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Items: 1 to 50 of 130

1.

Cholinergic synapse pathway gene polymorphisms associated with allergen-induced late asthmatic responses.

Rajasekaran A, He D, Yue A, Singh A, Shannon CP, FitzGerald JM, Boulet LP, O'Byrne PM, Gauvreau GM, Tebbutt SJ.

ERJ Open Res. 2019 Nov 4;5(4). pii: 00107-2019. doi: 10.1183/23120541.00107-2019. eCollection 2019 Oct.

PMID:
31720291
2.

Atopic March: Collegium Internationale Allergologicum Update 2020.

Aw M, Penn J, Gauvreau GM, Lima H, Sehmi R.

Int Arch Allergy Immunol. 2019 Oct 8:1-10. doi: 10.1159/000502958. [Epub ahead of print] Review.

3.

Anti-alarmin approaches entering clinical trials.

Gauvreau GM, White L, Davis BE.

Curr Opin Pulm Med. 2019 Aug 12. doi: 10.1097/MCP.0000000000000615. [Epub ahead of print]

PMID:
31408015
4.

Effects of interleukin-6 receptor blockade on allergen-induced airway responses in mild asthmatics.

Revez JA, Bain LM, Watson RM, Towers M, Collins T, Killian KJ, O'Byrne PM, Gauvreau GM, Upham JW, Ferreira MA.

Clin Transl Immunology. 2019 Jun 14;8(6):e1044. doi: 10.1002/cti2.1044. eCollection 2019.

5.

Effect of sex on group 2 innate lymphoid cells in the airways of mild and severe asthmatics.

Aw M, Nair P, Salter B, Chen R, Machida K, Inman M, O'Byrne PM, Gauvreau GM, Sehmi R.

Allergy. 2019 Jul;74(7):1397-1400. doi: 10.1111/all.13742. Epub 2019 Feb 26. No abstract available.

PMID:
30741429
6.

An evaluation of roflumilast and PDE4 inhibitors with a focus on the treatment of asthma.

Al-Sajee D, Yin X, Gauvreau GM.

Expert Opin Pharmacother. 2019 Apr;20(5):609-620. doi: 10.1080/14656566.2019.1570132. Epub 2019 Feb 5. Review.

PMID:
30722707
7.

Allergen challenge increases capsaicin-evoked cough responses in patients with allergic asthma.

Satia I, Watson R, Scime T, Dockry RJ, Sen S, Ford JW, Mitchell PD, Fowler SJ, Gauvreau GM, O'Byrne PM, Smith JA.

J Allergy Clin Immunol. 2019 Sep;144(3):788-795.e1. doi: 10.1016/j.jaci.2018.11.050. Epub 2019 Jan 17.

PMID:
30660644
8.

ERS technical standard on bronchial challenge testing: pathophysiology and methodology of indirect airway challenge testing.

Hallstrand TS, Leuppi JD, Joos G, Hall GL, Carlsen KH, Kaminsky DA, Coates AL, Cockcroft DW, Culver BH, Diamant Z, Gauvreau GM, Horvath I, de Jongh FHC, Laube BL, Sterk PJ, Wanger J; American Thoracic Society (ATS)/European Respiratory Society (ERS) Bronchoprovocation Testing Task Force.

Eur Respir J. 2018 Nov 15;52(5). pii: 1801033. doi: 10.1183/13993003.01033-2018. Print 2018 Nov.

PMID:
30361249
9.

Expression of IL-33 and TSLP and Their Receptors in Asthmatic Airways after Inhaled Allergen Challenge.

Al-Sajee D, Sehmi R, Hawke TJ, El-Gammal A, Howie KJ, Watson RM, Londei M, Gauvreau GM, O'Byrne PM.

Am J Respir Crit Care Med. 2018 Sep 15;198(6):805-807. doi: 10.1164/rccm.201712-2468LE. No abstract available.

PMID:
29733677
10.

IL-33 and Its Receptor ST2 after Inhaled Allergen Challenge in Allergic Asthmatics.

Mitchell PD, Salter BM, Oliveria JP, El-Gammal A, Tworek D, Smith SG, Sehmi R, Gauvreau GM, O Apos Byrne PM.

Int Arch Allergy Immunol. 2018;176(2):133-142. doi: 10.1159/000488015. Epub 2018 Apr 25.

PMID:
29694974
11.

Interleukin-25 and eosinophils progenitor cell mobilization in allergic asthma.

