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Defining HLA-II Ligand Processing and Binding Rules with Mass Spectrometry Enhances Cancer Epitope Prediction.

Abelin JG, Harjanto D, Malloy M, Suri P, Colson T, Goulding SP, Creech AL, Serrano LR, Nasir G, Nasrullah Y, McGann CD, Velez D, Ting YS, Poran A, Rothenberg DA, Chhangawala S, Rubinsteyn A, Hammerbacher J, Gaynor RB, Fritsch EF, Greshock J, Oslund RC, Barthelme D, Addona TA, Arieta CM, Rooney MS.

Immunity. 2019 Oct 15;51(4):766-779.e17. doi: 10.1016/j.immuni.2019.08.012. Epub 2019 Sep 5.


The impact of industry on oncology research and practice.

Moy B, Jagsi R, Gaynor RB, Ratain MJ.

Am Soc Clin Oncol Educ Book. 2015:130-7. doi: 10.14694/EdBook_AM.2015.35.130. Review.


AACR Cancer Progress Report 2014.

Arteaga CL, Adamson PC, Engelman JA, Foti M, Gaynor RB, Hilsenbeck SG, Limburg PJ, Lowe SW, Mardis ER, Ramsey S, Rebbeck TR, Richardson AL, Rubin EH, Weiner GJ.

Clin Cancer Res. 2014 Oct 1;20(19 Suppl):S1-S112. doi: 10.1158/1078-0432.CCR-14-2123. Epub 2014 Sep 16. No abstract available.


A novel CDK9 inhibitor shows potent antitumor efficacy in preclinical hematologic tumor models.

Yin T, Lallena MJ, Kreklau EL, Fales KR, Carballares S, Torrres R, Wishart GN, Ajamie RT, Cronier DM, Iversen PW, Meier TI, Foreman RT, Zeckner D, Sissons SE, Halstead BW, Lin AB, Donoho GP, Qian Y, Li S, Wu S, Aggarwal A, Ye XS, Starling JJ, Gaynor RB, de Dios A, Du J.

Mol Cancer Ther. 2014 Jun;13(6):1442-56. doi: 10.1158/1535-7163.MCT-13-0849. Epub 2014 Mar 31.


Turning the tide against cancer through sustained medical innovation: the pathway to progress.

Abernethy A, Abrahams E, Barker A, Buetow K, Burkholder R, Dalton WS, Foti M, Frueh F, Gaynor RB, Kean M, Khan Z, Lessor T, Lichtenfeld JL, Mendelsohn J, van't Veer L.

Clin Cancer Res. 2014 Mar 1;20(5):1081-6. doi: 10.1158/1078-0432.CCR-13-3430. Epub 2014 Feb 12. Review.


IKKalpha regulates the mitotic phase of the cell cycle by modulating Aurora A phosphorylation.

Prajapati S, Tu Z, Yamamoto Y, Gaynor RB.

Cell Cycle. 2006 Oct;5(20):2371-80. Epub 2006 Oct 16.


IKK alpha regulates estrogen-induced cell cycle progression by modulating E2F1 expression.

Tu Z, Prajapati S, Park KJ, Kelly NJ, Yamamoto Y, Gaynor RB.

J Biol Chem. 2006 Mar 10;281(10):6699-706. Epub 2006 Jan 5.


Exclusive ubiquitination and sumoylation on overlapping lysine residues mediate NF-kappaB activation by the human T-cell leukemia virus tax oncoprotein.

Lamsoul I, Lodewick J, Lebrun S, Brasseur R, Burny A, Gaynor RB, Bex F.

Mol Cell Biol. 2005 Dec;25(23):10391-406.


Selective identification of secreted and transmembrane breast cancer markers using Escherichia coli ampicillin secretion trap.

Ferguson DA, Muenster MR, Zang Q, Spencer JA, Schageman JJ, Lian Y, Garner HR, Gaynor RB, Huff JW, Pertsemlidis A, Ashfaq R, Schorge J, Becerra C, Williams NS, Graff JM.

Cancer Res. 2005 Sep 15;65(18):8209-17.


Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activation.

Park KJ, Krishnan V, O'Malley BW, Yamamoto Y, Gaynor RB.

Mol Cell. 2005 Apr 1;18(1):71-82.


