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Items: 1 to 50 of 54

1.

Bacterial encapsulins as orthogonal compartments for mammalian cell engineering.

Sigmund F, Massner C, Erdmann P, Stelzl A, Rolbieski H, Desai M, Bricault S, Wörner TP, Snijder J, Geerlof A, Fuchs H, Hrabĕ de Angelis M, Heck AJR, Jasanoff A, Ntziachristos V, Plitzko J, Westmeyer GG.

Nat Commun. 2018 May 18;9(1):1990. doi: 10.1038/s41467-018-04227-3.

2.

Baculovirus-driven protein expression in insect cells: A benchmarking study.

Stolt-Bergner P, Benda C, Bergbrede T, Besir H, Celie PHN, Chang C, Drechsel D, Fischer A, Geerlof A, Giabbai B, van den Heuvel J, Huber G, Knecht W, Lehner A, Lemaitre R, Nordén K, Pardee G, Racke I, Remans K, Sander A, Scholz J, Stadnik M, Storici P, Weinbruch D, Zaror I, Lua LHL, Suppmann S.

J Struct Biol. 2018 Aug;203(2):71-80. doi: 10.1016/j.jsb.2018.03.004. Epub 2018 Mar 12.

PMID:
29545204
3.

Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke.

Roth S, Singh V, Tiedt S, Schindler L, Huber G, Geerlof A, Antoine DJ, Anfray A, Orset C, Gauberti M, Fournier A, Holdt LM, Harris HE, Engelhardt B, Bianchi ME, Vivien D, Haffner C, Bernhagen J, Dichgans M, Liesz A.

Sci Transl Med. 2018 Mar 14;10(432). pii: eaao1313. doi: 10.1126/scitranslmed.aao1313.

PMID:
29540615
4.

Molecular basis for asymmetry sensing of siRNAs by the Drosophila Loqs-PD/Dcr-2 complex in RNA interference.

Tants JN, Fesser S, Kern T, Stehle R, Geerlof A, Wunderlich C, Juen M, Hartlmüller C, Böttcher R, Kunzelmann S, Lange O, Kreutz C, Förstemann K, Sattler M.

Nucleic Acids Res. 2017 Dec 1;45(21):12536-12550. doi: 10.1093/nar/gkx886.

5.

Segmental, Domain-Selective Perdeuteration and Small-Angle Neutron Scattering for Structural Analysis of Multi-Domain Proteins.

Sonntag M, Jagtap PKA, Simon B, Appavou MS, Geerlof A, Stehle R, Gabel F, Hennig J, Sattler M.

Angew Chem Int Ed Engl. 2017 Aug 1;56(32):9322-9325. doi: 10.1002/anie.201702904. Epub 2017 Jul 5.

PMID:
28636238
6.

Proteome-wide Identification of Glycosylation-dependent Interactors of Galectin-1 and Galectin-3 on Mesenchymal Retinal Pigment Epithelial (RPE) Cells.

Obermann J, Priglinger CS, Merl-Pham J, Geerlof A, Priglinger S, Götz M, Hauck SM.

Mol Cell Proteomics. 2017 Aug;16(8):1528-1546. doi: 10.1074/mcp.M116.066381. Epub 2017 Jun 2.

7.

Structure-function analysis of the DNA-binding domain of a transmembrane transcriptional activator.

Schlundt A, Buchner S, Janowski R, Heydenreich T, Heermann R, Lassak J, Geerlof A, Stehle R, Niessing D, Jung K, Sattler M.

Sci Rep. 2017 Apr 21;7(1):1051. doi: 10.1038/s41598-017-01031-9.

8.

ROS-Mediated Inhibition of S-nitrosoglutathione Reductase Contributes to the Activation of Anti-oxidative Mechanisms.

Kovacs I, Holzmeister C, Wirtz M, Geerlof A, Fröhlich T, Römling G, Kuruthukulangarakoola GT, Linster E, Hell R, Arnold GJ, Durner J, Lindermayr C.

Front Plant Sci. 2016 Nov 10;7:1669. eCollection 2016.

