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Sterile particle-induced inflammation is mediated by macrophages releasing IL-33 through a Bruton's tyrosine kinase-dependent pathway.

Mishra PK, Palma M, Buechel B, Moore J, Davra V, Chu N, Millman A, Hallab NJ, Kanneganti TD, Birge RB, Behrens EM, Rivera A, Beebe KS, Benevenia J, Gause WC.

Nat Mater. 2019 Mar;18(3):289-297. doi: 10.1038/s41563-018-0271-6. Epub 2019 Jan 21.


B Cells Produce the Tissue-Protective Protein RELMα during Helminth Infection, which Inhibits IL-17 Expression and Limits Emphysema.

Chen F, Wu W, Jin L, Millman A, Palma M, El-Naccache DW, Lothstein KE, Dong C, Edelblum KL, Gause WC.

Cell Rep. 2018 Dec 4;25(10):2775-2783.e3. doi: 10.1016/j.celrep.2018.11.038.


Helminth Infections Induce Tissue Tolerance Mitigating Immunopathology but Enhancing Microbial Pathogen Susceptibility.

Yap GS, Gause WC.

Front Immunol. 2018 Oct 16;9:2135. doi: 10.3389/fimmu.2018.02135. eCollection 2018. Review.


Pla2g1b Places Worms in Peril.

Palma M, El-Naccache DW, Gause WC.

Cell Host Microbe. 2017 Nov 8;22(5):717. doi: 10.1016/j.chom.2017.10.009. No abstract available.


Pla2g1b Places Worms in Peril.

Palma M, El-Naccache DW, Gause WC.

Cell Host Microbe. 2017 Oct 11;22(4):429-431. doi: 10.1016/j.chom.2017.09.015. Erratum in: Cell Host Microbe. 2017 Nov 8;22(5):717.


Correction: Cutting Edge: Helminth Coinfection Blocks Effector Differentiation of CD8 T Cells through Alternate Host Th2- and IL-10-Mediated Responses.

Marple A, Wu W, Shah S, Zhao Y, Du P, Gause WC, Yap GS.

J Immunol. 2017 Oct 15;199(8):3005. doi: 10.4049/jimmunol.1701193. No abstract available.


Cutting Edge: Helminth Coinfection Blocks Effector Differentiation of CD8 T Cells through Alternate Host Th2- and IL-10-Mediated Responses.

Marple A, Wu W, Shah S, Zhao Y, Du P, Gause WC, Yap GS.

J Immunol. 2017 Jan 15;198(2):634-639. doi: 10.4049/jimmunol.1601741. Epub 2016 Dec 12. Erratum in: J Immunol. 2017 Oct 15;199(8):3005.


Macrobiota - helminths as active participants and partners of the microbiota in host intestinal homeostasis.

Gause WC, Maizels RM.

Curr Opin Microbiol. 2016 Aug;32:14-18. doi: 10.1016/j.mib.2016.04.004. Epub 2016 Apr 23. Review.


Helminth infection promotes colonization resistance via type 2 immunity.

Ramanan D, Bowcutt R, Lee SC, Tang MS, Kurtz ZD, Ding Y, Honda K, Gause WC, Blaser MJ, Bonneau RA, Lim YA, Loke P, Cadwell K.

Science. 2016 Apr 29;352(6285):608-12. doi: 10.1126/science.aaf3229. Epub 2016 Apr 14.


Innate cell communication kick-starts pathogen-specific immunity.

Rivera A, Siracusa MC, Yap GS, Gause WC.

Nat Immunol. 2016 Apr;17(4):356-63. doi: 10.1038/ni.3375. Review.


Emerging functions of amphiregulin in orchestrating immunity, inflammation, and tissue repair.

Zaiss DMW, Gause WC, Osborne LC, Artis D.

Immunity. 2015 Feb 17;42(2):216-226. doi: 10.1016/j.immuni.2015.01.020. Review.


Neither primary nor memory immunity to Mycobacterium tuberculosis infection is compromised in mice with chronic enteric helminth infection.

