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Items: 1 to 50 of 73

1.

Genome-wide CRISPR screen for Zika virus resistance in human neural cells.

Li Y, Muffat J, Omer Javed A, Keys HR, Lungjangwa T, Bosch I, Khan M, Virgilio MC, Gehrke L, Sabatini DM, Jaenisch R.

Proc Natl Acad Sci U S A. 2019 May 7;116(19):9527-9532. doi: 10.1073/pnas.1900867116. Epub 2019 Apr 24.

PMID:
31019072
2.

Capturing sequence diversity in metagenomes with comprehensive and scalable probe design.

Metsky HC, Siddle KJ, Gladden-Young A, Qu J, Yang DK, Brehio P, Goldfarb A, Piantadosi A, Wohl S, Carter A, Lin AE, Barnes KG, Tully DC, Corleis B, Hennigan S, Barbosa-Lima G, Vieira YR, Paul LM, Tan AL, Garcia KF, Parham LA, Odia I, Eromon P, Folarin OA, Goba A; Viral Hemorrhagic Fever Consortium, Simon-Lorière E, Hensley L, Balmaseda A, Harris E, Kwon DS, Allen TM, Runstadler JA, Smole S, Bozza FA, Souza TML, Isern S, Michael SF, Lorenzana I, Gehrke L, Bosch I, Ebel G, Grant DS, Happi CT, Park DJ, Gnirke A, Sabeti PC, Matranga CB.

Nat Biotechnol. 2019 Feb;37(2):160-168. doi: 10.1038/s41587-018-0006-x. Epub 2019 Feb 4.

3.

Human induced pluripotent stem cell-derived glial cells and neural progenitors display divergent responses to Zika and dengue infections.

Muffat J, Li Y, Omer A, Durbin A, Bosch I, Bakiasi G, Richards E, Meyer A, Gehrke L, Jaenisch R.

Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):7117-7122. doi: 10.1073/pnas.1719266115. Epub 2018 Jun 18.

4.

Field-deployable viral diagnostics using CRISPR-Cas13.

Myhrvold C, Freije CA, Gootenberg JS, Abudayyeh OO, Metsky HC, Durbin AF, Kellner MJ, Tan AL, Paul LM, Parham LA, Garcia KF, Barnes KG, Chak B, Mondini A, Nogueira ML, Isern S, Michael SF, Lorenzana I, Yozwiak NL, MacInnis BL, Bosch I, Gehrke L, Zhang F, Sabeti PC.

Science. 2018 Apr 27;360(6387):444-448. doi: 10.1126/science.aas8836.

5.

Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis.

Khajuria RK, Munschauer M, Ulirsch JC, Fiorini C, Ludwig LS, McFarland SK, Abdulhay NJ, Specht H, Keshishian H, Mani DR, Jovanovic M, Ellis SR, Fulco CP, Engreitz JM, Schütz S, Lian J, Gripp KW, Weinberg OK, Pinkus GS, Gehrke L, Regev A, Lander ES, Gazda HT, Lee WY, Panse VG, Carr SA, Sankaran VG.

Cell. 2018 Mar 22;173(1):90-103.e19. doi: 10.1016/j.cell.2018.02.036. Epub 2018 Mar 15.

6.

Antibiotic-Induced Pathobiont Dissemination Accelerates Mortality in Severe Experimental Pancreatitis.

Soares FS, Amaral FC, Silva NLC, Valente MR, Santos LKR, Yamashiro LH, Scheffer MC, Castanheira FVES, Ferreira RG, Gehrke L, Alves-Filho JC, Silva LP, Báfica A, Spiller F.

Front Immunol. 2017 Dec 22;8:1890. doi: 10.3389/fimmu.2017.01890. eCollection 2017.

7.

Challenges of the Nano-Bio Interface in Lateral Flow and Dipstick Immunoassays.

de Puig H, Bosch I, Gehrke L, Hamad-Schifferli K.

Trends Biotechnol. 2017 Dec;35(12):1169-1180. doi: 10.1016/j.tibtech.2017.09.001. Epub 2017 Sep 28. Review.

