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Items: 1 to 50 of 72

1.

Antifibrotic Effects of Amyloid-Beta and Its Loss in Cirrhotic Liver.

Buniatian GH, Weiskirchen R, Weiss TS, Schwinghammer U, Fritz M, Seferyan T, Proksch B, Glaser M, Lourhmati A, Buadze M, Borkham-Kamphorst E, Gaunitz F, Gleiter CH, Lang T, Schaeffeler E, Tremmel R, Cynis H, Frey WH 2nd, Gebhardt R, Friedman SL, Mikulits W, Schwab M, Danielyan L.

Cells. 2020 Feb 17;9(2). pii: E452. doi: 10.3390/cells9020452.

2.

Deep sequencing and automated histochemistry of human tissue slice cultures improve their usability as preclinical model for cancer research.

Haehnel S, Reiche K, Loeffler D, Horn A, Blumert C, Puppel SH, Kaiser N, Rapp F, Rade M, Horn F, Meixensberger J, Bechmann I, Gaunitz F, Winter K.

Sci Rep. 2019 Dec 27;9(1):19961. doi: 10.1038/s41598-019-56509-5.

3.

Carnosine increases efficiency of temozolomide and irradiation treatment of isocitrate dehydrogenase-wildtype glioblastoma cells in culture.

Dietterle J, Oppermann H, Glasow A, Neumann K, Meixensberger J, Gaunitz F.

Future Oncol. 2019 Nov;15(32):3683-3691. doi: 10.2217/fon-2019-0447. Epub 2019 Oct 30.

PMID:
31664860
4.

The Chk1 inhibitor SAR-020106 sensitizes human glioblastoma cells to irradiation, to temozolomide, and to decitabine treatment.

Patties I, Kallendrusch S, Böhme L, Kendzia E, Oppermann H, Gaunitz F, Kortmann RD, Glasow A.

J Exp Clin Cancer Res. 2019 Oct 21;38(1):420. doi: 10.1186/s13046-019-1434-2.

5.

Non-enzymatic reaction of carnosine and glyceraldehyde-3-phosphate accompanies metabolic changes of the pentose phosphate pathway.

Oppermann H, Birkemeyer C, Meixensberger J, Gaunitz F.

Cell Prolif. 2020 Feb;53(2):e12702. doi: 10.1111/cpr.12702. Epub 2019 Oct 19.

6.

Solid-phase extraction-liquid chromatography-tandem mass spectrometry method for the qualitative analysis of 61 synthetic cannabinoid metabolites in urine.

Gaunitz F, Kieliba T, Thevis M, Mercer-Chalmers-Bender K.

Drug Test Anal. 2020 Jan;12(1):27-40. doi: 10.1002/dta.2680. Epub 2019 Oct 18.

PMID:
31412168
7.

Carnosine inhibits glioblastoma growth independent from PI3K/Akt/mTOR signaling.

Oppermann H, Faust H, Yamanishi U, Meixensberger J, Gaunitz F.

PLoS One. 2019 Jun 27;14(6):e0218972. doi: 10.1371/journal.pone.0218972. eCollection 2019.

8.

In vitro metabolic profiling of synthetic cannabinoids by pooled human liver microsomes, cytochrome P450 isoenzymes, and Cunninghamella elegans and their detection in urine samples.

Gaunitz F, Dahm P, Mogler L, Thomas A, Thevis M, Mercer-Chalmers-Bender K.

Anal Bioanal Chem. 2019 Jun;411(16):3561-3579. doi: 10.1007/s00216-019-01837-8. Epub 2019 Jun 10.

PMID:
31183523
9.

The proton-coupled oligopeptide transporters PEPT2, PHT1 and PHT2 mediate the uptake of carnosine in glioblastoma cells.

Oppermann H, Heinrich M, Birkemeyer C, Meixensberger J, Gaunitz F.

Amino Acids. 2019 Jul;51(7):999-1008. doi: 10.1007/s00726-019-02739-w. Epub 2019 May 9.

PMID:
31073693
10.

Assessment of ApoC1, LuzP6, C12orf75 and OCC-1 in cystic glioblastoma using MALDI-TOF mass spectrometry, immunohistochemistry and qRT-PCR.

