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Items: 1 to 50 of 514

1.

Identification of targetable BRAF ΔN486_P490 variant by whole genome sequencing leading to dabrafenib-induced remission of a BRAF-mutant pancreatic adenocarcinoma.

Wrzeszczynski KO, Rahman S, Frank MO, Arora K, Shah M, Geiger H, Felice V, Manaa D, Dikoglu E, Khaira D, Chimpiri AR, Michelini VV, Jobanputra V, Darnell RB, Powers S, Choi M.

Cold Spring Harb Mol Case Stud. 2019 Sep 13. pii: mcs.a004424. doi: 10.1101/mcs.a004424. [Epub ahead of print]

2.

Functional and clinical characterization of the alternatively spliced isoform AML1-ETO9a in adult patients with translocation t(8;21)(q22;q22.1) acute myeloid leukemia (AML).

Agrawal M, Schwarz P, Giaimo BD, Bedzhov I, Corbacioglu A, Weber D, Gaidzik VI, Jahn N, Rücker FG, Schroeder T, Kindler T, Wattad M, Götze K, Lübbert M, Salwender H, Ringhoffer M, Lange E, Koller E, Thol F, Heuser M, Ganser A, Bullinger L, Paschka P, Döhner H, Geiger H, Borggrefe T, Döhner K, Oswald F.

Leukemia. 2019 Aug 28. doi: 10.1038/s41375-019-0551-4. [Epub ahead of print] No abstract available.

PMID:
31462736
3.

Correction to: Sequencing and curation strategies for identifying candidate glioblastoma treatments.

Frank MO, Koyama T, Rhrissorrakrai K, Robine N, Utro F, Emde AK, Chen BJ, Arora K, Shah M, Geiger H, Felice V, Dikoglu E, Rahman S, Fang X, Vacic V, Bergmann EA, Moore Vogel JL, Reeves C, Khaira D, Calabro A, Kim D, Lamendola-Essel MF, Esteves C, Agius P, Stolte C, Boockvar J, Demopoulos A, Placantonakis DG, Golfinos JG, Brennan C, Bruce J, Lassman AB, Canoll P, Grommes C, Daras M, Diamond E, Omuro A, Pentsova E, Orange DE, Harvey SJ, Posner JB, Michelini VV, Jobanputra V, Zody MC, Kelly J, Parida L, Wrzeszczynski KO, Royyuru AK, Darnell RB.

BMC Med Genomics. 2019 Aug 2;12(1):114. doi: 10.1186/s12920-019-0563-y.

4.

Aortic stiffness is independently associated with interstitial myocardial fibrosis by native T1 and accelerated in the presence of chronic kidney disease.

Chen M, Arcari L, Engel J, Freiwald T, Platschek S, Zhou H, Zainal H, Buettner S, Zeiher AM, Geiger H, Hauser I, Nagel E, Puntmann VO.

Int J Cardiol Heart Vasc. 2019 Jun 26;24:100389. doi: 10.1016/j.ijcha.2019.100389. eCollection 2019 Sep.

5.

Blood ceramides as novel markers for renal impairment in systemic lupus erythematosus.

Patyna S, Büttner S, Eckes T, Obermüller N, Bartel C, Braner A, Trautmann S, Thomas D, Geiger H, Pfeilschifter J, Koch A.

Prostaglandins Other Lipid Mediat. 2019 Jul 10;144:106348. doi: 10.1016/j.prostaglandins.2019.106348. [Epub ahead of print]

PMID:
31301404
6.

SCANVIS: a tool for SCoring, ANnotating and VISualizing splice junctions.

Agius P, Geiger H, Robine N.

Bioinformatics. 2019 Jun 14. pii: btz452. doi: 10.1093/bioinformatics/btz452. [Epub ahead of print]

PMID:
31197308
7.

Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance.

Zhang C, Fondufe-Mittendorf YN, Wang C, Chen J, Cheng Q, Zhou D, Zheng Y, Geiger H, Liang Y.