Rafi W, Bhatt K, Gause WC, Salgame P.

Infect Immun. 2015 Mar;83(3):1217-23. doi: 10.1128/IAI.03004-14. Epub 2015 Jan 20.


Immunity to parasitic infections at mucous-protected environmental interfaces.

Gause WC, Wilson MS.

Parasite Immunol. 2014 Sep;36(9):397-9. doi: 10.1111/pim.12131. No abstract available.


Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion.

Chen F, Wu W, Millman A, Craft JF, Chen E, Patel N, Boucher JL, Urban JF Jr, Kim CC, Gause WC.

Nat Immunol. 2014 Oct;15(10):938-46. doi: 10.1038/ni.2984. Epub 2014 Aug 31.


Immunology. How helminths go viral.

Maizels RM, Gause WC.

Science. 2014 Aug 1;345(6196):517-8. doi: 10.1126/science.1258443. Epub 2014 Jul 31. No abstract available.


Systemic impact of intestinal helminth infections.

Mishra PK, Palma M, Bleich D, Loke P, Gause WC.

Mucosal Immunol. 2014 Jul;7(4):753-62. doi: 10.1038/mi.2014.23. Epub 2014 Apr 16. Review.


A2B adenosine receptor induces protective antihelminth type 2 immune responses.

Patel N, Wu W, Mishra PK, Chen F, Millman A, Csóka B, Koscsó B, Eltzschig HK, Haskó G, Gause WC.

Cell Host Microbe. 2014 Mar 12;15(3):339-50. doi: 10.1016/j.chom.2014.02.001.


Antibodies trap tissue migrating helminth larvae and prevent tissue damage by driving IL-4Rα-independent alternative differentiation of macrophages.

Esser-von Bieren J, Mosconi I, Guiet R, Piersgilli A, Volpe B, Chen F, Gause WC, Seitz A, Verbeek JS, Harris NL.

PLoS Pathog. 2013;9(11):e1003771. doi: 10.1371/journal.ppat.1003771. Epub 2013 Nov 14.


Effect of helminth-induced immunity on infections with microbial pathogens.

Salgame P, Yap GS, Gause WC.

Nat Immunol. 2013 Nov;14(11):1118-1126. doi: 10.1038/ni.2736. Review.


Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths.

Gause WC, Wynn TA, Allen JE.

Nat Rev Immunol. 2013 Aug;13(8):607-14. doi: 10.1038/nri3476. Epub 2013 Jul 5. Review.


Prevention of type 1 diabetes through infection with an intestinal nematode parasite requires IL-10 in the absence of a Th2-type response.

Mishra PK, Patel N, Wu W, Bleich D, Gause WC.

Mucosal Immunol. 2013 Mar;6(2):297-308. doi: 10.1038/mi.2012.71. Epub 2012 Jul 18.


An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection.

Chen F, Liu Z, Wu W, Rozo C, Bowdridge S, Millman A, Van Rooijen N, Urban JF Jr, Wynn TA, Gause WC.

Nat Med. 2012 Jan 15;18(2):260-6. doi: 10.1038/nm.2628.


Micrometer-sized titanium particles can induce potent Th2-type responses through TLR4-independent pathways.

Mishra PK, Wu W, Rozo C, Hallab NJ, Benevenia J, Gause WC.

J Immunol. 2011 Dec 15;187(12):6491-8. doi: 10.4049/jimmunol.1101392. Epub 2011 Nov 16.


Adenosine promotes alternative macrophage activation via A2A and A2B receptors.

Csóka B, Selmeczy Z, Koscsó B, Németh ZH, Pacher P, Murray PJ, Kepka-Lenhart D, Morris SM Jr, Gause WC, Leibovich SJ, Haskó G.

FASEB J. 2012 Jan;26(1):376-86. doi: 10.1096/fj.11-190934. Epub 2011 Sep 16.


Preexisting helminth infection induces inhibition of innate pulmonary anti-tuberculosis defense by engaging the IL-4 receptor pathway.

Potian JA, Rafi W, Bhatt K, McBride A, Gause WC, Salgame P.

