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Cardiotrophin-like Cytokine Increases Macrophage-Foam Cell Transition.

Pasquin S, Laplante V, Kouadri S, Milasan A, Mayer G, Tormo AJ, Savin V, Sharma M, Martel C, Gauchat JF.

J Immunol. 2018 Oct 15;201(8):2462-2471. doi: 10.4049/jimmunol.1800733. Epub 2018 Sep 12.


Effect of human very low-density lipoproteins on cardiotrophin-like cytokine factor 1 (CLCF1) activity.

Pasquin S, Chehboun S, Dejda A, Meliani Y, Savin V, Warner GJ, Bosse R, Tormo A, Mayer G, Sharma M, Sapieha P, Martel C, Gauchat JF.

Sci Rep. 2018 Mar 5;8(1):3990. doi: 10.1038/s41598-018-22400-y.


Anti-apoptotic potential of several antidiabetic medicinal plants of the eastern James Bay Cree pharmacopeia in cultured kidney cells.

Li S, Pasquin S, Eid HM, Gauchat JF, Saleem A, Haddad PS.

BMC Complement Altern Med. 2018 Jan 30;18(1):37. doi: 10.1186/s12906-018-2104-1.


Epstein-Barr virus-induced gene 3 (EBI3) can mediate IL-6 trans-signaling.

Chehboun S, Labrecque-Carbonneau J, Pasquin S, Meliani Y, Meddah B, Ferlin W, Sharma M, Tormo A, Masson JF, Gauchat JF.

J Biol Chem. 2017 Apr 21;292(16):6644-6656. doi: 10.1074/jbc.M116.762021. Epub 2017 Mar 9.


Cytokines of the LIF/CNTF family and metabolism.

Pasquin S, Sharma M, Gauchat JF.

Cytokine. 2016 Jun;82:122-4. doi: 10.1016/j.cyto.2015.12.019. Epub 2016 Jan 23. Review.


Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells.

Duerr CU, McCarthy CD, Mindt BC, Rubio M, Meli AP, Pothlichet J, Eva MM, Gauchat JF, Qureshi ST, Mazer BD, Mossman KL, Malo D, Gamero AM, Vidal SM, King IL, Sarfati M, Fritz JH.

Nat Immunol. 2016 Jan;17(1):65-75. doi: 10.1038/ni.3308. Epub 2015 Nov 23.


Ciliary neurotrophic factor (CNTF): New facets of an old molecule for treating neurodegenerative and metabolic syndrome pathologies.

Pasquin S, Sharma M, Gauchat JF.

Cytokine Growth Factor Rev. 2015 Oct;26(5):507-15. doi: 10.1016/j.cytogfr.2015.07.007. Epub 2015 Jul 3. Review.


Renal and Hematological Effects of CLCF-1, a B-Cell-Stimulating Cytokine of the IL-6 Family.

Savin VJ, Sharma M, Zhou J, Gennochi D, Fields T, Sharma R, McCarthy ET, Srivastava T, Domen J, Tormo A, Gauchat JF.

J Immunol Res. 2015;2015:714964. doi: 10.1155/2015/714964. Epub 2015 Jun 4.


Janus kinase 2/signal transducer and activator of transcription 3 inhibitors attenuate the effect of cardiotrophin-like cytokine factor 1 and human focal segmental glomerulosclerosis serum on glomerular filtration barrier.

Sharma M, Zhou J, Gauchat JF, Sharma R, McCarthy ET, Srivastava T, Savin VJ.

Transl Res. 2015 Oct;166(4):384-98. doi: 10.1016/j.trsl.2015.03.002. Epub 2015 Mar 16.


A novel role for STAT5 in DC: Controlling the Th2-response.

Tormo AJ, Gauchat JF.

JAKSTAT. 2013 Oct 1;2(4):e25352. doi: 10.4161/jkst.25352. Epub 2013 Jun 10.


Prototypic long pentraxin PTX3 is present in breast milk, spreads in tissues, and protects neonate mice from Pseudomonas aeruginosa lung infection.

Jaillon S, Mancuso G, Hamon Y, Beauvillain C, Cotici V, Midiri A, Bottazzi B, Nebuloni M, Garlanda C, Frémaux I, Gauchat JF, Descamps P, Beninati C, Mantovani A, Jeannin P, Delneste Y.

J Immunol. 2013 Aug 15;191(4):1873-82. doi: 10.4049/jimmunol.1201642. Epub 2013 Jul 17.