Haematologica. 2019 Jun 6. pii: haematol.2018.207092. doi: 10.3324/haematol.2018.207092. [Epub ahead of print]

8.

The lifespan quantitative trait locus gene Securin controls hematopoietic progenitor cell function.

Brown A, Schuetz D, Han Y, Daria D, Nattamai KJ, Eiwen K, Sakk V, Pospiech J, Saller T, van Zant G, Wagner W, Geiger H.

Haematologica. 2019 May 9. pii: haematol.2018.213009. doi: 10.3324/haematol.2018.213009. [Epub ahead of print]

9.

Sequencing and curation strategies for identifying candidate glioblastoma treatments.

Frank MO, Koyama T, Rhrissorrakrai K, Robine N, Utro F, Emde AK, Chen BJ, Arora K, Shah M, Geiger H, Felice V, Dikoglu E, Rahman S, Fang A, Vacic V, Bergmann EA, Vogel JLM, Reeves C, Khaira D, Calabro A, Kim D, Lamendola-Essel MF, Esteves C, Agius P, Stolte C, Boockvar J, Demopoulos A, Placantonakis DG, Golfinos JG, Brennan C, Bruce J, Lassman AB, Canoll P, Grommes C, Daras M, Diamond E, Omuro A, Pentsova E, Orange DE, Harvey SJ, Posner JB, Michelini VV, Jobanputra V, Zody MC, Kelly J, Parida L, Wrzeszczynski KO, Royyuru AK, Darnell RB.

BMC Med Genomics. 2019 Apr 25;12(1):56. doi: 10.1186/s12920-019-0500-0. Erratum in: BMC Med Genomics. 2019 Aug 2;12(1):114.

10.

Immunogenic neoantigens derived from gene fusions stimulate T cell responses.

Yang W, Lee KW, Srivastava RM, Kuo F, Krishna C, Chowell D, Makarov V, Hoen D, Dalin MG, Wexler L, Ghossein R, Katabi N, Nadeem Z, Cohen MA, Tian SK, Robine N, Arora K, Geiger H, Agius P, Bouvier N, Huberman K, Vanness K, Havel JJ, Sims JS, Samstein RM, Mandal R, Tepe J, Ganly I, Ho AL, Riaz N, Wong RJ, Shukla N, Chan TA, Morris LGT.

Nat Med. 2019 May;25(5):767-775. doi: 10.1038/s41591-019-0434-2. Epub 2019 Apr 22.

PMID:
31011208
11.

Hematopoietic Stem Cell Dynamics Are Regulated by Progenitor Demand: Lessons from a Quantitative Modeling Approach.

Klose M, Florian MC, Gerbaulet A, Geiger H, Glauche I.

Stem Cells. 2019 Jul;37(7):948-957. doi: 10.1002/stem.3005. Epub 2019 Apr 3.

PMID:
30897261
12.

Inter-molecular inter-actions in a phenol-substituted benzimidazole.

Geiger DK, Geiger HC, Moore SM.

Acta Crystallogr E Crystallogr Commun. 2019 Jan 29;75(Pt 2):272-276. doi: 10.1107/S2056989019001270. eCollection 2019 Feb 1.

13.

Genetic mechanisms of primary chemotherapy resistance in pediatric acute myeloid leukemia.

McNeer NA, Philip J, Geiger H, Ries RE, Lavallée VP, Walsh M, Shah M, Arora K, Emde AK, Robine N, Alonzo TA, Kolb EA, Gamis AS, Smith M, Gerhard DS, Guidry-Auvil J, Meshinchi S, Kentsis A.

Leukemia. 2019 Aug;33(8):1934-1943. doi: 10.1038/s41375-019-0402-3. Epub 2019 Feb 13.

14.

Non-Steroidal Biphenyl Gelators: Correlation of Xerogel Structure with Solid-State Structure and Circular Dichroism Spectroscopy.

Geiger HC, Geiger DK, Roberts WR, Morell DL, Huttunen P, Schulman JL, Tran M, Farthing D.