Enhanced chemosensitivity to irinotecan by RNA interference-mediated down-regulation of the nuclear factor-kappaB p65 subunit.

Guo J, Verma UN, Gaynor RB, Frenkel EP, Becerra CR.

Clin Cancer Res. 2004 May 15;10(10):3333-41.


IkappaB kinases: key regulators of the NF-kappaB pathway.

Yamamoto Y, Gaynor RB.

Trends Biochem Sci. 2004 Feb;29(2):72-9. Review.


Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling.

Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K.

EMBO J. 2003 Dec 1;22(23):6277-88.


A role for extracellular matrix binding receptors in regulating hematopoietic growth factor signaling.

Gaynor RB.

Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13737-8. Epub 2003 Nov 17. No abstract available.


Nuclear role of I kappa B Kinase-gamma/NF-kappa B essential modulator (IKK gamma/NEMO) in NF-kappa B-dependent gene expression.

Verma UN, Yamamoto Y, Prajapati S, Gaynor RB.

J Biol Chem. 2004 Jan 30;279(5):3509-15. Epub 2003 Nov 3.


Protein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activity.

Prajapati S, Verma U, Yamamoto Y, Kwak YT, Gaynor RB.

J Biol Chem. 2004 Jan 16;279(3):1739-46. Epub 2003 Oct 29.


Functional correlates of mutations in beta-catenin exon 3 phosphorylation sites.

Provost E, Yamamoto Y, Lizardi I, Stern J, D'Aquila TG, Gaynor RB, Rimm DL.

J Biol Chem. 2003 Aug 22;278(34):31781-9. Epub 2003 Jun 10.


Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression.

Yamamoto Y, Verma UN, Prajapati S, Kwak YT, Gaynor RB.

Nature. 2003 Jun 5;423(6940):655-9.


Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties.

Kwak YT, Guo J, Prajapati S, Park KJ, Surabhi RM, Miller B, Gehrig P, Gaynor RB.

Mol Cell. 2003 Apr;11(4):1055-66.


Small interfering RNAs directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells.

Verma UN, Surabhi RM, Schmaltieg A, Becerra C, Gaynor RB.

Clin Cancer Res. 2003 Apr;9(4):1291-300.


Identification of NF-kappa B-regulated genes induced by TNFalpha utilizing expression profiling and RNA interference.

Zhou A, Scoggin S, Gaynor RB, Williams NS.

Oncogene. 2003 Apr 3;22(13):2054-64. Erratum in: Oncogene. 2004 Dec 16;23(58):9447.


Identification and validation of genes involved in the pathogenesis of colorectal cancer using cDNA microarrays and RNA interference.

Williams NS, Gaynor RB, Scoggin S, Verma U, Gokaslan T, Simmang C, Fleming J, Tavana D, Frenkel E, Becerra C.

Clin Cancer Res. 2003 Mar;9(3):931-46.


IKKalpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf.

Albanese C, Wu K, D'Amico M, Jarrett C, Joyce D, Hughes J, Hulit J, Sakamaki T, Fu M, Ben-Ze'ev A, Bromberg JF, Lamberti C, Verma U, Gaynor RB, Byers SW, Pestell RG.

Mol Biol Cell. 2003 Feb;14(2):585-99.


TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway.

Takaesu G, Surabhi RM, Park KJ, Ninomiya-Tsuji J, Matsumoto K, Gaynor RB.

J Mol Biol. 2003 Feb 7;326(1):105-15.


Constitutive activation of NF-kappaB in Ki-ras-transformed prostate epithelial cells.

Kim BY, Gaynor RB, Song K, Dritschilo A, Jung M.

Oncogene. 2002 Jul 4;21(29):4490-7.


Regulation of Ikappa B kinase (IKK)gamma /NEMO function by IKKbeta -mediated phosphorylation.

Prajapati S, Gaynor RB.

J Biol Chem. 2002 Jul 5;277(27):24331-9. Epub 2002 Apr 23.


I-kappa B kinases alpha and beta have distinct roles in regulating murine T cell function.

Ren H, Schmalstieg A, van Oers NS, Gaynor RB.

J Immunol. 2002 Apr 15;168(8):3721-31.


