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Eradicating metastatic cancer and the eco-evolutionary dynamics of Anthropocene extinctions.

Gatenby RA, Artzy-Randrup Y, Epstein T, Reed DR, Brown JS.

Cancer Res. 2019 Nov 26. pii: canres.1941.2019. doi: 10.1158/0008-5472.CAN-19-1941. [Epub ahead of print]


Evolutionary dynamics of competing phenotype-structured populations in periodically fluctuating environments.

Ardaševa A, Gatenby RA, Anderson ARA, Byrne HM, Maini PK, Lorenzi T.

J Math Biol. 2019 Oct 22. doi: 10.1007/s00285-019-01441-5. [Epub ahead of print]


Leveraging transcriptional dynamics to improve BRAF inhibitor responses in melanoma.

Smalley I, Kim E, Li J, Spence P, Wyatt CJ, Eroglu Z, Sondak VK, Messina JL, Babacan NA, Maria-Engler SS, De Armas L, Williams SL, Gatenby RA, Chen YA, Anderson ARA, Smalley KSM.

EBioMedicine. 2019 Oct;48:178-190. doi: 10.1016/j.ebiom.2019.09.023. Epub 2019 Oct 5.


The Goldilocks Window of Personalized Chemotherapy: Getting the Immune Response Just Right.

Park DS, Robertson-Tessi M, Luddy KA, Maini PK, Bonsall MB, Gatenby RA, Anderson ARA.

Cancer Res. 2019 Oct 15;79(20):5302-5315. doi: 10.1158/0008-5472.CAN-18-3712. Epub 2019 Aug 6.


ENvironmental Dynamics Underlying Responsive Extreme Survivors (ENDURES) of Glioblastoma: A Multidisciplinary Team-based, Multifactorial Analytical Approach.

Johnston SK, Whitmire P, Massey SC, Kumthekar P, Porter AB, Raghunand N, Gonzalez-Cuyar LF, Mrugala MM, Hawkins-Daarud A, Jackson PR, Hu LS, Sarkaria JN, Wang L, Gatenby RA, Egan KM, Canoll P, Swanson KR; ENDURES consortium.

Am J Clin Oncol. 2019 Aug;42(8):655-661. doi: 10.1097/COC.0000000000000564.


First Strike-Second Strike Strategies in Metastatic Cancer: Lessons from the Evolutionary Dynamics of Extinction.

Gatenby RA, Zhang J, Brown JS.

Cancer Res. 2019 Jul 1;79(13):3174-3177. doi: 10.1158/0008-5472.CAN-19-0807. Epub 2019 Jun 20.


Illuminating the Numbers: Integrating Mathematical Models to Optimize Photomedicine Dosimetry and Combination Therapies.

Spring BQ, Lang RT, Kercher EM, Rizvi I, Wenham RM, Conejo-Garcia JR, Hasan T, Gatenby RA, Enderling H.

Front Phys. 2019 Apr;7. pii: 46. doi: 10.3389/fphy.2019.00046. Epub 2019 Apr 2.


The Physics of Cancer.

White FM, Gatenby RA, Fischbach C.

Cancer Res. 2019 May 1;79(9):2107-2110. doi: 10.1158/0008-5472.CAN-18-3937. Epub 2019 Apr 24.


Signal transmission through elements of the cytoskeleton form an optimized information network in eukaryotic cells.

Frieden BR, Gatenby RA.

Sci Rep. 2019 Apr 16;9(1):6110. doi: 10.1038/s41598-019-42343-2. Erratum in: Sci Rep. 2019 Oct 8;9(1):14726.


Multidrug Cancer Therapy in Metastatic Castrate-Resistant Prostate Cancer: An Evolution-Based Strategy.

West JB, Dinh MN, Brown JS, Zhang J, Anderson AR, Gatenby RA.

Clin Cancer Res. 2019 Jul 15;25(14):4413-4421. doi: 10.1158/1078-0432.CCR-19-0006. Epub 2019 Apr 16.


The 2019 mathematical oncology roadmap.

