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Items: 1 to 50 of 89

1.

Development and validation of LC-MS/MS method for quantification of novel PP2A - β-catenin signalling inhibitor, S011-2111 in mice plasma: Application to its preclinical pharmacokinetic studies.

Riyazuddin M, Husain A, Valicherla GR, Verma S, Gupta AP, Praveena KS, Singh A, Avula SR, Sashidhara KV, Datta D, Gayen JR.

J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Nov 1;1130-1131:121829. doi: 10.1016/j.jchromb.2019.121829. Epub 2019 Oct 21.

PMID:
31670104
2.

LC-ESI-MS/MS method for the simultaneous determination of isoformononetin, daidzein, and equol in rat plasma: Application to a preclinical pharmacokinetic study.

Raju KSR, Rashid M, Gundeti M, Taneja I, Malik MY, Singh SK, Chaturvedi S, Challagundla M, Singh SP, Gayen JR, Wahajuddin M.

J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Oct 15;1129:121776. doi: 10.1016/j.jchromb.2019.121776. Epub 2019 Aug 28.

PMID:
31629309
3.

Pharmacokinetics and brain targeting of trans-resveratrol loaded mixed micelles in rats following intravenous administration.

Katekar R, Thombre G, Riyazuddin M, Husain A, Rani H, Praveena KS, Gayen JR.

Pharm Dev Technol. 2019 Nov 27:1-8. doi: 10.1080/10837450.2019.1680690. [Epub ahead of print]

PMID:
31609159
4.

Pancreastatin inhibitor PSTi8 attenuates hyperinsulinemia induced obesity and inflammation mediated insulin resistance via MAPK/NOX3-JNK pathway.

Gupta AP, Syed AA, Garg R, Goand UK, Singh P, Riyazuddin M, Valicherla GR, Husain A, Gayen JR.

Eur J Pharmacol. 2019 Dec 1;864:172723. doi: 10.1016/j.ejphar.2019.172723. Epub 2019 Oct 3.

PMID:
31586632
5.

Pancreastatin inhibitor, PSTi8 ameliorates metabolic health by modulating AKT/GSK-3β and PKCλ/ζ/SREBP1c pathways in high fat diet induced insulin resistance in peri-/post-menopausal rats.

Valicherla GR, Gupta AP, Hossain Z, Riyazuddin M, Syed AA, Husain A, Lahiri S, Dave KM, Gayen JR.

Peptides. 2019 Oct;120:170147. doi: 10.1016/j.peptides.2019.170147. Epub 2019 Aug 29.

PMID:
31473204
6.

Increased bone marrow-specific adipogenesis by clofazimine causes impaired fracture healing, osteopenia and osteonecrosis without extra-skeletal effects in rats.

Porwal K, Pal S, Tewari D, Pal China S, Singh P, Tewari M, Prajapati G, Singh P, Cheruvu S, Khan YA, Sanyal S, Gayen JR, Ampapathi R, Mridha AR, Chattopadhyay N.

Toxicol Sci. 2019 Aug 8. pii: kfz172. doi: 10.1093/toxsci/kfz172. [Epub ahead of print]

PMID:
31393584
7.

Leprosy drug clofazimine activates peroxisome proliferator-activated receptor-γ and synergizes with imatinib to inhibit chronic myeloid leukemia cells.

Kumar H, Chattopadhyay S, Das N, Shree S, Patel D, Mohapatra J, Gurjar A, Kushwaha S, Singh AK, Dubey S, Lata K, Kushwaha R, Mohammed R, Ghosh Dastidar K, Yadav N, Vishwakarma AL, Gayen JR, Bandyopadhyay S, Chatterjee A, Jain MR, Tripathi AK, Trivedi AK, Chattopadhyay N, Ramachandran R, Sanyal S.

Haematologica. 2019 Aug 1. pii: haematol.2018.194910. doi: 10.3324/haematol.2018.194910. [Epub ahead of print]

8.

A nutraceutical composition containing diosmin and hesperidin has osteogenic and anti-resorptive effects and expands the anabolic window of teriparatide.

