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Time and Cost of Hospitalisation for Salvage Therapy in Adults with Philadelphia Chromosome-Negative B Cell Precursor Relapsed or Refractory Acute Lymphoblastic Leukaemia in Spain.

Boluda B, Rodríguez-Veiga R, Martínez-Cuadrón D, Lorenzo I, Sanz J, Regadera A, Sempere A, Senent L, Cervera JV, Solves P, Reitan J, Gea S, Sanz MA, Montesinos P.

Pharmacoecon Open. 2019 Jun;3(2):229-235. doi: 10.1007/s41669-018-0098-8.


Diagnostic Biomarkers: Are We Moving from Discovery to Clinical Application?

Parker LA, Chilet-Rosell E, Hernández-Aguado I, Pastor-Valero M, Gea S, Lumbreras B.

Clin Chem. 2018 Nov;64(11):1657-1667. doi: 10.1373/clinchem.2018.292854. Epub 2018 Sep 13.


NLRP3 Inflammasome and Caspase-1/11 Pathway Orchestrate Different Outcomes in the Host Protection Against Trypanosoma cruzi Acute Infection.

Paroli AF, Gonzalez PV, Díaz-Luján C, Onofrio LI, Arocena A, Cano RC, Carrera-Silva EA, Gea S.

Front Immunol. 2018 May 3;9:913. doi: 10.3389/fimmu.2018.00913. eCollection 2018.


L-arginine supplementation reduces mortality and improves disease outcome in mice infected with Trypanosoma cruzi.

Carbajosa S, Rodríguez-Angulo HO, Gea S, Chillón-Marinas C, Poveda C, Maza MC, Colombet D, Fresno M, Gironès N.

PLoS Negl Trop Dis. 2018 Jan 16;12(1):e0006179. doi: 10.1371/journal.pntd.0006179. eCollection 2018 Jan.


Total Leishmania antigens with Poly(I:C) induce Th1 protective response.

Sanchez MV, Eliçabe RJ, Di Genaro MS, Germanó MJ, Gea S, García Bustos MF, Salomón MC, Scodeller EA, Cargnelutti DE.

Parasite Immunol. 2017 Nov;39(11). doi: 10.1111/pim.12491. Epub 2017 Oct 9.


Altered bone marrow lymphopoiesis and interleukin-6-dependent inhibition of thymocyte differentiation contribute to thymic atrophy during Trypanosoma cruzi infection.

Carbajosa S, Gea S, Chillón-Marinas C, Poveda C, Del Carmen Maza M, Fresno M, Gironès N.

Oncotarget. 2017 Mar 14;8(11):17551-17561. doi: 10.18632/oncotarget.14886.


IL-6 Improves the Nitric Oxide-Induced Cytotoxic CD8+ T Cell Dysfunction in Human Chagas Disease.

Sanmarco LM, Visconti LM, Eberhardt N, Ramello MC, Ponce NE, Spitale NB, Vozza ML, Bernardi GA, Gea S, Minguez AR, Aoki MP.

Front Immunol. 2016 Dec 23;7:626. doi: 10.3389/fimmu.2016.00626. eCollection 2016.


Chronic Trypanosoma cruzi infection potentiates adipose tissue macrophage polarization toward an anti-inflammatory M2 phenotype and contributes to diabetes progression in a diet-induced obesity model.

Cabalén ME, Cabral MF, Sanmarco LM, Andrada MC, Onofrio LI, Ponce NE, Aoki MP, Gea S, Cano RC.

Oncotarget. 2016 Mar 22;7(12):13400-15. doi: 10.18632/oncotarget.7630.


Trypanosoma cruzi infection is a potent risk factor for non-alcoholic steatohepatitis enhancing local and systemic inflammation associated with strong oxidative stress and metabolic disorders.

Onofrio LI, Arocena AR, Paroli AF, Cabalén ME, Andrada MC, Cano RC, Gea S.

PLoS Negl Trop Dis. 2015 Feb 10;9(2):e0003464. doi: 10.1371/journal.pntd.0003464. eCollection 2015 Feb.


Impact of tumor necrosis factor receptor p55 deficiency in susceptibility of C57BL/6 mice to infection with Leishmania (Leishmania) amazonensis.

Cargnelutti DE, Salomón MC, Celedon V, Cuello-Carrión FD, Gea S, Di Genaro MS, Scodeller EA.

