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Items: 1 to 50 of 389

1.

Macitentan reduces progression of TGF-β1-induced pulmonary fibrosis and pulmonary hypertension.

Bellaye PS, Yanagihara T, Granton E, Sato S, Shimbori C, Upagupta C, Imani J, Hambly N, Ask K, Gauldie J, Iglarz M, Kolb M.

Eur Respir J. 2018 Jul 5. pii: 1701857. doi: 10.1183/13993003.01857-2017. [Epub ahead of print] No abstract available.

PMID:
29976656
2.

Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis.

Jones MG, Andriotis OG, Roberts JJ, Lunn K, Tear VJ, Cao L, Ask K, Smart DE, Bonfanti A, Johnson P, Alzetani A, Conforti F, Doherty R, Lai CY, Johnson B, Bourdakos KN, Fletcher SV, Marshall BG, Jogai S, Brereton CJ, Chee SJ, Ottensmeier CH, Sime P, Gauldie J, Kolb M, Mahajan S, Fabre A, Bhaskar A, Jarolimek W, Richeldi L, O'Reilly KM, Monk PD, Thurner PJ, Davies DE.

Elife. 2018 Jul 3;7. pii: e36354. doi: 10.7554/eLife.36354.

3.

Lysyl Oxidase-Like 1 Protein Deficiency Protects Mice from Adenoviral Transforming Growth Factor-β1-induced Pulmonary Fibrosis.

Bellaye PS, Shimbori C, Upagupta C, Sato S, Shi W, Gauldie J, Ask K, Kolb M.

Am J Respir Cell Mol Biol. 2018 Apr;58(4):461-470. doi: 10.1165/rcmb.2017-0252OC.

PMID:
29115860
4.

Adenoviral vector-mediated GM-CSF gene transfer improves anti-mycobacterial immunity in mice - role of regulatory T cells.

Singpiel A, Kramer J, Maus R, Stolper J, Bittersohl LF, Gauldie J, Kolb M, Welte T, Sparwasser T, Maus UA.

Immunobiology. 2018 Mar;223(3):331-341. doi: 10.1016/j.imbio.2017.10.042. Epub 2017 Oct 26.

PMID:
29089144
5.

Amplification of TGFβ Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis.

Tatler AL, Goodwin AT, Gbolahan O, Saini G, Porte J, John AE, Clifford RL, Violette SM, Weinreb PH, Parfrey H, Wolters PJ, Gauldie J, Kolb M, Jenkins G.

PLoS One. 2016 Aug 5;11(8):e0158047. doi: 10.1371/journal.pone.0158047. eCollection 2016.

6.

Fibroblast growth factor-1 attenuates TGF-β1-induced lung fibrosis.

Shimbori C, Bellaye PS, Xia J, Gauldie J, Ask K, Ramos C, Becerril C, Pardo A, Selman M, Kolb M.

J Pathol. 2016 Oct;240(2):197-210. doi: 10.1002/path.4768.

PMID:
27425145
7.

Surfactant dysfunction during overexpression of TGF-β1 precedes profibrotic lung remodeling in vivo.

Lopez-Rodriguez E, Boden C, Echaide M, Perez-Gil J, Kolb M, Gauldie J, Maus UA, Ochs M, Knudsen L.

Am J Physiol Lung Cell Mol Physiol. 2016 Jun 1;310(11):L1260-71. doi: 10.1152/ajplung.00065.2016. Epub 2016 Apr 22.

8.

Mucking around in the Genome: MUC5B in Idiopathic Pulmonary Fibrosis.

Kolb M, White ES, Gauldie J.

Am J Respir Crit Care Med. 2016 Feb 15;193(4):355-7. doi: 10.1164/rccm.201512-2360ED. No abstract available.

PMID:
26871671
9.

Stretch-induced Activation of Transforming Growth Factor-β1 in Pulmonary Fibrosis.

Froese AR, Shimbori C, Bellaye PS, Inman M, Obex S, Fatima S, Jenkins G, Gauldie J, Ask K, Kolb M.

Am J Respir Crit Care Med. 2016 Jul 1;194(1):84-96. doi: 10.1164/rccm.201508-1638OC.

PMID:
26771871
10.

Editorial: Extracellular Matrix: The Common Thread of Disease Progression in Fibrosis?

