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Items: 22

1.

Divergent off-target effects of RSK N-terminal and C-terminal kinase inhibitors in cardiac myocytes.

Stathopoulou K, Schobesberger S, Bork NI, Sprenger JU, Perera RK, Sotoud H, Geertz B, David JP, Christ T, Nikolaev VO, Cuello F.

Cell Signal. 2019 Nov;63:109362. doi: 10.1016/j.cellsig.2019.109362. Epub 2019 Jul 22.

PMID:
31344438
2.

Human iPS cell-derived engineered heart tissue does not affect ventricular arrhythmias in a guinea pig cryo-injury model.

Pecha S, Yorgan K, Röhl M, Geertz B, Hansen A, Weinberger F, Sehner S, Ehmke H, Reichenspurner H, Eschenhagen T, Schwoerer AP.

Sci Rep. 2019 Jul 8;9(1):9831. doi: 10.1038/s41598-019-46409-z.

3.

Implantation of hiPSC-derived Cardiac-muscle Patches after Myocardial Injury in a Guinea Pig Model.

Castro L, Geertz B, Reinsch M, Aksehirlioglu B, Hansen A, Eschenhagen T, Reichenspurner H, Weinberger F, Pecha S.

J Vis Exp. 2019 Mar 18;(145). doi: 10.3791/58810.

PMID:
30933073
4.

Preserved cardiovascular homeostasis despite blunted acetylcholine-induced dilation in mice with endothelial muscarinic M3 receptor deletion.

Rhoden A, Speiser J, Geertz B, Uebeler J, Schmidt K, de Wit C, Eschenhagen T.

Acta Physiol (Oxf). 2019 May;226(1):e13262. doi: 10.1111/apha.13262. Epub 2019 Feb 18.

PMID:
30716211
5.

Mechanistic role of the CREB-regulated transcription coactivator 1 in cardiac hypertrophy.

Morhenn K, Quentin T, Wichmann H, Steinmetz M, Prondzynski M, Söhren KD, Christ T, Geertz B, Schröder S, Schöndube FA, Hasenfuss G, Schlossarek S, Zimmermann WH, Carrier L, Eschenhagen T, Cardinaux JR, Lutz S, Oetjen E.

J Mol Cell Cardiol. 2019 Feb;127:31-43. doi: 10.1016/j.yjmcc.2018.12.001. Epub 2018 Dec 4.

PMID:
30521840
6.

Pharmacological inhibition of DNA methylation attenuates pressure overload-induced cardiac hypertrophy in rats.

Stenzig J, Schneeberger Y, Löser A, Peters BS, Schaefer A, Zhao RR, Ng SL, Höppner G, Geertz B, Hirt MN, Tan W, Wong E, Reichenspurner H, Foo RS, Eschenhagen T.

J Mol Cell Cardiol. 2018 Jul;120:53-63. doi: 10.1016/j.yjmcc.2018.05.012. Epub 2018 May 21.

PMID:
29792884
7.

Activation of Autophagy Ameliorates Cardiomyopathy in Mybpc3-Targeted Knockin Mice.

Singh SR, Zech ATL, Geertz B, Reischmann-Düsener S, Osinska H, Prondzynski M, Krämer E, Meng Q, Redwood C, van der Velden J, Robbins J, Schlossarek S, Carrier L.

Circ Heart Fail. 2017 Oct;10(10). pii: e004140. doi: 10.1161/CIRCHEARTFAILURE.117.004140.

8.

Myeloperoxidase Mediates Postischemic Arrhythmogenic Ventricular Remodeling.

Mollenhauer M, Friedrichs K, Lange M, Gesenberg J, Remane L, Kerkenpaß C, Krause J, Schneider J, Ravekes T, Maass M, Halbach M, Peinkofer G, Saric T, Mehrkens D, Adam M, Deuschl FG, Lau D, Geertz B, Manchanda K, Eschenhagen T, Kubala L, Rudolph TK, Wu Y, Tang WHW, Hazen SL, Baldus S, Klinke A, Rudolph V.

Circ Res. 2017 Jun 23;121(1):56-70. doi: 10.1161/CIRCRESAHA.117.310870. Epub 2017 Apr 12.

9.

Diltiazem prevents stress-induced contractile deficits in cardiomyocytes, but does not reverse the cardiomyopathy phenotype in Mybpc3-knock-in mice.

Flenner F, Geertz B, Reischmann-Düsener S, Weinberger F, Eschenhagen T, Carrier L, Friedrich FW.

J Physiol. 2017 Jun 15;595(12):3987-3999. doi: 10.1113/JP273769. Epub 2017 Feb 7.

10.

Cardiac repair in guinea pigs with human engineered heart tissue from induced pluripotent stem cells.

Weinberger F, Breckwoldt K, Pecha S, Kelly A, Geertz B, Starbatty J, Yorgan T, Cheng KH, Lessmann K, Stolen T, Scherrer-Crosbie M, Smith G, Reichenspurner H, Hansen A, Eschenhagen T.

Sci Transl Med. 2016 Nov 2;8(363):363ra148.

PMID:
27807283
11.

Knock-out of nexilin in mice leads to dilated cardiomyopathy and endomyocardial fibroelastosis.

Aherrahrou Z, Schlossarek S, Stoelting S, Klinger M, Geertz B, Weinberger F, Kessler T, Aherrahrou R, Moreth K, Bekeredjian R, Hrabě de Angelis M, Just S, Rottbauer W, Eschenhagen T, Schunkert H, Carrier L, Erdmann J.