Bhattacharyya S, Pal S, Mohamed R, Singh P, Chattopadhyay S, Pal China S, Porwal K, Sanyal S, Gayen JR, Chattopadhyay N.

Biomed Pharmacother. 2019 Oct;118:109207. doi: 10.1016/j.biopha.2019.109207. Epub 2019 Jul 12.

9.

Fructose-induced AGEs-RAGE signaling in skeletal muscle contributes to impairment of glucose homeostasis.

Rai AK, Jaiswal N, Maurya CK, Sharma A, Ahmad I, Ahmad S, Gupta AP, Gayen JR, Tamrakar AK.

J Nutr Biochem. 2019 Sep;71:35-44. doi: 10.1016/j.jnutbio.2019.05.016. Epub 2019 Jun 8.

PMID:
31272030
10.

Pancreastatin inhibitor activates AMPK pathway via GRP78 and ameliorates dexamethasone induced fatty liver disease in C57BL/6 mice.

Gupta AP, Singh P, Garg R, Valicherla GR, Riyazuddin M, Syed AA, Hossain Z, Gayen JR.

Biomed Pharmacother. 2019 Aug;116:108959. doi: 10.1016/j.biopha.2019.108959. Epub 2019 May 17.

11.

Neuropharmacokinetics: a bridging tool between CNS drug development and therapeutic outcome.

Chaturvedi S, Rashid M, Malik MY, Agarwal A, Singh SK, Gayen JR, Wahajuddin M.

Drug Discov Today. 2019 May;24(5):1166-1175. doi: 10.1016/j.drudis.2019.02.007. Epub 2019 Mar 18. Review.

PMID:
30898661
12.

Role of brown adipose tissue in modulating adipose tissue inflammation and insulin resistance in high-fat diet fed mice.

Shankar K, Kumar D, Gupta S, Varshney S, Rajan S, Srivastava A, Gupta A, Gupta AP, Vishwakarma AL, Gayen JR, Gaikwad AN.

Eur J Pharmacol. 2019 Jul 5;854:354-364. doi: 10.1016/j.ejphar.2019.02.044. Epub 2019 Feb 27.

PMID:
30822393
13.

Bioavailability Enhancement of Poorly Soluble Drugs: The Holy Grail in Pharma Industry.

Rashid M, Malik MY, Singh SK, Chaturvedi S, Gayen JR, Wahajuddin M.

Curr Pharm Des. 2019;25(9):987-1020. doi: 10.2174/1381612825666190130110653.

PMID:
30706801
14.

Rosiglitazone up-regulates glial fibrillary acidic protein via HB-EGF secreted from astrocytes and neurons through PPARγ pathway and reduces apoptosis in high-fat diet-fed mice.

Kushwaha R, Mishra J, Gupta AP, Gupta K, Vishwakarma J, Chattopadhyay N, Gayen JR, Kamthan M, Bandyopadhyay S.

J Neurochem. 2019 Jun;149(5):679-698. doi: 10.1111/jnc.14610. Epub 2018 Dec 7.

PMID:
30311190
15.

Determination of permeability, plasma protein binding, blood partitioning, pharmacokinetics and tissue distribution of Withanolide A in rats: A neuroprotective steroidal lactone.

Singh SK, Valicherla GR, Joshi P, Shahi S, Syed AA, Gupta AP, Hossain Z, Italiya K, Makadia V, Singh SK, Wahajuddin M, Gayen JR.

Drug Dev Res. 2018 Nov;79(7):339-351. doi: 10.1002/ddr.21463. Epub 2018 Oct 4.

PMID:
30284738
16.

Elucidation of pharmacokinetics of novel DNA ligase I inhibitor, S012-1332 in rats: Integration of in vitro and in vivo findings.

Riyazuddin M, Valicherla GR, Husain A, Hussain MK, Shukla M, Katekar R, Gupta AP, Singh P, Banerjee D, Hajela K, Gayen JR.

J Pharm Biomed Anal. 2019 Jan 5;162:205-214. doi: 10.1016/j.jpba.2018.09.031. Epub 2018 Sep 18.

PMID:
30265980
17.

Evaluation of oral pharmacokinetics, in vitro metabolism, blood partitioning and plasma protein binding of novel antidiabetic agent, S009-0629 in rats.