Evangelou P, Groll M, Oppermann H, Gaunitz F, Eisenlöffel C, Müller W, Eschrich K, Schänzer A, Nestler U.

Med Mol Morphol. 2019 Dec;52(4):217-225. doi: 10.1007/s00795-019-00223-8. Epub 2019 Apr 20.

11.

D,L-Methadone does not improve radio- and chemotherapy in glioblastoma in vitro.

Oppermann H, Matusova M, Glasow A, Dietterle J, Baran-Schmidt R, Neumann K, Meixensberger J, Gaunitz F.

Cancer Chemother Pharmacol. 2019 Jun;83(6):1017-1024. doi: 10.1007/s00280-019-03816-3. Epub 2019 Mar 19.

PMID:
30888463
12.

Carnosine's inhibitory effect on glioblastoma cell growth is independent of its cleavage.

Oppermann H, Purcz K, Birkemeyer C, Baran-Schmidt R, Meixensberger J, Gaunitz F.

Amino Acids. 2019 May;51(5):761-772. doi: 10.1007/s00726-019-02713-6. Epub 2019 Mar 12.

PMID:
30863889
13.

β-Catenin and Yes-Associated Protein 1 Cooperate in Hepatoblastoma Pathogenesis.

Min Q, Molina L, Li J, Adebayo Michael AO, Russell JO, Preziosi ME, Singh S, Poddar M, Matz-Soja M, Ranganathan S, Bell AW, Gebhardt R, Gaunitz F, Yu J, Tao J, Monga SP.

Am J Pathol. 2019 May;189(5):1091-1104. doi: 10.1016/j.ajpath.2019.02.002. Epub 2019 Feb 19. Erratum in: Am J Pathol. 2019 Aug;189(8):1680.

PMID:
30794807
14.

Phase I metabolic profiling of the synthetic cannabinoids THJ-018 and THJ-2201 in human urine in comparison to human liver microsome and cytochrome P450 isoenzyme incubation.

Gaunitz F, Thomas A, Fietzke M, Franz F, Auwärter V, Thevis M, Mercer-Chalmers-Bender K.

Int J Legal Med. 2019 Jul;133(4):1049-1064. doi: 10.1007/s00414-018-1964-8. Epub 2018 Dec 18.

PMID:
30564916
15.

Correction to: Post-mortem distribution of the synthetic cannabinoid MDMB-CHMICA and its metabolites in a case of combined drug intoxication.

Gaunitz F, Lehmann S, Thomas A, Thevis M, Rothschild MA, Mercer-Chalmers-Bender K.

Int J Legal Med. 2019 May;133(3):973. doi: 10.1007/s00414-018-1976-4.

PMID:
30515589
16.

Post-mortem distribution of the synthetic cannabinoid MDMB-CHMICA and its metabolites in a case of combined drug intoxication.

Gaunitz F, Lehmann S, Thomas A, Thevis M, Rothschild MA, Mercer-Chalmers-Bender K.

Int J Legal Med. 2018 Nov;132(6):1645-1657. doi: 10.1007/s00414-018-1911-8. Epub 2018 Sep 15. Erratum in: Int J Legal Med. 2018 Dec 5;:.

PMID:
30219927
17.

Carnosine selectively inhibits migration of IDH-wildtype glioblastoma cells in a co-culture model with fibroblasts.

Oppermann H, Dietterle J, Purcz K, Morawski M, Eisenlöffel C, Müller W, Meixensberger J, Gaunitz F.

Cancer Cell Int. 2018 Aug 13;18:111. doi: 10.1186/s12935-018-0611-2. eCollection 2018.

18.

Carnosine influences transcription via epigenetic regulation as demonstrated by enhanced histone acetylation of the pyruvate dehydrogenase kinase 4 promoter in glioblastoma cells.

Oppermann H, Alvanos A, Seidel C, Meixensberger J, Gaunitz F.

Amino Acids. 2019 Jan;51(1):61-71. doi: 10.1007/s00726-018-2619-2. Epub 2018 Jul 20.

PMID:
30030619
19.

The Wnt/β-catenin pathway determines the predisposition and efficiency of liver-to-pancreas reprogramming.

