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Role of endolysosomes and pH in the pathogenesis and treatment of glioblastoma.

Halcrow P, Datta G, Ohm JE, Soliman ML, Chen X, Geiger JD.

Cancer Rep. 2019 Dec;2(6). doi: 10.1002/cnr2.1177. Epub 2019 May 6.


Importance of measuring endolysosome, cytosolic, and extracellular pH in understanding the pathogenesis of and possible treatments for glioblastoma multiforme.

Halcrow P, Khan N, Datta G, Ohm JE, Chen X, Geiger JD.

Cancer Rep. 2019 Dec;2(6). doi: 10.1002/cnr2.1193. Epub 2019 Jun 2.


Two-pore channels regulate Tat endolysosome escape and Tat-mediated HIV-1 LTR transactivation.

Khan N, Halcrow PW, Lakpa KL, Afghah Z, Miller NM, Dowdy SF, Geiger JD, Chen X.

FASEB J. 2020 Mar;34(3):4147-4162. doi: 10.1096/fj.201902534R. Epub 2020 Jan 16.


Bioenergetic adaptations to HIV infection. Could modulation of energy substrate utilization improve brain health in people living with HIV-1?

Deme P, Rojas C, Slusher BS, Rais R, Afghah Z, Geiger JD, Haughey NJ.

Exp Neurol. 2020 May;327:113181. doi: 10.1016/j.expneurol.2020.113181. Epub 2020 Jan 11. Review.


Formation of nematic order in 3D systems of hard colloidal ellipsoids.

Roller J, Geiger JD, Voggenreiter M, Meijer JM, Zumbusch A.

Soft Matter. 2020 Jan 28;16(4):1021-1028. doi: 10.1039/c9sm01926j. Epub 2019 Dec 19.


Protease Inhibitors, Saquinavir and Darunavir, Inhibit Oligodendrocyte Maturation: Implications for Lysosomal Stress.

Festa L, Roth LM, K Jensen B, Geiger JD, Jordan-Sciutto KL, Grinspan JB.

J Neuroimmune Pharmacol. 2019 Nov 28. doi: 10.1007/s11481-019-09893-8. [Epub ahead of print]


Role of endolysosomes and inter-organellar signaling in brain disease.

Afghah Z, Chen X, Geiger JD.

Neurobiol Dis. 2020 Feb;134:104670. doi: 10.1016/j.nbd.2019.104670. Epub 2019 Nov 9. Review.


Use of Cryoanalgesia for Pain Management for the Modified Ravitch Procedure in Children.

Pilkington M, Harbaugh CM, Hirschl RB, Geiger JD, Gadepalli SK.

J Pediatr Surg. 2019 Oct 25. pii: S0022-3468(19)30662-1. doi: 10.1016/j.jpedsurg.2019.09.016. [Epub ahead of print]


Readily Releasable Stores of Calcium in Neuronal Endolysosomes: Physiological and Pathophysiological Relevance.

Lakpa KL, Halcrow PW, Chen X, Geiger JD.

Adv Exp Med Biol. 2020;1131:681-697. doi: 10.1007/978-3-030-12457-1_27. Review.


Effect of Tandem Autologous Stem Cell Transplant vs Single Transplant on Event-Free Survival in Patients With High-Risk Neuroblastoma: A Randomized Clinical Trial.

Park JR, Kreissman SG, London WB, Naranjo A, Cohn SL, Hogarty MD, Tenney SC, Haas-Kogan D, Shaw PJ, Kraveka JM, Roberts SS, Geiger JD, Doski JJ, Voss SD, Maris JM, Grupp SA, Diller L.

JAMA. 2019 Aug 27;322(8):746-755. doi: 10.1001/jama.2019.11642.


BK channels regulate extracellular Tat-mediated HIV-1 LTR transactivation.

Khan N, Lakpa KL, Halcrow PW, Afghah Z, Miller NM, Geiger JD, Chen X.

Sci Rep. 2019 Aug 22;9(1):12285. doi: 10.1038/s41598-019-48777-y.


Involvement of organelles and inter-organellar signaling in the pathogenesis of HIV-1 associated neurocognitive disorder and Alzheimer's disease.

Khan N, Haughey NJ, Nath A, Geiger JD.