Kolb M, Gauldie J, Bellaye PS.

Arthritis Rheumatol. 2016 May;68(5):1053-6. doi: 10.1002/art.39569. No abstract available.

11.

Dissecting fibrosis: therapeutic insights from the small-molecule toolbox.

Nanthakumar CB, Hatley RJ, Lemma S, Gauldie J, Marshall RP, Macdonald SJ.

Nat Rev Drug Discov. 2015 Oct;14(10):693-720. doi: 10.1038/nrd4592. Epub 2015 Sep 4. Review.

PMID:
26338155
12.

Streptococcus pneumoniae triggers progression of pulmonary fibrosis through pneumolysin.

Knippenberg S, Ueberberg B, Maus R, Bohling J, Ding N, Tort Tarres M, Hoymann HG, Jonigk D, Izykowski N, Paton JC, Ogunniyi AD, Lindig S, Bauer M, Welte T, Seeger W, Guenther A, Sisson TH, Gauldie J, Kolb M, Maus UA.

Thorax. 2015 Jul;70(7):636-46. doi: 10.1136/thoraxjnl-2014-206420. Epub 2015 May 11.

PMID:
25964315
13.

Novel chimpanzee adenovirus-vectored respiratory mucosal tuberculosis vaccine: overcoming local anti-human adenovirus immunity for potent TB protection.

Jeyanathan M, Thanthrige-Don N, Afkhami S, Lai R, Damjanovic D, Zganiacz A, Feng X, Yao XD, Rosenthal KL, Medina MF, Gauldie J, Ertl HC, Xing Z.

Mucosal Immunol. 2015 Nov;8(6):1373-87. doi: 10.1038/mi.2015.29. Epub 2015 Apr 15.

PMID:
25872483
14.

A novel profibrotic mechanism mediated by TGFβ-stimulated collagen prolyl hydroxylase expression in fibrotic lung mesenchymal cells.

Luo Y, Xu W, Chen H, Warburton D, Dong R, Qian B, Selman M, Gauldie J, Kolb M, Shi W.

J Pathol. 2015 Jul;236(3):384-94. doi: 10.1002/path.4530. Epub 2015 Apr 8.

15.

Modulation of pulmonary fibrosis by IL-13Rα2.

Lumsden RV, Worrell JC, Boylan D, Walsh SM, Cramton J, Counihan I, O'Beirne S, Medina MF, Gauldie J, Fabre A, Donnelly SC, Kane R, Keane MP.

Am J Physiol Lung Cell Mol Physiol. 2015 Apr 1;308(7):L710-8. doi: 10.1152/ajplung.00120.2014. Epub 2015 Feb 6.

16.

Matrix metalloproteinase-19 promotes metastatic behavior in vitro and is associated with increased mortality in non-small cell lung cancer.

Yu G, Herazo-Maya JD, Nukui T, Romkes M, Parwani A, Juan-Guardela BM, Robertson J, Gauldie J, Siegfried JM, Kaminski N, Kass DJ.

Am J Respir Crit Care Med. 2014 Oct 1;190(7):780-90. doi: 10.1164/rccm.201310-1903OC.

17.

Type 1 interferon gene transfer enhances host defense against pulmonary Streptococcus pneumoniae infection via activating innate leukocytes.

Damjanovic D, Khera A, Medina MF, Ennis J, Turner JD, Gauldie J, Xing Z.

Mol Ther Methods Clin Dev. 2014 Mar 19;1:5. doi: 10.1038/mtm.2014.5. eCollection 2014.

18.

The small heat-shock protein αB-crystallin is essential for the nuclear localization of Smad4: impact on pulmonary fibrosis.

Bellaye PS, Wettstein G, Burgy O, Besnard V, Joannes A, Colas J, Causse S, Marchal-Somme J, Fabre A, Crestani B, Kolb M, Gauldie J, Camus P, Garrido C, Bonniaud P.

J Pathol. 2014 Mar;232(4):458-72. doi: 10.1002/path.4314.

PMID:
24307592
19.

New treatment and markers of prognosis for idiopathic pulmonary fibrosis: lessons learned from translational research.

Baroke E, Gauldie J, Kolb M.

Expert Rev Respir Med. 2013 Oct;7(5):465-78. doi: 10.1586/17476348.2013.838015. Review.