Cohen H, Barash H, Meivar-Levy I, Molakandov K, Ben-Shimon M, Gurevich M, Zoabi F, Har-Zahav A, Gebhardt R, Gaunitz F, Gurevich M, Mor E, Ravassard P, Greenberger S, Ferber S.

Hepatology. 2018 Oct;68(4):1589-1603. doi: 10.1002/hep.29827. Epub 2018 May 24.

PMID:
29394503
20.

Phenotypic Screen Identifies a Small Molecule Modulating ERK2 and Promoting Stem Cell Proliferation.

Yin C, Fufa T, Chandrasekar G, Aeluri M, Zaky V, Abdelhady S, Rodríguez AB, Jakobsson J, Varnoosfaderani FS, Mahalingam J, Liu J, Larsson O, Hovatta O, Gaunitz F, Göndör A, Andäng M, Kitambi SS.

Front Pharmacol. 2017 Oct 24;8:726. doi: 10.3389/fphar.2017.00726. eCollection 2017.

21.

The chemical composition of the pharmacologically active Thymus species, its antibacterial activity against Streptococcus mutans and the antiadherent effects of T. vulgaris on the bacterial colonization of the in situ pellicle.

Schött G, Liesegang S, Gaunitz F, Gleß A, Basche S, Hannig C, Speer K.

Fitoterapia. 2017 Sep;121:118-128. doi: 10.1016/j.fitote.2017.07.005. Epub 2017 Jul 10.

PMID:
28705510
22.

Analysis of cellular and molecular antitumor effects upon inhibition of SATB1 in glioblastoma cells.

Frömberg A, Rabe M, Oppermann H, Gaunitz F, Aigner A.

BMC Cancer. 2017 Jan 3;17(1):3. doi: 10.1186/s12885-016-3006-6.

23.

Modulation of GLO1 Expression Affects Malignant Properties of Cells.

Hutschenreuther A, Bigl M, Hemdan NY, Debebe T, Gaunitz F, Birkenmeier G.

Int J Mol Sci. 2016 Dec 18;17(12). pii: E2133. doi: 10.3390/ijms17122133.

24.

Pyruvate attenuates the anti-neoplastic effect of carnosine independently from oxidative phosphorylation.

Oppermann H, Schnabel L, Meixensberger J, Gaunitz F.

Oncotarget. 2016 Dec 27;7(52):85848-85860. doi: 10.18632/oncotarget.13039.

25.

Metabolic response of glioblastoma cells associated with glucose withdrawal and pyruvate substitution as revealed by GC-MS.

Oppermann H, Ding Y, Sharma J, Berndt Paetz M, Meixensberger J, Gaunitz F, Birkemeyer C.

Nutr Metab (Lond). 2016 Oct 18;13:70. doi: 10.1186/s12986-016-0131-9. eCollection 2016.

26.

Understanding cytoskeleton regulators in glioblastoma multiforme for therapy design.

Masoumi S, Harisankar A, Gracias A, Bachinger F, Fufa T, Chandrasekar G, Gaunitz F, Walfridsson J, Kitambi SS.

Drug Des Devel Ther. 2016 Sep 12;10:2881-2897. eCollection 2016.

27.

Inhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolism-dependent manner.

Bunik VI, Mkrtchyan G, Grabarska A, Oppermann H, Daloso D, Araujo WL, Juszczak M, Rzeski W, Bettendorff L, Fernie AR, Meixensberger J, Stepulak A, Gaunitz F.

Oncotarget. 2016 May 3;7(18):26400-21. doi: 10.18632/oncotarget.8387.

28.

Specific inhibition by synthetic analogs of pyruvate reveals that the pyruvate dehydrogenase reaction is essential for metabolism and viability of glioblastoma cells.

Bunik VI, Artiukhov A, Kazantsev A, Goncalves R, Daloso D, Oppermann H, Kulakovskaya E, Lukashev N, Fernie A, Brand M, Gaunitz F.

Oncotarget. 2015 Nov 24;6(37):40036-52. doi: 10.18632/oncotarget.5486.

29.

Global increase of p16INK4a in APC-deficient mouse liver drives clonal growth of p16INK4a-negative tumors.