The composite cytokine p28/cytokine-like factor 1 sustains B cell proliferation and promotes plasma cell differentiation.

Tormo AJ, Meliani Y, Beaupré LA, Sharma M, Fritz JH, Elson G, Crabé S, Gauchat JF.

J Immunol. 2013 Aug 15;191(4):1657-65. doi: 10.4049/jimmunol.1201595. Epub 2013 Jul 8.


A polyglutamic acid motif confers IL-27 hydroxyapatite and bone-binding properties.

Tormo AJ, Beaupré LA, Elson G, Crabé S, Gauchat JF.

J Immunol. 2013 Mar 15;190(6):2931-7. doi: 10.4049/jimmunol.1201460. Epub 2013 Feb 6.


The cytokines cardiotrophin-like cytokine/cytokine-like factor-1 (CLC/CLF) and ciliary neurotrophic factor (CNTF) differ in their receptor specificities.

Tormo AJ, Letellier MC, Lissilaa R, Batraville LA, Sharma M, Ferlin W, Elson G, Crabé S, Gauchat JF.

Cytokine. 2012 Dec;60(3):653-60. doi: 10.1016/j.cyto.2012.08.014. Epub 2012 Sep 15.


IL-6 activates STAT5 in T cells.

Tormo AJ, Letellier MC, Sharma M, Elson G, Crabé S, Gauchat JF.

Cytokine. 2012 Nov;60(2):575-82. doi: 10.1016/j.cyto.2012.07.002. Epub 2012 Jul 31.


The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling.

Crabé S, Guay-Giroux A, Tormo AJ, Duluc D, Lissilaa R, Guilhot F, Mavoungou-Bigouagou U, Lefouili F, Cognet I, Ferlin W, Elson G, Jeannin P, Gauchat JF.

J Immunol. 2009 Dec 15;183(12):7692-702. doi: 10.4049/jimmunol.0901464.


Penta-acylated lipopolisaccharide binds to murine MD-2 but does not induce the oligomerization of TLR4 required for signal transduction.

Tsuneyoshi N, Kohara J, Bahrun U, Saitoh S, Akashi S, Gauchat JF, Kimoto M, Fukudome K.

Cell Immunol. 2006 Nov;244(1):57-64. Epub 2007 Apr 8.


IFN-gamma-mediated inhibition of human IgE synthesis by IL-21 is associated with a polymorphism in the IL-21R gene.

Pène J, Guglielmi L, Gauchat JF, Harrer N, Woisetschläger M, Boulay V, Fabre JM, Demoly P, Yssel H.

J Immunol. 2006 Oct 15;177(8):5006-13.


Continued administration of ciliary neurotrophic factor protects mice from inflammatory pathology in experimental autoimmune encephalomyelitis.

Kuhlmann T, Remington L, Cognet I, Bourbonniere L, Zehntner S, Guilhot F, Herman A, Guay-Giroux A, Antel JP, Owens T, Gauchat JF.

Am J Pathol. 2006 Aug;169(2):584-98.


Preparation and characterization of truncated human lipopolysaccharide-binding protein in Escherichia coli.

Kohara J, Tsuneyoshi N, Gauchat JF, Kimoto M, Fukudome K.

Protein Expr Purif. 2006 Oct;49(2):276-83. Epub 2006 Jun 6.


Inactivation of cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold-induced sweating syndrome in a patient.

Rousseau F, Gauchat JF, McLeod JG, Chevalier S, Guillet C, Guilhot F, Cognet I, Froger J, Hahn AF, Knappskog PM, Gascan H, Boman H.

Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):10068-73. Epub 2006 Jun 16.


Comparison of lipopolysaccharide-binding functions of CD14 and MD-2.

Koraha J, Tsuneyoshi N, Kimoto M, Gauchat JF, Nakatake H, Fukudome K.

Clin Diagn Lab Immunol. 2005 Nov;12(11):1292-7.


Detection of epsilon class switching and IgE synthesis in human B cells.

Pène J, Guilhot F, Cognet I, Guglielmi P, Guay-Giroux A, Bonnefoy JY, Elson GC, Yssel H, Gauchat JF.

Methods Mol Biol. 2006;315:319-29.


Cardiotrophin-like cytokine labelling using Bir A biotin ligase: a sensitive tool to study receptor expression by immune and non-immune cells.

Cognet I, Guilhot F, Gabriac M, Chevalier S, Chouikh Y, Herman-Bert A, Guay-Giroux A, Corneau S, Magistrelli G, Elson GC, Gascan H, Gauchat JF.

