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Correction: LCE: an open web portal to explore gene expression and clinical associations in lung cancer.

Cai L, Lin S, Girard L, Zhou Y, Yang L, Ci B, Zhou Q, Luo D, Yao B, Tang H, Allen J, Huffman K, Gazdar A, Heymach J, Wistuba I, Xiao G, Minna J, Xie Y.

Oncogene. 2020 Jan;39(3):718-719. doi: 10.1038/s41388-019-1000-6.


ClickGene: an open cloud-based platform for big pan-cancer data genome-wide association study, visualization and exploration.

Bi JH, Tong YF, Qiu ZW, Yang XF, Minna J, Gazdar AF, Song K.

BioData Min. 2019 Jun 26;12:12. doi: 10.1186/s13040-019-0202-3. eCollection 2019.


Author Correction: Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data.

Rudin CM, Poirier JT, Byers LA, Dive C, Dowlati A, George J, Heymach JV, Johnson JE, Lehman JM, MacPherson D, Massion PP, Minna JD, Oliver TG, Quaranta V, Sage J, Thomas RK, Vakoc CR, Gazdar AF.

Nat Rev Cancer. 2019 Jul;19(7):415. doi: 10.1038/s41568-019-0164-2.


Comparison of four DLL3 antibodies performance in high grade neuroendocrine lung tumor samples and cell cultures.

Brcic L, Kuchler C, Eidenhammer S, Pabst D, Quehenberger F, Gazdar AF, Popper H.

Diagn Pathol. 2019 May 20;14(1):47. doi: 10.1186/s13000-019-0827-z.


Development and Validation of a Pathology Image Analysis-based Predictive Model for Lung Adenocarcinoma Prognosis - A Multi-cohort Study.

Luo X, Yin S, Yang L, Fujimoto J, Yang Y, Moran C, Kalhor N, Weissferdt A, Xie Y, Gazdar A, Minna J, Wistuba II, Mao Y, Xiao G.

Sci Rep. 2019 May 3;9(1):6886. doi: 10.1038/s41598-019-42845-z.


Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data.

Rudin CM, Poirier JT, Byers LA, Dive C, Dowlati A, George J, Heymach JV, Johnson JE, Lehman JM, MacPherson D, Massion PP, Minna JD, Oliver TG, Quaranta V, Sage J, Thomas RK, Vakoc CR, Gazdar AF.

Nat Rev Cancer. 2019 May;19(5):289-297. doi: 10.1038/s41568-019-0133-9. Review. Erratum in: Nat Rev Cancer. 2019 Jun 7;:.


Small cell lung cancers made from scratch.

Gazdar AF, Minna JD.

J Exp Med. 2019 Mar 4;216(3):476-478. doi: 10.1084/jem.20182216. Epub 2019 Feb 13.


LCE: an open web portal to explore gene expression and clinical associations in lung cancer.

Cai L, Lin S, Girard L, Zhou Y, Yang L, Ci B, Zhou Q, Luo D, Yao B, Tang H, Allen J, Huffman K, Gazdar A, Heymach J, Wistuba I, Xiao G, Minna J, Xie Y.

Oncogene. 2019 Apr;38(14):2551-2564. doi: 10.1038/s41388-018-0588-2. Epub 2018 Dec 7. Erratum in: Oncogene. 2019 Sep 9;:.


A quantitative method for assessing smoke associated molecular damage in lung cancers.

Song K, Bi JH, Qiu ZW, Felizardo R, Girard L, Minna JD, Gazdar AF.

Transl Lung Cancer Res. 2018 Aug;7(4):439-449. doi: 10.21037/tlcr.2018.07.01.


Preface: lung cancer in never smokers.

Gazdar AF.

Transl Lung Cancer Res. 2018 Aug;7(4):437-438. doi: 10.21037/tlcr.2018.06.06. No abstract available.


Crebbp Loss Drives Small Cell Lung Cancer and Increases Sensitivity to HDAC Inhibition.

Jia D, Augert A, Kim DW, Eastwood E, Wu N, Ibrahim AH, Kim KB, Dunn CT, Pillai SPS, Gazdar AF, Bolouri H, Park KS, MacPherson D.

Cancer Discov. 2018 Nov;8(11):1422-1437. doi: 10.1158/2159-8290.CD-18-0385. Epub 2018 Sep 4.


Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers.

