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Items: 1 to 50 of 109

1.

Repositioning Flubendazole for Spinal Cord Injury.

Yu CG, Bondada V, Ghoshal S, Singh R, Pistilli CK, Dayaram K, Iqbal H, Sands M, Davis KL, Bondada S, Geddes JW.

J Neurotrauma. 2019 Mar 15. doi: 10.1089/neu.2018.6160. [Epub ahead of print]

PMID:
30747048
2.

Phage display for identification of serum biomarkers of traumatic brain injury.

Ghoshal S, Bondada V, Saatman KE, Guttmann RP, Geddes JW.

J Neurosci Methods. 2016 Oct 15;272:33-37. doi: 10.1016/j.jneumeth.2016.04.026. Epub 2016 May 7.

3.

Calpain-5 Expression in the Retina Localizes to Photoreceptor Synapses.

Schaefer KA, Toral MA, Velez G, Cox AJ, Baker SA, Borcherding NC, Colgan DF, Bondada V, Mashburn CB, Yu CG, Geddes JW, Tsang SH, Bassuk AG, Mahajan VB.

Invest Ophthalmol Vis Sci. 2016 May 1;57(6):2509-21. doi: 10.1167/iovs.15-18680.

4.

Dietary Supplementation with Organoselenium Accelerates Recovery of Bladder Expression, but Does Not Improve Locomotor Function, following Spinal Cord Injury.

Meyer CA, Singh R, Jones MT, Yu CG, Power RF, Geddes JW.

PLoS One. 2016 Jan 29;11(1):e0147716. doi: 10.1371/journal.pone.0147716. eCollection 2016.

5.

Current status of fluid biomarkers in mild traumatic brain injury.

Kulbe JR, Geddes JW.

Exp Neurol. 2016 Jan;275 Pt 3:334-352. doi: 10.1016/j.expneurol.2015.05.004. Epub 2015 May 14. Review.

6.

Ketone bodies mediate antiseizure effects through mitochondrial permeability transition.

Kim DY, Simeone KA, Simeone TA, Pandya JD, Wilke JC, Ahn Y, Geddes JW, Sullivan PG, Rho JM.

Ann Neurol. 2015 Jul;78(1):77-87. doi: 10.1002/ana.24424. Epub 2015 May 6.

7.

Calpain 5 is highly expressed in the central nervous system (CNS), carries dual nuclear localization signals, and is associated with nuclear promyelocytic leukemia protein bodies.

Singh R, Brewer MK, Mashburn CB, Lou D, Bondada V, Graham B, Geddes JW.

J Biol Chem. 2014 Jul 11;289(28):19383-94. doi: 10.1074/jbc.M114.575159. Epub 2014 May 16.

8.

Ceftriaxone increases glutamate uptake and reduces striatal tyrosine hydroxylase loss in 6-OHDA Parkinson's model.

Chotibut T, Davis RW, Arnold JC, Frenchek Z, Gurwara S, Bondada V, Geddes JW, Salvatore MF.

Mol Neurobiol. 2014 Jun;49(3):1282-92. doi: 10.1007/s12035-013-8598-0. Epub 2013 Dec 3.

9.

Fenbendazole improves pathological and functional recovery following traumatic spinal cord injury.

Yu CG, Singh R, Crowdus C, Raza K, Kincer J, Geddes JW.

Neuroscience. 2014 Jan 3;256:163-9. doi: 10.1016/j.neuroscience.2013.10.039. Epub 2013 Oct 30.

10.

Pharmacological analysis of the cortical neuronal cytoskeletal protective efficacy of the calpain inhibitor SNJ-1945 in a mouse traumatic brain injury model.

Bains M, Cebak JE, Gilmer LK, Barnes CC, Thompson SN, Geddes JW, Hall ED.

J Neurochem. 2013 Apr;125(1):125-32. doi: 10.1111/jnc.12118. Epub 2013 Jan 28.

11.

Calpain 1 knockdown improves tissue sparing and functional outcomes after spinal cord injury in rats.

Yu CG, Li Y, Raza K, Yu XX, Ghoshal S, Geddes JW.

J Neurotrauma. 2013 Mar 15;30(6):427-33. doi: 10.1089/neu.2012.2561. Epub 2013 Mar 26.

12.

WldS prevents axon degeneration through increased mitochondrial flux and enhanced mitochondrial Ca2+ buffering.

Avery MA, Rooney TM, Pandya JD, Wishart TM, Gillingwater TH, Geddes JW, Sullivan PG, Freeman MR.

Curr Biol. 2012 Apr 10;22(7):596-600. doi: 10.1016/j.cub.2012.02.043. Epub 2012 Mar 15.

13.

Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease.

