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Unique structural features in an Nramp metal transporter impart substrate-specific proton cotransport and a kinetic bias to favor import.

Bozzi AT, Bane LB, Zimanyi CM, Gaudet R.

J Gen Physiol. 2019 Oct 16. pii: jgp.201912428. doi: 10.1085/jgp.201912428. [Epub ahead of print]


High-Affinity Alkynyl Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT).

Policarpo RL, Decultot L, May E, Kuzmič P, Carlson S, Huang D, Chu V, Wright BA, Dhakshinamoorthy S, Kannt A, Rani S, Dittakavi S, Panarese JD, Gaudet R, Shair MD.

J Med Chem. 2019 Oct 25. doi: 10.1021/acs.jmedchem.9b01238. [Epub ahead of print]


Mechanics and pharmacology of substrate selection and transport by eukaryotic ABC exporters.

Srikant S, Gaudet R.

Nat Struct Mol Biol. 2019 Sep;26(9):792-801. doi: 10.1038/s41594-019-0280-4. Epub 2019 Aug 26. Review.


Interaction specificity of clustered protocadherins inferred from sequence covariation and structural analysis.

Nicoludis JM, Green AG, Walujkar S, May EJ, Sotomayor M, Marks DS, Gaudet R.

Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):17825-17830. doi: 10.1073/pnas.1821063116. Epub 2019 Aug 20.


The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling.

Abdel-Nour M, Carneiro LAM, Downey J, Tsalikis J, Outlioua A, Prescott D, Da Costa LS, Hovingh ES, Farahvash A, Gaudet RG, Molinaro R, van Dalen R, Lau CCY, Azimi FC, Escalante NK, Trotman-Grant A, Lee JE, Gray-Owen SD, Divangahi M, Chen JJ, Philpott DJ, Arnoult D, Girardin SE.

Science. 2019 Jul 5;365(6448). pii: eaaw4144. doi: 10.1126/science.aaw4144.


Homozygous TRPV4 mutation causes congenital distal spinal muscular atrophy and arthrogryposis.

Velilla J, Marchetti MM, Toth-Petroczy A, Grosgogeat C, Bennett AH, Carmichael N, Estrella E, Darras BT, Frank NY, Krier J, Gaudet R, Gupta VA.

Neurol Genet. 2019 Mar 7;5(2):e312. doi: 10.1212/NXG.0000000000000312. eCollection 2019 Apr.


Sacs R272C missense homozygous mice develop an ataxia phenotype.

Larivière R, Sgarioto N, Márquez BT, Gaudet R, Choquet K, McKinney RA, Watt AJ, Brais B.

Mol Brain. 2019 Mar 12;12(1):19. doi: 10.1186/s13041-019-0438-3.


Structures in multiple conformations reveal distinct transition metal and proton pathways in an Nramp transporter.

Bozzi AT, Zimanyi CM, Nicoludis JM, Lee BK, Zhang CH, Gaudet R.

Elife. 2019 Feb 4;8. pii: e41124. doi: 10.7554/eLife.41124.


Batrachotoxin acts as a stent to hold open homotetrameric prokaryotic voltage-gated sodium channels.

Finol-Urdaneta RK, McArthur JR, Goldschen-Ohm MP, Gaudet R, Tikhonov DB, Zhorov BS, French RJ.

J Gen Physiol. 2019 Feb 4;151(2):186-199. doi: 10.1085/jgp.201812278. Epub 2018 Dec 26.


Structural Basis of TRPV4 N Terminus Interaction with Syndapin/PACSIN1-3 and PIP2.

Goretzki B, Glogowski NA, Diehl E, Duchardt-Ferner E, Hacker C, Gaudet R, Hellmich UA.

Structure. 2018 Dec 4;26(12):1583-1593.e5. doi: 10.1016/j.str.2018.08.002. Epub 2018 Sep 20.


High-Throughput Screening Identifies Genes Required for Candida albicans Induction of Macrophage Pyroptosis.

O'Meara TR, Duah K, Guo CX, Maxson ME, Gaudet RG, Koselny K, Wellington M, Powers ME, MacAlpine J, O'Meara MJ, Veri AO, Grinstein S, Noble SM, Krysan D, Gray-Owen SD, Cowen LE.

MBio. 2018 Aug 21;9(4). pii: e01581-18. doi: 10.1128/mBio.01581-18.