Huang F, Ni M, Chalishazar MD, Huffman KE, Kim J, Cai L, Shi X, Cai F, Zacharias LG, Ireland AS, Li K, Gu W, Kaushik AK, Liu X, Gazdar AF, Oliver TG, Minna JD, Hu Z, DeBerardinis RJ.

Cell Metab. 2018 Sep 4;28(3):369-382.e5. doi: 10.1016/j.cmet.2018.06.005. Epub 2018 Jun 28.


Retraction notice to "Sun exposure related methylation in malignant and non-malignant skin lesions" [Cancer Letters 245/1-2 (2007) 112-120].

Sathyanarayana UG, Moore AY, Li L, Padar A, Majmudar K, Stastny V, Makarla P, Suzuki M, Minna JD, Feng Z, Gazdar AF.

Cancer Lett. 2018 Sep 28;432:272. doi: 10.1016/j.canlet.2018.07.010. No abstract available.


Comprehensive analysis of lung cancer pathology images to discover tumor shape and boundary features that predict survival outcome.

Wang S, Chen A, Yang L, Cai L, Xie Y, Fujimoto J, Gazdar A, Xiao G.

Sci Rep. 2018 Jul 10;8(1):10393. doi: 10.1038/s41598-018-27707-4.


A Bayesian hidden Potts mixture model for analyzing lung cancer pathology images.

Li Q, Wang X, Liang F, Yi F, Xie Y, Gazdar A, Xiao G.

Biostatistics. 2019 Oct 1;20(4):565-581. doi: 10.1093/biostatistics/kxy019.


Main bronchus location is a predictor for metastasis and prognosis in lung adenocarcinoma: A large cohort analysis.

Yang L, Wang S, Gerber DE, Zhou Y, Xu F, Liu J, Liang H, Xiao G, Zhou Q, Gazdar A, Xie Y.

Lung Cancer. 2018 Jun;120:22-26. doi: 10.1016/j.lungcan.2018.03.011. Epub 2018 Mar 19.


Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer.

McMillan EA, Ryu MJ, Diep CH, Mendiratta S, Clemenceau JR, Vaden RM, Kim JH, Motoyaji T, Covington KR, Peyton M, Huffman K, Wu X, Girard L, Sung Y, Chen PH, Mallipeddi PL, Lee JY, Hanson J, Voruganti S, Yu Y, Park S, Sudderth J, DeSevo C, Muzny DM, Doddapaneni H, Gazdar A, Gibbs RA, Hwang TH, Heymach JV, Wistuba I, Coombes KR, Williams NS, Wheeler DA, MacMillan JB, Deberardinis RJ, Roth MG, Posner BA, Minna JD, Kim HS, White MA.

Cell. 2018 May 3;173(4):864-878.e29. doi: 10.1016/j.cell.2018.03.028. Epub 2018 Apr 19.


Dysregulation of fibulin-5 and matrix metalloproteases in epithelial ovarian cancer.

Manders DB, Kishore HA, Gazdar AF, Keller PW, Tsunezumi J, Yanagisawa H, Lea J, Word RA.

Oncotarget. 2018 Feb 14;9(18):14251-14267. doi: 10.18632/oncotarget.24484. eCollection 2018 Mar 6.


Small cell lung cancer tumors and preclinical models display heterogeneity of neuroendocrine phenotypes.

Zhang W, Girard L, Zhang YA, Haruki T, Papari-Zareei M, Stastny V, Ghayee HK, Pacak K, Oliver TG, Minna JD, Gazdar AF.

Transl Lung Cancer Res. 2018 Feb;7(1):32-49. doi: 10.21037/tlcr.2018.02.02.


Morphologic and Other Forms of Heterogeneity in Small Cell Lung Cancer: What Can We Learn from Them?

Gazdar AF.

J Thorac Oncol. 2018 Feb;13(2):148-150. doi: 10.1016/j.jtho.2017.11.004. No abstract available.


The Epithelial Sodium Channel (αENaC) Is a Downstream Therapeutic Target of ASCL1 in Pulmonary Neuroendocrine Tumors.

He M, Liu S, Gallolu Kankanamalage S, Borromeo MD, Girard L, Gazdar AF, Minna JD, Johnson JE, Cobb MH.

Transl Oncol. 2018 Apr;11(2):292-299. doi: 10.1016/j.tranon.2018.01.004. Epub 2018 Feb 2.