Blalock EM, Buechel HM, Popovic J, Geddes JW, Landfield PW.

J Chem Neuroanat. 2011 Oct;42(2):118-26. doi: 10.1016/j.jchemneu.2011.06.007. Epub 2011 Jul 2.

14.

A multi-mode shock tube for investigation of blast-induced traumatic brain injury.

Reneer DV, Hisel RD, Hoffman JM, Kryscio RJ, Lusk BT, Geddes JW.

J Neurotrauma. 2011 Jan;28(1):95-104. doi: 10.1089/neu.2010.1513.

15.

Color changing photonic crystals detect blast exposure.

Cullen DK, Xu Y, Reneer DV, Browne KD, Geddes JW, Yang S, Smith DH.

Neuroimage. 2011 Jan;54 Suppl 1:S37-44. doi: 10.1016/j.neuroimage.2010.10.076. Epub 2010 Oct 30.

16.

Targeting individual calpain isoforms for neuroprotection.

Geddes JW, Saatman KE.

Exp Neurol. 2010 Nov;226(1):6-7. doi: 10.1016/j.expneurol.2010.07.025. Epub 2010 Aug 3. No abstract available.

17.

Dimebon inhibits calcium-induced swelling of rat brain mitochondria but does not alter calcium retention or cytochrome C release.

Naga KK, Geddes JW.

Neuromolecular Med. 2011 Mar;13(1):31-6. doi: 10.1007/s12017-010-8130-x. Epub 2010 Jul 13.

18.

Involvement of ERK2 in traumatic spinal cord injury.

Yu CG, Yezierski RP, Joshi A, Raza K, Li Y, Geddes JW.

J Neurochem. 2010 Apr;113(1):131-42. doi: 10.1111/j.1471-4159.2010.06579.x. Epub 2010 Jan 12.

19.

Calpain 1 and Calpastatin expression is developmentally regulated in rat brain.

Li Y, Bondada V, Joshi A, Geddes JW.

Exp Neurol. 2009 Dec;220(2):316-9. doi: 10.1016/j.expneurol.2009.09.004. Epub 2009 Sep 12.

20.

Special Issue: Mitochondria and neurodegeneration.

Geddes JW, Sullivan PG.

Exp Neurol. 2009 Aug;218(2):169-70. doi: 10.1016/j.expneurol.2009.05.011. Epub 2009 May 14. No abstract available.

PMID:
19446552
21.

Mitochondrial micro-calpain is not involved in the processing of apoptosis-inducing factor.

Joshi A, Bondada V, Geddes JW.

Exp Neurol. 2009 Aug;218(2):221-7. doi: 10.1016/j.expneurol.2009.04.013. Epub 2009 Apr 23.

22.

N-methyl-D-aspartate receptor antagonists have variable affect in 3-nitropropionic acid toxicity.

Nasr P, Carbery T, Geddes JW.

Neurochem Res. 2009 Mar;34(3):490-8. doi: 10.1007/s11064-008-9809-3. Epub 2008 Aug 8.

23.

Intraspinal MDL28170 microinjection improves functional and pathological outcome following spinal cord injury.

Yu CG, Joshi A, Geddes JW.

J Neurotrauma. 2008 Jul;25(7):833-40. doi: 10.1089/neu.2007.0490.

24.

N terminus of calpain 1 is a mitochondrial targeting sequence.

Badugu R, Garcia M, Bondada V, Joshi A, Geddes JW.

J Biol Chem. 2008 Feb 8;283(6):3409-17. Epub 2007 Dec 10.

25.
26.

Sustained calpain inhibition improves locomotor function and tissue sparing following contusive spinal cord injury.

Yu CG, Geddes JW.

Neurochem Res. 2007 Dec;32(12):2046-53. Epub 2007 May 3.

PMID:
17476592
27.

Artifactual dendritic beading in rat spinal cord induced by perfusion with cold saline and paraformaldehyde.

Zhang SX, Holmberg EG, Geddes JW.

J Neurosci Methods. 2007 Jun 15;163(1):38-43. Epub 2007 Feb 22.

PMID:
17397933
28.

Synaptic mitochondria are more susceptible to Ca2+overload than nonsynaptic mitochondria.

Brown MR, Sullivan PG, Geddes JW.

J Biol Chem. 2006 Apr 28;281(17):11658-68. Epub 2006 Mar 3.

29.

Mitochondrial localization of mu-calpain.

Garcia M, Bondada V, Geddes JW.

Biochem Biophys Res Commun. 2005 Dec 16;338(2):1241-7. Epub 2005 Oct 24.

PMID:
16259951
30.

alpha-Synuclein: a potent inducer of tau pathology.

Geddes JW.

Exp Neurol. 2005 Apr;192(2):244-50. Review. No abstract available.

