct 29.

12.

Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids.

Nantasanti S, Spee B, Kruitwagen HS, Chen C, Geijsen N, Oosterhoff LA, van Wolferen ME, Pelaez N, Fieten H, Wubbolts RW, Grinwis GC, Chan J, Huch M, Vries RRG, Clevers H, de Bruin A, Rothuizen J, Penning LC, Schotanus BA.

Stem Cell Reports. 2015 Nov 10;5(5):895-907. doi: 10.1016/j.stemcr.2015.09.002. Epub 2015 Oct 8.

13.

DAZL regulates Tet1 translation in murine embryonic stem cells.

Welling M, Chen HH, Muñoz J, Musheev MU, Kester L, Junker JP, Mischerikow N, Arbab M, Kuijk E, Silberstein L, Kharchenko PV, Geens M, Niehrs C, van de Velde H, van Oudenaarden A, Heck AJ, Geijsen N.

EMBO Rep. 2015 Jul;16(7):791-802. doi: 10.15252/embr.201540538. Epub 2015 Jun 15.

14.

Efficient intracellular delivery of native proteins.

D'Astolfo DS, Pagliero RJ, Pras A, Karthaus WR, Clevers H, Prasad V, Lebbink RJ, Rehmann H, Geijsen N.

Cell. 2015 Apr 23;161(3):674-690. doi: 10.1016/j.cell.2015.03.028.

15.

Efficient cryopreservation of human pluripotent stem cells by surface-based vitrification.

Neubauer JC, Beier AF, Geijsen N, Zimmermann H.

Methods Mol Biol. 2015;1257:321-8. doi: 10.1007/978-1-4939-2193-5_13.

PMID:
25428013
16.

DAZL limits pluripotency, differentiation, and apoptosis in developing primordial germ cells.

Chen HH, Welling M, Bloch DB, Muñoz J, Mientjes E, Chen X, Tramp C, Wu J, Yabuuchi A, Chou YF, Buecker C, Krainer A, Willemsen R, Heck AJ, Geijsen N.

Stem Cell Reports. 2014 Nov 11;3(5):892-904. doi: 10.1016/j.stemcr.2014.09.003. Epub 2014 Oct 11.

17.

Creating human organs in chimaera pigs: an ethical source of immunocompatible organs?

Shaw D, Dondorp W, Geijsen N, de Wert G.

J Med Ethics. 2015 Dec;41(12):970-4. doi: 10.1136/medethics-2014-102224. Epub 2014 Nov 5.

PMID:
25378549
18.

Epigenetic characterization of the FMR1 promoter in induced pluripotent stem cells from human fibroblasts carrying an unmethylated full mutation.

de Esch CE, Ghazvini M, Loos F, Schelling-Kazaryan N, Widagdo W, Munshi ST, van der Wal E, Douben H, Gunhanlar N, Kushner SA, Pijnappel WW, de Vrij FM, Geijsen N, Gribnau J, Willemsen R.

Stem Cell Reports. 2014 Oct 14;3(4):548-55. doi: 10.1016/j.stemcr.2014.07.013. Epub 2014 Sep 11.

19.

Modeling motor neuron disease: the matter of time.

Arbab M, Baars S, Geijsen N.

Trends Neurosci. 2014 Nov;37(11):642-52. doi: 10.1016/j.tins.2014.07.008. Epub 2014 Aug 21. Review.

PMID:
25156326
20.

Pluripotency in the light of the developmental hourglass.

Kuijk E, Geijsen N, Cuppen E.

Biol Rev Camb Philos Soc. 2015 May;90(2):428-43. doi: 10.1111/brv.12117. Epub 2014 May 23. Review.

PMID:
24860945
21.

European stem cell research in legal shackles.

Nielen MG, de Vries SA, Geijsen N.

EMBO J. 2013 Dec 11;32(24):3107-11. doi: 10.1038/emboj.2013.249. Epub 2013 Nov 22. Review.

22.

Primed to perish: heightened mitochondrial priming explains hESC apoptosis sensitivity.

Geijsen N.

Cell Stem Cell. 2013 Oct 3;13(4):371-2. doi: 10.1016/j.stem.2013.09.011.

23.