J Microbiol Immunol Infect. 2016 Apr;49(2):271-5. doi: 10.1016/j.jmii.2014.03.009. Epub 2014 May 22.


Large volume injection in gas chromatography using the through oven transfer adsorption desorption interface operating under vacuum.

Aragón Á, Toledano RM, Gea S, Cortés JM, Vázquez AM, Villén J.

Talanta. 2014 Jun;123:39-44. doi: 10.1016/j.talanta.2014.01.064. Epub 2014 Feb 4.


Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma.

Morelatto R, Itoiz ME, Guiñazú N, Piccini D, Gea S, López-de Blanc S.

Med Oral Patol Oral Cir Bucal. 2014 May 1;19(3):e242-7.


Myeloid-derived suppressor cells are key players in the resolution of inflammation during a model of acute infection.

Arocena AR, Onofrio LI, Pellegrini AV, Carrera Silva AE, Paroli A, Cano RC, Aoki MP, Gea S.

Eur J Immunol. 2014 Jan;44(1):184-94. doi: 10.1002/eji.201343606. Epub 2013 Dec 2.


Mechanical and thermal properties of bacterial-cellulose-fibre-reinforced Mater-Bi(®) bionanocomposite.

Nainggolan H, Gea S, Bilotti E, Peijs T, Hutagalung SD.

Beilstein J Nanotechnol. 2013 May 23;4:325-9. doi: 10.3762/bjnano.4.37. Print 2013.


Trypanosoma cruzi, the causative agent of Chagas disease, modulates interleukin-6-induced STAT3 phosphorylation via gp130 cleavage in different host cells.

Ponce NE, Carrera-Silva EA, Pellegrini AV, Cazorla SI, Malchiodi EL, Lima AP, Gea S, Aoki MP.

Biochim Biophys Acta. 2013 Mar;1832(3):485-94. doi: 10.1016/j.bbadis.2012.12.003. Epub 2012 Dec 16.


In vitro activity of N-benzenesulfonylbenzotriazole on Trypanosoma cruzi epimastigote and trypomastigote forms.

Becerra MC, Guiñazú N, Hergert LY, Pellegrini A, Mazzieri MR, Gea S, Albesa I.

Exp Parasitol. 2012 May;131(1):57-62. doi: 10.1016/j.exppara.2012.02.028. Epub 2012 Mar 8.


The role of Toll-like receptors and adaptive immunity in the development of protective or pathological immune response triggered by the Trypanosoma cruzi protozoan.

Pellegrini A, Guiñazu N, Giordanengo L, Cano RC, Gea S.

Future Microbiol. 2011 Dec;6(12):1521-33. doi: 10.2217/fmb.11.122. Review.


Toll-like receptor-2 and interleukin-6 mediate cardiomyocyte protection from apoptosis during Trypanosoma cruzi murine infection.

Ponce NE, Cano RC, Carrera-Silva EA, Lima AP, Gea S, Aoki MP.

Med Microbiol Immunol. 2012 May;201(2):145-55. doi: 10.1007/s00430-011-0216-z. Epub 2011 Oct 9.


Nonimmune Cells Contribute to Crosstalk between Immune Cells and Inflammatory Mediators in the Innate Response to Trypanosoma cruzi Infection.

Aoki MP, Carrera-Silva EA, Cuervo H, Fresno M, Gironès N, Gea S.

J Parasitol Res. 2012;2012:737324. doi: 10.1155/2012/737324. Epub 2011 Aug 18.


Investigation into the structural, morphological, mechanical and thermal behaviour of bacterial cellulose after a two-step purification process.

Gea S, Reynolds CT, Roohpour N, Wirjosentono B, Soykeabkaew N, Bilotti E, Peijs T.

Bioresour Technol. 2011 Oct;102(19):9105-10. doi: 10.1016/j.biortech.2011.04.077. Epub 2011 Apr 29.


Trypanosoma cruzi antigen immunization induces a higher B cell survival in BALB/c mice, a susceptible strain, compared to C57BL/6 B lymphocytes, a resistant strain to cardiac autoimmunity.

Pellegrini A, Carrera-Silva EA, Arocena A, Cano RC, Aoki MP, Gea S.

Med Microbiol Immunol. 2011 Nov;200(4):209-18. doi: 10.1007/s00430-011-0192-3. Epub 2011 Mar 24.


Importance of TLR2 on hepatic immune and non-immune cells to attenuate the strong inflammatory liver response during Trypanosoma cruzi acute infection.

