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Items: 19

1.

Characterization of the interactions of chemically-modified therapeutic nucleic acids with plasma proteins using a fluorescence polarization assay.

Gaus HJ, Gupta R, Chappell AE, Østergaard ME, Swayze EE, Seth PP.

Nucleic Acids Res. 2018 Dec 19. doi: 10.1093/nar/gky1260. [Epub ahead of print]

2.

Characterizing the effect of GalNAc and phosphorothioate backbone on binding of antisense oligonucleotides to the asialoglycoprotein receptor.

Schmidt K, Prakash TP, Donner AJ, Kinberger GA, Gaus HJ, Low A, Østergaard ME, Bell M, Swayze EE, Seth PP.

Nucleic Acids Res. 2017 Mar 17;45(5):2294-2306. doi: 10.1093/nar/gkx060.

3.

Elucidation of the Biotransformation Pathways of a Galnac3-conjugated Antisense Oligonucleotide in Rats and Monkeys.

Shemesh CS, Yu RZ, Gaus HJ, Greenlee S, Post N, Schmidt K, Migawa MT, Seth PP, Zanardi TA, Prakash TP, Swayze EE, Henry SP, Wang Y.

Mol Ther Nucleic Acids. 2016 May 10;5:e319. doi: 10.1038/mtna.2016.31.

4.

Pharmacokinetic and Pharmacodynamic Investigations of ION-353382, a Model Antisense Oligonucleotide: Using Alpha-2-Macroglobulin and Murinoglobulin Double-Knockout Mice.

Shemesh CS, Yu RZ, Gaus HJ, Seth PP, Swayze EE, Bennett FC, Geary RS, Henry SP, Wang Y.

Nucleic Acid Ther. 2016 Aug;26(4):223-35. doi: 10.1089/nat.2016.0607. Epub 2016 Mar 31.

PMID:
27031383
5.

Efficient Synthesis and Biological Evaluation of 5'-GalNAc Conjugated Antisense Oligonucleotides.

Østergaard ME, Yu J, Kinberger GA, Wan WB, Migawa MT, Vasquez G, Schmidt K, Gaus HJ, Murray HM, Low A, Swayze EE, Prakash TP, Seth PP.

Bioconjug Chem. 2015 Aug 19;26(8):1451-5. doi: 10.1021/acs.bioconjchem.5b00265. Epub 2015 Jun 10.

PMID:
26011654
6.

Formation of the N(2)-acetyl-2,6-diaminopurine oligonucleotide impurity caused by acetyl capping.

Rodriguez AA, Cedillo I, Mowery BP, Gaus HJ, Krishnamoorthy SS, McPherson AK.

Bioorg Med Chem Lett. 2014 Aug 1;24(15):3243-6. doi: 10.1016/j.bmcl.2014.06.025. Epub 2014 Jun 18.

PMID:
24980055
7.

Antisense oligonucleotides containing conformationally constrained 2',4'-(N-methoxy)aminomethylene and 2',4'-aminooxymethylene and 2'-O,4'-C-aminomethylene bridged nucleoside analogues show improved potency in animal models.

Prakash TP, Siwkowski A, Allerson CR, Migawa MT, Lee S, Gaus HJ, Black C, Seth PP, Swayze EE, Bhat B.

J Med Chem. 2010 Feb 25;53(4):1636-50. doi: 10.1021/jm9013295.

PMID:
20108935
8.

Human Dicer binds short single-strand and double-strand RNA with high affinity and interacts with different regions of the nucleic acids.

Lima WF, Murray H, Nichols JG, Wu H, Sun H, Prakash TP, Berdeja AR, Gaus HJ, Crooke ST.

J Biol Chem. 2009 Jan 23;284(4):2535-48. doi: 10.1074/jbc.M803748200. Epub 2008 Nov 18.

9.

Cross-species pharmacokinetic comparison from mouse to man of a second-generation antisense oligonucleotide, ISIS 301012, targeting human apolipoprotein B-100.

Yu RZ, Kim TW, Hong A, Watanabe TA, Gaus HJ, Geary RS.

Drug Metab Dispos. 2007 Mar;35(3):460-8. Epub 2006 Dec 15.

PMID:
17172312
10.

Formation of 4,4'-dimethoxytrityl-C-phosphonate oligonucleotides.

Capaldi DC, Gaus HJ, Carty RL, Moore MN, Turney BJ, Decottignies SD, McArdle JV, Scozzari AN, Ravikumar VT, Krotz AH.

Bioorg Med Chem Lett. 2004 Sep 20;14(18):4683-90.

PMID:
15324888
11.

Solution stability and degradation pathway of deoxyribonucleoside phosphoramidites in acetonitrile.

Krotz AH, Rentel C, Gorman D, Olsen P, Gaus HJ, McArdle JV, Scozzari AN.

Nucleosides Nucleotides Nucleic Acids. 2004 May;23(5):767-75.

PMID:
15281365
12.

Hepatic distribution of a phosphorothioate oligodeoxynucleotide within rodents following intravenous administration.

Graham MJ, Crooke ST, Lemonidis KM, Gaus HJ, Templin MV, Crooke RM.

Biochem Pharmacol. 2001 Aug 1;62(3):297-306.

PMID:
11434902
13.

Monitoring solution-phase combinatorial library synthesis by capillary electrophoresis.

Gaus HJ, Kung PP, Brooks D, Cook PD, Cummins LL.

Biotechnol Bioeng. 1998-1999;61(3):169-77.

PMID:
10397804
14.

Characterization of oligonucleotide metabolism in vivo via liquid chromatography/electrospray tandem mass spectrometry with a quadrupole ion trap mass spectrometer.

Griffey RH, Greig MJ, Gaus HJ, Liu K, Monteith D, Winniman M, Cummins LL.

J Mass Spectrom. 1997 Mar;32(3):305-13.

PMID:
9075339
15.

On-line HPLC electrospray mass spectrometry of phosphorothioate oligonucleotide metabolites.

Gaus HJ, Owens SR, Winniman M, Cooper S, Cummins LL.

Anal Chem. 1997 Feb 1;69(3):313-9.

PMID:
9030048
16.

Negative ionization micro electrospray mass spectrometry of oligonucleotides and their complexes.

Greig MJ, Gaus HJ, Griffey RH.

Rapid Commun Mass Spectrom. 1996;10(1):47-50.

PMID:
8563016
17.

Analysis of double-stranded oligonucleotides by electrospray mass spectrometry.

Bayer E, Bauer T, Schmeer K, Bleicher K, Maier M, Gaus HJ.

Anal Chem. 1994 Nov 15;66(22):3858-63.

PMID:
7810895
18.

Optimization of capillary electrophoresis of mixtures of basic peptides and comparison with HPLC.

Gaus HJ, Beck-Sickinger AG, Bayer E.

Anal Chem. 1993 May 15;65(10):1399-405.

PMID:
8517549
19.

Separation of cardiac glycosides by micellar electrokinetic capillary electrophoresis.

Gaus HJ, Treumann A, Kreis W, Bayer E.

J Chromatogr. 1993 Apr 16;635(2):319-27.

PMID:
8486748

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