9.

Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation.

Jung B, Messias AC, Schorpp K, Geerlof A, Schneider G, Saur D, Hadian K, Sattler M, Wanker EE, Hasenöder S, Lickert H.

Sci Rep. 2016 Mar 2;6:22540. doi: 10.1038/srep22540.

10.

Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation.

Jung B, Padula D, Burtscher I, Landerer C, Lutter D, Theis F, Messias AC, Geerlof A, Sattler M, Kremmer E, Boldt K, Ueffing M, Lickert H.

PLoS One. 2016 Feb 22;11(2):e0149477. doi: 10.1371/journal.pone.0149477. eCollection 2016.

11.

Epithelial-to-Mesenchymal Transition of RPE Cells In Vitro Confers Increased β1,6-N-Glycosylation and Increased Susceptibility to Galectin-3 Binding.

Priglinger CS, Obermann J, Szober CM, Merl-Pham J, Ohmayer U, Behler J, Gruhn F, Kreutzer TC, Wertheimer C, Geerlof A, Priglinger SG, Hauck SM.

PLoS One. 2016 Jan 13;11(1):e0146887. doi: 10.1371/journal.pone.0146887. eCollection 2016.

12.

Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction.

Vincendeau M, Hadian K, Messias AC, Brenke JK, Halander J, Griesbach R, Greczmiel U, Bertossi A, Stehle R, Nagel D, Demski K, Velvarska H, Niessing D, Geerlof A, Sattler M, Krappmann D.

Sci Rep. 2016 Jan 7;6:18934. doi: 10.1038/srep18934.

13.

An Aptamer against the Matrix Binding Domain on the Hepatitis B Virus Capsid Impairs Virion Formation.

Orabi A, Bieringer M, Geerlof A, Bruss V.

J Virol. 2015 Sep;89(18):9281-7. doi: 10.1128/JVI.00466-15. Epub 2015 Jul 1.

14.

Structural Analysis of Protein-RNA Complexes in Solution Using NMR Paramagnetic Relaxation Enhancements.

Hennig J, Warner LR, Simon B, Geerlof A, Mackereth CD, Sattler M.

Methods Enzymol. 2015;558:333-62. doi: 10.1016/bs.mie.2015.02.006. Epub 2015 Mar 26.

PMID:
26068746
15.

Differential inhibition of Arabidopsis superoxide dismutases by peroxynitrite-mediated tyrosine nitration.

Holzmeister C, Gaupels F, Geerlof A, Sarioglu H, Sattler M, Durner J, Lindermayr C.

J Exp Bot. 2015 Feb;66(3):989-99. doi: 10.1093/jxb/eru458. Epub 2014 Nov 26.

16.

Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation.

Jeltsch KM, Hu D, Brenner S, Zöller J, Heinz GA, Nagel D, Vogel KU, Rehage N, Warth SC, Edelmann SL, Gloury R, Martin N, Lohs C, Lech M, Stehklein JE, Geerlof A, Kremmer E, Weber A, Anders HJ, Schmitz I, Schmidt-Supprian M, Fu M, Holtmann H, Krappmann D, Ruland J, Kallies A, Heikenwalder M, Heissmeyer V.

Nat Immunol. 2014 Nov;15(11):1079-89. doi: 10.1038/ni.3008. Epub 2014 Oct 5.

PMID:
25282160
17.

Structural basis for the assembly of the Sxl-Unr translation regulatory complex.

Hennig J, Militti C, Popowicz GM, Wang I, Sonntag M, Geerlof A, Gabel F, Gebauer F, Sattler M.

Nature. 2014 Nov 13;515(7526):287-90. doi: 10.1038/nature13693. Epub 2014 Sep 7.

PMID:
25209665
18.

Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation.

Schlundt A, Heinz GA, Janowski R, Geerlof A, Stehle R, Heissmeyer V, Niessing D, Sattler M.

Nat Struct Mol Biol. 2014 Aug;21(8):671-8. doi: 10.1038/nsmb.2855. Epub 2014 Jul 13.

PMID:
25026077
19.