Brain Res. 2019 Nov 1;1722:146389. doi: 10.1016/j.brainres.2019.146389. Epub 2019 Aug 16. Review.


HIV-1 gp120 Promotes Lysosomal Exocytosis in Human Schwann Cells.

Datta G, Miller NM, Afghah Z, Geiger JD, Chen X.

Front Cell Neurosci. 2019 Jul 17;13:329. doi: 10.3389/fncel.2019.00329. eCollection 2019.


Antiretroviral Drugs Promote Amyloidogenesis by De-Acidifying Endolysosomes.

Hui L, Ye Y, Soliman ML, Lakpa KL, Miller NM, Afghah Z, Geiger JD, Chen X.

J Neuroimmune Pharmacol. 2019 Jul 23. doi: 10.1007/s11481-019-09862-1. [Epub ahead of print]


Morphine-Induced Modulation of Endolysosomal Iron Mediates Upregulation of Ferritin Heavy Chain in Cortical Neurons.

Nash B, Tarn K, Irollo E, Luchetta J, Festa L, Halcrow P, Datta G, Geiger JD, Meucci O.

eNeuro. 2019 Jul 31;6(4). pii: ENEURO.0237-19.2019. doi: 10.1523/ENEURO.0237-19.2019. Print 2019 Jul/Aug.


Efficacy and risk profile of self-expandable stents in the management of pediatric esophageal pathology.

Fallon BP, Overman RE, Geiger JD, Jarboe MD, Kunisaki SM.

J Pediatr Surg. 2019 Jun;54(6):1233-1238. doi: 10.1016/j.jpedsurg.2019.02.025. Epub 2019 Feb 28.


Development of AD-Like Pathology in Skeletal Muscle.

Chen X, Miller NM, Afghah Z, Geiger JD.

J Parkinsons Dis Alzheimers Dis. 2019;6(1). doi: 10.13188/2376-922x.1000028. Epub 2019 Apr 2.


Acidifying Endolysosomes Prevented Low-Density Lipoprotein-Induced Amyloidogenesis.

Hui L, Soliman ML, Geiger NH, Miller NM, Afghah Z, Lakpa KL, Chen X, Geiger JD.

J Alzheimers Dis. 2019;67(1):393-410. doi: 10.3233/JAD-180941.


Retroperitoneal exploration with Vicryl mesh and fibrin tissue sealant for refractory chylous ascites.

Carr BD, Grant CN, Overman RE, Gadepalli SK, Geiger JD.

J Pediatr Surg. 2019 Mar;54(3):604-607. doi: 10.1016/j.jpedsurg.2018.09.011. Epub 2018 Oct 2.


Effects of silica nanoparticles on endolysosome function in primary cultured neurons 1.

Ye Y, Hui L, Lakpa KL, Xing Y, Wollenzien H, Chen X, Zhao JX, Geiger JD.

Can J Physiol Pharmacol. 2019 Apr;97(4):297-305. doi: 10.1139/cjpp-2018-0401. Epub 2018 Oct 12.


Comparing outcomes with thoracic epidural and intercostal nerve cryoablation after Nuss procedure.

Harbaugh CM, Johnson KN, Kein CE, Jarboe MD, Hirschl RB, Geiger JD, Gadepalli SK.

J Surg Res. 2018 Nov;231:217-223. doi: 10.1016/j.jss.2018.05.048. Epub 2018 Jun 21.


A genome-wide analysis of colorectal cancer in a child with Noonan syndrome.

Prasad RM, Mody RJ, Myers G, Mullins M, Naji Z, Geiger JD.

Pediatr Blood Cancer. 2018 Nov;65(11):e27362. doi: 10.1002/pbc.27362. Epub 2018 Jul 24.


Robotic resection of recurrent pediatric lipoblastoma.

Criss CN, Grant C, Ralls MW, Geiger JD.

Asian J Endosc Surg. 2019 Jan;12(1):128-131. doi: 10.1111/ases.12493. Epub 2018 May 10.


Asymptomatic congenital lung malformations: Is nonoperative management a viable alternative?

Criss CN, Musili N, Matusko N, Baker S, Geiger JD, Kunisaki SM.

J Pediatr Surg. 2018 Jun;53(6):1092-1097. doi: 10.1016/j.jpedsurg.2018.02.065. Epub 2018 Mar 5.