Tang W, Smith SG, Du W, Gugilla A, Du J, Oliveria JP, Howie K, Salter BM, Gauvreau GM, O'Byrne PM, Sehmi R.

Clin Transl Allergy. 2018 Feb 13;8:5. doi: 10.1186/s13601-018-0190-2. eCollection 2018.

12.

The effects of a CCR3 inhibitor, AXP1275, on allergen-induced airway responses in adults with mild-to-moderate atopic asthma.

Gauvreau GM, FitzGerald JM, Boulet LP, Watson RM, Hui L, Villineuve H, Scime TX, Schlatman AR, Obminski C, Kum J, Boehme S, Ly TW, Bacon KB, O'Byrne PM.

Clin Exp Allergy. 2018 Apr;48(4):445-451. doi: 10.1111/cea.13114. Epub 2018 Mar 13.

PMID:
29423947
13.

Sputum cytology during late-phase responses to inhalation challenge with different allergens.

Revez JA, Killian KJ, O'Byrne PM, Boulet LP, Upham JW, Gauvreau GM, Ferreira MAR.

Allergy. 2018 Jul;73(7):1470-1478. doi: 10.1111/all.13415. Epub 2018 Feb 6.

PMID:
29337345
14.

Changes in regulatory B-cell levels in bone marrow, blood, and sputum of patients with asthma following inhaled allergen challenge.

Oliveria JP, El-Gammal AI, Yee M, Obminski CD, Scime TX, Watson RM, Howie K, O'Byrne PM, Sehmi R, Gauvreau GM.

J Allergy Clin Immunol. 2018 Apr;141(4):1495-1498.e9. doi: 10.1016/j.jaci.2017.11.013. Epub 2017 Dec 6. No abstract available.

15.

Secreted PLA2 group X orchestrates innate and adaptive immune responses to inhaled allergen.

Nolin JD, Lai Y, Ogden HL, Manicone AM, Murphy RC, An D, Frevert CW, Ghomashchi F, Naika GS, Gelb MH, Gauvreau GM, Piliponsky AM, Altemeier WA, Hallstrand TS.

JCI Insight. 2017 Nov 2;2(21). pii: 94929. doi: 10.1172/jci.insight.94929.

16.

Novel Blood-based Transcriptional Biomarker Panels Predict the Late-Phase Asthmatic Response.

Singh A, Shannon CP, Kim YW, Yang CX, Balshaw R, Cohen Freue GV, Gauvreau GM, FitzGerald JM, Boulet LP, O'Byrne PM, Tebbutt SJ.

Am J Respir Crit Care Med. 2018 Feb 15;197(4):450-462. doi: 10.1164/rccm.201701-0110OC.

PMID:
29087730
17.

Antialarmins for treatment of asthma: future perspectives.

Al-Sajee D, Oliveria JP, Sehmi R, Gauvreau GM.

Curr Opin Pulm Med. 2018 Jan;24(1):32-41. doi: 10.1097/MCP.0000000000000443. Review.

PMID:
29084017
18.

Pauca sed Matura: Few, but Ripe.

Gauvreau GM, Sehmi R.

Am J Respir Crit Care Med. 2017 Dec 1;196(11):1361-1362. doi: 10.1164/rccm.201709-1848ED. No abstract available.

PMID:
28926280
19.

Human Bronchial Epithelial Cell-derived Factors from Severe Asthmatic Subjects Stimulate Eosinophil Differentiation.

Salter BMA, Smith SG, Mukherjee M, Plante S, Krisna S, Nusca G, Oliveria JP, Irshad A, Gauvreau GM, Chakir J, Nair P, Sehmi R.

Am J Respir Cell Mol Biol. 2018 Jan;58(1):99-106. doi: 10.1165/rcmb.2016-0262OC.

PMID:
28853918
20.

Methacholine Challenge: Comparison of Airway Responsiveness Produced by a Vibrating Mesh Nebulizer Versus a Jet Nebulizer.

Blais CM, Cockcroft DW, Veilleux J, Boulay MÈ, Boulet LP, Gauvreau GM, Scime TX, Watson RM, O'Byrne PM, Davis BE.

J Aerosol Med Pulm Drug Deliv. 2018 Apr;31(2):88-93. doi: 10.1089/jamp.2017.1392. Epub 2017 Aug 16.

PMID:
28813613
21.

Increased IgE+ B Cells in Sputum, but Not Blood, Bone Marrow, or Tonsils, after Inhaled Allergen Challenge in Subjects with Asthma.