Small-cell lung cancer: what we know, what we need to know and the path forward.

Gazdar AF, Bunn PA, Minna JD.

Nat Rev Cancer. 2017 Nov 10;17(12):765. doi: 10.1038/nrc.2017.106. [Epub ahead of print]


Small-cell lung cancer: what we know, what we need to know and the path forward.

Gazdar AF, Bunn PA, Minna JD.

Nat Rev Cancer. 2017 Dec;17(12):725-737. doi: 10.1038/nrc.2017.87. Epub 2017 Oct 27. Review. Erratum in: Nat Rev Cancer. 2017 Nov 10;:.


Meta-analysis approaches to combine multiple gene set enrichment studies.

Lu W, Wang X, Zhan X, Gazdar A.

Stat Med. 2018 Feb 20;37(4):659-672. doi: 10.1002/sim.7540. Epub 2017 Oct 19.


Evaluation of the 7th and 8th editions of the AJCC/UICC TNM staging systems for lung cancer in a large North American cohort.

Yang L, Wang S, Zhou Y, Lai S, Xiao G, Gazdar A, Xie Y.

Oncotarget. 2017 May 24;8(40):66784-66795. doi: 10.18632/oncotarget.18158. eCollection 2017 Sep 15.


GLI1 Blockade Potentiates the Antitumor Activity of PI3K Antagonists in Lung Squamous Cell Carcinoma.

Kasiri S, Shao C, Chen B, Wilson AN, Yenerall P, Timmons BC, Girard L, Tian H, Behrens C, Wistuba II, Gazdar AF, Kim J.

Cancer Res. 2017 Aug 15;77(16):4448-4459. doi: 10.1158/0008-5472.CAN-16-3315. Epub 2017 Jun 26.


Integrative gene set enrichment analysis utilizing isoform-specific expression.

Li L, Wang X, Xiao G, Gazdar A.

Genet Epidemiol. 2017 Sep;41(6):498-510. doi: 10.1002/gepi.22052. Epub 2017 Jun 4.


Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors.

Dalvi MP, Wang L, Zhong R, Kollipara RK, Park H, Bayo J, Yenerall P, Zhou Y, Timmons BC, Rodriguez-Canales J, Behrens C, Mino B, Villalobos P, Parra ER, Suraokar M, Pataer A, Swisher SG, Kalhor N, Bhanu NV, Garcia BA, Heymach JV, Coombes K, Xie Y, Girard L, Gazdar AF, Kittler R, Wistuba II, Minna JD, Martinez ED.

Cell Rep. 2017 May 23;19(8):1669-1684. doi: 10.1016/j.celrep.2017.04.077.


Genome-wide copy number variation pattern analysis and a classification signature for non-small cell lung cancer.

Qiu ZW, Bi JH, Gazdar AF, Song K.

Genes Chromosomes Cancer. 2017 Jul;56(7):559-569. doi: 10.1002/gcc.22460. Epub 2017 May 4.


Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is frequently over-expressed and functions as an oncogene in several tumor types.

Windhorst S, Song K, Gazdar AF.

Biochem Pharmacol. 2017 Aug 1;137:1-9. doi: 10.1016/j.bcp.2017.03.023. Epub 2017 Apr 2. Review.


Role of CPS1 in Cell Growth, Metabolism and Prognosis in LKB1-Inactivated Lung Adenocarcinoma.

Çeliktas M, Tanaka I, Tripathi SC, Fahrmann JF, Aguilar-Bonavides C, Villalobos P, Delgado O, Dhillon D, Dennison JB, Ostrin EJ, Wang H, Behrens C, Do KA, Gazdar AF, Hanash SM, Taguchi A.

J Natl Cancer Inst. 2017 Mar 1;109(3):1-9. doi: 10.1093/jnci/djw231.


Characterization of Human Cancer Cell Lines by Reverse-phase Protein Arrays.

Li J, Zhao W, Akbani R, Liu W, Ju Z, Ling S, Vellano CP, Roebuck P, Yu Q, Eterovic AK, Byers LA, Davies MA, Deng W, Gopal YN, Chen G, von Euw EM, Slamon D, Conklin D, Heymach JV, Gazdar AF, Minna JD, Myers JN, Lu Y, Mills GB, Liang H.

Cancer Cell. 2017 Feb 13;31(2):225-239. doi: 10.1016/j.ccell.2017.01.005.