Applications of sequence coevolution in membrane protein biochemistry.

Nicoludis JM, Gaudet R.

Biochim Biophys Acta Biomembr. 2018 Apr;1860(4):895-908. doi: 10.1016/j.bbamem.2017.10.004. Epub 2017 Oct 7. Review.


Sites Contributing to TRPA1 Activation by the Anesthetic Propofol Identified by Photoaffinity Labeling.

Woll KA, Skinner KA, Gianti E, Bhanu NV, Garcia BA, Carnevale V, Eckenhoff RG, Gaudet R.

Biophys J. 2017 Nov 21;113(10):2168-2172. doi: 10.1016/j.bpj.2017.08.040. Epub 2017 Sep 19.


TIFA Signaling in Gastric Epithelial Cells Initiates the cag Type 4 Secretion System-Dependent Innate Immune Response to Helicobacter pylori Infection.

Gall A, Gaudet RG, Gray-Owen SD, Salama NR.

MBio. 2017 Aug 15;8(4). pii: e01168-17. doi: 10.1128/mBio.01168-17.


D-helix influences dimerization of the ATP-binding cassette (ABC) transporter associated with antigen processing 1 (TAP1) nucleotide-binding domain.

Vakkasoglu AS, Srikant S, Gaudet R.

PLoS One. 2017 May 23;12(5):e0178238. doi: 10.1371/journal.pone.0178238. eCollection 2017.


A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases.

Bradshaw N, Levdikov VM, Zimanyi CM, Gaudet R, Wilkinson AJ, Losick R.

Elife. 2017 May 20;6. pii: e26111. doi: 10.7554/eLife.26111.


Innate Recognition of Intracellular Bacterial Growth Is Driven by the TIFA-Dependent Cytosolic Surveillance Pathway.

Gaudet RG, Guo CX, Molinaro R, Kottwitz H, Rohde JR, Dangeard AS, Arrieumerlou C, Girardin SE, Gray-Owen SD.

Cell Rep. 2017 May 16;19(7):1418-1430. doi: 10.1016/j.celrep.2017.04.063.


A Partial Calcium-Free Linker Confers Flexibility to Inner-Ear Protocadherin-15.

Powers RE, Gaudet R, Sotomayor M.

Structure. 2017 Mar 7;25(3):482-495. doi: 10.1016/j.str.2017.01.014. Epub 2017 Feb 23.


Evolution of Cell-Autonomous Effector Mechanisms in Macrophages versus Non-Immune Cells.

Gaudet RG, Bradfield CJ, MacMicking JD.

Microbiol Spectr. 2016 Dec;4(6). doi: 10.1128/microbiolspec.MCHD-0050-2016. Review.


Crystal Structure and Conformational Change Mechanism of a Bacterial Nramp-Family Divalent Metal Transporter.

Bozzi AT, Bane LB, Weihofen WA, Singharoy A, Guillen ER, Ploegh HL, Schulten K, Gaudet R.

Structure. 2016 Dec 6;24(12):2102-2114. doi: 10.1016/j.str.2016.09.017. Epub 2016 Nov 10.


Heptose Sounds the Alarm: Innate Sensing of a Bacterial Sugar Stimulates Immunity.

Gaudet RG, Gray-Owen SD.

PLoS Pathog. 2016 Sep 22;12(9):e1005807. doi: 10.1371/journal.ppat.1005807. eCollection 2016 Sep. No abstract available.


Conserved methionine dictates substrate preference in Nramp-family divalent metal transporters.

Bozzi AT, Bane LB, Weihofen WA, McCabe AL, Singharoy A, Chipot CJ, Schulten K, Gaudet R.

Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):10310-5. doi: 10.1073/pnas.1607734113. Epub 2016 Aug 29.


Antiparallel protocadherin homodimers use distinct affinity- and specificity-mediating regions in cadherin repeats 1-4.

Nicoludis JM, Vogt BE, Green AG, Schärfe CP, Marks DS, Gaudet R.

Elife. 2016 Jul 29;5. pii: e18449. doi: 10.7554/eLife.18449.


Novel mutations highlight the key role of the ankyrin repeat domain in TRPV4-mediated neuropathy.