Oliveria JP, Salter BM, MacLean J, Kotwal S, Smith A, Harris JM, Scheerens H, Sehmi R, Gauvreau GM.

Am J Respir Crit Care Med. 2017 Jul 1;196(1):107-109. doi: 10.1164/rccm.201611-2274LE. No abstract available.

PMID:
28665197
22.

Allergen-induced Increases in Sputum Levels of Group 2 Innate Lymphoid Cells in Subjects with Asthma.

Chen R, Smith SG, Salter B, El-Gammal A, Oliveria JP, Obminski C, Watson R, O'Byrne PM, Gauvreau GM, Sehmi R.

Am J Respir Crit Care Med. 2017 Sep 15;196(6):700-712. doi: 10.1164/rccm.201612-2427OC.

PMID:
28422515
23.

The PD20 but not the PC20 in a methacholine challenge test is device independent.

Coates AL, Dell SD, Cockcroft DW, Gauvreau GM.

Ann Allergy Asthma Immunol. 2017 Apr;118(4):508-509. doi: 10.1016/j.anai.2017.01.010. Epub 2017 Mar 6. No abstract available.

PMID:
28274734
24.

Methacholine challenge tests to demonstrate therapeutic equivalence of terbutaline sulfate via different Turbuhaler® devices in patients with mild to moderate asthma: Appraisal of a four-way crossover design.

Bjermer L, Gauvreau GM, Postma DS, O'Byrne PM, van den Berge M, Boulet LP, Beckman O, Persson T, Román J, Carlholm M, Schützer KM, Eckerwall G.

Pulm Pharmacol Ther. 2017 Jun;44:1-6. doi: 10.1016/j.pupt.2017.02.004. Epub 2017 Feb 20.

PMID:
28232118
25.

Asthmatic subjects with allergy have elevated levels of IgE+ B cells in the airways.

Oliveria JP, Salter BM, Phan S, Obminski CD, Munoz CE, Smith SG, Scime T, Watson RM, Sehmi R, Gauvreau GM.

J Allergy Clin Immunol. 2017 Aug;140(2):590-593.e9. doi: 10.1016/j.jaci.2016.12.981. Epub 2017 Feb 16. No abstract available.

PMID:
28213181
26.

Glucagon-like peptide-1 receptor expression on human eosinophils and its regulation of eosinophil activation.

Mitchell PD, Salter BM, Oliveria JP, El-Gammal A, Tworek D, Smith SG, Sehmi R, Gauvreau GM, Butler M, O'Byrne PM.

Clin Exp Allergy. 2017 Mar;47(3):331-338. doi: 10.1111/cea.12860. Epub 2017 Jan 28.

PMID:
27928844
27.

Allergen-Induced Increases in Interleukin-25 and Interleukin-25 Receptor Expression in Mature Eosinophils from Atopic Asthmatics.

Tang W, Smith SG, Salter B, Oliveria JP, Mitchell P, Nusca GM, Howie K, Gauvreau GM, O'Byrne PM, Sehmi R.

Int Arch Allergy Immunol. 2016;170(4):234-242. Epub 2016 Sep 30.

28.

The effects of a CXCR1/CXCR2 antagonist on neutrophil migration in mild atopic asthmatic subjects.

Todd CM, Salter BM, Murphy DM, Watson RM, Howie KJ, Milot J, Sadeh J, Boulet LP, O'Byrne PM, Gauvreau GM.

Pulm Pharmacol Ther. 2016 Dec;41:34-39. doi: 10.1016/j.pupt.2016.09.005. Epub 2016 Sep 14.

PMID:
27640067
29.

Dysregulation of Vascular Endothelial Progenitor Cells Lung-Homing in Subjects with COPD.

Salter BM, Manzoor F, Beaudin S, Kjarsgaard M, Nair P, Gauvreau GM, Sehmi R.

Can Respir J. 2016;2016:1472823. doi: 10.1155/2016/1472823. Epub 2016 May 12.

30.

A dual CysLT1/2 antagonist attenuates allergen-induced airway responses in subjects with mild allergic asthma.

Gauvreau GM, Boulet LP, FitzGerald JM, Cockcroft DW, Davis BE, Leigh R, Tanaka M, Fourre JA, Tanaka M, Nabata T, O'Byrne PM.

Allergy. 2016 Dec;71(12):1721-1727. doi: 10.1111/all.12987. Epub 2016 Aug 9.

PMID:
27444660
31.