8.

Rapid antigen tests for dengue virus serotypes and Zika virus in patient serum.

Bosch I, de Puig H, Hiley M, Carré-Camps M, Perdomo-Celis F, Narváez CF, Salgado DM, Senthoor D, O'Grady M, Phillips E, Durbin A, Fandos D, Miyazaki H, Yen CW, Gélvez-Ramírez M, Warke RV, Ribeiro LS, Teixeira MM, Almeida RP, Muñóz-Medina JE, Ludert JE, Nogueira ML, Colombo TE, Terzian ACB, Bozza PT, Calheiros AS, Vieira YR, Barbosa-Lima G, Vizzoni A, Cerbino-Neto J, Bozza FA, Souza TML, Trugilho MRO, de Filippis AMB, de Sequeira PC, Marques ETA, Magalhaes T, Díaz FJ, Restrepo BN, Marín K, Mattar S, Olson D, Asturias EJ, Lucera M, Singla M, Medigeshi GR, de Bosch N, Tam J, Gómez-Márquez J, Clavet C, Villar L, Hamad-Schifferli K, Gehrke L.

Sci Transl Med. 2017 Sep 27;9(409). pii: eaan1589. doi: 10.1126/scitranslmed.aan1589.

9.

Surface-Enhanced Raman Spectroscopy-Based Sandwich Immunoassays for Multiplexed Detection of Zika and Dengue Viral Biomarkers.

Sánchez-Purrà M, Carré-Camps M, de Puig H, Bosch I, Gehrke L, Hamad-Schifferli K.

ACS Infect Dis. 2017 Oct 13;3(10):767-776. doi: 10.1021/acsinfecdis.7b00110. Epub 2017 Sep 6.

PMID:
28875696
10.

Zika virus evolution and spread in the Americas.

Metsky HC, Matranga CB, Wohl S, Schaffner SF, Freije CA, Winnicki SM, West K, Qu J, Baniecki ML, Gladden-Young A, Lin AE, Tomkins-Tinch CH, Ye SH, Park DJ, Luo CY, Barnes KG, Shah RR, Chak B, Barbosa-Lima G, Delatorre E, Vieira YR, Paul LM, Tan AL, Barcellona CM, Porcelli MC, Vasquez C, Cannons AC, Cone MR, Hogan KN, Kopp EW, Anzinger JJ, Garcia KF, Parham LA, Ramírez RMG, Montoya MCM, Rojas DP, Brown CM, Hennigan S, Sabina B, Scotland S, Gangavarapu K, Grubaugh ND, Oliveira G, Robles-Sikisaka R, Rambaut A, Gehrke L, Smole S, Halloran ME, Villar L, Mattar S, Lorenzana I, Cerbino-Neto J, Valim C, Degrave W, Bozza PT, Gnirke A, Andersen KG, Isern S, Michael SF, Bozza FA, Souza TML, Bosch I, Yozwiak NL, MacInnis BL, Sabeti PC.

Nature. 2017 Jun 15;546(7658):411-415. doi: 10.1038/nature22402. Epub 2017 May 24.

11.

Induction of Expansion and Folding in Human Cerebral Organoids.

Li Y, Muffat J, Omer A, Bosch I, Lancaster MA, Sur M, Gehrke L, Knoblich JA, Jaenisch R.

Cell Stem Cell. 2017 Mar 2;20(3):385-396.e3. doi: 10.1016/j.stem.2016.11.017. Epub 2016 Dec 29.

12.

A comparison of nanoparticle-antibody conjugation strategies in sandwich immunoassays.

Tam JO, de Puig H, Yen CW, Bosch I, Gómez-Márquez J, Clavet C, Hamad-Schifferli K, Gehrke L.

J Immunoassay Immunochem. 2017;38(4):355-377. doi: 10.1080/15321819.2016.1269338. Epub 2016 Dec 16.

13.

RNAs Containing Modified Nucleotides Fail To Trigger RIG-I Conformational Changes for Innate Immune Signaling.

Durbin AF, Wang C, Marcotrigiano J, Gehrke L.