Carrera-Silva EA, Guiñazu N, Pellegrini A, Cano RC, Arocena A, Aoki MP, Gea S.

PLoS Negl Trop Dis. 2010 Nov 2;4(11):e863. doi: 10.1371/journal.pntd.0000863.


Association of clomipramine and allopurinol for the treatment of the experimental infection with Trypanosoma cruzi.

Gobbi P, Baez A, Lo Presti MS, Fernández AR, Enders JE, Fretes R, Gea S, Paglini-Oliva PA, Rivarola HW.

Parasitol Res. 2010 Oct;107(5):1279-83. doi: 10.1007/s00436-010-2002-z. Epub 2010 Aug 3.


Induction of NADPH oxidase activity and reactive oxygen species production by a single Trypanosoma cruzi antigen.

Guiñazú N, Carrera-Silva EA, Becerra MC, Pellegrini A, Albesa I, Gea S.

Int J Parasitol. 2010 Nov;40(13):1531-8. doi: 10.1016/j.ijpara.2010.05.012. Epub 2010 Jul 14.


Tympanic membrane boundary deformations derived from static displacements observed with computerized tomography in human and gerbil.

Gea SL, Decraemer WF, Funnell WR, Dirckx JJ, Maier H.

J Assoc Res Otolaryngol. 2010 Mar;11(1):1-17. doi: 10.1007/s10162-009-0192-9. Epub 2009 Oct 16. Erratum in: J Assoc Res Otolaryngol. 2010 Sep;11(3):525. Funnell, Robert W J [corrected to Funnell, W Robert J].


TLR2, TLR4 and TLR9 are differentially modulated in liver lethally injured from BALB/c and C57BL/6 mice during Trypanosoma cruzi acute infection.

Carrera-Silva EA, Cano RC, Guiñazú N, Aoki MP, Pellegrini A, Gea S.

Mol Immunol. 2008 Aug;45(13):3580-8. doi: 10.1016/j.molimm.2008.05.004. Epub 2008 Jun 18. Erratum in: Mol Immunol. 2012 Sep;52(2):96. Eugenio Antonio, Carrera-Silva [corrected to Carrera-Silva, Eugenio Antonio]; Carolina, Cano Roxana [corrected to Cano, Roxana Carolina]; Natalia, Guiñazu [corrected to Guiñazú, Natalia]; Pilar, Aoki Maria [corrected to Aoki, Maria Pilar]; Andrea, Pelle.


Inducible nitric oxide synthase and arginase expression in heart tissue during acute Trypanosoma cruzi infection in mice: arginase I is expressed in infiltrating CD68+ macrophages.

Cuervo H, Pineda MA, Aoki MP, Gea S, Fresno M, Gironès N.

J Infect Dis. 2008 Jun 15;197(12):1772-82. doi: 10.1086/529527.


Spleen B cells from BALB/c are more prone to activation than spleen B cells from C57BL/6 mice during a secondary immune response to cruzipain.

Pellegrini A, Guiñazú N, Aoki MP, Calero IC, Carrera-Silva EA, Girones N, Fresno M, Gea S.

Int Immunol. 2007 Dec;19(12):1395-402. Epub 2007 Oct 27.


Allopurinol is effective to modify the evolution of Trypanosoma cruzi infection in mice.

Gobbi P, Lo Presti MS, Fernández AR, Enders JE, Fretes R, Gea S, Paglini-Oliva PA, Rivarola HW.

Parasitol Res. 2007 Oct;101(5):1459-62. Epub 2007 Jul 10.


Immunisation with a major Trypanosoma cruzi antigen promotes pro-inflammatory cytokines, nitric oxide production and increases TLR2 expression.

Guiñazú N, Pellegrini A, Carrera-Silva EA, Aoki MP, Cabanillas AM, Gìronés N, Fresno M, Cano R, Gea S.

Int J Parasitol. 2007 Sep;37(11):1243-54. Epub 2007 Apr 6.


Cytokines and cell adhesion receptors in the regulation of immunity to Trypanosoma cruzi.

Savino W, Villa-Verde DM, Mendes-da-Cruz DA, Silva-Monteiro E, Perez AR, Aoki Mdel P, Bottasso O, Guiñazú N, Silva-Barbosa SD, Gea S.

Cytokine Growth Factor Rev. 2007 Feb-Apr;18(1-2):107-24. Epub 2007 Mar 6. Review.