Efficacy and safety of multiple doses of QGE031 (ligelizumab) versus omalizumab and placebo in inhibiting allergen-induced early asthmatic responses.

Gauvreau GM, Arm JP, Boulet LP, Leigh R, Cockcroft DW, Davis BE, Mayers I, FitzGerald JM, Dahlen B, Killian KJ, Laviolette M, Carlsten C, Lazarinis N, Watson RM, Milot J, Swystun V, Bowen M, Hui L, Lantz AS, Meiser K, Maahs S, Lowe PJ, Skerjanec A, Drollmann A, O'Byrne PM.

J Allergy Clin Immunol. 2016 Oct;138(4):1051-1059. doi: 10.1016/j.jaci.2016.02.027. Epub 2016 Apr 7.

PMID:
27185571
32.

Identifying Molecular Mechanisms of the Late-Phase Asthmatic Response by Integrating Cellular, Gene, and Metabolite Levels in Blood.

Singh A, Shannon CP, Kim YW, DeMarco ML, Gauvreau GM, FitzGerald JM, Boulet LP, O'Byrne PM, Le Cao KA, Tebbutt SJ.

Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S98. doi: 10.1513/AnnalsATS.201510-694MG.

PMID:
27027968
33.

Allergen-induced Changes in Bone Marrow and Airway Dendritic Cells in Subjects with Asthma.

El-Gammal A, Oliveria JP, Howie K, Watson R, Mitchell P, Chen R, Baatjes A, Smith S, Al-Sajee D, Hawke TJ, Killian KJ, Gauvreau GM, O'Byrne PM.

Am J Respir Crit Care Med. 2016 Jul 15;194(2):169-77. doi: 10.1164/rccm.201508-1623OC.

PMID:
26844926
34.

IL-25 and IL-33 induce Type 2 inflammation in basophils from subjects with allergic asthma.

Salter BM, Oliveria JP, Nusca G, Smith SG, Tworek D, Mitchell PD, Watson RM, Sehmi R, Gauvreau GM.

Respir Res. 2016 Jan 14;17:5. doi: 10.1186/s12931-016-0321-z.

35.

CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors.

Panousis C, Dhagat U, Edwards KM, Rayzman V, Hardy MP, Braley H, Gauvreau GM, Hercus TR, Smith S, Sehmi R, McMillan L, Dottore M, McClure BJ, Fabri LJ, Vairo G, Lopez AF, Parker MW, Nash AD, Wilson NJ, Wilson MJ, Owczarek CM.

MAbs. 2016;8(3):436-53. doi: 10.1080/19420862.2015.1119352. Epub 2015 Dec 14.

36.

IL-25 Receptor Expression on Airway Dendritic Cells after Allergen Challenge in Subjects with Asthma.

Tworek D, Smith SG, Salter BM, Baatjes AJ, Scime T, Watson R, Obminski C, Gauvreau GM, O'Byrne PM.

Am J Respir Crit Care Med. 2016 May 1;193(9):957-64. doi: 10.1164/rccm.201509-1751OC.

PMID:
26625138
37.

The Effects of Repeated Bronchoprovocation on FEV1 in Subjects with Asthma.

Janssen LJ, Gauvreau GM, Killian KJ, O'Byrne PM.

Ann Am Thorac Soc. 2015 Oct;12(10):1589-91. doi: 10.1513/AnnalsATS.201506-325LE. No abstract available.

PMID:
26448357
38.

Expression of activation markers in circulating basophils and the relationship to allergen-induced bronchoconstriction in subjects with mild allergic asthma.

Salter BM, Nusca G, Tworek D, Oliveria JP, Smith SG, Watson RM, Scime T, Obminski C, Sehmi R, Gauvreau GM.

J Allergy Clin Immunol. 2016 Mar;137(3):936-8.e7. doi: 10.1016/j.jaci.2015.08.024. Epub 2015 Oct 5. No abstract available.

PMID:
26441227
39.

Effects of ASM-024, a modulator of acetylcholine receptor function, on airway responsiveness and allergen-induced responses in patients with mild asthma.

Boulet LP, Gauvreau GM, Cockcroft DW, Davis B, Vachon L, Cormier Y, O'Byrne PM.

Can Respir J. 2015 Jul-Aug;22(4):230-4.

40.

Treatment with anti-OX40L or anti-TSLP does not alter the frequency of T regulatory cells in allergic asthmatics.

Baatjes AJ, Smith SG, Dua B, Watson R, Gauvreau GM, O'Byrne PM.

