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Items: 1 to 50 of 77


Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy.

Wei J, Long L, Zheng W, Dhungana Y, Lim SA, Guy C, Wang Y, Wang YD, Qian C, Xu B, Kc A, Saravia J, Huang H, Yu J, Doench JG, Geiger TL, Chi H.

Nature. 2019 Dec;576(7787):471-476. doi: 10.1038/s41586-019-1821-z. Epub 2019 Dec 11.


Anti-TNF therapy in IBD exerts its therapeutic effect through macrophage IL-10 signalling.

Koelink PJ, Bloemendaal FM, Li B, Westera L, Vogels EWM, van Roest M, Gloudemans AK, van 't Wout AB, Korf H, Vermeire S, Te Velde AA, Ponsioen CY, D'Haens GR, Verbeek JS, Geiger TL, Wildenberg ME, van den Brink GR.

Gut. 2019 Sep 10. pii: gutjnl-2019-318264. doi: 10.1136/gutjnl-2019-318264. [Epub ahead of print]


Pediatric patients with acute lymphoblastic leukemia generate abundant and functional neoantigen-specific CD8+ T cell responses.

Zamora AE, Crawford JC, Allen EK, Guo XJ, Bakke J, Carter RA, Abdelsamed HA, Moustaki A, Li Y, Chang TC, Awad W, Dallas MH, Mullighan CG, Downing JR, Geiger TL, Chen T, Green DR, Youngblood BA, Zhang J, Thomas PG.

Sci Transl Med. 2019 Jun 26;11(498). pii: eaat8549. doi: 10.1126/scitranslmed.aat8549.


Modulation of PI3K signaling to improve CAR T cell function.

Zheng W, Jones LL, Geiger TL.

Oncotarget. 2018 Nov 9;9(88):35807-35808. doi: 10.18632/oncotarget.26334. eCollection 2018 Nov 9. No abstract available.


IL-6 Promotes T Cell Proliferation and Expansion under Inflammatory Conditions in Association with Low-Level RORγt Expression.

Li B, Jones LL, Geiger TL.

J Immunol. 2018 Nov 15;201(10):2934-2946. doi: 10.4049/jimmunol.1800016. Epub 2018 Oct 12.


PI3K orchestration of the in vivo persistence of chimeric antigen receptor-modified T cells.

Zheng W, O'Hear CE, Alli R, Basham JH, Abdelsamed HA, Palmer LE, Jones LL, Youngblood B, Geiger TL.

Leukemia. 2018 May;32(5):1157-1167. doi: 10.1038/s41375-017-0008-6. Epub 2018 Feb 2.


Hypocalcemic Tetany After Transfusion of a Small Amount of Blood Product.

Sharma A, Geiger TL, Federico S, Kamens J, Giles F, Cunningham L.

J Pediatr Hematol Oncol. 2017 Nov;39(8):629-632. doi: 10.1097/MPH.0000000000000955. No abstract available.


The neoepitope landscape in pediatric cancers.

Chang TC, Carter RA, Li Y, Li Y, Wang H, Edmonson MN, Chen X, Arnold P, Geiger TL, Wu G, Peng J, Dyer M, Downing JR, Green DR, Thomas PG, Zhang J.

Genome Med. 2017 Aug 31;9(1):78. doi: 10.1186/s13073-017-0468-3.


Autoimmune susceptibility imposed by public TCRβ chains.

Zhao Y, Nguyen P, Vogel P, Li B, Jones LL, Geiger TL.

Sci Rep. 2016 Nov 21;6:37543. doi: 10.1038/srep37543.


Correction: Differential T Cell Cytokine Receptivity and Not Signal Quality Distinguishes IL-6 and IL-10 Signaling during Th17 Differentiation.

Jones LL, Alli R, Li B, Geiger TL.

J Immunol. 2016 Jul 15;197(2):674-5. doi: 10.4049/jimmunol.1600853. No abstract available.


Atg5 Is Essential for the Development and Survival of Innate Lymphocytes.

O'Sullivan TE, Geary CD, Weizman OE, Geiger TL, Rapp M, Dorn GW 2nd, Overholtzer M, Sun JC.

Cell Rep. 2016 May 31;15(9):1910-9. doi: 10.1016/j.celrep.2016.04.082. Epub 2016 May 19.


Preferential Use of Public TCR during Autoimmune Encephalomyelitis.

Zhao Y, Nguyen P, Ma J, Wu T, Jones LL, Pei D, Cheng C, Geiger TL.

J Immunol. 2016 Jun 15;196(12):4905-14. doi: 10.4049/jimmunol.1501029. Epub 2016 May 11.


Transforming Growth Factor-β Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands.

Cortez VS, Cervantes-Barragan L, Robinette ML, Bando JK, Wang Y, Geiger TL, Gilfillan S, Fuchs A, Vivier E, Sun JC, Cella M, Colonna M.

Immunity. 2016 May 17;44(5):1127-39. doi: 10.1016/j.immuni.2016.03.007. Epub 2016 May 3.


Differential T Cell Cytokine Receptivity and Not Signal Quality Distinguishes IL-6 and IL-10 Signaling during Th17 Differentiation.