J Immunol Methods. 2005 Jun;301(1-2):53-65. Epub 2005 Apr 26.


clc is co-expressed with clf or cntfr in developing mouse muscles.

de Bovis B, Derouet D, Gauchat JF, Elson G, Gascan H, Delapeyrière O.

Cell Commun Signal. 2005 Jan 31;3(1):1.


The functional and structural properties of MD-2 required for lipopolysaccharide binding are absent in MD-1.

Tsuneyoshi N, Fukudome K, Kohara J, Tomimasu R, Gauchat JF, Nakatake H, Kimoto M.

J Immunol. 2005 Jan 1;174(1):340-4.


Expression of biologically active mouse ciliary neutrophic factor (CNTF) and soluble CNTFRalpha in Escherichia coli and characterization of their functional specificities.

Cognet I, Guilhot F, Chevalier S, Guay-Giroux A, Bert A, Elson GC, Gascan H, Gauchat JF.

Eur Cytokine Netw. 2004 Jul-Sep;15(3):255-62.


Two different contact sites are recruited by cardiotrophin-like cytokine (CLC) to generate the CLC/CLF and CLC/sCNTFRalpha composite cytokines.

Perret D, Guillet C, Elson G, Froger J, Plun-Favreau H, Rousseau F, Chabbert M, Gauchat JF, Gascan H.

J Biol Chem. 2004 Oct 15;279(42):43961-70. Epub 2004 Jul 22.


Direct bacterial protein PAMP recognition by human NK cells involves TLRs and triggers alpha-defensin production.

Chalifour A, Jeannin P, Gauchat JF, Blaecke A, Malissard M, N'Guyen T, Thieblemont N, Delneste Y.

Blood. 2004 Sep 15;104(6):1778-83. Epub 2004 May 27.


Cutting edge: IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells.

Pène J, Gauchat JF, Lécart S, Drouet E, Guglielmi P, Boulay V, Delwail A, Foster D, Lecron JC, Yssel H.

J Immunol. 2004 May 1;172(9):5154-7.


GPL, a novel cytokine receptor related to GP130 and leukemia inhibitory factor receptor.

Diveu C, Lelièvre E, Perret D, Lak-Hal AH, Froger J, Guillet C, Chevalier S, Rousseau F, Wesa A, Preisser L, Chabbert M, Gauchat JF, Galy A, Gascan H, Morel A.

J Biol Chem. 2003 Dec 12;278(50):49850-9. Epub 2003 Sep 22.


The outer membrane protein X from Escherichia coli exhibits immune properties.

Maisnier-Patin K, Malissard M, Jeannin P, Haeuw JF, Corbière JC, Hoeffel G, Gauchat JF, Nguyen T, Saez JM, Delneste Y.

Vaccine. 2003 Sep 8;21(25-26):3765-74.


Expression of recombinant proteins in a lipid A mutant of Escherichia coli BL21 with a strongly reduced capacity to induce dendritic cell activation and maturation.

Cognet I, de Coignac AB, Magistrelli G, Jeannin P, Aubry JP, Maisnier-Patin K, Caron G, Chevalier S, Humbert F, Nguyen T, Beck A, Velin D, Delneste Y, Malissard M, Gauchat JF.

J Immunol Methods. 2003 Jan 15;272(1-2):199-210.


Primary human articular chondrocytes, dedifferentiated chondrocytes, and synoviocytes exhibit differential responsiveness to interleukin-4: correlation with the expression pattern of the common receptor gamma chain.

Guicheux J, Palmer G, Relic B, Mezin F, Caverzasio J, Apostolides P, Gauchat JF, Gabay C, Guerne PA.

J Cell Physiol. 2002 Jul;192(1):93-101.


A role for CD147 in thymic development.

Renno T, Wilson A, Dunkel C, Coste I, Maisnier-Patin K, Benoit de Coignac A, Aubry JP, Lees RK, Bonnefoy JY, MacDonald HR, Gauchat JF.

J Immunol. 2002 May 15;168(10):4946-50.


Functionally active fusion protein of the novel composite cytokine CLC/soluble CNTF receptor.

Guillet C, Lelièvre E, Plun-Favreau H, Froger J, Chabbert M, Hermann J, Benoit de Coignac A, Bonnefoy JY, Gascan H, Gauchat JF, Elson G.

Eur J Biochem. 2002 Apr;269(7):1932-41.


