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Items: 1 to 50 of 95

1.

Positive allosteric modulation of the α7 nicotinic acetylcholine receptor as a treatment for cognitive deficits after traumatic brain injury.

Titus DJ, Johnstone T, Johnson NH, London SH, Chapalamadugu M, Hogenkamp D, Gee KW, Atkins CM.

PLoS One. 2019 Oct 3;14(10):e0223180. doi: 10.1371/journal.pone.0223180. eCollection 2019.

2.

Enaminone Modulators of Extrasynaptic α4β3δ γ-Aminobutyric AcidA Receptors Reverse Electrographic Status Epilepticus in the Rat After Acute Organophosphorus Poisoning.

Johnstone TBC, McCarren HS, Spampanato J, Dudek FE, McDonough JH, Hogenkamp D, Gee KW.

Front Pharmacol. 2019 May 24;10:560. doi: 10.3389/fphar.2019.00560. eCollection 2019.

3.

Positive allosteric modulators of nonbenzodiazepine γ-aminobutyric acidA receptor subtypes for the treatment of chronic pain.

Johnstone TBC, Xie JY, Qu C, Wasiak DJ, Hogenkamp DJ, Porreca F, Gee KW.

Pain. 2019 Jan;160(1):198-209. doi: 10.1097/j.pain.0000000000001392.

PMID:
30204648
4.

Role of β2/3-specific GABA-A receptor isoforms in the development of hippocampus kindling epileptogenesis.

Reddy DS, Yoshimura RF, Ramanathan G, Carver C, Johnstone TB, Hogenkamp DJ, Gee KW.

Epilepsy Behav. 2018 May;82:57-63. doi: 10.1016/j.yebeh.2018.02.020. Epub 2018 Mar 26.

PMID:
29587186
5.

Allosteric modulation of nicotinic and GABAA receptor subtypes differentially modify autism-like behaviors in the BTBR mouse model.

Yoshimura RF, Tran MB, Hogenkamp DJ, Ayala NL, Johnstone T, Dunnigan AJ, Gee TK, Gee KW.

Neuropharmacology. 2017 Nov;126:38-47. doi: 10.1016/j.neuropharm.2017.08.029. Epub 2017 Aug 24.

PMID:
28842344
6.

First in human trial of a type I positive allosteric modulator of alpha7-nicotinic acetylcholine receptors: Pharmacokinetics, safety, and evidence for neurocognitive effect of AVL-3288.

Gee KW, Olincy A, Kanner R, Johnson L, Hogenkamp D, Harris J, Tran M, Edmonds SA, Sauer W, Yoshimura R, Johnstone T, Freedman R.

J Psychopharmacol. 2017 Apr;31(4):434-441. doi: 10.1177/0269881117691590. Epub 2017 Feb 15.

PMID:
28196430
7.

Pharmacological profile of a 17β-heteroaryl-substituted neuroactive steroid.

Hogenkamp DJ, Tran MB, Yoshimura RF, Johnstone TB, Kanner R, Gee KW.

Psychopharmacology (Berl). 2014 Sep;231(17):3517-24. doi: 10.1007/s00213-014-3494-5. Epub 2014 Feb 28.

PMID:
24682501
8.

Limited central side effects of a β-subunit subtype-selective GABAA receptor allosteric modulator.

Yoshimura RF, Tran MB, Hogenkamp DJ, Johnstone TB, Xie JY, Porreca F, Gee KW.

J Psychopharmacol. 2014 May;28(5):472-8. doi: 10.1177/0269881113507643. Epub 2013 Oct 9.

PMID:
24108410
9.

Design, synthesis, and activity of a series of arylpyrid-3-ylmethanones as type I positive allosteric modulators of α7 nicotinic acetylcholine receptors.

Hogenkamp DJ, Ford-Hutchinson TA, Li WY, Whittemore ER, Yoshimura RF, Tran MB, Johnstone TB, Bascom GD, Rollins H, Lu L, Gee KW.

J Med Chem. 2013 Nov 14;56(21):8352-65. doi: 10.1021/jm400704g. Epub 2013 Oct 30.

10.

Diagnostic accuracy of preoperative alpha-fetoprotein as an ovarian tumor marker in children and adolescents: not as good as we thought?

Loh AH, Gee KW, Chua JH.

Pediatr Surg Int. 2013 Jul;29(7):709-13. doi: 10.1007/s00383-013-3316-6. Epub 2013 May 8.

PMID:
23653236
11.

The monoamine oxidase (MAO) inhibitor tranylcypromine enhances nicotine self-administration in rats through a mechanism independent of MAO inhibition.

Lotfipour S, Arnold MM, Hogenkamp DJ, Gee KW, Belluzzi JD, Leslie FM.

Neuropharmacology. 2011 Jul-Aug;61(1-2):95-104. doi: 10.1016/j.neuropharm.2011.03.007. Epub 2011 Mar 23.

