Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 139


A Mouse Model for the Study of SYK Function through Chemical Genetics Demonstrates SYK-Dependent Signaling through the B Cell Receptor, but Not TLR4.

Wang WH, Krisenko MO, Higgins RL, Morman RE, Geahlen RL.

Immunohorizons. 2019 Jul 1;3(7):254-261. doi: 10.4049/immunohorizons.1800084.


Identification of the Direct Substrates of the ABL Kinase via Kinase Assay Linked Phosphoproteomics with Multiple Drug Treatments.

Arrington J, Xue L, Wang WH, Geahlen RL, Tao WA.

J Proteome Res. 2019 Apr 5;18(4):1679-1690. doi: 10.1021/acs.jproteome.8b00942. Epub 2019 Mar 21.


Spleen Tyrosine Kinase-Mediated Autophagy Is Required for Epithelial-Mesenchymal Plasticity and Metastasis in Breast Cancer.

Shinde A, Hardy SD, Kim D, Akhand SS, Jolly MK, Wang WH, Anderson JC, Khodadadi RB, Brown WS, George JT, Liu S, Wan J, Levine H, Willey CD, Krusemark CJ, Geahlen RL, Wendt MK.

Cancer Res. 2019 Apr 15;79(8):1831-1843. doi: 10.1158/0008-5472.CAN-18-2636. Epub 2019 Feb 7.


Regulation of epithelial-mesenchymal transition and metastasis by TGF-β, P-bodies, and autophagy.

Hardy SD, Shinde A, Wang WH, Wendt MK, Geahlen RL.

Oncotarget. 2017 Oct 17;8(61):103302-103314. doi: 10.18632/oncotarget.21871. eCollection 2017 Nov 28.


Identification of Upstream Kinases by Fluorescence Complementation Mass Spectrometry.

Zeng L, Wang WH, Arrington J, Shao G, Geahlen RL, Hu CD, Tao WA.

ACS Cent Sci. 2017 Oct 25;3(10):1078-1085. doi: 10.1021/acscentsci.7b00261. Epub 2017 Sep 13.


Measuring nanoscale viscoelastic parameters of cells directly from AFM force-displacement curves.

Efremov YM, Wang WH, Hardy SD, Geahlen RL, Raman A.

Sci Rep. 2017 May 8;7(1):1541. doi: 10.1038/s41598-017-01784-3.


Stress Granules Modulate SYK to Cause Microglial Cell Dysfunction in Alzheimer's Disease.

Ghosh S, Geahlen RL.

EBioMedicine. 2015 Oct 3;2(11):1785-98. doi: 10.1016/j.ebiom.2015.09.053. eCollection 2015 Nov. Erratum in: EBioMedicine. 2016 Jun;8:349.


A Computational Study of the Effects of Syk Activity on B Cell Receptor Signaling Dynamics.

McGee RL, Krisenko MO, Geahlen RL, Rundell AE, Buzzard GT.

Processes (Basel). 2015 Mar;3(1):75-97. Epub 2015 Feb 11.


Syk Is Recruited to Stress Granules and Promotes Their Clearance through Autophagy.

Krisenko MO, Higgins RL, Ghosh S, Zhou Q, Trybula JS, Wang WH, Geahlen RL.

J Biol Chem. 2015 Nov 13;290(46):27803-15. doi: 10.1074/jbc.M115.642900. Epub 2015 Oct 1.


Fast, multi-frequency, and quantitative nanomechanical mapping of live cells using the atomic force microscope.

Cartagena-Rivera AX, Wang WH, Geahlen RL, Raman A.

Sci Rep. 2015 Jun 29;5:11692. doi: 10.1038/srep11692.


In-Depth Analyses of B Cell Signaling Through Tandem Mass Spectrometry of Phosphopeptides Enriched by PolyMAC.

Iliuk A, Jayasundera K, Wang WH, Schluttenhofer R, Geahlen RL, Tao WA.

Int J Mass Spectrom. 2015 Feb 1;377:744-753.