Ueberham E, Glöckner P, Göhler C, Straub BK, Teupser D, Schönig K, Braeuning A, Höhn AK, Jerchow B, Birchmeier W, Gaunitz F, Arendt T, Sansom O, Gebhardt R, Ueberham U.

Mol Cancer Res. 2015 Feb;13(2):239-49. doi: 10.1158/1541-7786.MCR-14-0278-T. Epub 2014 Sep 30.

30.

The antineoplastic effect of carnosine is accompanied by induction of PDK4 and can be mimicked by L-histidine.

Letzien U, Oppermann H, Meixensberger J, Gaunitz F.

Amino Acids. 2014 Apr;46(4):1009-19. doi: 10.1007/s00726-014-1664-8. Epub 2014 Jan 8.

PMID:
24398899
31.

Inhibition of tumour cell growth by carnosine: some possible mechanisms.

Hipkiss AR, Gaunitz F.

Amino Acids. 2014 Feb;46(2):327-37. doi: 10.1007/s00726-013-1627-5. Epub 2013 Dec 1. Review.

PMID:
24292217
32.

Dual luciferase assay for secreted luciferases based on Gaussia and NanoLuc.

Heise K, Oppermann H, Meixensberger J, Gebhardt R, Gaunitz F.

Assay Drug Dev Technol. 2013 May;11(4):244-52. doi: 10.1089/adt.2013.509.

PMID:
23679848
33.

Organotypic slice cultures of human glioblastoma reveal different susceptibilities to treatments.

Merz F, Gaunitz F, Dehghani F, Renner C, Meixensberger J, Gutenberg A, Giese A, Schopow K, Hellwig C, Schäfer M, Bauer M, Stöcker H, Taucher-Scholz G, Durante M, Bechmann I.

Neuro Oncol. 2013 Jun;15(6):670-81. doi: 10.1093/neuonc/not003. Epub 2013 Apr 10. Erratum in: Neuro Oncol. 2014 Sep;16(9):1297.

34.

Carnosine and cancer: a perspective.

Gaunitz F, Hipkiss AR.

Amino Acids. 2012 Jul;43(1):135-42. doi: 10.1007/s00726-012-1271-5. Epub 2012 Mar 28.

PMID:
22454085
35.

Hedgehog signaling in glioblastoma multiforme.

Braun S, Oppermann H, Mueller A, Renner C, Hovhannisyan A, Baran-Schmidt R, Gebhardt R, Hipkiss A, Thiery J, Meixensberger J, Gaunitz F.

Cancer Biol Ther. 2012 May;13(7):487-95. doi: 10.4161/cbt.19591. Epub 2012 May 1.

PMID:
22406999
36.

Identification of factors involved in the anti-tumor activity of carnosine on glioblastomas using a proteomics approach.

Asperger A, Renner C, Menzel M, Gebhardt R, Meixensberger J, Gaunitz F.

Cancer Invest. 2011 May;29(4):272-81. doi: 10.3109/07357907.2010.550666. Epub 2011 Feb 23.

PMID:
21345069
37.

Involvement of p32 and microtubules in alteration of mitochondrial functions by rubella virus.

Claus C, Chey S, Heinrich S, Reins M, Richardt B, Pinkert S, Fechner H, Gaunitz F, Schäfer I, Seibel P, Liebert UG.

J Virol. 2011 Apr;85(8):3881-92. doi: 10.1128/JVI.02492-10. Epub 2011 Jan 19.

38.

Differential and stereoselective in vitro cytotoxicity of eremophilane sesquiterpenes of Petasites hybridus rhizomes in rat hepatocytes.

Bodensieck A, Gaunitz F, Gebhardt R, Danesch U, Bauer R.

Planta Med. 2011 Jan;77(1):32-9. doi: 10.1055/s-0030-1250112. Epub 2010 Jul 22.

PMID:
20652855
39.

Carnosine retards tumor growth in vivo in an NIH3T3-HER2/neu mouse model.

Renner C, Zemitzsch N, Fuchs B, Geiger KD, Hermes M, Hengstler J, Gebhardt R, Meixensberger J, Gaunitz F.

Mol Cancer. 2010 Jan 6;9:2. doi: 10.1186/1476-4598-9-2.

40.

Alpha2-macroglobulin inhibits the malignant properties of astrocytoma cells by impeding beta-catenin signaling.