Human Immunodeficiency Virus Transactivator of Transcription-Induced Increases in Depression-like Effects Are Linked to Oxidative Stress.

Geiger JD, Chen X.

Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Oct;2(7):552-553. doi: 10.1016/j.bpsc.2017.08.002. Epub 2017 Oct 5. No abstract available.


Apolipoprotein E isoform dependently affects Tat-mediated HIV-1 LTR transactivation.

Khan N, Datta G, Geiger JD, Chen X.

J Neuroinflammation. 2018 Mar 20;15(1):91. doi: 10.1186/s12974-018-1129-1.


Outcomes of Adolescent and Young Adults Receiving High Ligation and Mesh Repairs: A 16-Year Experience.

Criss CN, Gish N, Gish J, Carr B, McLeod JS, Church JT, Hsieh L, Matusko N, Geiger JD, Hirschl RB, Gadepalli SK.

J Laparoendosc Adv Surg Tech A. 2018 Feb;28(2):223-228. doi: 10.1089/lap.2017.0511. Epub 2017 Dec 20.


Proteomic analysis of six- and twelve-month hippocampus and cerebellum in a murine Down syndrome model.

Vacano GN, Gibson DS, Turjoman AA, Gawryluk JW, Geiger JD, Duncan M, Patterson D.

Neurobiol Aging. 2018 Mar;63:96-109. doi: 10.1016/j.neurobiolaging.2017.11.010. Epub 2017 Nov 26.


The lipid raft-dwelling protein US9 can be manipulated to target APP compartmentalization, APP processing, and neurodegenerative disease pathogenesis.

Brandimarti R, Hill GS, Geiger JD, Meucci O.

Sci Rep. 2017 Nov 8;7(1):15103. doi: 10.1038/s41598-017-15128-8.


A Novel Intuitively Controlled Articulating Instrument for Reoperative Foregut Surgery: A Case Report.

Criss CN, Ralls MW, Johnson KN, Awtar S, Jarboe MD, Geiger JD.

J Laparoendosc Adv Surg Tech A. 2017 Sep;27(9):983-986. doi: 10.1089/lap.2017.0107. Epub 2017 Jul 20.


Caffeine Blocks HIV-1 Tat-Induced Amyloid Beta Production and Tau Phosphorylation.

Soliman ML, Geiger JD, Chen X.

J Neuroimmune Pharmacol. 2017 Mar;12(1):163-170. doi: 10.1007/s11481-016-9707-4. Epub 2016 Sep 15.


Review at a multidisciplinary tumor board impacts critical management decisions of pediatric patients with cancer.

Thenappan A, Halaweish I, Mody RJ, Smith EA, Geiger JD, Ehrlich PF, Jasty Rao R, Hutchinson R, Yanik G, Rabah RM, Heider A, Stoll T, Newman EA.

Pediatr Blood Cancer. 2017 Feb;64(2):254-258. doi: 10.1002/pbc.26201. Epub 2016 Aug 31. Review.


Role of Endolysosomes in Skeletal Muscle Pathology Observed in a Cholesterol-Fed Rabbit Model of Alzheimer's Disease.

Chen X, Wagener JF, Ghribi O, Geiger JD.

Front Aging Neurosci. 2016 Jun 8;8:129. doi: 10.3389/fnagi.2016.00129. eCollection 2016.


Future Supply of Pediatric Surgeons: Analytical Study of the Current and Projected Supply of Pediatric Surgeons in the Context of a Rapidly Changing Process for Specialty and Subspecialty Training.

Ricketts TC, Adamson WT, Fraher EP, Knapton A, Geiger JD, Abdullah F, Klein MD.

Ann Surg. 2017 Mar;265(3):609-615. doi: 10.1097/SLA.0000000000001810.


Analysis of risk factors contributing to morbidity from gastrojejunostomy feeding tubes in children.

Demehri FR, Simha S, Herrman E, Jarboe MD, Geiger JD, Teitelbaum DH, Gadepalli SK.

J Pediatr Surg. 2016 Jun;51(6):1005-9. doi: 10.1016/j.jpedsurg.2016.02.072. Epub 2016 Mar 2.


Release of calcium from endolysosomes increases calcium influx through N-type calcium channels: Evidence for acidic store-operated calcium entry in neurons.