Calling in SYK: SYK's dual role as a tumor promoter and tumor suppressor in cancer.

Krisenko MO, Geahlen RL.

Biochim Biophys Acta. 2015 Jan;1853(1):254-63. doi: 10.1016/j.bbamcr.2014.10.022. Epub 2014 Nov 4. Review.


Syk interacts with and phosphorylates nucleolin to stabilize Bcl-x(L) mRNA and promote cell survival.

Wang WH, Childress MO, Geahlen RL.

Mol Cell Biol. 2014 Oct;34(20):3788-99. doi: 10.1128/MCB.00937-14. Epub 2014 Aug 4.


Getting Syk: spleen tyrosine kinase as a therapeutic target.

Geahlen RL.

Trends Pharmacol Sci. 2014 Aug;35(8):414-22. doi: 10.1016/ Epub 2014 Jun 26. Review.


Nanomechanical property maps of breast cancer cells as determined by multiharmonic atomic force microscopy reveal Syk-dependent changes in microtubule stability mediated by MAP1B.

Krisenko MO, Cartagena A, Raman A, Geahlen RL.

Biochemistry. 2015 Jan 13;54(1):60-8. doi: 10.1021/bi500325n. Epub 2014 Jun 18.


Global phosphoproteomics of activated B cells using complementary metal ion functionalized soluble nanopolymers.

Jayasundera KB, Iliuk AB, Nguyen A, Higgins R, Geahlen RL, Tao WA.

Anal Chem. 2014 Jul 1;86(13):6363-71. doi: 10.1021/ac500599r. Epub 2014 Jun 20.


Differential recognition of syk-binding sites by each of the two phosphotyrosine-binding pockets of the Vav SH2 domain.

Chen CH, Piraner D, Gorenstein NM, Geahlen RL, Beth Post C.

Biopolymers. 2013 Nov;99(11):897-907. doi: 10.1002/bip.22371.


Intracellular targets for a phosphotyrosine peptidomimetic include the mitotic kinesin, MCAK.

Huang R, Oh H, Arrendale A, Martin VA, Galan J, Workman EJ, Stout JR, Walczak CE, Tao WA, Borch RF, Geahlen RL.

Biochem Pharmacol. 2013 Sep 1;86(5):597-611. doi: 10.1016/j.bcp.2013.06.024. Epub 2013 Jul 4.


Identification of direct tyrosine kinase substrates based on protein kinase assay-linked phosphoproteomics.

Xue L, Geahlen RL, Tao WA.

Mol Cell Proteomics. 2013 Oct;12(10):2969-80. doi: 10.1074/mcp.O113.027722. Epub 2013 Jun 22.


Modulation by Syk of Bcl-2, calcium and the calpain-calpastatin proteolytic system in human breast cancer cells.

Fei B, Yu S, Geahlen RL.

Biochim Biophys Acta. 2013 Oct;1833(10):2153-64. doi: 10.1016/j.bbamcr.2013.05.010. Epub 2013 May 16.


A quantitative proteomics-based competition binding assay to characterize pITAM-protein interactions.

Hu L, Yang L, Lipchik AM, Geahlen RL, Parker LL, Tao WA.

Anal Chem. 2013 May 21;85(10):5071-7. doi: 10.1021/ac400359t. Epub 2013 May 8.


Syk inhibits the activity of protein kinase A by phosphorylating tyrosine 330 of the catalytic subunit.

Yu S, Huang H, Iliuk A, Wang WH, Jayasundera KB, Tao WA, Post CB, Geahlen RL.

J Biol Chem. 2013 Apr 12;288(15):10870-81. doi: 10.1074/jbc.M112.426130. Epub 2013 Feb 27.


Multiplexed quantitation of protein expression and phosphorylation based on functionalized soluble nanopolymers.

Pan L, Iliuk A, Yu S, Geahlen RL, Tao WA.

J Am Chem Soc. 2012 Nov 7;134(44):18201-4. doi: 10.1021/ja308453m. Epub 2012 Oct 24.


A peptide-based biosensor assay to detect intracellular Syk kinase activation and inhibition.