PMID:
15755542
31.

Proteasome or calpain inhibition does not alter cellular tau levels in neuroblastoma cells or primary neurons.

Brown MR, Bondada V, Keller JN, Thorpe J, Geddes JW.

J Alzheimers Dis. 2005 Feb;7(1):15-24.

PMID:
15750211
32.

X-irradiation reduces lesion scarring at the contusion site of adult rat spinal cord.

Zhang SX, Geddes JW, Owens JL, Holmberg EG.

Histol Histopathol. 2005 Apr;20(2):519-30. doi: 10.14670/HH-20.519.

PMID:
15736057
33.

Nicotine attenuates morphological deficits in a contusion model of spinal cord injury.

Ravikumar R, Fugaccia I, Scheff SW, Geddes JW, Srinivasan C, Toborek M.

J Neurotrauma. 2005 Feb;22(2):240-51.

PMID:
15716630
34.

Brain region-specific, age-related, alterations in mitochondrial responses to elevated calcium.

Brown MR, Geddes JW, Sullivan PG.

J Bioenerg Biomembr. 2004 Aug;36(4):401-6.

PMID:
15377879
35.

Nitrogen disruption of synaptoneurosomes: an alternative method to isolate brain mitochondria.

Brown MR, Sullivan PG, Dorenbos KA, Modafferi EA, Geddes JW, Steward O.

J Neurosci Methods. 2004 Aug 30;137(2):299-303.

PMID:
15262074
36.

Tat-calpastatin fusion proteins transduce primary rat cortical neurons but do not inhibit cellular calpain activity.

Sengoku T, Bondada V, Hassane D, Dubal S, Geddes JW.

Exp Neurol. 2004 Jul;188(1):161-70.

PMID:
15191812
37.

Nicotine attenuates oxidative stress, activation of redox-regulated transcription factors and induction of proinflammatory genes in compressive spinal cord trauma.

Ravikumar R, Flora G, Geddes JW, Hennig B, Toborek M.

Brain Res Mol Brain Res. 2004 May 19;124(2):188-98.

PMID:
15135227
38.

Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses.

Blalock EM, Geddes JW, Chen KC, Porter NM, Markesbery WR, Landfield PW.

Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2173-8. Epub 2004 Feb 9.

39.

Calpain facilitates the neuron death induced by 3-nitropropionic acid and contributes to the necrotic morphology.

Pang Z, Bondada V, Sengoku T, Siman R, Geddes JW.

J Neuropathol Exp Neurol. 2003 Jun;62(6):633-43.

PMID:
12834108
40.

Glutamate regulates caveolin expression in rat hippocampal neurons.

Bu J, Bruckner SR, Sengoku T, Geddes JW, Estus S.

J Neurosci Res. 2003 Apr 15;72(2):185-90.

PMID:
12671992
41.
43.

3-nitropropionic acid-induced changes in bilayer fluidity in synaptosomal membranes: implications for Huntington's disease.

LaFontaine MA, Geddes JW, Butterfield DA.

Neurochem Res. 2002 Jun;27(6):507-11.

PMID:
12199156
44.

Increased protein oxidation and decreased creatine kinase BB expression and activity after spinal cord contusion injury.

Aksenova M, Butterfield DA, Zhang SX, Underwood M, Geddes JW.

J Neurotrauma. 2002 Apr;19(4):491-502.

PMID:
11990354
45.

Protein oxidation in the brain in Alzheimer's disease.

Aksenov MY, Aksenova MV, Butterfield DA, Geddes JW, Markesbery WR.

Neuroscience. 2001;103(2):373-83.

PMID:
11246152
47.

Cytoskeletal disruption following contusion injury to the rat spinal cord.

Zhang SX, Underwood M, Landfield A, Huang FF, Gison S, Geddes JW.

J Neuropathol Exp Neurol. 2000 Apr;59(4):287-96.

PMID:
10759184
48.

3-nitropropionic acid induced in vivo protein oxidation in striatal and cortical synaptosomes: insights into Huntington's disease.

La Fontaine MA, Geddes JW, Banks A, Butterfield DA.

Brain Res. 2000 Mar 10;858(2):356-62.

PMID:
10708687
49.

Does dopamine contribute to striatal damage caused by impaired mitochondrial function?

Maragos WF, Jakel RJ, Chesnut MD, Geddes JW, Dwoskin LP.

Ann N Y Acad Sci. 1999;893:345-9. No abstract available.

PMID:
10672263
50.

Toxicity of pyroglutaminated amyloid beta-peptides 3(pE)-40 and -42 is similar to that of A beta1-40 and -42.

Tekirian TL, Yang AY, Glabe C, Geddes JW.

J Neurochem. 1999 Oct;73(4):1584-9.

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