Rockne RC, Hawkins-Daarud A, Swanson KR, Sluka JP, Glazier JA, Macklin P, Hormuth DA, Jarrett AM, Lima EABF, Tinsley Oden J, Biros G, Yankeelov TE, Curtius K, Al Bakir I, Wodarz D, Komarova N, Aparicio L, Bordyuh M, Rabadan R, Finley SD, Enderling H, Caudell J, Moros EG, Anderson ARA, Gatenby RA, Kaznatcheev A, Jeavons P, Krishnan N, Pelesko J, Wadhwa RR, Yoon N, Nichol D, Marusyk A, Hinczewski M, Scott JG.

Phys Biol. 2019 Jun 19;16(4):041005. doi: 10.1088/1478-3975/ab1a09. Review.


Multiparameter MRI Predictors of Long-Term Survival in Glioblastoma Multiforme.

Stringfield O, Arrington JA, Johnston SK, Rognin NG, Peeri NC, Balagurunathan Y, Jackson PR, Clark-Swanson KR, Swanson KR, Egan KM, Gatenby RA, Raghunand N.

Tomography. 2019 Mar;5(1):135-144. doi: 10.18383/j.tom.2018.00052.


Optimal control to develop therapeutic strategies for metastatic castrate resistant prostate cancer.

Cunningham JJ, Brown JS, Gatenby RA, Staňková K.

J Theor Biol. 2018 Dec 14;459:67-78. doi: 10.1016/j.jtbi.2018.09.022. Epub 2018 Sep 20.


Optimizing Cancer Treatment Using Game Theory: A Review.

Stanková K, Brown JS, Dalton WS, Gatenby RA.

JAMA Oncol. 2019 Jan 1;5(1):96-103. doi: 10.1001/jamaoncol.2018.3395.


Eco-evolutionary causes and consequences of temporal changes in intratumoural blood flow.

Gillies RJ, Brown JS, Anderson ARA, Gatenby RA.

Nat Rev Cancer. 2018 Sep;18(9):576-585. doi: 10.1038/s41568-018-0030-7. Review.


Chiral Monomers Ensure Orientational Specificity of Monomer Binding During Polymer Self-Replication.

Subramanian H, Gatenby RA.

J Mol Evol. 2018 Jun;86(5):255-263. doi: 10.1007/s00239-018-9845-9. Epub 2018 May 3.


Evolutionary advantage of directional symmetry breaking in self-replicating polymers.

Subramanian H, Gatenby RA.

J Theor Biol. 2018 Jun 7;446:128-136. doi: 10.1016/j.jtbi.2018.03.012. Epub 2018 Mar 12.


Spatial Heterogeneity and Evolutionary Dynamics Modulate Time to Recurrence in Continuous and Adaptive Cancer Therapies.

Gallaher JA, Enriquez-Navas PM, Luddy KA, Gatenby RA, Anderson ARA.

Cancer Res. 2018 Apr 15;78(8):2127-2139. doi: 10.1158/0008-5472.CAN-17-2649. Epub 2018 Jan 30.


Integrating evolutionary dynamics into treatment of metastatic castrate-resistant prostate cancer.

Zhang J, Cunningham JJ, Brown JS, Gatenby RA.

Nat Commun. 2017 Nov 28;8(1):1816. doi: 10.1038/s41467-017-01968-5.


Cellular information dynamics through transmembrane flow of ions.

Gatenby RA, Frieden BR.

Sci Rep. 2017 Nov 8;7(1):15075. doi: 10.1038/s41598-017-15182-2.


The Warburg effect as an adaptation of cancer cells to rapid fluctuations in energy demand.

Epstein T, Gatenby RA, Brown JS.

PLoS One. 2017 Sep 18;12(9):e0185085. doi: 10.1371/journal.pone.0185085. eCollection 2017.


Radiologic Pearls for Internists: A Case-Based Review.

McGettigan MJ, Gatenby RA.

Am J Med. 2018 Jan;131(1):9-16. doi: 10.1016/j.amjmed.2017.08.022. Epub 2017 Sep 7. Review.


Spatial vs. non-spatial eco-evolutionary dynamics in a tumor growth model.

You L, Brown JS, Thuijsman F, Cunningham JJ, Gatenby RA, Zhang J, Staňková K.

J Theor Biol. 2017 Dec 21;435:78-97. doi: 10.1016/j.jtbi.2017.08.022. Epub 2017 Sep 21.


Is the Genetic Paradigm of Cancer Complete?

Gatenby RA.

Radiology. 2017 Jul;284(1):1-3. doi: 10.1148/radiol.2017171004. No abstract available.