12.

Allosteric modulation of related ligand-gated ion channels synergistically induces long-term potentiation in the hippocampus and enhances cognition.

Johnstone TB, Gu Z, Yoshimura RF, Villegier AS, Hogenkamp DJ, Whittemore ER, Huang JC, Tran MB, Belluzzi JD, Yakel JL, Gee KW.

J Pharmacol Exp Ther. 2011 Mar;336(3):908-15. doi: 10.1124/jpet.110.176255. Epub 2010 Dec 15.

13.

Limiting activity at beta1-subunit-containing GABAA receptor subtypes reduces ataxia.

Gee KW, Tran MB, Hogenkamp DJ, Johnstone TB, Bagnera RE, Yoshimura RF, Huang JC, Belluzzi JD, Whittemore ER.

J Pharmacol Exp Ther. 2010 Mar;332(3):1040-53. doi: 10.1124/jpet.109.161885. Epub 2009 Nov 25.

14.

Negative allosteric modulation of nicotinic acetylcholine receptors blocks nicotine self-administration in rats.

Yoshimura RF, Hogenkamp DJ, Li WY, Tran MB, Belluzzi JD, Whittemore ER, Leslie FM, Gee KW.

J Pharmacol Exp Ther. 2007 Dec;323(3):907-15. Epub 2007 Sep 14.

PMID:
17873105
15.

Enaminone amides as novel orally active GABAA receptor modulators.

Hogenkamp DJ, Johnstone TB, Huang JC, Li WY, Tran M, Whittemore ER, Bagnera RE, Gee KW.

J Med Chem. 2007 Jul 12;50(14):3369-79. Epub 2007 Jun 16.

PMID:
17571865
16.

Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators.

Ng HJ, Whittemore ER, Tran MB, Hogenkamp DJ, Broide RS, Johnstone TB, Zheng L, Stevens KE, Gee KW.

Proc Natl Acad Sci U S A. 2007 May 8;104(19):8059-64. Epub 2007 Apr 30.

17.

Reversible lipidization for the oral delivery of leu-enkephalin.

Wang J, Hogenkamp DJ, Tran M, Li WY, Yoshimura RF, Johnstone TB, Shen WC, Gee KW.

J Drug Target. 2006 Apr;14(3):127-36.

PMID:
16753826
18.

Modifying quinolone antibiotics yields new anxiolytics.

Johnstone TB, Hogenkamp DJ, Coyne L, Su J, Halliwell RF, Tran MB, Yoshimura RF, Li WY, Wang J, Gee KW.

Nat Med. 2004 Jan;10(1):31-2. Epub 2003 Nov 30.

PMID:
14647497
19.
20.

Response-rate suppression in operant paradigm as predictor of soporific potency in rats and identification of three novel sedative-hypnotic neuroactive steroids.

Vanover KE, Edgar DM, Seidel WF, Hogenkamp DJ, Fick DB, Lan NC, Gee KW, Carter RB.

J Pharmacol Exp Ther. 1999 Dec;291(3):1317-23.

PMID:
10565857
21.

Positive allosteric modulators of the GABA(A) receptor: differential interaction of benzodiazepines and neuroactive steroids with ethanol.

Vanover KE, Suruki M, Robledo S, Huber M, Wieland S, Lan NC, Gee KW, Wood PL, Carter RB.

Psychopharmacology (Berl). 1999 Jan;141(1):77-82.

PMID:
9952068
22.

Anxiolytic and anticonvulsant activity of a synthetic neuroactive steroid Co 3-0593.

Wieland S, Belluzzi J, Hawkinson JE, Hogenkamp D, Upasani R, Stein L, Wood PL, Gee KW, Lan NC.

Psychopharmacology (Berl). 1997 Nov;134(1):46-54.

PMID:
9399366
23.

CCD-3693: an orally bioavailable analog of the endogenous neuroactive steroid, pregnanolone, demonstrates potent sedative hypnotic actions in the rat.

Edgar DM, Seidel WF, Gee KW, Lan NC, Field G, Xia H, Hawkinson JE, Wieland S, Carter RB, Wood PL.

J Pharmacol Exp Ther. 1997 Jul;282(1):420-9.

PMID:
9223583
24.

Partial agonism by 3alpha,21-dihydroxy-5beta-pregnan-20-one at the gamma-aminobutyric acidA receptor neurosteroid site.

Xue BG, Whittemore ER, Park CH, Woodward RM, Lan NC, Gee KW.

J Pharmacol Exp Ther. 1997 Jun;281(3):1095-101.

PMID:
9190841
25.

Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor.

Carter RB, Wood PL, Wieland S, Hawkinson JE, Belelli D, Lambert JJ, White HS, Wolf HH, Mirsadeghi S, Tahir SH, Bolger MB, Lan NC, Gee KW.