MBio. 2016 Sep 20;7(5). pii: e00833-16. doi: 10.1128/mBio.00833-16.

14.

Rapid, Low-Cost Detection of Zika Virus Using Programmable Biomolecular Components.

Pardee K, Green AA, Takahashi MK, Braff D, Lambert G, Lee JW, Ferrante T, Ma D, Donghia N, Fan M, Daringer NM, Bosch I, Dudley DM, O'Connor DH, Gehrke L, Collins JJ.

Cell. 2016 May 19;165(5):1255-1266. doi: 10.1016/j.cell.2016.04.059. Epub 2016 May 6.

15.

Extinction Coefficient of Gold Nanostars.

de Puig H, Tam JO, Yen CW, Gehrke L, Hamad-Schifferli K.

J Phys Chem C Nanomater Interfaces. 2015 Jul 30;119(30):17408-17415. doi: 10.1021/acs.jpcc.5b03624. Epub 2015 Jul 15.

16.

Diazepam or midazolam for orotracheal intubation in the ICU?

Gehrke L, Oliveira RP, Becker M, Friedman G.

Rev Assoc Med Bras (1992). 2015 Jan-Feb;61(1):30-4. doi: 10.1590/1806-9282.61.01.030. Epub 2015 Jan 1.

17.

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses.

Yen CW, de Puig H, Tam JO, Gómez-Márquez J, Bosch I, Hamad-Schifferli K, Gehrke L.

Lab Chip. 2015 Apr 7;15(7):1638-41. doi: 10.1039/c5lc00055f.

18.

Characterization of shed medicinal leech mucus reveals a diverse microbiota.

Ott BM, Rickards A, Gehrke L, Rio RV.

Front Microbiol. 2015 Jan 9;5:757. doi: 10.3389/fmicb.2014.00757. eCollection 2014.

19.

Diverse intracellular pathogens activate type III interferon expression from peroxisomes.

Odendall C, Dixit E, Stavru F, Bierne H, Franz KM, Durbin AF, Boulant S, Gehrke L, Cossart P, Kagan JC.

Nat Immunol. 2014 Aug;15(8):717-26. doi: 10.1038/ni.2915. Epub 2014 Jun 22.

20.

Metadata-driven comparative analysis tool for sequences (meta-CATS): an automated process for identifying significant sequence variations that correlate with virus attributes.

Pickett BE, Liu M, Sadat EL, Squires RB, Noronha JM, He S, Jen W, Zaremba S, Gu Z, Zhou L, Larsen CN, Bosch I, Gehrke L, McGee M, Klem EB, Scheuermann RH.

Virology. 2013 Dec;447(1-2):45-51. doi: 10.1016/j.virol.2013.08.021. Epub 2013 Sep 14.

21.

Relative adrenal insufficiency as a predictor of disease severity and mortality in severe septic shock.

Dalegrave D, Silva RL, Becker M, Gehrke LV, Friedman G.

Rev Bras Ter Intensiva. 2012 Dec;24(4):362-8.

22.

A phylogenetic analysis using full-length viral genomes of South American dengue serotype 3 in consecutive Venezuelan outbreaks reveals a novel NS5 mutation.

Schmidt DJ, Pickett BE, Camacho D, Comach G, Xhaja K, Lennon NJ, Rizzolo K, de Bosch N, Becerra A, Nogueira ML, Mondini A, da Silva EV, Vasconcelos PF, Muñoz-Jordán JL, Santiago GA, Ocazionez R, Gehrke L, Lefkowitz EJ, Birren BW, Henn MR, Bosch I.

Infect Genet Evol. 2011 Dec;11(8):2011-9. doi: 10.1016/j.meegid.2011.09.010. Epub 2011 Sep 23.

23.

NF90 binds the dengue virus RNA 3' terminus and is a positive regulator of dengue virus replication.

Gomila RC, Martin GW, Gehrke L.

PLoS One. 2011 Feb 28;6(2):e16687. doi: 10.1371/journal.pone.0016687.

24.