Lindner I, Hemdan NY, Buchold M, Huse K, Bigl M, Oerlecke I, Ricken A, Gaunitz F, Sack U, Naumann A, Hollborn M, Thal D, Gebhardt R, Birkenmeier G.

Cancer Res. 2010 Jan 1;70(1):277-87. doi: 10.1158/0008-5472.CAN-09-1462. Erratum in: Cancer Res. 2010 Mar 1;70(5):2140.

41.

Carnosine inhibits ATP production in cells from malignant glioma.

Renner C, Asperger A, Seyffarth A, Meixensberger J, Gebhardt R, Gaunitz F.

Neurol Res. 2010 Feb;32(1):101-5. doi: 10.1179/016164109X12518779082237. Epub 2009 Nov 11.

PMID:
19909581
42.

Comparative in vitro toxicity of seven zinc-salts towards neuronal PC12 cells.

Pavlica S, Gaunitz F, Gebhardt R.

Toxicol In Vitro. 2009 Jun;23(4):653-9. doi: 10.1016/j.tiv.2009.03.003. Epub 2009 Mar 21.

PMID:
19306923
43.

4-Aminoethylamino-emodin--a novel potent inhibitor of GSK-3beta--acts as an insulin-sensitizer avoiding downstream effects of activated beta-catenin.

Gebhardt R, Lerche KS, Götschel F, Günther R, Kolander J, Teich L, Zellmer S, Hofmann HJ, Eger K, Hecht A, Gaunitz F.

J Cell Mol Med. 2010 Jun;14(6A):1276-93. doi: 10.1111/j.1582-4934.2009.00701.x. Epub 2009 Oct 3.

44.

Real-time RT-PCR discriminating mRNA encoding osteocalcin from unspecific targets.

Burkhardt JK, Halama D, Frerich B, Gaunitz F.

Anal Bioanal Chem. 2009 Feb;393(4):1351-5. doi: 10.1007/s00216-008-2528-4. Epub 2008 Nov 30.

PMID:
19043696
45.

Cytotoxicity of advanced glycation endproducts in human micro- and astroglial cell lines depends on the degree of protein glycation.

Bigl K, Gaunitz F, Schmitt A, Rothemund S, Schliebs R, Münch G, Arendt T.

J Neural Transm (Vienna). 2008 Nov;115(11):1545-56. doi: 10.1007/s00702-008-0126-4. Epub 2008 Sep 30.

PMID:
18825304
46.

Inflammatory cytokines increase extracellular procathepsin D in permanent and primary endothelial cell cultures.

Erdmann S, Ricken A, Hummitzsch K, Merkwitz C, Schliebe N, Gaunitz F, Strotmann R, Spanel-Borowski K.

Eur J Cell Biol. 2008 May;87(5):311-23. doi: 10.1016/j.ejcb.2008.01.005. Epub 2008 Apr 2.

PMID:
18387691
47.

Correlation between beta-catenin mutations and expression of Wnt-signaling target genes in hepatocellular carcinoma.

Austinat M, Dunsch R, Wittekind C, Tannapfel A, Gebhardt R, Gaunitz F.

Mol Cancer. 2008 Feb 18;7:21. doi: 10.1186/1476-4598-7-21.

48.

The expression of prolactin and its cathepsin D-mediated cleavage in the bovine corpus luteum vary with the estrous cycle.

Erdmann S, Ricken A, Merkwitz C, Struman I, Castino R, Hummitzsch K, Gaunitz F, Isidoro C, Martial J, Spanel-Borowski K.

Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1365-77. Epub 2007 Sep 4.

49.

Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress.

Lin Q, Weis S, Yang G, Weng YH, Helston R, Rish K, Smith A, Bordner J, Polte T, Gaunitz F, Dennery PA.

J Biol Chem. 2007 Jul 13;282(28):20621-33. Epub 2007 Apr 12.

50.

Hepatocellular expression of glutamine synthetase: an indicator of morphogen actions as master regulators of zonation in adult liver.

Gebhardt R, Baldysiak-Figiel A, Krügel V, Ueberham E, Gaunitz F.

Prog Histochem Cytochem. 2007;41(4):201-66. Epub 2007 Feb 8. Review.

PMID:
17368308

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