Tris-base buffer: a promising new inhibitor for cancer progression and metastasis.

Ibrahim-Hashim A, Abrahams D, Enriquez-Navas PM, Luddy K, Gatenby RA, Gillies RJ.

Cancer Med. 2017 Jul;6(7):1720-1729. doi: 10.1002/cam4.1032. Epub 2017 May 29.


Adaptation to Stochastic Temporal Variations in Intratumoral Blood Flow: The Warburg Effect as a Bet Hedging Strategy.

Gravenmier CA, Siddique M, Gatenby RA.

Bull Math Biol. 2018 May;80(5):954-970. doi: 10.1007/s11538-017-0261-x. Epub 2017 May 15.


Innovations in Diagnostic Imaging and the Transformation of the Clinical Practice of Radiology in Collaborative, Multidisciplinary Cancer Care.

Arrington JA, Klippenstein DL, Gatenby RA.

Cancer Control. 2017 Apr;24(2):115-117. No abstract available.


Mutations, evolution and the central role of a self-defined fitness function in the initiation and progression of cancer.

Gatenby RA, Brown J.

Biochim Biophys Acta Rev Cancer. 2017 Apr;1867(2):162-166. doi: 10.1016/j.bbcan.2017.03.005. Epub 2017 Mar 21. Review.


Defining Cancer Subpopulations by Adaptive Strategies Rather Than Molecular Properties Provides Novel Insights into Intratumoral Evolution.

Ibrahim-Hashim A, Robertson-Tessi M, Enriquez-Navas PM, Damaghi M, Balagurunathan Y, Wojtkowiak JW, Russell S, Yoonseok K, Lloyd MC, Bui MM, Brown JS, Anderson ARA, Gillies RJ, Gatenby RA.

Cancer Res. 2017 May 1;77(9):2242-2254. doi: 10.1158/0008-5472.CAN-16-2844. Epub 2017 Mar 1.


Aggregation Effects and Population-Based Dynamics as a Source of Therapy Resistance in Cancer.

Brown JS, Cunningham JJ, Gatenby RA.

IEEE Trans Biomed Eng. 2017 Mar;64(3):512-518. doi: 10.1109/TBME.2016.2623564. Epub 2016 Nov 1.


Stem Cell Plasticity and Niche Dynamics in Cancer Progression.

Picco N, Gatenby RA, Anderson ARA.

IEEE Trans Biomed Eng. 2017 Mar;64(3):528-537. doi: 10.1109/TBME.2016.2607183. Epub 2016 Sep 8.


Quantitative Clinical Imaging Methods for Monitoring Intratumoral Evolution.

Kim JY, Gatenby RA.

Methods Mol Biol. 2017;1513:61-81. Review.


Identifying spatial imaging biomarkers of glioblastoma multiforme for survival group prediction.

Zhou M, Chaudhury B, Hall LO, Goldgof DB, Gillies RJ, Gatenby RA.

J Magn Reson Imaging. 2017 Jul;46(1):115-123. doi: 10.1002/jmri.25497. Epub 2016 Sep 28.


Predicting Malignant Nodules from Screening CT Scans.

Hawkins S, Wang H, Liu Y, Garcia A, Stringfield O, Krewer H, Li Q, Cherezov D, Gatenby RA, Balagurunathan Y, Goldgof D, Schabath MB, Hall L, Gillies RJ.

J Thorac Oncol. 2016 Dec;11(12):2120-2128. doi: 10.1016/j.jtho.2016.07.002. Epub 2016 Jul 13. Erratum in: J Thorac Oncol. 2018 Feb;13(2):280-281.


Transmissible cancers, are they more common than thought?

Ujvari B, Gatenby RA, Thomas F.

Evol Appl. 2016 May 17;9(5):633-4. doi: 10.1111/eva.12372. eCollection 2016 Jun. No abstract available.


Darwinian Dynamics of Intratumoral Heterogeneity: Not Solely Random Mutations but Also Variable Environmental Selection Forces.

Lloyd MC, Cunningham JJ, Bui MM, Gillies RJ, Brown JS, Gatenby RA.

Cancer Res. 2016 Jun 1;76(11):3136-44. doi: 10.1158/0008-5472.CAN-15-2962. Epub 2016 Mar 23.


Exploiting evolutionary principles to prolong tumor control in preclinical models of breast cancer.