RNA conformational changes in the life cycles of RNA viruses, viroids, and virus-associated RNAs.

Simon AE, Gehrke L.

Biochim Biophys Acta. 2009 Sep-Oct;1789(9-10):571-83. doi: 10.1016/j.bbagrm.2009.05.005. Epub 2009 Jun 6. Review.

25.

Nucleotide sequences and modifications that determine RIG-I/RNA binding and signaling activities.

Uzri D, Gehrke L.

J Virol. 2009 May;83(9):4174-84. doi: 10.1128/JVI.02449-08. Epub 2009 Feb 18.

26.

Biochemical approaches for characterizing RNA-protein complexes in preparation for high resolution structure analysis.

Gomila RC, Gehrke L.

Methods Mol Biol. 2008;451:279-91. doi: 10.1007/978-1-59745-102-4_20.

PMID:
18370263
27.

Alfalfa mosaic virus coat protein bridges RNA and RNA-dependent RNA polymerase in vitro.

Reichert VL, Choi M, Petrillo JE, Gehrke L.

Virology. 2007 Jul 20;364(1):214-26. Epub 2007 Apr 2.

29.

Coat protein activation of alfalfa mosaic virus replication is concentration dependent.

Guogas LM, Laforest SM, Gehrke L.

J Virol. 2005 May;79(9):5752-61.

30.

Evaluation of the conformational switch model for alfalfa mosaic virus RNA replication.

Petrillo JE, Rocheleau G, Kelley-Clarke B, Gehrke L.

J Virol. 2005 May;79(9):5743-51.

31.

Cofolding organizes alfalfa mosaic virus RNA and coat protein for replication.

Guogas LM, Filman DJ, Hogle JM, Gehrke L.

Science. 2004 Dec 17;306(5704):2108-11.

33.
34.

Synthesis and biological evaluation of 2-indolyloxazolines as a new class of tubulin polymerization inhibitors. Discovery of A-289099 as an orally active antitumor agent.

Li Q, Woods KW, Claiborne A, Gwaltney SL 2nd, Barr KJ, Liu G, Gehrke L, Credo RB, Hui YH, Lee J, Warner RB, Kovar P, Nukkala MA, Zielinski NA, Tahir SK, Fitzgerald M, Kim KH, Marsh K, Frost D, Ng SC, Rosenberg S, Sham HL.

Bioorg Med Chem Lett. 2002 Feb 11;12(3):465-9.

PMID:
11814821
35.

New antimitotic agents with activity in multi-drug-resistant cell lines and in vivo efficacy in murine tumor models.

Szczepankiewicz BG, Liu G, Jae HS, Tasker AS, Gunawardana IW, von Geldern TW, Gwaltney SL 2nd, Wu-Wong JR, Gehrke L, Chiou WJ, Credo RB, Alder JD, Nukkala MA, Zielinski NA, Jarvis K, Mollison KW, Frost DJ, Bauch JL, Hui YH, Claiborne AK, Li Q, Rosenberg SH.

J Med Chem. 2001 Dec 6;44(25):4416-30.

PMID:
11728187
36.

New ways of initiating translation in eukaryotes.

Schneider R, Agol VI, Andino R, Bayard F, Cavener DR, Chappell SA, Chen JJ, Darlix JL, Dasgupta A, Donzé O, Duncan R, Elroy-Stein O, Farabaugh PJ, Filipowicz W, Gale M Jr, Gehrke L, Goldman E, Groner Y, Harford JB, Hatzglou M, He B, Hellen CU, Hentze MW, Hershey J, Hershey P, Hohn T, Holcik M, Hunter CP, Igarashi K, Jackson R, Jagus R, Jefferson LS, Joshi B, Kaempfer R, Katze M, Kaufman RJ, Kiledjian M, Kimball SR, Kimchi A, Kirkegaard K, Koromilas AE, Krug RM, Kruys V, Lamphear BJ, Lemon S, Lloyd RE, Maquat LE, Martinez-Salas E, Mathews MB, Mauro VP, Miyamoto S, Mohr I, Morris DR, Moss EG, Nakashima N, Palmenberg A, Parkin NT, Pe'ery T, Pelletier J, Peltz S, Pestova TV, Pilipenko EV, Prats AC, Racaniello V, Read GS, Rhoads RE, Richter JD, Rivera-Pomar R, Rouault T, Sachs A, Sarnow P, Scheper GC, Schiff L, Schoenberg DR, Semler BL, Siddiqui A, Skern T, Sonenberg N, Sossin W, Standart N, Tahara SM, Thomas AA, Toulmé JJ, Wilusz J, Wimmer E, Witherell G, Wormington M.