Gels. 2018 Apr 16;4(2). pii: E34. doi: 10.3390/gels4020034.

15.

Impaired immune surveillance accelerates accumulation of senescent cells and aging.

Ovadya Y, Landsberger T, Leins H, Vadai E, Gal H, Biran A, Yosef R, Sagiv A, Agrawal A, Shapira A, Windheim J, Tsoory M, Schirmbeck R, Amit I, Geiger H, Krizhanovsky V.

Nat Commun. 2018 Dec 21;9(1):5435. doi: 10.1038/s41467-018-07825-3.

16.

Human papillomavirus and the landscape of secondary genetic alterations in oral cancers.

Gillison ML, Akagi K, Xiao W, Jiang B, Pickard RKL, Li J, Swanson BJ, Agrawal AD, Zucker M, Stache-Crain B, Emde AK, Geiger HM, Robine N, Coombes KR, Symer DE.

Genome Res. 2019 Jan;29(1):1-17. doi: 10.1101/gr.241141.118. Epub 2018 Dec 18.

17.

A recurrent novel MGA-NUTM1 fusion identifies a new subtype of high-grade spindle cell sarcoma.

Diolaiti D, Dela Cruz FS, Gundem G, Bouvier N, Boulad M, Zhang Y, Chou AJ, Dunkel IJ, Sanghvi R, Shah M, Geiger H, Rahman S, Felice V, Wrzeszczynski KO, Darnell RB, Antonescu CR, French CA, Papaemmanuil E, Kung AL, Shukla N.

Cold Spring Harb Mol Case Stud. 2018 Dec 17;4(6). pii: a003194. doi: 10.1101/mcs.a003194. Print 2018 Dec.

18.

Comparison of interventional and surgical myocardial revascularization in kidney transplant recipients - A single-centre retrospective analysis.

Lang J, Buettner S, Weiler H, Papadopoulos N, Geiger H, Hauser I, Vasa-Nicotera M, Zeiher A, Fichtlscherer S, Honold J.

Int J Cardiol Heart Vasc. 2018 Nov 4;21:96-102. doi: 10.1016/j.ijcha.2018.10.010. eCollection 2018 Dec.

19.

LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells.

Grigoryan A, Guidi N, Senger K, Liehr T, Soller K, Marka G, Vollmer A, Markaki Y, Leonhardt H, Buske C, Lipka DB, Plass C, Zheng Y, Mulaw MA, Geiger H, Florian MC.

Genome Biol. 2018 Nov 7;19(1):189. doi: 10.1186/s13059-018-1557-3.

20.

Distinct Dynamics of Stem and Progenitor Cells in Blood of Polytraumatized Patients.

Vogel M, Christow H, Manz I, Denkinger M, Amoah A, Schütz D, Brown A, Möhrle B, Schaffer A, Kalbitz M, Gebhard F, Mayer B, Huber-Lang M, Geiger H.

Shock. 2019 Apr;51(4):430-438. doi: 10.1097/SHK.0000000000001198.

21.

Rational identification of a Cdc42 inhibitor presents a new regimen for long-term hematopoietic stem cell mobilization.

Liu W, Du W, Shang X, Wang L, Evelyn C, Florian MC, A Ryan M, Rayes A, Zhao X, Setchell K, Meller J, Guo F, Nassar N, Geiger H, Pang Q, Zheng Y.

Leukemia. 2019 Mar;33(3):749-761. doi: 10.1038/s41375-018-0251-5. Epub 2018 Sep 25.

PMID:
30254339
22.

Aging alters the epigenetic asymmetry of HSC division.

Florian MC, Klose M, Sacma M, Jablanovic J, Knudson L, Nattamai KJ, Marka G, Vollmer A, Soller K, Sakk V, Cabezas-Wallscheid N, Zheng Y, Mulaw MA, Glauche I, Geiger H.