Allergy. 2015 Nov;70(11):1505-8. doi: 10.1111/all.12708. Epub 2015 Aug 25.

PMID:
26213896
41.

Allergen-induced airway responses.

Gauvreau GM, El-Gammal AI, O'Byrne PM.

Eur Respir J. 2015 Sep;46(3):819-31. doi: 10.1183/13993003.00536-2015. Epub 2015 Jul 23. Review.

42.

Increased numbers of activated group 2 innate lymphoid cells in the airways of patients with severe asthma and persistent airway eosinophilia.

Smith SG, Chen R, Kjarsgaard M, Huang C, Oliveria JP, O'Byrne PM, Gauvreau GM, Boulet LP, Lemiere C, Martin J, Nair P, Sehmi R.

J Allergy Clin Immunol. 2016 Jan;137(1):75-86.e8. doi: 10.1016/j.jaci.2015.05.037. Epub 2015 Jul 17.

PMID:
26194544
43.

Thymic stromal lymphopoietin activation of basophils in patients with allergic asthma is IL-3 dependent.

Salter BM, Oliveria JP, Nusca G, Smith SG, Watson RM, Comeau M, Sehmi R, Gauvreau GM.

J Allergy Clin Immunol. 2015 Dec;136(6):1636-1644. doi: 10.1016/j.jaci.2015.03.039. Epub 2015 May 9.

PMID:
25962901
44.

Comparison of the provocative concentration of methacholine causing a 20% fall in FEV1 between the AeroEclipse II breath-actuated nebulizer and the wright nebulizer in adult subjects with asthma.

El-Gammal AI, Killian KJ, Scime TX, Beaudin S, Schlatman A, Cockcroft DW, Gauvreau GM.

Ann Am Thorac Soc. 2015 Jul;12(7):1039-43. doi: 10.1513/AnnalsATS.201412-571BC.

PMID:
25871542
45.

Inhibition of allergen-induced basophil activation by ASM-024, a nicotinic receptor ligand.

Watson BM, Oliveria JP, Nusca GM, Smith SG, Beaudin S, Dua B, Watson RM, Assayag EI, Cormier YF, Sehmi R, Gauvreau GM.

Int Arch Allergy Immunol. 2014;165(4):255-64. doi: 10.1159/000370068. Epub 2015 Feb 5.

PMID:
25660404
46.

Thymic stromal lymphopoietin and IL-33 modulate migration of hematopoietic progenitor cells in patients with allergic asthma.

Smith SG, Gugilla A, Mukherjee M, Merim K, Irshad A, Tang W, Kinoshita T, Watson B, Oliveria JP, Comeau M, O'Byrne PM, Gauvreau GM, Sehmi R.

J Allergy Clin Immunol. 2015 Jun;135(6):1594-602. doi: 10.1016/j.jaci.2014.12.1918. Epub 2015 Feb 3.

PMID:
25656998
47.

A nonsteroidal glucocorticoid receptor agonist inhibits allergen-induced late asthmatic responses.

Gauvreau GM, Boulet LP, Leigh R, Cockcroft DW, Killian KJ, Davis BE, Deschesnes F, Watson RM, Swystun V, Mårdh CK, Wessman P, Jorup C, Aurivillius M, O'Byrne PM.

Am J Respir Crit Care Med. 2015 Jan 15;191(2):161-7. doi: 10.1164/rccm.201404-0623OC.

PMID:
25473939
48.

Human mast cell and basophil/eosinophil progenitors.

Gauvreau GM, Denburg JA.

Methods Mol Biol. 2015;1220:59-68. doi: 10.1007/978-1-4939-1568-2_4.

PMID:
25388244
49.

T helper 17 cells and related cytokines after allergen inhalation challenge in allergic asthmatics.

Naji N, Smith SG, Gauvreau GM, O'Byrne PM.

Int Arch Allergy Immunol. 2014;165(1):27-34. doi: 10.1159/000367789. Epub 2014 Oct 4.

PMID:
25301201
50.

Th17/Treg ratio derived using DNA methylation analysis is associated with the late phase asthmatic response.

Singh A, Yamamoto M, Ruan J, Choi JY, Gauvreau GM, Olek S, Hoffmueller U, Carlsten C, FitzGerald JM, Boulet LP, O'Byrne PM, Tebbutt SJ.

Allergy Asthma Clin Immunol. 2014 Jun 24;10(1):32. doi: 10.1186/1710-1492-10-32. eCollection 2014.

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