J Exp Med. 2011 Aug 29;208(9):1863-74. doi: 10.1084/jem.20091473. Epub 2011 Aug 8.


Heligmosomoides polygyrus: one species still.

Maizels RM, Hewitson JP, Gause WC.

Trends Parasitol. 2011 Mar;27(3):100-1. doi: 10.1016/ Epub 2010 Dec 14. No abstract available.


To B or not to B: B cells and the Th2-type immune response to helminths.

Harris N, Gause WC.

Trends Immunol. 2011 Feb;32(2):80-8. doi: 10.1016/ Epub 2010 Dec 14. Review.


Regulation of alternative macrophage activation by chromatin remodeling.

Bowdridge S, Gause WC.

Nat Immunol. 2010 Oct;11(10):879-81. doi: 10.1038/ni1010-879. No abstract available.


B cells have distinct roles in host protection against different nematode parasites.

Liu Q, Kreider T, Bowdridge S, Liu Z, Song Y, Gaydo AG, Urban JF Jr, Gause WC.

J Immunol. 2010 May 1;184(9):5213-23. doi: 10.4049/jimmunol.0902879. Epub 2010 Mar 31.


Regulation of type 1 diabetes, tuberculosis, and asthma by parasites.

Liu Z, Liu Q, Bleich D, Salgame P, Gause WC.

J Mol Med (Berl). 2010 Jan;88(1):27-38. doi: 10.1007/s00109-009-0546-0. Epub 2009 Oct 21. Review.


Helminth infection can reduce insulitis and type 1 diabetes through CD25- and IL-10-independent mechanisms.

Liu Q, Sundar K, Mishra PK, Mousavi G, Liu Z, Gaydo A, Alem F, Lagunoff D, Bleich D, Gause WC.

Infect Immun. 2009 Dec;77(12):5347-58. doi: 10.1128/IAI.01170-08. Epub 2009 Sep 14.


Characterisation of effector mechanisms at the host:parasite interface during the immune response to tissue-dwelling intestinal nematode parasites.

Patel N, Kreider T, Urban JF Jr, Gause WC.

Int J Parasitol. 2009 Jan;39(1):13-21. doi: 10.1016/j.ijpara.2008.08.003. Epub 2008 Aug 30. Review.


Th2 cytokine-induced alterations in intestinal smooth muscle function depend on alternatively activated macrophages.

Zhao A, Urban JF Jr, Anthony RM, Sun R, Stiltz J, van Rooijen N, Wynn TA, Gause WC, Shea-Donohue T.

Gastroenterology. 2008 Jul;135(1):217-225.e1. doi: 10.1053/j.gastro.2008.03.077. Epub 2008 Apr 4.


Neutrophils clear bacteria associated with parasitic nematodes augmenting the development of an effective Th2-type response.

Pesce JT, Liu Z, Hamed H, Alem F, Whitmire J, Lin H, Liu Q, Urban JF Jr, Gause WC.

J Immunol. 2008 Jan 1;180(1):464-74.


Protective immune mechanisms in helminth infection.

Anthony RM, Rutitzky LI, Urban JF Jr, Stadecker MJ, Gause WC.

Nat Rev Immunol. 2007 Dec;7(12):975-87. Review.


The role of B cells in the development of CD4 effector T cells during a polarized Th2 immune response.

Liu Q, Liu Z, Rozo CT, Hamed HA, Alem F, Urban JF Jr, Gause WC.

J Immunol. 2007 Sep 15;179(6):3821-30.


Alternatively activated macrophages in helminth infections.

Kreider T, Anthony RM, Urban JF Jr, Gause WC.

Curr Opin Immunol. 2007 Aug;19(4):448-53. Epub 2007 Aug 16. Review.


Infection with parasitic nematodes confounds vaccination efficacy.

Urban JF Jr, Steenhard NR, Solano-Aguilar GI, Dawson HD, Iweala OI, Nagler CR, Noland GS, Kumar N, Anthony RM, Shea-Donohue T, Weinstock J, Gause WC.