Sullivan JM, Zimanyi CM, Aisenberg W, Bears B, Chen DH, Day JW, Bird TD, Siskind CE, Gaudet R, Sumner CJ.

Neurol Genet. 2015 Oct 22;1(4):e29. doi: 10.1212/NXG.0000000000000029. eCollection 2015 Dec.


Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition.

Kahle KT, Schmouth JF, Lavastre V, Latremoliere A, Zhang J, Andrews N, Omura T, Laganière J, Rochefort D, Hince P, Castonguay G, Gaudet R, Mapplebeck JC, Sotocinal SG, Duan J, Ward C, Khanna AR, Mogil JS, Dion PA, Woolf CJ, Inquimbert P, Rouleau GA.

Sci Signal. 2016 Mar 29;9(421):ra32. doi: 10.1126/scisignal.aad0163.


Protamine Administration Via the Ascending Aorta May Prevent Cardiopulmonary Instability.

Chaney MA, Devin Roberts J, Wroblewski K, Shahul S, Gaudet R, Jeevanandam V.

J Cardiothorac Vasc Anesth. 2016 Jun;30(3):647-55. doi: 10.1053/j.jvca.2015.11.014. Epub 2015 Nov 19.


Data publication with the structural biology data grid supports live analysis.

Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P.

Nat Commun. 2016 Mar 7;7:10882. doi: 10.1038/ncomms10882.


Structure and Sequence Analyses of Clustered Protocadherins Reveal Antiparallel Interactions that Mediate Homophilic Specificity.

Nicoludis JM, Lau SY, Schärfe CP, Marks DS, Weihofen WA, Gaudet R.

Structure. 2015 Nov 3;23(11):2087-98. doi: 10.1016/j.str.2015.09.005. Epub 2015 Oct 15.


How the TRPA1 receptor transmits painful stimuli: Inner workings revealed by electron cryomicroscopy.

Brewster MS, Gaudet R.

Bioessays. 2015 Nov;37(11):1184-92. doi: 10.1002/bies.201500085. Epub 2015 Sep 21. Review.


The Touching Tail of a Mechanotransduction Channel.

Knecht ZA, Gaudet R, Garrity PA.

Cell. 2015 Sep 10;162(6):1214-6. doi: 10.1016/j.cell.2015.08.049.


Occam's Razor and the Diagnosis of Mantle Cell Lymphoma.

Lui JK, Gillespie W, Gaudet R, Brettler DB.

Am J Med. 2015 Dec;128(12):e25-6. doi: 10.1016/j.amjmed.2015.06.050. Epub 2015 Jul 30. No abstract available.


INNATE IMMUNITY. Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity.

Gaudet RG, Sintsova A, Buckwalter CM, Leung N, Cochrane A, Li J, Cox AD, Moffat J, Gray-Owen SD.

Science. 2015 Jun 12;348(6240):1251-5. doi: 10.1126/science.aaa4921.


Insights into the molecular foundations of electrical excitation.

Gaudet R, Roux B, Minor DL Jr.

J Mol Biol. 2015 Jan 16;427(1):1-2. doi: 10.1016/j.jmb.2014.12.006. No abstract available.


Structural characterization of the late competence protein ComFB from Bacillus subtilis.

Sysoeva TA, Bane LB, Xiao DY, Bose B, Chilton SS, Gaudet R, Burton BM.

Biosci Rep. 2015 Mar 31;35(2). pii: e00183. doi: 10.1042/BSR20140174.


Phenotypic spectrum and incidence of TRPV4 mutations in patients with inherited axonal neuropathy.

Sullivan JM, Landouré G, Gaudet R, Sumner CJ.

Neurology. 2014 Nov 18;83(21):1991. doi: 10.1212/WNL.0000000000001041. No abstract available.


Mechanistic determinants of the directionality and energetics of active export by a heterodimeric ABC transporter.

Grossmann N, Vakkasoglu AS, Hulpke S, Abele R, Gaudet R, Tampé R.

Nat Commun. 2014 Nov 7;5:5419. doi: 10.1038/ncomms6419.


Sacs knockout mice present pathophysiological defects underlying autosomal recessive spastic ataxia of Charlevoix-Saguenay.

Larivière R, Gaudet R, Gentil BJ, Girard M, Conte TC, Minotti S, Leclerc-Desaulniers K, Gehring K, McKinney RA, Shoubridge EA, McPherson PS, Durham HD, Brais B.