Enriquez-Navas PM, Kam Y, Das T, Hassan S, Silva A, Foroutan P, Ruiz E, Martinez G, Minton S, Gillies RJ, Gatenby RA.

Sci Transl Med. 2016 Feb 24;8(327):327ra24. doi: 10.1126/scitranslmed.aad7842.


The evolutionary ecology of transmissible cancers.

Ujvari B, Gatenby RA, Thomas F.

Infect Genet Evol. 2016 Apr;39:293-303. doi: 10.1016/j.meegid.2016.02.005. Epub 2016 Feb 6. Review.


Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane.

Damaghi M, Tafreshi NK, Lloyd MC, Sprung R, Estrella V, Wojtkowiak JW, Morse DL, Koomen JM, Bui MM, Gatenby RA, Gillies RJ.

Nat Commun. 2015 Dec 10;6:8752. doi: 10.1038/ncomms9752.


Application of Evolutionary Principles to Cancer Therapy.

Enriquez-Navas PM, Wojtkowiak JW, Gatenby RA.

Cancer Res. 2015 Nov 15;75(22):4675-80. doi: 10.1158/0008-5472.CAN-15-1337. Epub 2015 Nov 2. Review.


Steering Evolution with Sequential Therapy to Prevent the Emergence of Bacterial Antibiotic Resistance.

Nichol D, Jeavons P, Fletcher AG, Bonomo RA, Maini PK, Paul JL, Gatenby RA, Anderson AR, Scott JG.

PLoS Comput Biol. 2015 Sep 11;11(9):e1004493. doi: 10.1371/journal.pcbi.1004493. eCollection 2015 Sep.


Ancient hot and cold genes and chemotherapy resistance emergence.

Wu A, Zhang Q, Lambert G, Khin Z, Gatenby RA, Kim HJ, Pourmand N, Bussey K, Davies PC, Sturm JC, Austin RH.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10467-72. doi: 10.1073/pnas.1512396112. Epub 2015 Aug 3.


Evolutionary perspective of cancer: myth, metaphors, and reality.

Arnal A, Ujvari B, Crespi B, Gatenby RA, Tissot T, Vittecoq M, Ewald PW, Casali A, Ducasse H, Jacqueline C, Missé D, Renaud F, Roche B, Thomas F.

Evol Appl. 2015 Jul;8(6):541-4. doi: 10.1111/eva.12265. Epub 2015 May 27.


Cancer: an emergent property of disturbed resource-rich environments? Ecology meets personalized medicine.

Ducasse H, Arnal A, Vittecoq M, Daoust SP, Ujvari B, Jacqueline C, Tissot T, Ewald P, Gatenby RA, King KC, Bonhomme F, Brodeur J, Renaud F, Solary E, Roche B, Thomas F.

Evol Appl. 2015 Jul;8(6):527-40. doi: 10.1111/eva.12232. Epub 2015 Mar 26. Review.


The multiple facets of Peto's paradox: a life-history model for the evolution of cancer suppression.

Brown JS, Cunningham JJ, Gatenby RA.

Philos Trans R Soc Lond B Biol Sci. 2015 Jul 19;370(1673). pii: 20140221. doi: 10.1098/rstb.2014.0221.


Pathology to enhance precision medicine in oncology: lessons from landscape ecology.

Lloyd MC, Rejniak KA, Brown JS, Gatenby RA, Minor ES, Bui MM.

Adv Anat Pathol. 2015 Jul;22(4):267-72. doi: 10.1097/PAP.0000000000000078. Review.


Heterogeneity in intratumoral regions with rapid gadolinium washout correlates with estrogen receptor status and nodal metastasis.

Chaudhury B, Zhou M, Goldgof DB, Hall LO, Gatenby RA, Gillies RJ, Patel BK, Weinfurtner RJ, Drukteinis JS.

J Magn Reson Imaging. 2015 Nov;42(5):1421-30. doi: 10.1002/jmri.24921. Epub 2015 Apr 17.


Impact of metabolic heterogeneity on tumor growth, invasion, and treatment outcomes.

Robertson-Tessi M, Gillies RJ, Gatenby RA, Anderson AR.

Cancer Res. 2015 Apr 15;75(8):1567-79. doi: 10.1158/0008-5472.CAN-14-1428.

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