PLoS Biol. 2018 Sep 20;16(9):e2003389. doi: 10.1371/journal.pbio.2003389. eCollection 2018 Sep.

23.

Tracking of Adipose-Derived Mesenchymal Stromal/Stem Cells in a Model of Cisplatin-Induced Acute Kidney Injury: Comparison of Bioluminescence Imaging versus qRT-PCR.

Schubert R, Sann J, Frueh JT, Ullrich E, Geiger H, Baer PC.

Int J Mol Sci. 2018 Aug 29;19(9). pii: E2564. doi: 10.3390/ijms19092564.

24.

Epigenetic age-predictor for mice based on three CpG sites.

Han Y, Eipel M, Franzen J, Sakk V, Dethmers-Ausema B, Yndriago L, Izeta A, de Haan G, Geiger H, Wagner W.

Elife. 2018 Aug 24;7. pii: e37462. doi: 10.7554/eLife.37462.

25.

Analytical Validation of Clinical Whole-Genome and Transcriptome Sequencing of Patient-Derived Tumors for Reporting Targetable Variants in Cancer.

Wrzeszczynski KO, Felice V, Abhyankar A, Kozon L, Geiger H, Manaa D, London F, Robinson D, Fang X, Lin D, Lamendola-Essel MF, Khaira D, Dikoglu E, Emde AK, Robine N, Shah M, Arora K, Basturk O, Bhanot U, Kentsis A, Mansukhani MM, Bhagat G, Jobanputra V.

J Mol Diagn. 2018 Nov;20(6):822-835. doi: 10.1016/j.jmoldx.2018.06.007. Epub 2018 Aug 21.

26.

Fp217 Marburg virus and acute kidney injury.

Koch B, Dolnik O, Filzmayer M, Becker S, Geiger H, Baer P.

Nephrol Dial Transplant. 2018 Nov 1;33(11):2069. doi: 10.1093/ndt/gfy281. No abstract available.

PMID:
30137420
27.

Chromosome integrity checkpoints in stem and progenitor cells: transitions upon differentiation, pathogenesis, and aging.

Brown A, Geiger H.

Cell Mol Life Sci. 2018 Oct;75(20):3771-3779. doi: 10.1007/s00018-018-2891-z. Epub 2018 Jul 31. Review.

28.

Multi-level magma plumbing at Agung and Batur volcanoes increases risk of hazardous eruptions.

Geiger H, Troll VR, Jolis EM, Deegan FM, Harris C, Hilton DR, Freda C.

Sci Rep. 2018 Jul 12;8(1):10547. doi: 10.1038/s41598-018-28125-2.

29.

A non-myeloablative conditioning approach for long-term engraftment of human and mouse hematopoietic stem cells.

Du W, Liu W, Mizukawa B, Shang X, Sipple J, Wunderlich M, Geiger H, Davies S, Mulloy J, Pang Q, Zheng Y.

Leukemia. 2018 Sep;32(9):2041-2046. doi: 10.1038/s41375-018-0200-3. Epub 2018 Jun 29. No abstract available.

30.

DARK Classics in Chemical Neuroscience: Psilocybin.

Geiger HA, Wurst MG, Daniels RN.

ACS Chem Neurosci. 2018 Oct 17;9(10):2438-2447. doi: 10.1021/acschemneuro.8b00186. Epub 2018 Jul 16.

PMID:
29956917
31.

Aged murine hematopoietic stem cells drive aging-associated immune remodeling.

Leins H, Mulaw M, Eiwen K, Sakk V, Liang Y, Denkinger M, Geiger H, Schirmbeck R.

Blood. 2018 Aug 9;132(6):565-576. doi: 10.1182/blood-2018-02-831065. Epub 2018 Jun 11.

32.

Effect of Different Preconditioning Regimens on the Expression Profile of Murine Adipose-Derived Stromal/Stem Cells.

Baer PC, Overath JM, Urbschat A, Schubert R, Koch B, Bohn AA, Geiger H.