Hum Mol Genet. 2015 Feb 1;24(3):727-39. doi: 10.1093/hmg/ddu491. Epub 2014 Sep 26.


High-resolution views of TRPV1 and their implications for the TRP channel superfamily.

Hellmich UA, Gaudet R.

Handb Exp Pharmacol. 2014;223:991-1004. doi: 10.1007/978-3-319-05161-1_11. Review.


Structural biology of TRP channels.

Hellmich UA, Gaudet R.

Handb Exp Pharmacol. 2014;223:963-90. doi: 10.1007/978-3-319-05161-1_10. Review.


Sorting out a promiscuous superfamily: towards cadherin connectomics.

Sotomayor M, Gaudet R, Corey DP.

Trends Cell Biol. 2014 Sep;24(9):524-36. doi: 10.1016/j.tcb.2014.03.007. Epub 2014 Apr 30. Review.


Lithium chloride attenuates cell death in oculopharyngeal muscular dystrophy by perturbing Wnt/β-catenin pathway.

Abu-Baker A, Laganiere J, Gaudet R, Rochefort D, Brais B, Neri C, Dion PA, Rouleau GA.

Cell Death Dis. 2013 Oct 3;4:e821. doi: 10.1038/cddis.2013.342.


Neisseria gonorrhoeae-derived heptose elicits an innate immune response and drives HIV-1 expression.

Malott RJ, Keller BO, Gaudet RG, McCaw SE, Lai CC, Dobson-Belaire WN, Hobbs JL, St Michael F, Cox AD, Moraes TF, Gray-Owen SD.

Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10234-9. doi: 10.1073/pnas.1303738110. Epub 2013 Jun 3.


Potassium-chloride cotransporter 3 interacts with Vav2 to synchronize the cell volume decrease response with cell protrusion dynamics.

Salin-Cantegrel A, Shekarabi M, Rasheed S, Charron FM, Laganière J, Gaudet R, Dion PA, Lapointe JY, Rouleau GA.

PLoS One. 2013 May 28;8(5):e65294. doi: 10.1371/journal.pone.0065294. Print 2013.


Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli.

Garcia-Elias A, Mrkonjic S, Pardo-Pastor C, Inada H, Hellmich UA, Rubio-Moscardó F, Plata C, Gaudet R, Vicente R, Valverde MA.

Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9553-8. doi: 10.1073/pnas.1220231110. Epub 2013 May 20.


What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel?

Perálvarez-Marín A, Doñate-Macian P, Gaudet R.

FEBS J. 2013 Nov;280(21):5471-87. doi: 10.1111/febs.12302. Epub 2013 May 28. Review.


Noddy, a mouse harboring a missense mutation in protocadherin-15, reveals the impact of disrupting a critical interaction site between tip-link cadherins in inner ear hair cells.

Geng R, Sotomayor M, Kinder KJ, Gopal SR, Gerka-Stuyt J, Chen DH, Hardisty-Hughes RE, Ball G, Parker A, Gaudet R, Furness D, Brown SD, Corey DP, Alagramam KN.

J Neurosci. 2013 Mar 6;33(10):4395-404. doi: 10.1523/JNEUROSCI.4514-12.2013.


Comparative analysis of the expression profile of Wnk1 and Wnk1/Hsn2 splice variants in developing and adult mouse tissues.

Shekarabi M, Lafrenière RG, Gaudet R, Laganière J, Marcinkiewicz MM, Dion PA, Rouleau GA.

PLoS One. 2013;8(2):e57807. doi: 10.1371/journal.pone.0057807. Epub 2013 Feb 25.


Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction.

Sotomayor M, Weihofen WA, Gaudet R, Corey DP.

Nature. 2012 Dec 6;492(7427):128-32. doi: 10.1038/nature11590. Epub 2012 Nov 7.


Distinct properties of Ca2+-calmodulin binding to N- and C-terminal regulatory regions of the TRPV1 channel.

Lau SY, Procko E, Gaudet R.

J Gen Physiol. 2012 Nov;140(5):541-55. doi: 10.1085/jgp.201210810.


Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel.

Inada H, Procko E, Sotomayor M, Gaudet R.

Biochemistry. 2012 Aug 7;51(31):6195-206. Epub 2012 Jul 25.

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