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Items: 10


Targeting Merkel Cell Carcinoma by Engineered T Cells Specific to T-Antigens of Merkel Cell Polyomavirus.

Gavvovidis I, Leisegang M, Willimsky G, Miller N, Nghiem P, Blankenstein T.

Clin Cancer Res. 2018 Aug 1;24(15):3644-3655. doi: 10.1158/1078-0432.CCR-17-2661. Epub 2018 Apr 18.


Tumor-Infiltrating Merkel Cell Polyomavirus-Specific T Cells Are Diverse and Associated with Improved Patient Survival.

Miller NJ, Church CD, Dong L, Crispin D, Fitzgibbon MP, Lachance K, Jing L, Shinohara M, Gavvovidis I, Willimsky G, McIntosh M, Blankenstein T, Koelle DM, Nghiem P.

Cancer Immunol Res. 2017 Feb;5(2):137-147. doi: 10.1158/2326-6066.CIR-16-0210. Epub 2017 Jan 16.


Identification of human T-cell receptors with optimal affinity to cancer antigens using antigen-negative humanized mice.

Obenaus M, Leitão C, Leisegang M, Chen X, Gavvovidis I, van der Bruggen P, Uckert W, Schendel DJ, Blankenstein T.

Nat Biotechnol. 2015 Apr;33(4):402-7. doi: 10.1038/nbt.3147. Epub 2015 Mar 16.


A novel MCPH1 isoform complements the defective chromosome condensation of human MCPH1-deficient cells.

Gavvovidis I, Rost I, Trimborn M, Kaiser FJ, Purps J, Wiek C, Hanenberg H, Neitzel H, Schindler D.

PLoS One. 2012;7(8):e40387. doi: 10.1371/journal.pone.0040387. Epub 2012 Aug 30.


MCPH1 regulates chromosome condensation and shaping as a composite modulator of condensin II.

Yamashita D, Shintomi K, Ono T, Gavvovidis I, Schindler D, Neitzel H, Trimborn M, Hirano T.

J Cell Biol. 2011 Sep 19;194(6):841-54. doi: 10.1083/jcb.201106141. Epub 2011 Sep 12.


Misregulation of mitotic chromosome segregation in a new type of autosomal recessive primary microcephaly.

Marchal JA, Ghani M, Schindler D, Gavvovidis I, Winkler T, Esquitino V, Sternberg N, Busche A, Krawitz P, Hecht J, Robinson P, Mundlos S, Graul-Neumann L, Sperling K, Trimborn M, Neitzel H.

Cell Cycle. 2011 Sep 1;10(17):2967-77. Epub 2011 Sep 1.


MCPH1 patient cells exhibit delayed release from DNA damage-induced G2/M checkpoint arrest.

Gavvovidis I, Pöhlmann C, Marchal JA, Stumm M, Yamashita D, Hirano T, Schindler D, Neitzel H, Trimborn M.

Cell Cycle. 2010 Dec 15;9(24):4893-9. Epub 2010 Dec 15.


Establishment of a mouse model with misregulated chromosome condensation due to defective Mcph1 function.

Trimborn M, Ghani M, Walther DJ, Dopatka M, Dutrannoy V, Busche A, Meyer F, Nowak S, Nowak J, Zabel C, Klose J, Esquitino V, Garshasbi M, Kuss AW, Ropers HH, Mueller S, Poehlmann C, Gavvovidis I, Schindler D, Sperling K, Neitzel H.

PLoS One. 2010 Feb 16;5(2):e9242. doi: 10.1371/journal.pone.0009242.


Prenatal exclusion/confirmation of Fanconi anemia via flow cytometry: a pilot study.

Bechtold A, Friedl R, Kalb R, Gottwald B, Neveling K, Gavvovidis I, Herterich S, Schindler D, Hoehn H.

Fetal Diagn Ther. 2006;21(1):118-24.


The first missense alteration in the MCPH1 gene causes autosomal recessive microcephaly with an extremely mild cellular and clinical phenotype.

Trimborn M, Richter R, Sternberg N, Gavvovidis I, Schindler D, Jackson AP, Prott EC, Sperling K, Gillessen-Kaesbach G, Neitzel H.

Hum Mutat. 2005 Nov;26(5):496.


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