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Items: 8


SHP2 Inhibition Prevents Adaptive Resistance to MEK inhibitors in Multiple Cancer Models.

Fedele C, Ran H, Diskin B, Wei W, Jen J, Geer MJ, Araki K, Ozerdem U, Simeone DM, Miller G, Neel BG, Tang KH.

Cancer Discov. 2018 Jul 25. pii: CD-18-0444. doi: 10.1158/2159-8290.CD-18-0444. [Epub ahead of print]


Congenital macrothrombocytopenia with focal myelofibrosis due to mutations in human G6b-B is rescued in humanized mice.

Hofmann I, Geer MJ, Vögtle T, Crispin A, Campagna DR, Barr A, Calicchio ML, Heising S, van Geffen JP, Kuijpers MJE, Heemskerk JWM, Eble JA, Schmitz-Abe K, Obeng EA, Douglas M, Freson K, Pondarré C, Favier R, Jarvis GE, Markianos K, Turro E, Ouwehand WH, Mazharian A, Fleming MD, Senis YA.

Blood. 2018 Jun 13. pii: blood-2017-08-802769. doi: 10.1182/blood-2017-08-802769. [Epub ahead of print]


Uncoupling of the ITIM receptor G6b-B from the tyrosine phosphatases Shp1 and Shp2 disrupts platelet homeostasis in mice.

Geer MJ, van Geffen JP, Gopalasingam P, Vögtle T, Smith CW, Heising S, Kuijpers MJE, Tullemans BME, Jarvis GE, Eble JA, Jeeves M, Overduin M, Heemskerk JWM, Mazharian A, Senis YA.

Blood. 2018 Jun 11. pii: blood-2017-10-802975. doi: 10.1182/blood-2017-10-802975. [Epub ahead of print]


Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148.

Mori J, Nagy Z, Di Nunzio G, Smith CW, Geer MJ, Al Ghaithi R, van Geffen JP, Heising S, Boothman L, Tullemans BME, Correia JN, Tee L, Kuijpers MJE, Harrison P, Heemskerk JWM, Jarvis GE, Tarakhovsky A, Weiss A, Mazharian A, Senis YA.

Blood. 2018 Mar 8;131(10):1122-1144. doi: 10.1182/blood-2017-02-768077. Epub 2018 Jan 4.


ITIM receptors: more than just inhibitors of platelet activation.

Coxon CH, Geer MJ, Senis YA.

Blood. 2017 Jun 29;129(26):3407-3418. doi: 10.1182/blood-2016-12-720185. Epub 2017 May 2. Review.


An allele of sequoia dominantly enhances a trio mutant phenotype to influence Drosophila larval behavior.

Dean KE, Fields A, Geer MJ, King EC, Lynch BT, Manohar RR, McCall JR, Palozola KC, Zhang Y, Liebl EC.

PLoS One. 2013 Dec 20;8(12):e84149. doi: 10.1371/journal.pone.0084149. eCollection 2013.


Pulmonary chemoreflex responses are potentiated by tumor necrosis factor-alpha in mice.

Lin RL, Lin YJ, Geer MJ, Kryscio R, Lee LY.

J Appl Physiol (1985). 2013 Jun;114(11):1536-43. doi: 10.1152/japplphysiol.01301.2012. Epub 2013 Mar 28.


A computerized magnetic resonance imaging study of corpus callosum morphology in schizophrenia.

Woodruff PW, Pearlson GD, Geer MJ, Barta PE, Chilcoat HD.

Psychol Med. 1993 Feb;23(1):45-56. Review.


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