Vet Parasitol. 2007 Aug 19;148(1):14-20. Epub 2007 Jun 22.


Memory T(H)2 cells induce alternatively activated macrophages to mediate protection against nematode parasites.

Anthony RM, Urban JF Jr, Alem F, Hamed HA, Rozo CT, Boucher JL, Van Rooijen N, Gause WC.

Nat Med. 2006 Aug;12(8):955-60. Epub 2006 Jul 30.


IL-18 stimulates IL-13-mediated IFN-gamma-sensitive host resistance in vivo.

Liu Q, Liu Z, Whitmire J, Alem F, Hamed H, Pesce J, Urban JF Jr, Gause WC.

Eur J Immunol. 2006 May;36(5):1187-98.


cDNA synthesis and real-time PCR using RNA from laser-captured cells.

Morimoto M, Morimoto M, Whitmire J, Star RA, Urban JF Jr, Gause WC.

CSH Protoc. 2006 Jun 1;2006(1). pii: pdb.prot4108. doi: 10.1101/pdb.prot4108. No abstract available.


Laser Capture Microdissection (LCM): Preparation and Sectioning of Frozen Tissue Blocks and Purification of RNA from Isolated Cells.

Morimoto M, Morimoto M, Whitmire J, Star RA, Urban JF Jr, Gause WC.

CSH Protoc. 2006 Jun 1;2006(1). pii: pdb.prot4107. doi: 10.1101/pdb.prot4107. No abstract available.


Adenosine augments IL-10 production by macrophages through an A2B receptor-mediated posttranscriptional mechanism.

Németh ZH, Lutz CS, Csóka B, Deitch EA, Leibovich SJ, Gause WC, Tone M, Pacher P, Vizi ES, Haskó G.

J Immunol. 2005 Dec 15;175(12):8260-70.


Immune regulation of protease-activated receptor-1 expression in murine small intestine during Nippostrongylus brasiliensis infection.

Zhao A, Morimoto M, Dawson H, Elfrey JE, Madden KB, Gause WC, Min B, Finkelman FD, Urban JF Jr, Shea-Donohue T.

J Immunol. 2005 Aug 15;175(4):2563-9.


IL-2 and autocrine IL-4 drive the in vivo development of antigen-specific Th2 T cells elicited by nematode parasites.

Liu Z, Liu Q, Hamed H, Anthony RM, Foster A, Finkelman FD, Urban JF Jr, Gause WC.

J Immunol. 2005 Feb 15;174(4):2242-9.


Requirements for the development of IL-4-producing T cells during intestinal nematode infections: what it takes to make a Th2 cell in vivo.

Liu Z, Liu Q, Pesce J, Anthony RM, Lamb E, Whitmire J, Hamed H, Morimoto M, Urban JF Jr, Gause WC.

Immunol Rev. 2004 Oct;201:57-74. Review.


Simultaneous deficiency in CD28 and STAT6 results in chronic ectoparasite-induced inflammatory skin disease.

Liu Q, Arseculeratne C, Liu Z, Whitmire J, Grusby MJ, Finkelman FD, Darling TN, Cheever AW, Swearengen J, Urban JF, Gause WC.

Infect Immun. 2004 Jul;72(7):3706-15.


Enteric nematodes induce stereotypic STAT6-dependent alterations in intestinal epithelial cell function.

Madden KB, Yeung KA, Zhao A, Gause WC, Finkelman FD, Katona IM, Urban JF Jr, Shea-Donohue T.

J Immunol. 2004 May 1;172(9):5616-21.


Peripheral CD4 T cells rapidly accumulate at the host: parasite interface during an inflammatory Th2 memory response.

Morimoto M, Morimoto M, Whitmire J, Xiao S, Anthony RM, Mirakami H, Star RA, Urban JF Jr, Gause WC.

J Immunol. 2004 Feb 15;172(4):2424-30.


The immune response to parasitic helminths: insights from murine models.

Gause WC, Urban JF Jr, Stadecker MJ.

Trends Immunol. 2003 May;24(5):269-77. Review. No abstract available.


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