Valicherla GR, Italiya KS, Gupta CP, Mishra S, Riyazuddin M, Syed AA, Singh SK, Shahi S, Taneja G, Wahajuddin M, Goel A, Gayen JR.

Drug Dev Res. 2018 Jun;79(4):173-183. doi: 10.1002/ddr.21433.

PMID:
29989222
18.

Discovery of pancreastatin inhibitor PSTi8 for the treatment of insulin resistance and diabetes: studies in rodent models of diabetes mellitus.

Hossain Z, Valicherla GR, Gupta AP, Syed AA, Riyazuddin M, Chandra S, Siddiqi MI, Gayen JR.

Sci Rep. 2018 Jun 7;8(1):8715. doi: 10.1038/s41598-018-27018-8.

19.

Glucose and lipid metabolism alterations in liver and adipose tissue pre-dispose p47phox knockout mice to systemic insulin resistance.

Kanuri BN, Rebello SC, Pathak P, Agarwal H, Kanshana JS, Awasthi D, Gupta AP, Gayen JR, Jagavelu K, Dikshit M.

Free Radic Res. 2018 May;52(5):568-582. doi: 10.1080/10715762.2018.1453136. Epub 2018 Apr 3.

PMID:
29544378
20.

LC-MS/MS method for the simultaneous quantification of luteolin, wedelolactone and apigenin in mice plasma using hansen solubility parameters for liquid-liquid extraction: Application to pharmacokinetics of Eclipta alba chloroform fraction.

Cheruvu HS, Yadav NK, Valicherla GR, Arya RK, Hussain Z, Sharma C, Arya KR, Singh RK, Datta D, Gayen JR.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Apr 1;1081-1082:76-86. doi: 10.1016/j.jchromb.2018.01.035. Epub 2018 Jan 31.

PMID:
29518720
21.

Development and validation of UPLC-MS/MS assay for quantification of cladrin: Absolute bioavailability and dose proportionality study in rats.

Rashid M, Singh SK, Malik MY, Jahan S, Chaturvedi S, Taneja I, Raju KS, Naseem Z, Gayen JR, Wahajuddin M.

J Pharm Biomed Anal. 2018 Apr 15;152:289-297. doi: 10.1016/j.jpba.2018.01.044. Epub 2018 Jan 31.

PMID:
29454264
22.

Erratum. Pathophysiological Mechanism of Bone Loss in Type 2 Diabetes Involves Inverse Regulation of Osteoblast Function by PGC-1α and Skeletal Muscle Atrogenes: AdipoR1 as a Potential Target for Reversing Diabetes-Induced Osteopenia. Diabetes 2015;64:2609-2623.

Khan MP, Singh AK, Joharapurkar AA, Yadav M, Shree S, Kumar H, Gurjar A, Mishra JS, Tiwari MC, Nagar GK, Kumar S, Ramachandran R, Sharan A, Jain MR, Trivedi AK, Maurya R, Godbole MM, Gayen JR, Sanyal S, Chattopadhyay N.

Diabetes. 2017 Dec;66(12):3142-3143. doi: 10.2337/db17-er12b. Epub 2017 Oct 5. No abstract available.

23.

A Novel Benzocoumarin-Stilbene Hybrid as a DNA ligase I inhibitor with in vitro and in vivo anti-tumor activity in breast cancer models.

Hussain MK, Singh DK, Singh A, Asad M, Ansari MI, Shameem M, Krishna S, Valicherla GR, Makadia V, Meena S, Deshmukh AL, Gayen JR, Imran Siddiqi M, Datta D, Hajela K, Banerjee D.

Sci Rep. 2017 Sep 6;7(1):10715. doi: 10.1038/s41598-017-10864-3.

24.

Globular adiponectin reverses osteo-sarcopenia and altered body composition in ovariectomized rats.

China SP, Pal S, Chattopadhyay S, Porwal K, Kushwaha S, Bhattacharyya S, Mittal M, Gurjar AA, Barbhuyan T, Singh AK, Trivedi AK, Gayen JR, Sanyal S, Chattopadhyay N.