Jones LL, Alli R, Li B, Geiger TL.

J Immunol. 2016 Apr 1;196(7):2973-85. doi: 10.4049/jimmunol.1402953. Epub 2016 Feb 24. Erratum in: J Immunol. 2016 Jul 15;197(2):674-5.


Development and maturation of natural killer cells.

Geiger TL, Sun JC.

Curr Opin Immunol. 2016 Apr;39:82-9. doi: 10.1016/j.coi.2016.01.007. Epub 2016 Feb 2. Review.


Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation.

Gurung P, Li B, Subbarao Malireddi RK, Lamkanfi M, Geiger TL, Kanneganti TD.

Sci Rep. 2015 Sep 28;5:14488. doi: 10.1038/srep14488.


Gut Microbial Dysbiosis Due to Helicobacter Drives an Increase in Marginal Zone B Cells in the Absence of IL-10 Signaling in Macrophages.

Ray A, Basu S, Gharaibeh RZ, Cook LC, Kumar R, Lefkowitz EJ, Walker CR, Morrow CD, Franklin CL, Geiger TL, Salzman NH, Fodor A, Dittel BN.

J Immunol. 2015 Oct 1;195(7):3071-85. doi: 10.4049/jimmunol.1500153. Epub 2015 Aug 31.


New approaches for the immunotherapy of acute myeloid leukemia.

Geiger TL, Rubnitz JE.

Discov Med. 2015 Apr;19(105):275-84. Review.


IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T-cell-mediated colitis.

Li B, Gurung P, Malireddi RK, Vogel P, Kanneganti TD, Geiger TL.

Nat Commun. 2015 Jan 21;6:6131. doi: 10.1038/ncomms7131.


Anti-CD33 chimeric antigen receptor targeting of acute myeloid leukemia.

O'Hear C, Heiber JF, Schubert I, Fey G, Geiger TL.

Haematologica. 2015 Mar;100(3):336-44. doi: 10.3324/haematol.2014.112748. Epub 2014 Dec 5.


Bispecificity for myelin and neuronal self-antigens is a common feature of CD4 T cells in C57BL/6 mice.

Lucca LE, Desbois S, Ramadan A, Ben-Nun A, Eisenstein M, Carrié N, Guéry JC, Sette A, Nguyen P, Geiger TL, Mars LT, Liblau RS.

J Immunol. 2014 Oct 1;193(7):3267-77. doi: 10.4049/jimmunol.1400523. Epub 2014 Aug 18.


Nfil3 is crucial for development of innate lymphoid cells and host protection against intestinal pathogens.

Geiger TL, Abt MC, Gasteiger G, Firth MA, O'Connor MH, Geary CD, O'Sullivan TE, van den Brink MR, Pamer EG, Hanash AM, Sun JC.

J Exp Med. 2014 Aug 25;211(9):1723-31. doi: 10.1084/jem.20140212. Epub 2014 Aug 11.


IL-10 modulates DSS-induced colitis through a macrophage-ROS-NO axis.

Li B, Alli R, Vogel P, Geiger TL.

Mucosal Immunol. 2014 Jul;7(4):869-78. doi: 10.1038/mi.2013.103. Epub 2013 Dec 4.


Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin.

Curran MA, Geiger TL, Montalvo W, Kim M, Reiner SL, Al-Shamkhani A, Sun JC, Allison JP.

J Exp Med. 2013 Apr 8;210(4):743-55. doi: 10.1084/jem.20121190. Epub 2013 Apr 1.


Diversification and senescence of Foxp3+ regulatory T cells during experimental autoimmune encephalomyelitis.

Tauro S, Nguyen P, Li B, Geiger TL.

Eur J Immunol. 2013 May;43(5):1195-207. doi: 10.1002/eji.201242881. Epub 2013 Apr 9.


Context and location dependence of adaptive Foxp3(+) regulatory T cell formation during immunopathological conditions.

Heiber JF, Geiger TL.

Cell Immunol. 2012 Sep;279(1):60-5. doi: 10.1016/j.cellimm.2012.09.009. Epub 2012 Oct 1. Review.


The T cell response to IL-10 alters cellular dynamics and paradoxically promotes central nervous system autoimmunity.

Liu X, Alli R, Steeves M, Nguyen P, Vogel P, Geiger TL.

J Immunol. 2012 Jul 15;189(2):669-78. doi: 10.4049/jimmunol.1200607. Epub 2012 Jun 18.


Turning Tregs into class I suppressors.

Geiger TL.

Blood. 2012 Apr 12;119(15):3373-4. doi: 10.1182/blood-2012-02-410969.


Prediction of CD34(+) cell yield in hematopoietic cell products from children by peripheral blood CD34(+) cell counts.

Rujkijyanont P, Hipps J, Gan K, Yang J, Wang C, Geiger TL, Eldridge PW, Leung W.

Cytotherapy. 2012 Apr;14(4):473-82. doi: 10.3109/14653249.2011.652734.


Nature and nurture in Foxp3(+) regulatory T cell development, stability, and function.

Geiger TL, Tauro S.