Lipchik AM, Killins RL, Geahlen RL, Parker LL.

Biochemistry. 2012 Sep 25;51(38):7515-24. doi: 10.1021/bi300970h. Epub 2012 Sep 12.


Synthesis of a phosphoserine mimetic prodrug with potent 14-3-3 protein inhibitory activity.

Arrendale A, Kim K, Choi JY, Li W, Geahlen RL, Borch RF.

Chem Biol. 2012 Jun 22;19(6):764-71. doi: 10.1016/j.chembiol.2012.05.011.


Sensitive kinase assay linked with phosphoproteomics for identifying direct kinase substrates.

Xue L, Wang WH, Iliuk A, Hu L, Galan JA, Yu S, Hans M, Geahlen RL, Tao WA.

Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5615-20. doi: 10.1073/pnas.1119418109. Epub 2012 Mar 26.


Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular stores.

Martin VA, Wang WH, Lipchik AM, Parker LL, He Y, Zhang S, Zhang ZY, Geahlen RL.

Cell Signal. 2012 May;24(5):1064-73. doi: 10.1016/j.cellsig.2012.01.001. Epub 2012 Jan 11.


The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2.

Moon KD, Zhang X, Zhou Q, Geahlen RL.

Biochim Biophys Acta. 2012 Feb;1823(2):199-205. doi: 10.1016/j.bbamcr.2011.10.001. Epub 2011 Oct 12.


Two closely spaced tyrosines regulate NFAT signaling in B cells via Syk association with Vav.

Chen CH, Martin VA, Gorenstein NM, Geahlen RL, Post CB.

Mol Cell Biol. 2011 Jul;31(14):2984-96. doi: 10.1128/MCB.05043-11. Epub 2011 May 23.


Proteomic studies of Syk-interacting proteins using a novel amine-specific isotope tag and GFP nanotrap.

Galan JA, Paris LL, Zhang HJ, Adler J, Geahlen RL, Tao WA.

J Am Soc Mass Spectrom. 2011 Feb;22(2):319-28. doi: 10.1007/s13361-010-0030-7. Epub 2011 Jan 28.


Regulation of Syk by phosphorylation on serine in the linker insert.

Paris LL, Hu J, Galan J, Ong SS, Martin VA, Ma H, Tao WA, Harrison ML, Geahlen RL.

J Biol Chem. 2010 Dec 17;285(51):39844-54. doi: 10.1074/jbc.M110.164509. Epub 2010 Oct 18.


Kinetics of NF-κB nucleocytoplasmic transport probed by single-cell screening without imaging.

Wang J, Fei B, Zhan Y, Geahlen RL, Lu C.

Lab Chip. 2010 Nov 7;10(21):2911-6. doi: 10.1039/c0lc00094a. Epub 2010 Sep 8.


Quantitative analysis of protein translocations by microfluidic total internal reflection fluorescence flow cytometry.

Wang J, Fei B, Geahlen RL, Lu C.

Lab Chip. 2010 Oct 21;10(20):2673-9. doi: 10.1039/c0lc00131g. Epub 2010 Aug 27.


In-depth analyses of kinase-dependent tyrosine phosphoproteomes based on metal ion-functionalized soluble nanopolymers.

Iliuk AB, Martin VA, Alicie BM, Geahlen RL, Tao WA.

Mol Cell Proteomics. 2010 Oct;9(10):2162-72. doi: 10.1074/mcp.M110.000091. Epub 2010 Jun 17.


One-step extraction of subcellular proteins from eukaryotic cells.

Zhan Y, Martin VA, Geahlen RL, Lu C.

Lab Chip. 2010 Aug 21;10(16):2046-8. doi: 10.1039/c005152g. Epub 2010 Jun 14.


Role of the protein tyrosine kinase Syk in regulating cell-cell adhesion and motility in breast cancer cells.

Zhang X, Shrikhande U, Alicie BM, Zhou Q, Geahlen RL.