Role of the NF-kappaB pathway in the pathogenesis of human disease states.

Yamamoto Y, Gaynor RB.

Curr Mol Med. 2001 Jul;1(3):287-96. Review.


Sulindac enhances tumor necrosis factor-alpha-mediated apoptosis of lung cancer cell lines by inhibition of nuclear factor-kappaB.

Berman KS, Verma UN, Harburg G, Minna JD, Cobb MH, Gaynor RB.

Clin Cancer Res. 2002 Feb;8(2):354-60.


I-kappa B kinase beta is critical for B cell proliferation and antibody response.

Ren H, Schmalstieg A, Yuan D, Gaynor RB.

J Immunol. 2002 Jan 15;168(2):577-87.


Regulation of beta-catenin function by the IkappaB kinases.

Lamberti C, Lin KM, Yamamoto Y, Verma U, Verma IM, Byers S, Gaynor RB.

J Biol Chem. 2001 Nov 9;276(45):42276-86. Epub 2001 Aug 29.


IKKgamma /NEMO facilitates the recruitment of the IkappaB proteins into the IkappaB kinase complex.

Yamamoto Y, Kim DW, Kwak YT, Prajapati S, Verma U, Gaynor RB.

J Biol Chem. 2001 Sep 28;276(39):36327-36. Epub 2001 Jul 24.


Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer.

Yamamoto Y, Gaynor RB.

J Clin Invest. 2001 Jan;107(2):135-42. Review. No abstract available.


Mechanisms of NF-kappaB activation by the HTLV type 1 tax protein.

Li XH, Gaynor RB.

AIDS Res Hum Retroviruses. 2000 Nov 1;16(16):1583-90. Review.


Role of IKKgamma/nemo in assembly of the Ikappa B kinase complex.

Li XH, Fang X, Gaynor RB.

J Biol Chem. 2001 Feb 9;276(6):4494-500. Epub 2000 Nov 15.


IkappaB kinase alpha (IKKalpha) regulation of IKKbeta kinase activity.

Yamamoto Y, Yin MJ, Gaynor RB.

Mol Cell Biol. 2000 May;20(10):3655-66.


Domains in the SPT5 protein that modulate its transcriptional regulatory properties.

Ivanov D, Kwak YT, Guo J, Gaynor RB.

Mol Cell Biol. 2000 May;20(9):2970-83.


Analysis of domains in the IKKalpha and IKKbeta proteins that regulate their kinase activity.

Kwak YT, Guo J, Shen J, Gaynor RB.

J Biol Chem. 2000 May 12;275(19):14752-9.


The human T-cell leukemia virus type-1 Tax protein regulates the activity of the IkappaB kinase complex.

Li XH, Murphy KM, Palka KT, Surabhi RM, Gaynor RB.

J Biol Chem. 1999 Nov 26;274(48):34417-24.


Sulindac inhibits activation of the NF-kappaB pathway.

Yamamoto Y, Yin MJ, Lin KM, Gaynor RB.

J Biol Chem. 1999 Sep 17;274(38):27307-14.


Regulation of NF-kappaB by the HTLV-1 Tax protein.

Li XH, Gaynor RB.

Gene Expr. 1999;7(4-6):233-45. Review.


Role of the human and murine cyclin T proteins in regulating HIV-1 tat-activation.

Kwak YT, Ivanov D, Guo J, Nee E, Gaynor RB.

J Mol Biol. 1999 Apr 23;288(1):57-69.


Cyclin T1 domains involved in complex formation with Tat and TAR RNA are critical for tat-activation.

Ivanov D, Kwak YT, Nee E, Guo J, García-Martínez LF, Gaynor RB.

J Mol Biol. 1999 Apr 23;288(1):41-56.


Functional domains of Tat required for efficient human immunodeficiency virus type 1 reverse transcription.

Ulich C, Dunne A, Parry E, Hooker CW, Gaynor RB, Harrich D.

J Virol. 1999 Mar;73(3):2499-508.


The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta.

Yin MJ, Yamamoto Y, Gaynor RB.

Nature. 1998 Nov 5;396(6706):77-80.


Regulation of gene expression by HTLV-I Tax protein.

Bex F, Gaynor RB.

Methods. 1998 Sep;16(1):83-94. Review.


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