A new ELISA for the quantification of equine procalcitonin in plasma as potential inflammation biomarker in horses.

Rieger M, Kochleus C, Teschner D, Rascher D, Barton AK, Geerlof A, Kremmer E, Schmid M, Hartmann A, Gehlen H.

Anal Bioanal Chem. 2014 Sep;406(22):5507-12. doi: 10.1007/s00216-014-7944-z. Epub 2014 Jun 14.

PMID:
24928115
20.

Total internal reflection (TIRF)-based quantification of procalcitonin for sepsis diagnosis--a point-of-care testing application.

Rascher D, Geerlof A, Kremmer E, Krämer P, Michael S, Hartmann A, Rieger M.

Biosens Bioelectron. 2014 Sep 15;59:251-8. doi: 10.1016/j.bios.2014.03.052. Epub 2014 Apr 1.

PMID:
24732603
21.

Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3.

Muda K, Bertinetti D, Gesellchen F, Hermann JS, von Zweydorf F, Geerlof A, Jacob A, Ueffing M, Gloeckner CJ, Herberg FW.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E34-43. doi: 10.1073/pnas.1312701111. Epub 2013 Dec 18.

22.

Galectin-3 induces clustering of CD147 and integrin-β1 transmembrane glycoprotein receptors on the RPE cell surface.

Priglinger CS, Szober CM, Priglinger SG, Merl J, Euler KN, Kernt M, Gondi G, Behler J, Geerlof A, Kampik A, Ueffing M, Hauck SM.

PLoS One. 2013 Jul 29;8(7):e70011. doi: 10.1371/journal.pone.0070011. Print 2013.

23.

Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation.

Vogel KU, Edelmann SL, Jeltsch KM, Bertossi A, Heger K, Heinz GA, Zöller J, Warth SC, Hoefig KP, Lohs C, Neff F, Kremmer E, Schick J, Repsilber D, Geerlof A, Blum H, Wurst W, Heikenwälder M, Schmidt-Supprian M, Heissmeyer V.

Immunity. 2013 Apr 18;38(4):655-68. doi: 10.1016/j.immuni.2012.12.004. Epub 2013 Apr 11.

24.

Optimization of protein buffer cocktails using Thermofluor.

Reinhard L, Mayerhofer H, Geerlof A, Mueller-Dieckmann J, Weiss MS.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Feb 1;69(Pt 2):209-14. doi: 10.1107/S1744309112051858. Epub 2013 Jan 31.

25.

Structural characterization of a D-isomer specific 2-hydroxyacid dehydrogenase from Lactobacillus delbrueckii ssp. bulgaricus.

Holton SJ, Anandhakrishnan M, Geerlof A, Wilmanns M.

J Struct Biol. 2013 Feb;181(2):179-84. doi: 10.1016/j.jsb.2012.10.009. Epub 2012 Oct 27.

PMID:
23110853
26.

Efficient expression and purification of tag-free Epstein-Barr virus EBNA1 protein in Escherichia coli by auto-induction.

Mayer CE, Geerlof A, Schepers A.

Protein Expr Purif. 2012 Nov;86(1):7-11. doi: 10.1016/j.pep.2012.08.010. Epub 2012 Aug 26.

PMID:
22944205
27.

High-throughput protein expression screening and purification in Escherichia coli.

Vincentelli R, Cimino A, Geerlof A, Kubo A, Satou Y, Cambillau C.

Methods. 2011 Sep;55(1):65-72. doi: 10.1016/j.ymeth.2011.08.010. Epub 2011 Sep 8.

PMID:
21925268
28.

The pathologic effect of a novel neomorphic Fgf9(Y162C) allele is restricted to decreased vision and retarded lens growth.

Puk O, Möller G, Geerlof A, Krowiorz K, Ahmad N, Wagner S, Adamski J, de Angelis MH, Graw J.

PLoS One. 2011;6(8):e23678. doi: 10.1371/journal.pone.0023678. Epub 2011 Aug 17.

29.

Expression of protein complexes using multiple Escherichia coli protein co-expression systems: a benchmarking study.