Int J Mol Sci. 2018 Jun 10;19(6). pii: E1719. doi: 10.3390/ijms19061719.

33.

An exploration of O-H⋯O and C-H⋯π inter-actions in a long-chain-ester-substituted phenyl-phenol: methyl 10-[4-(4-hydroxyphenyl)phenoxy]decanoate.

Geiger DK, Geiger HC, Morell DL.

Acta Crystallogr E Crystallogr Commun. 2018 Apr 17;74(Pt 5):594-599. doi: 10.1107/S2056989017016589. eCollection 2018 May 1.

34.

Lectin Affinity Plasmapheresis for Middle East Respiratory Syndrome-Coronavirus and Marburg Virus Glycoprotein Elimination.

Koch B, Schult-Dietrich P, Büttner S, Dilmaghani B, Lohmann D, Baer PC, Dietrich U, Geiger H.

Blood Purif. 2018;46(2):126-133. doi: 10.1159/000487224. Epub 2018 Apr 26.

35.

Identification of Three Rheumatoid Arthritis Disease Subtypes by Machine Learning Integration of Synovial Histologic Features and RNA Sequencing Data.

Orange DE, Agius P, DiCarlo EF, Robine N, Geiger H, Szymonifka J, McNamara M, Cummings R, Andersen KM, Mirza S, Figgie M, Ivashkiv LB, Pernis AB, Jiang CS, Frank MO, Darnell RB, Lingampali N, Robinson WH, Gravallese E; Accelerating Medicines Partnership in Rheumatoid Arthritis and Lupus Network, Bykerk VP, Goodman SM, Donlin LT.

Arthritis Rheumatol. 2018 May;70(5):690-701. doi: 10.1002/art.40428. Epub 2018 Apr 2.

36.

Special section: Replication stress, a threat to the nuclear and mitochondrial genome.

Wiesmüller L, Scharffetter-Kochanek K, Geiger H.

Mutat Res. 2018 Mar;808:53-55. doi: 10.1016/j.mrfmmm.2018.01.001. Epub 2018 Jan 5. No abstract available.

PMID:
29426566
37.

Incidence, Risk Factors, and Outcome of Acute Kidney Injury in Neurocritical Care.

Büttner S, Stadler A, Mayer C, Patyna S, Betz C, Senft C, Geiger H, Jung O, Finkelmeier F.

J Intensive Care Med. 2018 Jan 1:885066617748596. doi: 10.1177/0885066617748596. [Epub ahead of print]

PMID:
29378487
38.

Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors.

Serrano-Lopez J, Nattamai K, Pease NA, Shephard MS, Wellendorf AM, Sertorio M, Smith EA, Geiger H, Wells SI, Cancelas JA, Privette Vinnedge LM.

Exp Hematol. 2018 Mar;59:40-50.e3. doi: 10.1016/j.exphem.2017.12.009. Epub 2017 Dec 27.

39.

Balance your folate or the yin and yang of folate in hematopoiesis.

Geiger H.

Haematologica. 2017 Dec;102(12):1969-1970. doi: 10.3324/haematol.2017.179838. No abstract available.

40.

How to Prevent Renal Cachexia? A Clinical Randomized Pilot Study Testing Oral Supplemental Nutrition in Hemodialysis Patients With and Without Human Immunodeficiency Virus Infection.

Zilles M, Betz C, Jung O, Gauer S, Hammerstingl R, Wächtershäuser A, Vogl TJ, Geiger H, Asbe-Vollkopf A, Pliquett RU.

J Ren Nutr. 2018 Jan;28(1):37-44. doi: 10.1053/j.jrn.2017.07.003. Epub 2017 Nov 14.

PMID:
29146139
41.

RHOA GTPase Controls YAP-Mediated EREG Signaling in Small Intestinal Stem Cell Maintenance.

Liu M, Zhang Z, Sampson L, Zhou X, Nalapareddy K, Feng Y, Akunuru S, Melendez J, Davis AK, Bi F, Geiger H, Xin M, Zheng Y.