Mol Cancer Res. 2009 May;7(5):634-44. doi: 10.1158/1541-7786.MCR-08-0371. Epub 2009 May 12.


Syk and pTyr'd: Signaling through the B cell antigen receptor.

Geahlen RL.

Biochim Biophys Acta. 2009 Jul;1793(7):1115-27. doi: 10.1016/j.bbamcr.2009.03.004. Epub 2009 Mar 21. Review.


The protein-tyrosine kinase Syk interacts with TRAF-interacting protein TRIP in breast epithelial cells.

Zhou Q, Geahlen RL.

Oncogene. 2009 Mar 12;28(10):1348-56. doi: 10.1038/onc.2008.493. Epub 2009 Jan 19.


Total internal reflection fluorescence flow cytometry.

Wang J, Bao N, Paris LL, Geahlen RL, Lu C.

Anal Chem. 2008 Dec 15;80(24):9840-4. doi: 10.1021/ac801940w.


Tyr130 phosphorylation triggers Syk release from antigen receptor by long-distance conformational uncoupling.

Zhang Y, Oh H, Burton RA, Burgner JW, Geahlen RL, Post CB.

Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11760-5. doi: 10.1073/pnas.0708583105. Epub 2008 Aug 8.


Detection of kinase translocation using microfluidic electroporative flow cytometry.

Wang J, Bao N, Paris LL, Wang HY, Geahlen RL, Lu C.

Anal Chem. 2008 Feb 15;80(4):1087-93. Epub 2007 Dec 22.


The microtubule-associated protein tau is phosphorylated by Syk.

Lebouvier T, Scales TM, Hanger DP, Geahlen RL, Lardeux B, Reynolds CH, Anderton BH, Derkinderen P.

Biochim Biophys Acta. 2008 Feb;1783(2):188-92. Epub 2007 Nov 21.


The SH3 domain of Lck modulates T-cell receptor-dependent activation of extracellular signal-regulated kinase through activation of Raf-1.

Li M, Ong SS, Rajwa B, Thieu VT, Geahlen RL, Harrison ML.

Mol Cell Biol. 2008 Jan;28(2):630-41. Epub 2007 Nov 12.


Generation of an analog-sensitive Syk tyrosine kinase for the study of signaling dynamics from the B cell antigen receptor.

Oh H, Ozkirimli E, Shah K, Harrison ML, Geahlen RL.

J Biol Chem. 2007 Nov 16;282(46):33760-8. Epub 2007 Oct 3.


A novel quantitative proteomics strategy to study phosphorylation-dependent peptide-protein interactions.

Zhou F, Galan J, Geahlen RL, Tao WA.

J Proteome Res. 2007 Jan;6(1):133-40.


Design and synthesis of phosphotyrosine peptidomimetic prodrugs.

Garrido-Hernandez H, Moon KD, Geahlen RL, Borch RF.

J Med Chem. 2006 Jun 1;49(11):3368-76.


Nucleocytoplasmic trafficking of the Syk protein tyrosine kinase.

Zhou F, Hu J, Ma H, Harrison ML, Geahlen RL.

Mol Cell Biol. 2006 May;26(9):3478-91.


Structural basis for the requirement of two phosphotyrosine residues in signaling mediated by Syk tyrosine kinase.

Groesch TD, Zhou F, Mattila S, Geahlen RL, Post CB.

J Mol Biol. 2006 Mar 10;356(5):1222-36. Epub 2005 Dec 27.


Effect of phosphorylation of ovalbumin on adsorption by aluminum-containing adjuvants and elution upon exposure to interstitial fluid.

Morefield GL, Jiang D, Romero-Mendez IZ, Geahlen RL, Hogenesch H, Hem SL.

Vaccine. 2005 Feb 10;23(12):1502-6.


Anti-sulfonylbenzoate antibodies as a tool for the detection of nucleotide-binding proteins for functional proteomics.

Moore LL, Fulton AM, Harrison ML, Geahlen RL.

J Proteome Res. 2004 Nov-Dec;3(6):1184-90.


Supplemental Content

Loading ...
Support Center