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Items: 17


A cytokine network involving IL-36γ, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage.

Ngo VL, Abo H, Maxim E, Harusato A, Geem D, Medina-Contreras O, Merlin D, Gewirtz AT, Nusrat A, Denning TL.

Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5076-E5085. doi: 10.1073/pnas.1718902115. Epub 2018 May 14.


IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria.

Flannigan KL, Ngo VL, Geem D, Harusato A, Hirota SA, Parkos CA, Lukacs NW, Nusrat A, Gaboriau-Routhiau V, Cerf-Bensussan N, Gewirtz AT, Denning TL.

Mucosal Immunol. 2017 May;10(3):673-684. doi: 10.1038/mi.2016.80. Epub 2016 Sep 14.


Contribution of Mesenteric Lymph Nodes and GALT to the Intestinal Foxp3+ Regulatory T-Cell Compartment.

Geem D, Ngo V, Harusato A, Chassaing B, Gewirtz AT, Newberry RD, Denning TL.

Cell Mol Gastroenterol Hepatol. 2016 May;2(3):274-280.


Macrophage Isolation from the Mouse Small and Large Intestine.

Harusato A, Geem D, Denning TL.

Methods Mol Biol. 2016;1422:171-80. doi: 10.1007/978-1-4939-3603-8_16.


Cutting Edge: IL-36 Receptor Promotes Resolution of Intestinal Damage.

Medina-Contreras O, Harusato A, Nishio H, Flannigan KL, Ngo V, Leoni G, Neumann PA, Geem D, Lili LN, Ramadas RA, Chassaing B, Gewirtz AT, Kohlmeier JE, Parkos CA, Towne JE, Nusrat A, Denning TL.

J Immunol. 2016 Jan 1;196(1):34-8. doi: 10.4049/jimmunol.1501312. Epub 2015 Nov 20.


Intestinal Antigen-Presenting Cells: Key Regulators of Immune Homeostasis and Inflammation.

Flannigan KL, Geem D, Harusato A, Denning TL.

Am J Pathol. 2015 Jul;185(7):1809-19. doi: 10.1016/j.ajpath.2015.02.024. Epub 2015 May 11. Review.


Phenotypic and functional profiling of mouse intestinal antigen presenting cells.

Harusato A, Flannigan KL, Geem D, Denning TL.

J Immunol Methods. 2015 Jun;421:20-26. doi: 10.1016/j.jim.2015.03.023. Epub 2015 Apr 17. Review.


Harnessing regulatory T cells for the treatment of inflammatory bowel disease.

Geem D, Harusato A, Flannigan K, Denning TL.

Inflamm Bowel Dis. 2015 Jun;21(6):1409-18. doi: 10.1097/MIB.0000000000000343. Review.


Small intestinal intraepithelial TCRγδ+ T lymphocytes are present in the premature intestine but selectively reduced in surgical necrotizing enterocolitis.

Weitkamp JH, Rosen MJ, Zhao Z, Koyama T, Geem D, Denning TL, Rock MT, Moore DJ, Halpern MD, Matta P, Denning PW.

PLoS One. 2014 Jun 6;9(6):e99042. doi: 10.1371/journal.pone.0099042. eCollection 2014. Erratum in: PLoS One. 2014;9(8):e105487.


Specific microbiota-induced intestinal Th17 differentiation requires MHC class II but not GALT and mesenteric lymph nodes.

Geem D, Medina-Contreras O, McBride M, Newberry RD, Koni PA, Denning TL.

J Immunol. 2014 Jul 1;193(1):431-8. doi: 10.4049/jimmunol.1303167. Epub 2014 Jun 4.


Fab'-bearing siRNA TNFα-loaded nanoparticles targeted to colonic macrophages offer an effective therapy for experimental colitis.

Laroui H, Viennois E, Xiao B, Canup BS, Geem D, Denning TL, Merlin D.

J Control Release. 2014 Jul 28;186:41-53. doi: 10.1016/j.jconrel.2014.04.046. Epub 2014 May 5.


Targeting intestinal inflammation with CD98 siRNA/PEI-loaded nanoparticles.

Laroui H, Geem D, Xiao B, Viennois E, Rakhya P, Denning T, Merlin D.

Mol Ther. 2014 Jan;22(1):69-80. doi: 10.1038/mt.2013.214. Epub 2013 Sep 12.


Isolation and characterization of dendritic cells and macrophages from the mouse intestine.

Geem D, Medina-Contreras O, Kim W, Huang CS, Denning TL.

J Vis Exp. 2012 May 21;(63):e4040. doi: 10.3791/4040.


T lymphocytes and vascular inflammation contribute to stress-dependent hypertension.

Marvar PJ, Vinh A, Thabet S, Lob HE, Geem D, Ressler KJ, Harrison DG.

Biol Psychiatry. 2012 May 1;71(9):774-82. doi: 10.1016/j.biopsych.2012.01.017. Epub 2012 Feb 22.


CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice.

Medina-Contreras O, Geem D, Laur O, Williams IR, Lira SA, Nusrat A, Parkos CA, Denning TL.

J Clin Invest. 2011 Dec;121(12):4787-95. doi: 10.1172/JCI59150.


Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell/APC ratio, source of mouse strain, and regional localization.

Denning TL, Norris BA, Medina-Contreras O, Manicassamy S, Geem D, Madan R, Karp CL, Pulendran B.

J Immunol. 2011 Jul 15;187(2):733-47. doi: 10.4049/jimmunol.1002701. Epub 2011 Jun 10.


Cortisol, stress, and attentional bias toward threat.

McHugh RK, Behar E, Gutner CA, Geem D, Otto MW.

Anxiety Stress Coping. 2010 Oct;23(5):529-45. doi: 10.1080/10615801003596969.


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