Unavailability of CD147 leads to selective erythrocyte trapping in the spleen.

Coste I, Gauchat JF, Wilson A, Izui S, Jeannin P, Delneste Y, MacDonald HR, Bonnefoy JY, Renno T.

Blood. 2001 Jun 15;97(12):3984-8.


Signaling pathways recruited by the cardiotrophin-like cytokine/cytokine-like factor-1 composite cytokine: specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component.

Lelièvre E, Plun-Favreau H, Chevalier S, Froger J, Guillet C, Elson GC, Gauchat JF, Gascan H.

J Biol Chem. 2001 Jun 22;276(25):22476-84. Epub 2001 Apr 6.


The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine.

Plun-Favreau H, Elson G, Chabbert M, Froger J, deLapeyrière O, Lelièvre E, Guillet C, Hermann J, Gauchat JF, Gascan H, Chevalier S.

EMBO J. 2001 Apr 2;20(7):1692-703.


Identification of an alternatively spliced variant of human CD86 mRNA.

Magistrelli G, Caron G, Gauchat JF, Jeannin P, Bonnefoy JY, Delneste Y.

Biochem Biophys Res Commun. 2001 Feb 9;280(5):1211-5.


A novel monoclonal antibody, C41, reveals IL-13Ralpha1 expression by murine germinal center B cells and follicular dendritic cells.

Poudrier J, Graber P, Herren S, Berney C, Gretener D, Kosco-Vilbois MH, Gauchat JF.

Eur J Immunol. 2000 Nov;30(11):3157-64.


Soluble CD86 is a costimulatory molecule for human T lymphocytes.

Jeannin P, Magistrelli G, Aubry JP, Caron G, Gauchat JF, Renno T, Herbault N, Goetsch L, Blaecke A, Dietrich PY, Bonnefoy JY, Delneste Y.

Immunity. 2000 Sep;13(3):303-12.


CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex.

Elson GC, Lelièvre E, Guillet C, Chevalier S, Plun-Favreau H, Froger J, Suard I, de Coignac AB, Delneste Y, Bonnefoy JY, Gauchat JF, Gascan H.

Nat Neurosci. 2000 Sep;3(9):867-72.


Detection of a polymorphism in exon 8 of the human CD86 gene.

Delneste Y, Bosotti R, Magistrelli G, Bonnefoy JY, Gauchat JF.

Immunogenetics. 2000 Jul;51(8-9):762-3. No abstract available.


Cloning of MMP-26. A novel matrilysin-like proteinase.

de Coignac AB, Elson G, Delneste Y, Magistrelli G, Jeannin P, Aubry JP, Berthier O, Schmitt D, Bonnefoy JY, Gauchat JF.

Eur J Biochem. 2000 Jun;267(11):3323-9.


A soluble form of CTLA-4 generated by alternative splicing is expressed by nonstimulated human T cells.

Magistrelli G, Jeannin P, Herbault N, Benoit De Coignac A, Gauchat JF, Bonnefoy JY, Delneste Y.

Eur J Immunol. 1999 Nov;29(11):3596-602.


BSMAP, a novel protein expressed specifically in the brain whose gene is localized on chromosome 19p12.

Elson GC, de Coignac AB, Aubry JP, Delneste Y, Magistrelli G, Holzwarth J, Bonnefoy JY, Gauchat JF.

Biochem Biophys Res Commun. 1999 Oct 14;264(1):55-62.


A soluble form of IL-13 receptor alpha 1 promotes IgG2a and IgG2b production by murine germinal center B cells.

Poudrier J, Graber P, Herren S, Gretener D, Elson G, Berney C, Gauchat JF, Kosco-Vilbois MH.

J Immunol. 1999 Aug 1;163(3):1153-61.


Identification of three alternatively spliced variants of human CD28 mRNA.

Magistrelli G, Jeannin P, Elson G, Gauchat JF, Nguyen TN, Bonnefoy JY, Delneste Y.

Biochem Biophys Res Commun. 1999 May 27;259(1):34-7.


The distribution of IL-13 receptor alpha1 expression on B cells, T cells and monocytes and its regulation by IL-13 and IL-4.

Graber P, Gretener D, Herren S, Aubry JP, Elson G, Poudrier J, Lecoanet-Henchoz S, Alouani S, Losberger C, Bonnefoy JY, Kosco-Vilbois MH, Gauchat JF.

Eur J Immunol. 1998 Dec;28(12):4286-98.

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