Bone. 2017 Dec;105:75-86. doi: 10.1016/j.bone.2017.08.005. Epub 2017 Aug 12.

PMID:
28811200
25.

Chitosan coated PluronicF127 micelles for effective delivery of Amphotericin B in experimental visceral leishmaniasis.

Singh PK, Pawar VK, Jaiswal AK, Singh Y, Srikanth CH, Chaurasia M, Bora HK, Raval K, Meher JG, Gayen JR, Dube A, Chourasia MK.

Int J Biol Macromol. 2017 Dec;105(Pt 1):1220-1231. doi: 10.1016/j.ijbiomac.2017.07.161. Epub 2017 Aug 3.

PMID:
28780414
26.

Isoalantolactone derivative promotes glucose utilization in skeletal muscle cells and increases energy expenditure in db/db mice via activating AMPK-dependent signaling.

Arha D, Ramakrishna E, Gupta AP, Rai AK, Sharma A, Ahmad I, Riyazuddin M, Gayen JR, Maurya R, Tamrakar AK.

Mol Cell Endocrinol. 2018 Jan 15;460:134-151. doi: 10.1016/j.mce.2017.07.015. Epub 2017 Jul 20.

PMID:
28736255
27.

Discovery of a Novel Small-Molecule Inhibitor that Targets PP2A-β-Catenin Signaling and Restricts Tumor Growth and Metastasis.

Maheshwari S, Avula SR, Singh A, Singh LR, Palnati GR, Arya RK, Cheruvu SH, Shahi S, Sharma T, Meena S, Singh AK, Kant R, Riyazuddin M, Bora HK, Siddiqi MI, Gayen JR, Sashidhara KV, Datta D.

Mol Cancer Ther. 2017 Sep;16(9):1791-1805. doi: 10.1158/1535-7163.MCT-16-0584. Epub 2017 May 12.

28.

Granin-derived peptides.

Troger J, Theurl M, Kirchmair R, Pasqua T, Tota B, Angelone T, Cerra MC, Nowosielski Y, Mätzler R, Troger J, Gayen JR, Trudeau V, Corti A, Helle KB.

Prog Neurobiol. 2017 Jul;154:37-61. doi: 10.1016/j.pneurobio.2017.04.003. Epub 2017 Apr 22. Review.

PMID:
28442394
29.

P-gp modulatory acetyl-11-keto-β-boswellic acid based nanoemulsified carrier system for augmented oral chemotherapy of docetaxel.

Pandey G, Mittapelly N, Valicherla GR, Shukla RP, Sharma S, Banala VT, Urandur S, Jajoriya AK, Mitra K, Mishra DP, Gayen JR, Mishra PR.

Colloids Surf B Biointerfaces. 2017 Jul 1;155:276-286. doi: 10.1016/j.colsurfb.2017.04.028. Epub 2017 Apr 15.

PMID:
28437753
30.

Corrigendum: Altered glucose and lipid homeostasis in liver and adipose tissue pre-dispose inducible NOS knockout mice to insulin resistance.

Kanuri BN, Kanshana JS, Rebello SC, Pathak P, Gupta AP, Gayen JR, Jagavelu K, Dikshit M.

Sci Rep. 2017 Apr 6;7:46010. doi: 10.1038/srep46010. No abstract available.

31.

Alcoholic Extract of Eclipta alba Shows In Vitro Antioxidant and Anticancer Activity without Exhibiting Toxicological Effects.

Yadav NK, Arya RK, Dev K, Sharma C, Hossain Z, Meena S, Arya KR, Gayen JR, Datta D, Singh RK.

Oxid Med Cell Longev. 2017;2017:9094641. doi: 10.1155/2017/9094641. Epub 2017 Jan 31.

32.

Preparation and in-vitro/in-vivo characterization of trans-resveratrol nanocrystals for oral administration.

Singh SK, Makadia V, Sharma S, Rashid M, Shahi S, Mishra PR, Wahajuddin M, Gayen JR.

Drug Deliv Transl Res. 2017 Jun;7(3):395-407. doi: 10.1007/s13346-017-0362-y.

PMID:
28194730
33.