The pluripotent genome in three dimensions is shaped around pluripotency factors.

de Wit E, Bouwman BA, Zhu Y, Klous P, Splinter E, Verstegen MJ, Krijger PH, Festuccia N, Nora EP, Welling M, Heard E, Geijsen N, Poot RA, Chambers I, de Laat W.

Nature. 2013 Sep 12;501(7466):227-31. doi: 10.1038/nature12420. Epub 2013 Jul 24.

PMID:
23883933
24.

Uncovering the true identity of naïve pluripotent stem cells.

Welling M, Geijsen N.

Trends Cell Biol. 2013 Sep;23(9):442-8. doi: 10.1016/j.tcb.2013.04.004. Epub 2013 May 17. Review.

PMID:
23685019
25.

Embryonic template-based generation and purification of pluripotent stem cell-derived cardiomyocytes for heart repair.

Dierickx P, Doevendans PA, Geijsen N, van Laake LW.

J Cardiovasc Transl Res. 2012 Oct;5(5):566-80. Epub 2012 Jul 18. Review.

PMID:
22806916
26.

Epigenetic reprogramming: Prdm14 hits the accelerator.

Geijsen N.

EMBO J. 2012 May 16;31(10):2247-8. doi: 10.1038/emboj.2012.117. Epub 2012 Apr 20. No abstract available.

27.

Cell lineage specific distribution of H3K27 trimethylation accumulation in an in vitro model for human implantation.

Teklenburg G, Weimar CH, Fauser BC, Macklon N, Geijsen N, Heijnen CJ, Chuva de Sousa Lopes SM, Kuijk EW.

PLoS One. 2012;7(3):e32701. doi: 10.1371/journal.pone.0032701. Epub 2012 Mar 7.

28.

The roles of FGF and MAP kinase signaling in the segregation of the epiblast and hypoblast cell lineages in bovine and human embryos.

Kuijk EW, van Tol LT, Van de Velde H, Wubbolts R, Welling M, Geijsen N, Roelen BA.

Development. 2012 Mar;139(5):871-82. doi: 10.1242/dev.071688. Epub 2012 Jan 25.

29.

Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice.

Arnold K, Sarkar A, Yram MA, Polo JM, Bronson R, Sengupta S, Seandel M, Geijsen N, Hochedlinger K.

Cell Stem Cell. 2011 Oct 4;9(4):317-29. doi: 10.1016/j.stem.2011.09.001.

30.

An ES-like pluripotent state in FGF-dependent murine iPS cells.

Di Stefano B, Buecker C, Ungaro F, Prigione A, Chen HH, Welling M, Eijpe M, Mostoslavsky G, Tesar P, Adjaye J, Geijsen N, Broccoli V.

PLoS One. 2010 Dec 30;5(12):e16092. doi: 10.1371/journal.pone.0016092.

31.

Different flavors of pluripotency, molecular mechanisms, and practical implications.

Buecker C, Geijsen N.

Cell Stem Cell. 2010 Nov 5;7(5):559-64. doi: 10.1016/j.stem.2010.10.007. Erratum in: Cell Stem Cell. 2010 Dec 3;7(6):759.

32.

The different shades of mammalian pluripotent stem cells.

Kuijk EW, Chuva de Sousa Lopes SM, Geijsen N, Macklon N, Roelen BA.

Hum Reprod Update. 2011 Mar-Apr;17(2):254-71. doi: 10.1093/humupd/dmq035. Epub 2010 Aug 12. Review.

33.

Modeling germ cell differentiation.

Geijsen N, Daley GQ.

StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute; 2008-.
2008 Nov 30.

34.

A murine ESC-like state facilitates transgenesis and homologous recombination in human pluripotent stem cells.

Buecker C, Chen HH, Polo JM, Daheron L, Bu L, Barakat TS, Okwieka P, Porter A, Gribnau J, Hochedlinger K, Geijsen N.

Cell Stem Cell. 2010 Jun 4;6(6):535-46. doi: 10.1016/j.stem.2010.05.003.

35.

Regulation of myelopoiesis through syntenin-mediated modulation of IL-5 receptor output.

Beekman JM, Verhagen LP, Geijsen N, Coffer PJ.