PMID:
24138691
20.

A human type 5 adenovirus-based tuberculosis vaccine induces robust T cell responses in humans despite preexisting anti-adenovirus immunity.

Smaill F, Jeyanathan M, Smieja M, Medina MF, Thanthrige-Don N, Zganiacz A, Yin C, Heriazon A, Damjanovic D, Puri L, Hamid J, Xie F, Foley R, Bramson J, Gauldie J, Xing Z.

Sci Transl Med. 2013 Oct 2;5(205):205ra134. doi: 10.1126/scitranslmed.3006843.

21.

Extracellular matrix microenvironment contributes actively to pulmonary fibrosis.

Shimbori C, Gauldie J, Kolb M.

Curr Opin Pulm Med. 2013 Sep;19(5):446-52. doi: 10.1097/MCP.0b013e328363f4de. Review.

PMID:
23872861
22.

Adenoviral-mediated gene transfer into bone marrow: an effective surgical technique in rat.

Rodriguez-Lecompte JC, Romero-Perez GA, Ramirez-Yañez G, Ask K, Gauldie J.

Eur Surg Res. 2013;50(3-4):282-91. doi: 10.1159/000351336. Epub 2013 Jun 18.

23.

Inflammation induced by MMP-9 enhances tumor regression of experimental breast cancer.

Leifler KS, Svensson S, Abrahamsson A, Bendrik C, Robertson J, Gauldie J, Olsson AK, Dabrosin C.

J Immunol. 2013 Apr 15;190(8):4420-30. doi: 10.4049/jimmunol.1202610. Epub 2013 Mar 15.

24.

Inhibition of HSP27 blocks fibrosis development and EMT features by promoting Snail degradation.

Wettstein G, Bellaye PS, Kolb M, Hammann A, Crestani B, Soler P, Marchal-Somme J, Hazoume A, Gauldie J, Gunther A, Micheau O, Gleave M, Camus P, Garrido C, Bonniaud P.

FASEB J. 2013 Apr;27(4):1549-60. doi: 10.1096/fj.12-220053. Epub 2013 Jan 3.

PMID:
23288928
25.

Molecular mechanisms of MMP9 overexpression and its role in emphysema pathogenesis of Smad3-deficient mice.

Xu B, Chen H, Xu W, Zhang W, Buckley S, Zheng SG, Warburton D, Kolb M, Gauldie J, Shi W.

Am J Physiol Lung Cell Mol Physiol. 2012 Jul;303(2):L89-96. doi: 10.1152/ajplung.00060.2012. Epub 2012 May 18.

26.

Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3.

Mackinnon AC, Gibbons MA, Farnworth SL, Leffler H, Nilsson UJ, Delaine T, Simpson AJ, Forbes SJ, Hirani N, Gauldie J, Sethi T.

Am J Respir Crit Care Med. 2012 Mar 1;185(5):537-46. doi: 10.1164/rccm.201106-0965OC. Epub 2011 Nov 17.

27.

Local delivery of GM-CSF protects mice from lethal pneumococcal pneumonia.

Steinwede K, Tempelhof O, Bolte K, Maus R, Bohling J, Ueberberg B, Länger F, Christman JW, Paton JC, Ask K, Maharaj S, Kolb M, Gauldie J, Welte T, Maus UA.

J Immunol. 2011 Nov 15;187(10):5346-56. doi: 10.4049/jimmunol.1101413. Epub 2011 Oct 14.

28.

Negative regulation of lung inflammation and immunopathology by TNF-α during acute influenza infection.

Damjanovic D, Divangahi M, Kugathasan K, Small CL, Zganiacz A, Brown EG, Hogaboam CM, Gauldie J, Xing Z.

Am J Pathol. 2011 Dec;179(6):2963-76. doi: 10.1016/j.ajpath.2011.09.003. Epub 2011 Oct 14.

29.

Fibrocytes in chronic lung disease--facts and controversies.

Maharaj SS, Baroke E, Gauldie J, Kolb MR.

Pulm Pharmacol Ther. 2012 Aug;25(4):263-7. doi: 10.1016/j.pupt.2011.09.002. Epub 2011 Sep 20. Review.

PMID:
21951688
30.