Hum Immunol. 2012 Mar;73(3):232-9. doi: 10.1016/j.humimm.2011.12.012. Epub 2011 Dec 27. Review.


A mouse model of clonal CD8+ T lymphocyte-mediated alopecia areata progressing to alopecia universalis.

Alli R, Nguyen P, Boyd K, Sundberg JP, Geiger TL.

J Immunol. 2012 Jan 1;188(1):477-86. doi: 10.4049/jimmunol.1100657. Epub 2011 Nov 23.


Altered differentiation, diminished pathogenicity, and regulatory activity of myelin-specific T cells expressing an enhanced affinity TCR.

Alli R, Nguyen P, Geiger TL.

J Immunol. 2011 Dec 1;187(11):5521-31. doi: 10.4049/jimmunol.1102202. Epub 2011 Oct 24.


Rational design of T cell receptors with enhanced sensitivity for antigen.

Alli R, Zhang ZM, Nguyen P, Zheng JJ, Geiger TL.

PLoS One. 2011 Mar 23;6(3):e18027. doi: 10.1371/journal.pone.0018027.


Identification of errors introduced during high throughput sequencing of the T cell receptor repertoire.

Nguyen P, Ma J, Pei D, Obert C, Cheng C, Geiger TL.

BMC Genomics. 2011 Feb 11;12:106. doi: 10.1186/1471-2164-12-106.


Discrete TCR repertoires and CDR3 features distinguish effector and Foxp3+ regulatory T lymphocytes in myelin oligodendrocyte glycoprotein-induced experimental allergic encephalomyelitis.

Nguyen P, Liu W, Ma J, Manirarora JN, Liu X, Cheng C, Geiger TL.

J Immunol. 2010 Oct 1;185(7):3895-904. doi: 10.4049/jimmunol.1001550. Epub 2010 Sep 1.


Rebalancing immune specificity and function in cancer by T-cell receptor gene therapy.

Udyavar A, Geiger TL.

Arch Immunol Ther Exp (Warsz). 2010 Oct;58(5):335-46. doi: 10.1007/s00005-010-0090-1. Epub 2010 Aug 1. Review.


MicroRNA-34a perturbs B lymphocyte development by repressing the forkhead box transcription factor Foxp1.

Rao DS, O'Connell RM, Chaudhuri AA, Garcia-Flores Y, Geiger TL, Baltimore D.

Immunity. 2010 Jul 23;33(1):48-59. doi: 10.1016/j.immuni.2010.06.013. Epub 2010 Jul 1.


Induction of B-cell immune tolerance by antigen-modified cytotoxic T lymphocytes.

Nguyen P, Geiger TL.

Transplantation. 2010 Mar 27;89(6):667-76. doi: 10.1097/TP.0b013e3181ca9048.


T cell receptor CDR3 sequence but not recognition characteristics distinguish autoreactive effector and Foxp3(+) regulatory T cells.

Liu X, Nguyen P, Liu W, Cheng C, Steeves M, Obenauer JC, Ma J, Geiger TL.

Immunity. 2009 Dec 18;31(6):909-20. doi: 10.1016/j.immuni.2009.09.023. Epub 2009 Dec 10.


Subtle affinity-enhancing mutations in a myelin oligodendrocyte glycoprotein-specific TCR alter specificity and generate new self-reactivity.

Udyavar A, Alli R, Nguyen P, Baker L, Geiger TL.

J Immunol. 2009 Apr 1;182(7):4439-47. doi: 10.4049/jimmunol.0804377.


Transfusion-associated immune modulation: a reason to TRIM platelet transfusions?

Geiger TL.

Transfusion. 2008 Sep;48(9):1772-3. doi: 10.1111/j.1537-2995.2008.01860.x. No abstract available.


Clinical and biologic features and treatment outcome of children with newly diagnosed acute myeloid leukemia and hyperleukocytosis.

Inaba H, Fan Y, Pounds S, Geiger TL, Rubnitz JE, Ribeiro RC, Pui CH, Razzouk BI.

Cancer. 2008 Aug 1;113(3):522-9. doi: 10.1002/cncr.23581.


Induction of tolerance and immunity by redirected B cell-specific cytolytic T lymphocytes.

Nguyen P, Duthoit CT, Geiger TL.

Gene Ther. 2007 Dec;14(24):1739-49. Epub 2007 Oct 11.


A kinetic and dynamic analysis of Foxp3 induced in T cells by TGF-beta.

Selvaraj RK, Geiger TL.

J Immunol. 2007 Jul 15;179(2):11 p following 1390.


A kinetic and dynamic analysis of Foxp3 induced in T cells by TGF-beta.

Selvaraj RK, Geiger TL.

J Immunol. 2007 Jun 15;178(12):7667-77. Erratum in: J Immunol. 2007 Jul 15;179(2):1390. Corrected and republished in: J Immunol. 2007 Jul 15;179(2):11 p following 1390.


A revised classification scheme for acute transfusion reactions.

Sanders RP, Geiger TL, Heddle N, Pui CH, Howard SC.

Transfusion. 2007 Apr;47(4):621-8.


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