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Items: 12

1.

Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis.

Cahill TJ 3rd, Thomsen AR, Tarrasch JT, Plouffe B, Nguyen AH, Yang F, Huang LY, Kahsai AW, Bassoni DL, Gavino BJ, Lamerdin JE, Triest S, Shukla AK, Berger B, Little J 4th, Antar A, Blanc A, Qu CX, Chen X, Kawakami K, Inoue A, Aoki J, Steyaert J, Sun JP, Bouvier M, Skiniotis G, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2562-2567. doi: 10.1073/pnas.1701529114. Epub 2017 Feb 21.

2.

Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library.

Ahn S, Kahsai AW, Pani B, Wang QT, Zhao S, Wall AL, Strachan RT, Staus DP, Wingler LM, Sun LD, Sinnaeve J, Choi M, Cho T, Xu TT, Hansen GM, Burnett MB, Lamerdin JE, Bassoni DL, Gavino BJ, Husemoen G, Olsen EK, Franch T, Costanzi S, Chen X, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1708-1713. doi: 10.1073/pnas.1620645114. Epub 2017 Jan 27.

3.

Mice with an isoform-ablating Mecp2 exon 1 mutation recapitulate the neurologic deficits of Rett syndrome.

Yasui DH, Gonzales ML, Aflatooni JO, Crary FK, Hu DJ, Gavino BJ, Golub MS, Vincent JB, Carolyn Schanen N, Olson CO, Rastegar M, Lasalle JM.

Hum Mol Genet. 2014 May 1;23(9):2447-58. doi: 10.1093/hmg/ddt640. Epub 2013 Dec 18. Erratum in: Hum Mol Genet. 2014 Dec 15;23(24):6695.

4.

A novel intergenic ETnII-β insertion mutation causes multiple malformations in polypodia mice.

Lehoczky JA, Thomas PE, Patrie KM, Owens KM, Villarreal LM, Galbraith K, Washburn J, Johnson CN, Gavino B, Borowsky AD, Millen KJ, Wakenight P, Law W, Van Keuren ML, Gavrilina G, Hughes ED, Saunders TL, Brihn L, Nadeau JH, Innis JW.

PLoS Genet. 2013;9(12):e1003967. doi: 10.1371/journal.pgen.1003967. Epub 2013 Dec 5.

5.

Interaction between troponin and myosin enhances contractile activity of myosin in cardiac muscle.

Schoffstall B, LaBarbera VA, Brunet NM, Gavino BJ, Herring L, Heshmati S, Kraft BH, Inchausti V, Meyer NL, Moonoo D, Takeda AK, Chase PB.

DNA Cell Biol. 2011 Sep;30(9):653-9. doi: 10.1089/dna.2010.1163. Epub 2011 Mar 27.

6.

Prelamin A and lamin A appear to be dispensable in the nuclear lamina.

Fong LG, Ng JK, Lammerding J, Vickers TA, Meta M, Coté N, Gavino B, Qiao X, Chang SY, Young SR, Yang SH, Stewart CL, Lee RT, Bennett CF, Bergo MO, Young SG.

J Clin Invest. 2006 Mar;116(3):743-52.

7.

Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.

Bergo MO, Gavino BJ, Hong C, Beigneux AP, McMahon M, Casey PJ, Young SG.

J Clin Invest. 2004 Feb;113(4):539-50.

8.

ATP-citrate lyase deficiency in the mouse.

Beigneux AP, Kosinski C, Gavino B, Horton JD, Skarnes WC, Young SG.

J Biol Chem. 2004 Mar 5;279(10):9557-64. Epub 2003 Dec 8.

9.

On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy.

Bergo MO, Lieu HD, Gavino BJ, Ambroziak P, Otto JC, Casey PJ, Walker QM, Young SG.

J Biol Chem. 2004 Feb 6;279(6):4729-36. Epub 2003 Nov 18.

10.

Defining the importance of phosphatidylserine synthase 2 in mice.

Bergo MO, Gavino BJ, Steenbergen R, Sturbois B, Parlow AF, Sanan DA, Skarnes WC, Vance JE, Young SG.

J Biol Chem. 2002 Dec 6;277(49):47701-8. Epub 2002 Oct 1.

11.

Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect.

Bergo MO, Gavino B, Ross J, Schmidt WK, Hong C, Kendall LV, Mohr A, Meta M, Genant H, Jiang Y, Wisner ER, Van Bruggen N, Carano RA, Michaelis S, Griffey SM, Young SG.

Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13049-54. Epub 2002 Sep 16.

12.

Biochemical studies of Zmpste24-deficient mice.

Leung GK, Schmidt WK, Bergo MO, Gavino B, Wong DH, Tam A, Ashby MN, Michaelis S, Young SG.

J Biol Chem. 2001 Aug 3;276(31):29051-8. Epub 2001 Jun 8.

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