Idiopathic pulmonary fibrosis: the matrix is the message.

J Kolb MR, Gauldie J.

Am J Respir Crit Care Med. 2011 Sep 15;184(6):627-9. doi: 10.1164/rccm.201107-1282ED. No abstract available.

PMID:
21920923
31.

Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis.

Yamashita CM, Dolgonos L, Zemans RL, Young SK, Robertson J, Briones N, Suzuki T, Campbell MN, Gauldie J, Radisky DC, Riches DW, Yu G, Kaminski N, McCulloch CA, Downey GP.

Am J Pathol. 2011 Oct;179(4):1733-45. doi: 10.1016/j.ajpath.2011.06.041. Epub 2011 Aug 24.

32.

Induction of specific human cytotoxic T cells using dendritic cells transduced with an adenovector encoding rat epidermal growth factor receptor 2.

Suresh K, Scheid E, Klotz L, Venkateswaran V, Gauldie J, Foley R.

Int J Oncol. 2011 Oct;39(4):907-13. doi: 10.3892/ijo.2011.1124. Epub 2011 Jul 14.

PMID:
21769423
33.

Cigarette smoke exposure aggravates air space enlargement and alveolar cell apoptosis in Smad3 knockout mice.

Farkas L, Farkas D, Warburton D, Gauldie J, Shi W, Stampfli MR, Voelkel NF, Kolb M.

Am J Physiol Lung Cell Mol Physiol. 2011 Oct;301(4):L391-401. doi: 10.1152/ajplung.00369.2010. Epub 2011 Jul 8.

34.

Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis.

Gibbons MA, MacKinnon AC, Ramachandran P, Dhaliwal K, Duffin R, Phythian-Adams AT, van Rooijen N, Haslett C, Howie SE, Simpson AJ, Hirani N, Gauldie J, Iredale JP, Sethi T, Forbes SJ.

Am J Respir Crit Care Med. 2011 Sep 1;184(5):569-81. doi: 10.1164/rccm.201010-1719OC.

PMID:
21680953
35.

Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8-mediated activation of TGF-β.

Kitamura H, Cambier S, Somanath S, Barker T, Minagawa S, Markovics J, Goodsell A, Publicover J, Reichardt L, Jablons D, Wolters P, Hill A, Marks JD, Lou J, Pittet JF, Gauldie J, Baron JL, Nishimura SL.

J Clin Invest. 2011 Jul;121(7):2863-75. doi: 10.1172/JCI45589. Epub 2011 Jun 6.

36.

Oxidative stress contributes to the induction and persistence of TGF-β1 induced pulmonary fibrosis.

Cui Y, Robertson J, Maharaj S, Waldhauser L, Niu J, Wang J, Farkas L, Kolb M, Gauldie J.

Int J Biochem Cell Biol. 2011 Aug;43(8):1122-33. doi: 10.1016/j.biocel.2011.04.005. Epub 2011 Apr 14.

PMID:
21514399
37.

Let It Be: microRNAs impact interstitial lung disease.

Lawson WE, Blackwell TS, Gauldie J.

Am J Respir Crit Care Med. 2011 Jan 1;183(1):1-2. doi: 10.1164/rccm.201009-1482ED. No abstract available.

PMID:
21193781
38.

Micro-computed tomography of pulmonary fibrosis in mice induced by adenoviral gene transfer of biologically active transforming growth factor-β1.

Rodt T, von Falck C, Dettmer S, Halter R, Maus R, Ask K, Kolb M, Gauldie J, Länger F, Hoy L, Welte T, Galanski M, Maus UA, Borlak J.

Respir Res. 2010 Dec 22;11:181. doi: 10.1186/1465-9921-11-181.

39.

Inhibition of intimal hyperplasia after stenting by over-expression of p15: a member of the INK4 family of cyclin-dependent kinase inhibitors.

Segev A, Nili N, Qiang B, Osherov AB, Giordano FJ, Jaffe R, Gauldie J, Sparkes JD, Fraser AR, Ladouceur-Wodzak M, Butany J, Strauss BH.

J Mol Cell Cardiol. 2011 Mar;50(3):417-25. doi: 10.1016/j.yjmcc.2010.11.007. Epub 2010 Nov 21.

PMID:
21081134
40.