Proportion of Never-Smoker Non-Small Cell Lung Cancer Patients at Three Diverse Institutions.

Pelosof L, Ahn C, Gao A, Horn L, Madrigales A, Cox J, McGavic D, Minna JD, Gazdar AF, Schiller J.

J Natl Cancer Inst. 2017 Jan 28;109(7). doi: 10.1093/jnci/djw295. Print 2017 Jan.


SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers.

Tagal V, Wei S, Zhang W, Brekken RA, Posner BA, Peyton M, Girard L, Hwang T, Wheeler DA, Minna JD, White MA, Gazdar AF, Roth MG.

Nat Commun. 2017 Jan 19;8:14098. doi: 10.1038/ncomms14098.


MYC Drives Progression of Small Cell Lung Cancer to a Variant Neuroendocrine Subtype with Vulnerability to Aurora Kinase Inhibition.

Mollaoglu G, Guthrie MR, Böhm S, Brägelmann J, Can I, Ballieu PM, Marx A, George J, Heinen C, Chalishazar MD, Cheng H, Ireland AS, Denning KE, Mukhopadhyay A, Vahrenkamp JM, Berrett KC, Mosbruger TL, Wang J, Kohan JL, Salama ME, Witt BL, Peifer M, Thomas RK, Gertz J, Johnson JE, Gazdar AF, Wechsler-Reya RJ, Sos ML, Oliver TG.

Cancer Cell. 2017 Feb 13;31(2):270-285. doi: 10.1016/j.ccell.2016.12.005. Epub 2017 Jan 12.


Non-malignant respiratory epithelial cells preferentially proliferate from resected non-small cell lung cancer specimens cultured under conditionally reprogrammed conditions.

Gao B, Huang C, Kernstine K, Pelekanou V, Kluger Y, Jiang T, Peters-Hall JR, Coquelin M, Girard L, Zhang W, Huffman K, Oliver D, Kinose F, Haura E, Teer JK, Rix U, Le AT, Aisner DL, Varella-Garcia M, Doebele RC, Covington KR, Hampton OA, Doddapaneni HV, Jayaseelan JC, Hu J, Wheeler DA, Shay JW, Rimm DL, Gazdar A, Minna JD.

Oncotarget. 2017 Feb 14;8(7):11114-11126. doi: 10.18632/oncotarget.14366.


SHOX2 is a Potent Independent Biomarker to Predict Survival of WHO Grade II-III Diffuse Gliomas.

Zhang YA, Zhou Y, Luo X, Song K, Ma X, Sathe A, Girard L, Xiao G, Gazdar AF.

EBioMedicine. 2016 Nov;13:80-89. doi: 10.1016/j.ebiom.2016.10.040. Epub 2016 Oct 28.


Comprehensive Computational Pathological Image Analysis Predicts Lung Cancer Prognosis.

Luo X, Zang X, Yang L, Huang J, Liang F, Rodriguez-Canales J, Wistuba II, Gazdar A, Xie Y, Xiao G.

J Thorac Oncol. 2017 Mar;12(3):501-509. doi: 10.1016/j.jtho.2016.10.017. Epub 2016 Nov 4.


ZEB1 drives epithelial-to-mesenchymal transition in lung cancer.

Larsen JE, Nathan V, Osborne JK, Farrow RK, Deb D, Sullivan JP, Dospoy PD, Augustyn A, Hight SK, Sato M, Girard L, Behrens C, Wistuba II, Gazdar AF, Hayward NK, Minna JD.

J Clin Invest. 2016 Sep 1;126(9):3219-35. doi: 10.1172/JCI76725. Epub 2016 Aug 8.


ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs.

Borromeo MD, Savage TK, Kollipara RK, He M, Augustyn A, Osborne JK, Girard L, Minna JD, Gazdar AF, Cobb MH, Johnson JE.

Cell Rep. 2016 Aug 2;16(5):1259-1272. doi: 10.1016/j.celrep.2016.06.081. Epub 2016 Jul 21.


An Expression Signature as an Aid to the Histologic Classification of Non-Small Cell Lung Cancer.

Girard L, Rodriguez-Canales J, Behrens C, Thompson DM, Botros IW, Tang H, Xie Y, Rekhtman N, Travis WD, Wistuba II, Minna JD, Gazdar AF.