Basic Res Cardiol. 2016 Jan;111(1):6. doi: 10.1007/s00395-015-0522-5. Epub 2015 Dec 10.

PMID:
26659360
12.

Ranolazine antagonizes catecholamine-induced dysfunction in isolated cardiomyocytes, but lacks long-term therapeutic effects in vivo in a mouse model of hypertrophic cardiomyopathy.

Flenner F, Friedrich FW, Ungeheuer N, Christ T, Geertz B, Reischmann S, Wagner S, Stathopoulou K, Söhren KD, Weinberger F, Schwedhelm E, Cuello F, Maier LS, Eschenhagen T, Carrier L.

Cardiovasc Res. 2016 Jan 1;109(1):90-102. doi: 10.1093/cvr/cvv247. Epub 2015 Nov 3.

PMID:
26531128
13.

I-1-deficiency negatively impacts survival in a cardiomyopathy mouse model.

Friedrich FW, Sotoud H, Geertz B, Weber S, Flenner F, Reischmann S, Eschenhagen T, Carrier L, El-Armouche A.

Int J Cardiol Heart Vasc. 2015 May 29;8:87-94. doi: 10.1016/j.ijcha.2015.05.010. eCollection 2015 Sep 1.

14.

Proteasome inhibition slightly improves cardiac function in mice with hypertrophic cardiomyopathy.

Schlossarek S, Singh SR, Geertz B, Schulz H, Reischmann S, Hübner N, Carrier L.

Front Physiol. 2014 Dec 16;5:484. doi: 10.3389/fphys.2014.00484. eCollection 2014.

15.

Mybpc3 gene therapy for neonatal cardiomyopathy enables long-term disease prevention in mice.

Mearini G, Stimpel D, Geertz B, Weinberger F, Krämer E, Schlossarek S, Mourot-Filiatre J, Stoehr A, Dutsch A, Wijnker PJ, Braren I, Katus HA, Müller OJ, Voit T, Eschenhagen T, Carrier L.

Nat Commun. 2014 Dec 2;5:5515. doi: 10.1038/ncomms6515.

PMID:
25463264
16.

Contractile abnormalities and altered drug response in engineered heart tissue from Mybpc3-targeted knock-in mice.

Stöhr A, Friedrich FW, Flenner F, Geertz B, Eder A, Schaaf S, Hirt MN, Uebeler J, Schlossarek S, Carrier L, Hansen A, Eschenhagen T.

J Mol Cell Cardiol. 2013 Oct;63:189-98. doi: 10.1016/j.yjmcc.2013.07.011. Epub 2013 Jul 26.

17.

Repair of Mybpc3 mRNA by 5'-trans-splicing in a Mouse Model of Hypertrophic Cardiomyopathy.

Mearini G, Stimpel D, Krämer E, Geertz B, Braren I, Gedicke-Hornung C, Précigout G, Müller OJ, Katus HA, Eschenhagen T, Voit T, Garcia L, Lorain S, Carrier L.

Mol Ther Nucleic Acids. 2013 Jul 2;2:e102. doi: 10.1038/mtna.2013.31.

18.

Rescue of cardiomyopathy through U7snRNA-mediated exon skipping in Mybpc3-targeted knock-in mice.

Gedicke-Hornung C, Behrens-Gawlik V, Reischmann S, Geertz B, Stimpel D, Weinberger F, Schlossarek S, Précigout G, Braren I, Eschenhagen T, Mearini G, Lorain S, Voit T, Dreyfus PA, Garcia L, Carrier L.

EMBO Mol Med. 2013 Jul;5(7):1128-45. doi: 10.1002/emmm.201202168. Epub 2013 May 29.

19.

Increased myofilament Ca2+ sensitivity and diastolic dysfunction as early consequences of Mybpc3 mutation in heterozygous knock-in mice.

Fraysse B, Weinberger F, Bardswell SC, Cuello F, Vignier N, Geertz B, Starbatty J, Krämer E, Coirault C, Eschenhagen T, Kentish JC, Avkiran M, Carrier L.

J Mol Cell Cardiol. 2012 Jun;52(6):1299-307. doi: 10.1016/j.yjmcc.2012.03.009. Epub 2012 Mar 23.

20.

Adrenergic stress reveals septal hypertrophy and proteasome impairment in heterozygous Mybpc3-targeted knock-in mice.

Schlossarek S, Schuermann F, Geertz B, Mearini G, Eschenhagen T, Carrier L.

J Muscle Res Cell Motil. 2012 May;33(1):5-15. doi: 10.1007/s10974-011-9273-6. Epub 2011 Nov 11.

PMID:
22076249
21.

Isoprenaline-induced increase in the 40/41 kDa pertussis toxin substrates and functional consequences on contractile response in rat heart.

Mende U, Eschenhagen T, Geertz B, Schmitz W, Scholz H, Schulte am Esch J, Sempell R, Steinfath M.

Naunyn Schmiedebergs Arch Pharmacol. 1992 Jan;345(1):44-50.

PMID:
1311426
22.

Distinct down-regulation of cardiac beta 1- and beta 2-adrenoceptors in different human heart diseases.

Steinfath M, Geertz B, Schmitz W, Scholz H, Haverich A, Breil I, Hanrath P, Reupcke C, Sigmund M, Lo HB.

Naunyn Schmiedebergs Arch Pharmacol. 1991 Feb;343(2):217-20.

PMID:
1648674

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