Mol Cell Biol. 2001 Dec;21(23):8238-46. No abstract available.

37.

Novel sulfonate derivatives: potent antimitotic agents.

Gwaltney SL 2nd, Imade HM, Li Q, Gehrke L, Credo RB, Warner RB, Lee JY, Kovar P, Frost D, Ng SC, Sham HL.

Bioorg Med Chem Lett. 2001 Jul 9;11(13):1671-3.

PMID:
11425534
38.

Novel sulfonate analogues of combretastatin A-4: potent antimitotic agents.

Gwaltney SL 2nd, Imade HM, Barr KJ, Li Q, Gehrke L, Credo RB, Warner RB, Lee JY, Kovar P, Wang J, Nukkala MA, Zielinski NA, Frost D, Ng SC, Sham HL.

Bioorg Med Chem Lett. 2001 Apr 9;11(7):871-4.

PMID:
11294380
39.

Modulation of drug resistance by alpha-tubulin in paclitaxel-resistant human lung cancer cell lines.

Han EK, Gehrke L, Tahir SK, Credo RB, Cherian SP, Sham H, Rosenberg SH, Ng S.

Eur J Cancer. 2000 Aug;36(12):1565-71. Erratum in: Eur J Cancer. 2007 Apr;43(6):1108. Kyu-Ho Han, E [corrected to Han, E K].

PMID:
10930805
40.

Confessions of a former nurse manager.

Gehrke LS.

J Emerg Nurs. 1999 Dec;25(6):556-8. No abstract available.

PMID:
10579787
42.

Viral coat protein peptides with limited sequence homology bind similar domains of alfalfa mosaic virus and tobacco streak virus RNAs.

Swanson MM, Ansel-McKinney P, Houser-Scott F, Yusibov V, Loesch-Fries LS, Gehrke L.

J Virol. 1998 Apr;72(4):3227-34.

43.

Cleavage site mapping and substrate-specificity of Leishmaniavirus 2-1 capsid endoribonuclease activity.

MacBeth KJ, Ro YT, Gehrke L, Patterson JL.

J Biochem. 1997 Jul;122(1):193-200.

44.
45.
46.

A plant viral coat protein RNA binding consensus sequence contains a crucial arginine.

Ansel-McKinney P, Scott SW, Swanson M, Ge X, Gehrke L.

EMBO J. 1996 Sep 16;15(18):5077-84. Erratum in: EMBO J 1996 Dec 16;15(24):7188-9.

47.
48.

Pharmacological characterization of A-127722: an orally active and highly potent ETA-selective receptor antagonist.

Opgenorth TJ, Adler AL, Calzadilla SV, Chiou WJ, Dayton BD, Dixon DB, Gehrke LJ, Hernandez L, Magnuson SR, Marsh KC, Novosad EI, Von Geldern TW, Wessale JL, Winn M, Wu-Wong JR.

J Pharmacol Exp Ther. 1996 Feb;276(2):473-81.

PMID:
8632312
49.

Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and post-transcriptional levels.

Rosenwald IB, Kaspar R, Rousseau D, Gehrke L, Leboulch P, Chen JJ, Schmidt EV, Sonenberg N, London IM.

J Biol Chem. 1995 Sep 8;270(36):21176-80.

50.

Magnetization transfer in cartilage and its constituent macromolecules.

Gray ML, Burstein D, Lesperance LM, Gehrke L.

Magn Reson Med. 1995 Sep;34(3):319-25.

PMID:
7500869

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