J Pharmacol Exp Ther. 1997 Mar;280(3):1284-95.

PMID:
9067315
26.

Synthesis and in vitro activity of 3 beta-substituted-3 alpha-hydroxypregnan-20-ones: allosteric modulators of the GABAA receptor.

Hogenkamp DJ, Tahir SH, Hawkinson JE, Upasani RB, Alauddin M, Kimbrough CL, Acosta-Burruel M, Whittemore ER, Woodward RM, Lan NC, Gee KW, Bolger MB.

J Med Chem. 1997 Jan 3;40(1):61-72.

PMID:
9016329
27.

Anxiolytic properties of endogenously occurring pregnanediols in two rodent models of anxiety.

Carboni E, Wieland S, Lan NC, Gee KW.

Psychopharmacology (Berl). 1996 Jul;126(2):173-8.

PMID:
8856837
28.

3 alpha-Hydroxy-3 beta-trifluoromethyl-5 alpha-pregnan-20-one (Co 2-1970): a partial agonist at the neuroactive steroid site of the gamma-aminobutyric acidA receptor.

Hawkinson JE, Drewe JA, Kimbrough CL, Chen JS, Hogenkamp DJ, Lan NC, Gee KW, Shen KZ, Whittemore ER, Woodward RM.

Mol Pharmacol. 1996 May;49(5):897-906.

PMID:
8622640
29.
30.

Modulation of human recombinant GABAA receptors by pregnanediols.

Belelli D, Lambert JJ, Peters JA, Gee KW, Lan NC.

Neuropharmacology. 1996;35(9-10):1223-31.

PMID:
9014137
31.

Soporific effect of the neurosteroid pregnanolone in relation to the substance's plasma level: a pilot study.

Schulz H, Jobert M, Gee KW, Ashbrook DW.

Neuropsychobiology. 1996;34(2):106-12.

PMID:
8904740
32.

Epalons as anticonvulsants: actions mediated by the GABAA receptor complex.

Gee KW.

Proc West Pharmacol Soc. 1996;39:55. No abstract available.

PMID:
8895969
33.
35.
36.

Benzodiazepines and peptides stimulate pregnenolone synthesis in brain mitochondria.

McCauley LD, Park CH, Lan NC, Tomich JM, Shively JE, Gee KW.

Eur J Pharmacol. 1995 Mar 24;276(1-2):145-53.

PMID:
7781684
37.

Selective actions of certain neuroactive pregnanediols at the gamma-aminobutyric acid type A receptor complex in rat brain.

McCauley LD, Liu V, Chen JS, Hawkinson JE, Lan NC, Gee KW.

Mol Pharmacol. 1995 Feb;47(2):354-62.

PMID:
7870044
38.

Differential effects of 4'-chlorodiazepam on expressed human GABAA receptors.

Lan NC, Chen JS, Johnson D, Gee KW.

J Neurochem. 1995 Feb;64(2):684-8.

PMID:
7830061
39.
40.

Neuroactive steroid actions at the GABAA receptor.

Lan NC, Gee KW.

Horm Behav. 1994 Dec;28(4):537-44. Review.

PMID:
7729823
41.

The neuroactive steroid 3 alpha-hydroxy-5 beta-pregnan-20-one is a two-component modulator of ligand binding to the GABAA receptor.

Hawkinson JE, Kimbrough CL, McCauley LD, Bolger MB, Lan NC, Gee KW.

Eur J Pharmacol. 1994 Oct 14;269(2):157-63.

PMID:
7851492
42.
43.
44.
45.

Complex interactions between the steroid derivative RU 5135 and the GABAA-receptor complex.

Cadoni C, Gee KW.

Eur J Pharmacol. 1992 Oct 1;227(2):147-51.

PMID:
1330646
46.

Pharmacology of a GABAA receptor coupled steroid recognition site.

Gee KW, Lan NC, Bolger MB, Wieland S, Belelli D, Chen JS.

Adv Biochem Psychopharmacol. 1992;47:111-7. Review. No abstract available.

PMID:
1354914
47.

Peripheral-type benzodiazepine receptors and the regulation of steroidogenesis in rat brain mitochondria.

McCauley LD, Lan NC, Tomich JM, Shively JE, Gee KW.

Adv Biochem Psychopharmacol. 1992;47:143-7. No abstract available.

PMID:
1324568
49.

Anxiolytic activity of the progesterone metabolite 5 alpha-pregnan-3 alpha-o1-20-one.

Wieland S, Lan NC, Mirasedeghi S, Gee KW.

Brain Res. 1991 Nov 29;565(2):263-8.

PMID:
1688192
50.

Differential responses of expressed recombinant human gamma-aminobutyric acidA receptors to neurosteroids.

Lan NC, Gee KW, Bolger MB, Chen JS.

J Neurochem. 1991 Nov;57(5):1818-21.

PMID:
1655982

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