Stem Cell Reports. 2017 Dec 12;9(6):1961-1975. doi: 10.1016/j.stemcr.2017.10.004. Epub 2017 Nov 9.

42.

Oxidative stress-induced JNK/AP-1 signaling is a major pathway involved in selective apoptosis of myelodysplastic syndrome cells by Withaferin-A.

Oben KZ, Alhakeem SS, McKenna MK, Brandon JA, Mani R, Noothi SK, Jinpeng L, Akunuru S, Dhar SK, Singh IP, Liang Y, Wang C, Abdel-Latif A, Stills HF Jr, St Clair DK, Geiger H, Muthusamy N, Tohyama K, Gupta RC, Bondada S.

Oncotarget. 2017 Aug 24;8(44):77436-77452. doi: 10.18632/oncotarget.20497. eCollection 2017 Sep 29.

43.

In Reply to George.

Geiger HJ.

Acad Med. 2017 Nov;92(11):1508-1509. doi: 10.1097/ACM.0000000000001948. No abstract available.

PMID:
29064995
44.

CTGF Is Expressed During Cystic Remodeling in the PKD/Mhm (cy/+) Rat Model for Autosomal-Dominant Polycystic Kidney Disease (ADPKD).

Gauer S, Holzmann Y, Kränzlin B, Hoffmann SC, Gretz N, Hauser IA, Goppelt-Struebe M, Geiger H, Obermüller N.

J Histochem Cytochem. 2017 Dec;65(12):743-755. doi: 10.1369/0022155417735513. Epub 2017 Oct 23.

45.

The Spindle Assembly Checkpoint Is Required for Hematopoietic Progenitor Cell Engraftment.

Brown A, Pospiech J, Eiwen K, Baker DJ, Moehrle B, Sakk V, Nattamai K, Vogel M, Grigoryan A, Geiger H.

Stem Cell Reports. 2017 Nov 14;9(5):1359-1368. doi: 10.1016/j.stemcr.2017.09.017. Epub 2017 Oct 19.

46.

Structural characterization, gelation ability, and energy-framework analysis of two bis(long-chain ester)-substituted 4,4'-biphenyl compounds.

Geiger DK, Geiger HC, Moore SM, Roberts WR.

Acta Crystallogr C Struct Chem. 2017 Oct 1;73(Pt 10):791-796. doi: 10.1107/S2053229617013237. Epub 2017 Sep 25.

PMID:
28978785
47.

Long-Term Therapy Outcomes When Treating Chronic Kidney Disease Patients with Paricalcitol in German and Austrian Clinical Practice (TOP Study).

Obermüller N, Rosenkranz AR, Müller HW, Hidde D, Veres A, Decker-Burgard S, Weisz I, Geiger H.

Int J Mol Sci. 2017 Sep 28;18(10). pii: E2057. doi: 10.3390/ijms18102057.

48.

Rho-inhibiting C2IN-C3 fusion toxin inhibits chemotactic recruitment of human monocytes ex vivo and in mice in vivo.

Martin T, Möglich A, Felix I, Förtsch C, Rittlinger A, Palmer A, Denk S, Schneider J, Notbohm L, Vogel M, Geiger H, Paschke S, Huber-Lang M, Barth H.

Arch Toxicol. 2018 Jan;92(1):323-336. doi: 10.1007/s00204-017-2058-y. Epub 2017 Sep 18.

49.

ATRX is a regulator of therapy induced senescence in human cells.

Kovatcheva M, Liao W, Klein ME, Robine N, Geiger H, Crago AM, Dickson MA, Tap WD, Singer S, Koff A.

Nat Commun. 2017 Aug 30;8(1):386. doi: 10.1038/s41467-017-00540-5.

50.

HSC Niche Biology and HSC Expansion Ex Vivo.

Kumar S, Geiger H.

Trends Mol Med. 2017 Sep;23(9):799-819. doi: 10.1016/j.molmed.2017.07.003. Epub 2017 Aug 8. Review.

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