Do Swiftlets have an ear for echolocation? The functional morphology of Swiftlets' middle ears.

Thomassen HA, Gea S, Maas S, Bout RG, Dirckx JJ, Decraemer WF, Povel GD.

Hear Res. 2007 Mar;225(1-2):25-37. Epub 2007 Jan 16.


Cardiovascular risk factors in chronic Chagas' disease are associated with a different profile of putative heart-pathogenic antibodies.

Diez C, Gea S, Marcipar I, Pezzotto SM, Beloscar J, Pellizzon O, Marcipar A, Bottasso O.

FEMS Immunol Med Microbiol. 2006 Oct;48(1):26-33.


Different signaling pathways are involved in cardiomyocyte survival induced by a Trypanosoma cruzi glycoprotein.

Aoki Mdel P, Cano RC, Pellegrini AV, Tanos T, Guiñazú NL, Coso OA, Gea S.

Microbes Infect. 2006 Jun;8(7):1723-31. Epub 2006 Apr 21.


Trypanosoma cruzi: chemotherapeutic effects of clomipramine in mice infected with an isolate obtained from an endemic area.

Rivarola HW, Bustamante JM, Lo Presti S, Fernández AR, Enders JE, Gea S, Fretes R, Paglini-Oliva P.

Exp Parasitol. 2005 Oct;111(2):80-6.


Immune response to a major Trypanosoma cruzi antigen, cruzipain, is differentially modulated in C57BL/6 and BALB/c mice.

Guiñazú N, Pellegrini A, Giordanengo L, Aoki MP, Rivarola HW, Cano R, Rodrigues MM, Gea S.

Microbes Infect. 2004 Nov;6(14):1250-8.


Immunosuppression, interleukin-10 synthesis and apoptosis are induced in rats inoculated with Cryptococcus neoformans glucuronoxylomannan.

Chiapello LS, Baronetti JL, Aoki MP, Gea S, Rubinstein H, Masih DT.

Immunology. 2004 Nov;113(3):392-400.


Thioridazine treatment prevents cardiopathy in Trypanosoma cruzi infected mice.

Lo Presti MS, Rivarola HW, Bustamante JM, Fernández AR, Enders JE, Fretes R, Gea S, Paglini-Oliva PA.

Int J Antimicrob Agents. 2004 Jun;23(6):634-6.


Cruzipain, a major Trypanosoma cruzi antigen, promotes arginase-2 expression and survival of neonatal mouse cardiomyocytes.

Aoki MP, Guiñazú NL, Pellegrini AV, Gotoh T, Masih DT, Gea S.

Am J Physiol Cell Physiol. 2004 Feb;286(2):C206-12. Epub 2003 Sep 17.


Cruzipain, a major Trypanosoma cruzi antigen, conditions the host immune response in favor of parasite.

Giordanengo L, Guiñazú N, Stempin C, Fretes R, Cerbán F, Gea S.

Eur J Immunol. 2002 Apr;32(4):1003-11.


Effects of clomipramine on Trypanosoma cruzi infection in mice.

Rivarola HW, Fernández AR, Enders JE, Fretes R, Gea S, Paglini-Oliva P.

Trans R Soc Trop Med Hyg. 2001 Sep-Oct;95(5):529-33.


Antibodies to an epitope from the Cha human autoantigen are markers of Chagas' disease.

Gironès N, Rodríguez CI, Basso B, Bellon JM, Resino S, Muñoz-Fernández MA, Gea S, Moretti E, Fresno M.

Clin Diagn Lab Immunol. 2001 Nov;8(6):1039-43.


Induction of antibodies reactive to cardiac myosin and development of heart alterations in cruzipain-immunized mice and their offspring.

Giordanengo L, Maldonado C, Rivarola HW, Iosa D, Girones N, Fresno M, Gea S.

Eur J Immunol. 2000 Nov;30(11):3181-9.


Cruzipain induces autoimmune response against skeletal muscle and tissue damage in mice.

Giordanengo L, Fretes R, Díaz H, Cano R, Bacile A, Vottero-Cima E, Gea S.

Muscle Nerve. 2000 Sep;23(9):1407-13.


Thioridazine treatment modifies the evolution of Trypanosoma cruzi infection in mice.

Rivarola HW, Fernández AR, Enders JE, Fretes R, Gea S, Suligoy M, Palma JA, Paglini-Oliva P.

Ann Trop Med Parasitol. 1999 Oct;93(7):695-702.


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