Busso D, Peleg Y, Heidebrecht T, Romier C, Jacobovitch Y, Dantes A, Salim L, Troesch E, Schuetz A, Heinemann U, Folkers GE, Geerlof A, Wilmanns M, Polewacz A, Quedenau C, Büssow K, Adamson R, Blagova E, Walton J, Cartwright JL, Bird LE, Owens RJ, Berrow NS, Wilson KS, Sussman JL, Perrakis A, Celie PH.

J Struct Biol. 2011 Aug;175(2):159-70. doi: 10.1016/j.jsb.2011.03.004. Epub 2011 Mar 5.

PMID:
21382497
30.

Bisubstrate specificity in histidine/tryptophan biosynthesis isomerase from Mycobacterium tuberculosis by active site metamorphosis.

Due AV, Kuper J, Geerlof A, von Kries JP, Wilmanns M.

Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3554-9. doi: 10.1073/pnas.1015996108. Epub 2011 Feb 14.

31.

Structural studies on the enzyme complex isopropylmalate isomerase (LeuCD) from Mycobacterium tuberculosis.

Manikandan K, Geerlof A, Zozulya AV, Svergun DI, Weiss MS.

Proteins. 2011 Jan;79(1):35-49. doi: 10.1002/prot.22856. Epub 2010 Oct 11.

PMID:
20938981
32.

Evidence for the cytotoxic effects of Mycobacterium tuberculosis phospholipase C towards macrophages.

Bakala N'goma JC, Schué M, Carrière F, Geerlof A, Canaan S.

Biochim Biophys Acta. 2010 Dec;1801(12):1305-13. doi: 10.1016/j.bbalip.2010.08.007. Epub 2010 Aug 21.

PMID:
20736081
33.

Stoichiometric protein complex formation and over-expression using the prokaryotic native operon structure.

Poulsen C, Holton S, Geerlof A, Wilmanns M, Song YH.

FEBS Lett. 2010 Feb 19;584(4):669-74. doi: 10.1016/j.febslet.2009.12.057. Epub 2010 Jan 18.

34.

Biochemical characterization of haloalkane dehalogenases DrbA and DmbC, Representatives of a Novel Subfamily.

Jesenská A, Monincová M, Koudeláková T, Hasan K, Chaloupková R, Prokop Z, Geerlof A, Damborsky J.

Appl Environ Microbiol. 2009 Aug;75(15):5157-60. doi: 10.1128/AEM.00199-09. Epub 2009 Jun 5.

35.

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the small subunit of isopropylmalate isomerase (Rv2987c) from Mycobacterium tuberculosis.

Karuppasamy M, Geerlof A, Schuldt L, Mueller-Dieckmann C, Weiss MS.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Feb 1;65(Pt 2):136-9. doi: 10.1107/S1744309108042516. Epub 2009 Jan 31.

36.

Methods for protein characterization by mass spectrometry, thermal shift (ThermoFluor) assay, and multiangle or static light scattering.

Nettleship JE, Brown J, Groves MR, Geerlof A.

Methods Mol Biol. 2008;426:299-318. doi: 10.1007/978-1-60327-058-8_19.

PMID:
18542872
37.

Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a resuscitation-promoting factor from Mycobacterium tuberculosis.

Ruggiero A, Tizzano B, Geerlof A, Pedone E, Pedone C, Wilmanns M, Berisio R.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Oct 1;63(Pt 10):870-3. Epub 2007 Sep 19.

38.

On the routine use of soft X-rays in macromolecular crystallography. Part IV. Efficient determination of anomalous substructures in biomacromolecules using longer X-ray wavelengths.

Mueller-Dieckmann C, Panjikar S, Schmidt A, Mueller S, Kuper J, Geerlof A, Wilmanns M, Singh RK, Tucker PA, Weiss MS.

Acta Crystallogr D Biol Crystallogr. 2007 Mar;63(Pt 3):366-80. Epub 2007 Feb 21.

PMID:
17327674
39.

Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens.