Hui L, Geiger NH, Bloor-Young D, Churchill GC, Geiger JD, Chen X.

Cell Calcium. 2015 Dec;58(6):617-27. doi: 10.1016/j.ceca.2015.10.001. Epub 2015 Oct 9.


Role of LDL cholesterol and endolysosomes in amyloidogenesis and Alzheimer's disease.

Chen X, Hui L, Geiger JD.

J Neurol Neurophysiol. 2014 Oct 1;5(5). pii: 236.


Caffeine, Through Adenosine A3 Receptor-Mediated Actions, Suppresses Amyloid-β Protein Precursor Internalization and Amyloid-β Generation.

Li S, Geiger NH, Soliman ML, Hui L, Geiger JD, Chen X.

J Alzheimers Dis. 2015;47(1):73-83. doi: 10.3233/JAD-142223.


Innovation in surgical technology and techniques: Challenges and ethical issues.

Geiger JD, Hirschl RB.

Semin Pediatr Surg. 2015 Jun;24(3):115-21. doi: 10.1053/j.sempedsurg.2015.02.008. Epub 2015 Mar 2. Review.


Altered Cholesterol Intracellular Trafficking and the Development of Pathological Hallmarks of Sporadic AD.

Chen X, Hui L, Soliman ML, Geiger JD.

J Parkinsons Dis Alzheimers Dis. 2014;1(1). pii: 8.


Creatine protects against mitochondrial dysfunction associated with HIV-1 Tat-induced neuronal injury.

Stevens PR, Gawryluk JW, Hui L, Chen X, Geiger JD.

Curr HIV Res. 2014;12(6):378-87.


Cholesterol-enriched diet disrupts the blood-testis barrier in rabbits.

Morgan DH, Ghribi O, Hui L, Geiger JD, Chen X.

Am J Physiol Endocrinol Metab. 2014 Dec 15;307(12):E1125-30. doi: 10.1152/ajpendo.00416.2014. Epub 2014 Oct 21.


Ketogenic diet sensitizes glucose control of hippocampal excitability.

Kawamura M Jr, Ruskin DN, Geiger JD, Boison D, Masino SA.

J Lipid Res. 2014 Nov;55(11):2254-60. doi: 10.1194/jlr.M046755. Epub 2014 Aug 28.


Acetate supplementation modulates brain adenosine metabolizing enzymes and adenosine A₂A receptor levels in rats subjected to neuroinflammation.

Smith MD, Bhatt DP, Geiger JD, Rosenberger TA.

J Neuroinflammation. 2014 Jun 4;11:99. doi: 10.1186/1742-2094-11-99.


Cellular Interactions and Signaling in neuroAIDS: Emerging Issues Colloquium.

Al-Harthi L, Buch S, Geiger JD, Gendelman HE, He JJ, Jordan-Sciutto KL, Kolson DL, Rappaport J, Roy S, Zheng J, Fox HS.

J Neuroimmune Pharmacol. 2014 Jun;9(3):269-76. doi: 10.1007/s11481-014-9545-1. Epub 2014 May 2.


Bipolar electrosurgical vessel-sealing device with compressive force monitoring.

Chen RK, Chastagner MW, Geiger JD, Shih AJ.

J Biomech Eng. 2014 Jun;136(6):061001. doi: 10.1115/1.4027269.


Amyloid beta accumulation in HIV-1 infected brain: the role of altered cholesterol homeostasis.

Chen X, Hui L, Geiger JD.

Clin Res HIV AIDS. 2014;1(2). pii: 1011. Epub 2014 Aug 31.


Thoracoscopic vs open lobectomy in infants and young children with congenital lung malformations.

Kunisaki SM, Powelson IA, Haydar B, Bowshier BC, Jarboe MD, Mychaliska GB, Geiger JD, Hirschl RB.

J Am Coll Surg. 2014 Feb;218(2):261-70. doi: 10.1016/j.jamcollsurg.2013.10.010. Epub 2013 Oct 24.


Endolysosome involvement in HIV-1 transactivator protein-induced neuronal amyloid beta production.

Chen X, Hui L, Geiger NH, Haughey NJ, Geiger JD.

Neurobiol Aging. 2013 Oct;34(10):2370-8. doi: 10.1016/j.neurobiolaging.2013.04.015. Epub 2013 May 11.

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