Altered glucose and lipid homeostasis in liver and adipose tissue pre-dispose inducible NOS knockout mice to insulin resistance.

Kanuri BN, Kanshana JS, Rebello SC, Pathak P, Gupta AP, Gayen JR, Jagavelu K, Dikshit M.

Sci Rep. 2017 Jan 20;7:41009. doi: 10.1038/srep41009. Erratum in: Sci Rep. 2017 Apr 06;7:46010.

34.

Cardioprotective Effect of Ulmus wallichiana Planchon in β-Adrenergic Agonist Induced Cardiac Hypertrophy.

Syed AA, Lahiri S, Mohan D, Valicherla GR, Gupta AP, Kumar S, Maurya R, Bora HK, Hanif K, Gayen JR.

Front Pharmacol. 2016 Dec 21;7:510. doi: 10.3389/fphar.2016.00510. eCollection 2016.

35.

Synthesis of substituted 2H-benzo[e]indazole-9-carboxylate as a potent antihyperglycemic agent that may act through IRS-1, Akt and GSK-3β pathways.

Taneja G, Gupta CP, Mishra S, Srivastava R, Rahuja N, Rawat AK, Pandey J, Gupta AP, Jaiswal N, Gayen JR, Tamrakar AK, Srivastava AK, Goel A.

Medchemcomm. 2016 Nov 15;8(2):329-337. doi: 10.1039/c6md00467a. eCollection 2017 Feb 1.

36.

Evaluation of anti-hypertensive activity of Ulmus wallichiana extract and fraction in SHR, DOCA-salt- and L-NAME-induced hypertensive rats.

Syed AA, Lahiri S, Mohan D, Valicherla GR, Gupta AP, Riyazuddin M, Kumar S, Maurya R, Hanif K, Gayen JR.

J Ethnopharmacol. 2016 Dec 4;193:555-565. doi: 10.1016/j.jep.2016.10.008. Epub 2016 Oct 5.

PMID:
27720848
37.

Phospholipid complexation of NMITLI118RT+: way to a prudent therapeutic approach for beneficial outcomes in ischemic stroke in rats.

Ahmad H, Arya A, Agrawal S, Samuel SS, Singh SK, Valicherla GR, Sangwan N, Mitra K, Gayen JR, Paliwal S, Shukla R, Dwivedi AK.

Drug Deliv. 2016 Nov;23(9):3606-3618. Epub 2016 Aug 12.

PMID:
27685355
38.

Pharmacokinetics and bioavailability assessment of Miltefosine in rats using high performance liquid chromatography tandem mass spectrometry.

Valicherla GR, Tripathi P, Singh SK, Syed AA, Riyazuddin M, Husain A, Javia D, Italiya KS, Mishra PR, Gayen JR.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Sep 15;1031:123-130. doi: 10.1016/j.jchromb.2016.07.042. Epub 2016 Jul 26.

PMID:
27475453
39.

UDP-galactopyranose mutase, a potential drug target against human pathogenic nematode Brugia malayi.

Misra S, Valicherla GR, Mohd Shahab, Gupta J, Gayen JR, Misra-Bhattacharya S.

Pathog Dis. 2016 Aug;74(6). pii: ftw072. doi: 10.1093/femspd/ftw072. Epub 2016 Jul 26.

PMID:
27465638
40.

Chronic hyperinsulinemia reduces insulin sensitivity and metabolic functions of brown adipocyte.

Rajan S, Shankar K, Beg M, Varshney S, Gupta A, Srivastava A, Kumar D, Mishra RK, Hussain Z, Gayen JR, Gaikwad AN.

J Endocrinol. 2016 Sep;230(3):275-90. doi: 10.1530/JOE-16-0099. Epub 2016 Jun 23.

PMID:
27340034
41.

Formulation optimization of Docetaxel loaded self-emulsifying drug delivery system to enhance bioavailability and anti-tumor activity.

Valicherla GR, Dave KM, Syed AA, Riyazuddin M, Gupta AP, Singh A, Wahajuddin, Mitra K, Datta D, Gayen JR.

Sci Rep. 2016 May 31;6:26895. doi: 10.1038/srep26895.

42.