Clin Cancer Res. 2016 Oct 1;22(19):4880-4889. Epub 2016 Jun 28.


Correction: "From Mice to Men and Back: An Assessment of Preclinical Model Systems for the Study of Lung Cancers".

Gazdar AF, Hirsch FR, Minna JD.

J Thorac Oncol. 2016 Jul;11(7):e88-9. doi: 10.1016/j.jtho.2016.04.003. No abstract available.


Genetic requirement for Mycl and efficacy of RNA Pol I inhibition in mouse models of small cell lung cancer.

Kim DW, Wu N, Kim YC, Cheng PF, Basom R, Kim D, Dunn CT, Lee AY, Kim K, Lee CS, Singh A, Gazdar AF, Harris CR, Eisenman RN, Park KS, MacPherson D.

Genes Dev. 2016 Jun 1;30(11):1289-99. doi: 10.1101/gad.279307.116.


A comprehensively characterized cell line panel highly representative of clinical ovarian high-grade serous carcinomas.

Thu KL, Papari-Zareei M, Stastny V, Song K, Peyton M, Martinez VD, Zhang YA, Castro IB, Varella-Garcia M, Liang H, Xing C, Kittler R, Milchgrub S, Castrillon DH, Davidson HL, Reynolds CP, Lam WL, Lea J, Gazdar AF.

Oncotarget. 2016 Jun 10;8(31):50489-50499. doi: 10.18632/oncotarget.9929. eCollection 2017 Aug 1.


A statistical method for detecting differentially expressed SNVs based on next-generation RNA-seq data.

Fu R, Wang P, Ma W, Taguchi A, Wong CH, Zhang Q, Gazdar A, Hanash SM, Zhou Q, Zhong H, Feng Z.

Biometrics. 2017 Mar;73(1):42-51. doi: 10.1111/biom.12548. Epub 2016 Jun 8.


Developing New, Rational Therapies for Recalcitrant Small Cell Lung Cancer.

Gazdar AF, Minna JD.

J Natl Cancer Inst. 2016 May 31;108(10). pii: djw119. doi: 10.1093/jnci/djw119. Print 2016 Oct. No abstract available.


ITPKA Gene Body Methylation Regulates Gene Expression and Serves as an Early Diagnostic Marker in Lung and Other Cancers.

Wang YW, Ma X, Zhang YA, Wang MJ, Yatabe Y, Lam S, Girard L, Chen JY, Gazdar AF.

J Thorac Oncol. 2016 Sep;11(9):1469-81. doi: 10.1016/j.jtho.2016.05.010. Epub 2016 May 24.


Telomerase inhibitor imetelstat has preclinical activity across the spectrum of non-small cell lung cancer oncogenotypes in a telomere length dependent manner.

Frink RE, Peyton M, Schiller JH, Gazdar AF, Shay JW, Minna JD.

Oncotarget. 2016 May 31;7(22):31639-51. doi: 10.18632/oncotarget.9335.


Inhibiting the Jumonji family: a potential new clinical approach to targeting aberrant epigenetic mechanisms.

Martinez ED, Gazdar AF.

Epigenomics. 2016 Mar;8(3):313-6. doi: 10.2217/epi.15.115. Epub 2016 Feb 26. No abstract available.


Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?

Bunn PA Jr, Minna JD, Augustyn A, Gazdar AF, Ouadah Y, Krasnow MA, Berns A, Brambilla E, Rekhtman N, Massion PP, Niederst M, Peifer M, Yokota J, Govindan R, Poirier JT, Byers LA, Wynes MW, McFadden DG, MacPherson D, Hann CL, Farago AF, Dive C, Teicher BA, Peacock CD, Johnson JE, Cobb MH, Wendel HG, Spigel D, Sage J, Yang P, Pietanza MC, Krug LM, Heymach J, Ujhazy P, Zhou C, Goto K, Dowlati A, Christensen CL, Park K, Einhorn LH, Edelman MJ, Giaccone G, Gerber DE, Salgia R, Owonikoko T, Malik S, Karachaliou N, Gandara DR, Slotman BJ, Blackhall F, Goss G, Thomas R, Rudin CM, Hirsch FR.

J Thorac Oncol. 2016 Apr;11(4):453-74. doi: 10.1016/j.jtho.2016.01.012. Epub 2016 Jan 30. Review. No abstract available.

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