Pulmonary hypertension and idiopathic pulmonary fibrosis: a tale of angiogenesis, apoptosis, and growth factors.

Farkas L, Gauldie J, Voelkel NF, Kolb M.

Am J Respir Cell Mol Biol. 2011 Jul;45(1):1-15. doi: 10.1165/rcmb.2010-0365TR. Epub 2010 Nov 5. Review.

PMID:
21057104
41.

Transforming growth factor-β: activation by neuraminidase and role in highly pathogenic H5N1 influenza pathogenesis.

Carlson CM, Turpin EA, Moser LA, O'Brien KB, Cline TD, Jones JC, Tumpey TM, Katz JM, Kelley LA, Gauldie J, Schultz-Cherry S.

PLoS Pathog. 2010 Oct 7;6(10):e1001136. doi: 10.1371/journal.ppat.1001136.

42.

Treatment combining RU486 and Ad5IL-12 vector attenuates the growth of experimentally formed prostate tumors and induces changes in the sentinel lymph nodes of mice.

Gabaglia CR, DeLaney A, Gee J, Halder R, Graham FL, Gauldie J, Sercarz EE, Braciak TA.

J Transl Med. 2010 Oct 14;8:98. doi: 10.1186/1479-5876-8-98.

43.

Transient overexpression of Gremlin results in epithelial activation and reversible fibrosis in rat lungs.

Farkas L, Farkas D, Gauldie J, Warburton D, Shi W, Kolb M.

Am J Respir Cell Mol Biol. 2011 Jun;44(6):870-8. doi: 10.1165/rcmb.2010-0070OC. Epub 2010 Aug 12.

44.

Have advanced research technologies made real impact on respiratory medicine?

Ask K, Eickelberg O, Gauldie J, Kaminski N, Kolb M.

Respirology. 2010 Aug;15(6):876-80. doi: 10.1111/j.1440-1843.2010.01811.x. Epub 2010 Jul 20. Review.

PMID:
20646243
45.

Metastatic growth from dormant cells induced by a col-I-enriched fibrotic environment.

Barkan D, El Touny LH, Michalowski AM, Smith JA, Chu I, Davis AS, Webster JD, Hoover S, Simpson RM, Gauldie J, Green JE.

Cancer Res. 2010 Jul 15;70(14):5706-16. doi: 10.1158/0008-5472.CAN-09-2356. Epub 2010 Jun 22.

46.

Overexpression of transforming growth factor-beta1 in fetal monkey lung results in prenatal pulmonary fibrosis.

Tarantal AF, Chen H, Shi TT, Lu CH, Fang AB, Buckley S, Kolb M, Gauldie J, Warburton D, Shi W.

Eur Respir J. 2010 Oct;36(4):907-14. doi: 10.1183/09031936.00011810. Epub 2010 Mar 29.

47.

Effects of budesonide and formoterol on allergen-induced airway responses, inflammation, and airway remodeling in asthma.

Kelly MM, O'Connor TM, Leigh R, Otis J, Gwozd C, Gauvreau GM, Gauldie J, O'Byrne PM.

J Allergy Clin Immunol. 2010 Feb;125(2):349-356.e13. doi: 10.1016/j.jaci.2009.09.011. Epub 2009 Dec 6.

PMID:
19969339
48.

Influence of the tissue microenvironment on Toll-like receptor expression by CD11c+ antigen-presenting cells isolated from mucosal tissues.

Takenaka S, McCormick S, Safroneeva E, Xing Z, Gauldie J.

Clin Vaccine Immunol. 2009 Nov;16(11):1615-23. doi: 10.1128/CVI.00216-09. Epub 2009 Sep 23.

49.

Ocular gene transfer of active TGF-beta induces changes in anterior segment morphology and elevated IOP in rats.

Robertson JV, Golesic E, Gauldie J, West-Mays JA.

Invest Ophthalmol Vis Sci. 2010 Jan;51(1):308-18. doi: 10.1167/iovs.09-3380. Epub 2009 Aug 20.

PMID:
19696167
50.

VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in rats.

Farkas L, Farkas D, Ask K, Möller A, Gauldie J, Margetts P, Inman M, Kolb M.

J Clin Invest. 2009 May;119(5):1298-311. doi: 10.1172/JCI36136. Epub 2009 Apr 20.

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