Theophylline, a methylxanthine drug induces osteopenia and alters calciotropic hormones, and prophylactic vitamin D treatment protects against these changes in rats.

Pal S, Khan K, China SP, Mittal M, Porwal K, Shrivastava R, Taneja I, Hossain Z, Mandalapu D, Gayen JR, Wahajuddin M, Sharma VL, Trivedi AK, Sanyal S, Bhadauria S, Godbole MM, Gupta SK, Chattopadhyay N.

Toxicol Appl Pharmacol. 2016 Mar 15;295:12-25. doi: 10.1016/j.taap.2016.02.002. Epub 2016 Feb 3.

PMID:
26851681
43.

Anti-breast tumor activity of Eclipta extract in-vitro and in-vivo: novel evidence of endoplasmic reticulum specific localization of Hsp60 during apoptosis.

Arya RK, Singh A, Yadav NK, Cheruvu SH, Hossain Z, Meena S, Maheshwari S, Singh AK, Shahab U, Sharma C, Singh K, Narender T, Mitra K, Arya KR, Singh RK, Gayen JR, Datta D.

Sci Rep. 2015 Dec 17;5:18457. doi: 10.1038/srep18457.

44.

No effect on pharmacokinetics of tamoxifen and 4-hydroxytamoxifen by multiple doses of red clover capsule in rats.

Raju KS, Taneja I, Valicherla GR, Challagundla MK, Rashid M, Syed AA, Gayen JR, Singh SP, Wahajuddin M.

Sci Rep. 2015 Nov 4;5:16126. doi: 10.1038/srep16126.

45.

Metabolic profiling of a novel antithrombotic compound, S002-333 and enantiomers: metabolic stability, species comparison and in vitro-in vivo extrapolation.

Saxena A, Valicherla GR, Jain GK, Bhatta RS, Saxena AK, Gayen JR.

Biopharm Drug Dispos. 2016 May;37(4):185-99. doi: 10.1002/bdd.1995.

PMID:
26477787
46.

Pharmacokinetics, dose proportionality and permeability of S002-333 and its enantiomers, a potent antithrombotic agent, in rabbits.

Saxena A, Valicherla GR, Joshi P, Saxena R, Cheruvu SH, Bhunia SS, Jain GK, Siddiqui HH, Saxena AK, Gayen JR.

Xenobiotica. 2015;45(11):1016-23. doi: 10.3109/00498254.2015.1034224. Epub 2015 Jun 18.

PMID:
26084373
47.

Development and validation of an LC-MS/MS method for simultaneous determination of piperaquine and 97-63, the active metabolite of CDRI 97-78, in rat plasma and its application in interaction study.

Wahajuddin M, Singh SP, Taneja I, Raju KS, Gayen JR, Siddiqui HH, Singh SK.

Drug Test Anal. 2016 Feb;8(2):221-7. doi: 10.1002/dta.1807. Epub 2015 May 14.

PMID:
25975936
48.

Simultaneous determination of centchroman and tamoxifen along with their metabolites in rat plasma using LC-MS/MS.

Rama Raju KS, Taneja I, Singh SP, Tripathi A, Mishra DP, Hussain KM, Gayen JR, Singh SK, Wahajuddin M.

Bioanalysis. 2015;7(8):967-79. doi: 10.4155/bio.14.253.

PMID:
25966009
49.

Simultaneous quantification of proposed anti-malarial combination comprising of lumefantrine and CDRI 97-78 in rat plasma using the HPLC-ESI-MS/MS method: application to drug interaction study.

Wahajuddin M, Singh SP, Taneja I, Raju KS, Gayen JR, Siddiqui HH, Singh SK.

Malar J. 2015 Apr 22;14:172. doi: 10.1186/s12936-015-0684-5.

50.

Saraca indica bark extract shows in vitro antioxidant, antibreast cancer activity and does not exhibit toxicological effects.

Yadav NK, Saini KS, Hossain Z, Omer A, Sharma C, Gayen JR, Singh P, Arya KR, Singh RK.

Oxid Med Cell Longev. 2015;2015:205360. doi: 10.1155/2015/205360. Epub 2015 Mar 16.

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