Blood. 2009 Oct 29;114(18):3917-27. doi: 10.1182/blood-2009-03-208850. Epub 2009 Aug 4.

36.

gPS navigates germ cells to pluripotency.

Geijsen N, Hochedlinger K.

Cell Stem Cell. 2009 Jul 2;5(1):3-4. doi: 10.1016/j.stem.2009.06.012.

37.

The growth factor environment defines distinct pluripotent ground states in novel blastocyst-derived stem cells.

Chou YF, Chen HH, Eijpe M, Yabuuchi A, Chenoweth JG, Tesar P, Lu J, McKay RD, Geijsen N.

Cell. 2008 Oct 31;135(3):449-61. doi: 10.1016/j.cell.2008.08.035.

38.

Dissection of 6.5 dpc mouse embryos.

Shea K, Geijsen N.

J Vis Exp. 2007 Feb 25;(2):160. doi: 10.3791/160.

39.

Seminal discoveries in regenerative medicine: contributions of the male germ line to understanding pluripotency.

Geijsen N, Jones DL.

Hum Mol Genet. 2008 Apr 15;17(R1):R16-22. doi: 10.1093/hmg/ddn084. Review.

PMID:
18632691
40.

In vitro generation of germ cells from murine embryonic stem cells.

West JA, Park IH, Daley GQ, Geijsen N.

Nat Protoc. 2006;1(4):2026-36.

PMID:
17487192
41.

Male germ cells.

Geijsen N, Daley GQ.

Methods Enzymol. 2006;418:307-14.

PMID:
17141043
42.

In vitro generation of germ cells: new techniques to solve current issues.

Baughman JM, Geijsen N.

Ann N Y Acad Sci. 2005 Dec;1061:33-40. Review.

PMID:
16467255
43.

Phosphatidylinositol 4-kinasebeta is critical for functional association of rab11 with the Golgi complex.

de Graaf P, Zwart WT, van Dijken RA, Deneka M, Schulz TK, Geijsen N, Coffer PJ, Gadella BM, Verkleij AJ, van der Sluijs P, van Bergen en Henegouwen PM.

Mol Biol Cell. 2004 Apr;15(4):2038-47. Epub 2004 Feb 6.

44.

Derivation of embryonic germ cells and male gametes from embryonic stem cells.

Geijsen N, Horoschak M, Kim K, Gribnau J, Eggan K, Daley GQ.

Nature. 2004 Jan 8;427(6970):148-54. Epub 2003 Dec 10.

PMID:
14668819
45.

Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein.

Geijsen N, Uings IJ, Pals C, Armstrong J, McKinnon M, Raaijmakers JA, Lammers JW, Koenderman L, Coffer PJ.

Science. 2001 Aug 10;293(5532):1136-8.

46.

Specificity in cytokine signal transduction: lessons learned from the IL-3/IL-5/GM-CSF receptor family.

Geijsen N, Koenderman L, Coffer PJ.

Cytokine Growth Factor Rev. 2001 Mar;12(1):19-25. Review.

PMID:
11312115
47.

Cytokine-mediated cPLA(2) phosphorylation is regulated by multiple MAPK family members.

Geijsen N, Dijkers PF, Lammers JJ, Koenderman L, Coffer PJ.

FEBS Lett. 2000 Apr 7;471(1):83-8.

48.

Association of RACK1 and PKCbeta with the common beta-chain of the IL-5/IL-3/GM-CSF receptor.

Geijsen N, Spaargaren M, Raaijmakers JA, Lammers JW, Koenderman L, Coffer PJ.

Oncogene. 1999 Sep 9;18(36):5126-30.

49.

Regulation of p21rac activation in human neutrophils.

Geijsen N, van Delft S, Raaijmakers JA, Lammers JW, Collard JG, Koenderman L, Coffer PJ.

Blood. 1999 Aug 1;94(3):1121-30.

50.

Comparison of the roles of mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase signal transduction in neutrophil effector function.

Coffer PJ, Geijsen N, M'rabet L, Schweizer RC, Maikoe T, Raaijmakers JA, Lammers JW, Koenderman L.

Biochem J. 1998 Jan 1;329 ( Pt 1):121-30.

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