Fogg MJ, Alzari P, Bahar M, Bertini I, Betton JM, Burmeister WP, Cambillau C, Canard B, Corrondo MA, Coll M, Daenke S, Dym O, Egloff MP, Enguita FJ, Geerlof A, Haouz A, Jones TA, Ma Q, Manicka SN, Migliardi M, Nordlund P, Owens RJ, Peleg Y, Schneider G, Schnell R, Stuart DI, Tarbouriech N, Unge T, Wilkinson AJ, Wilmanns M, Wilson KS, Zimhony O, Grimes JM.

Acta Crystallogr D Biol Crystallogr. 2006 Oct;62(Pt 10):1196-207. Epub 2006 Sep 19. Review. Erratum in: Acta Crystallogr D Biol Crystallogr. 2006 Dec;62(Pt 12):1571. Carrondo, M [corrected to Corrondo, M A].

40.

The impact of protein characterization in structural proteomics.

Geerlof A, Brown J, Coutard B, Egloff MP, Enguita FJ, Fogg MJ, Gilbert RJ, Groves MR, Haouz A, Nettleship JE, Nordlund P, Owens RJ, Ruff M, Sainsbury S, Svergun DI, Wilmanns M.

Acta Crystallogr D Biol Crystallogr. 2006 Oct;62(Pt 10):1125-36. Epub 2006 Sep 19. Review.

PMID:
17001090
41.

Implementation of semi-automated cloning and prokaryotic expression screening: the impact of SPINE.

Alzari PM, Berglund H, Berrow NS, Blagova E, Busso D, Cambillau C, Campanacci V, Christodoulou E, Eiler S, Fogg MJ, Folkers G, Geerlof A, Hart D, Haouz A, Herman MD, Macieira S, Nordlund P, Perrakis A, Quevillon-Cheruel S, Tarandeau F, van Tilbeurgh H, Unger T, Luna-Vargas MP, Velarde M, Willmanns M, Owens RJ.

Acta Crystallogr D Biol Crystallogr. 2006 Oct;62(Pt 10):1103-13. Epub 2006 Sep 19.

PMID:
17001088
42.

The Mycobacterium tuberculosis LipB enzyme functions as a cysteine/lysine dyad acyltransferase.

Ma Q, Zhao X, Nasser Eddine A, Geerlof A, Li X, Cronan JE, Kaufmann SH, Wilmanns M.

Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8662-7. Epub 2006 May 30.

43.
44.

Building the stator of the yeast vacuolar-ATPase: specific interaction between subunits E and G.

Féthière J, Venzke D, Diepholz M, Seybert A, Geerlof A, Gentzel M, Wilm M, Böttcher B.

J Biol Chem. 2004 Sep 24;279(39):40670-6. Epub 2004 Aug 2.

45.

Recombinant proteins fused to thermostable partners can be purified by heat incubation.

de Marco A, Casatta E, Savaresi S, Geerlof A.

J Biotechnol. 2004 Jan 22;107(2):125-33.

PMID:
14711496
46.

Solution scattering suggests cross-linking function of telethonin in the complex with titin.

Zou P, Gautel M, Geerlof A, Wilmanns M, Koch MH, Svergun DI.

J Biol Chem. 2003 Jan 24;278(4):2636-44. Epub 2002 Nov 20.

47.

Purification and characterization of phosphopantetheine adenylyltransferase from Escherichia coli.

Geerlof A, Lewendon A, Shaw WV.

J Biol Chem. 1999 Sep 17;274(38):27105-11.

48.

Cubic crystals of phosphopantetheine adenylyltransferase from Escherichia coli.

Izard T, Geerlof A, Lewendon A, Barker JJ.

Acta Crystallogr D Biol Crystallogr. 1999 Jun;55(Pt 6):1226-8.

PMID:
10329792
49.
50.

Cryoenzymic studies on yeast 3-phosphoglycerate kinase. Attempt to obtain the kinetics of the hinge-bending motion.

Geerlof A, Schmidt PP, Travers F, Barman T.

Biochemistry. 1997 May 6;36(18):5538-45.

PMID:
9154937

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