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Cytoplasmic convection currents and intracellular temperature gradients.

Howard R, Scheiner A, Cunningham J, Gatenby R.

PLoS Comput Biol. 2019 Nov 4;15(11):e1007372. doi: 10.1371/journal.pcbi.1007372. eCollection 2019 Nov.


Evolutionary dynamics of competing phenotype-structured populations in periodically fluctuating environments.

Ardaševa A, Gatenby RA, Anderson ARA, Byrne HM, Maini PK, Lorenzi T.

J Math Biol. 2019 Oct 22. doi: 10.1007/s00285-019-01441-5. [Epub ahead of print]


Leveraging transcriptional dynamics to improve BRAF inhibitor responses in melanoma.

Smalley I, Kim E, Li J, Spence P, Wyatt CJ, Eroglu Z, Sondak VK, Messina JL, Babacan NA, Maria-Engler SS, De Armas L, Williams SL, Gatenby RA, Chen YA, Anderson ARA, Smalley KSM.

EBioMedicine. 2019 Oct;48:178-190. doi: 10.1016/j.ebiom.2019.09.023. Epub 2019 Oct 5.


How Cells Handle DNA Breaks during Mitosis: Detection, Signaling, Repair, and Fate Choice.

Thompson R, Gatenby R, Sidi S.

Cells. 2019 Sep 7;8(9). pii: E1049. doi: 10.3390/cells8091049. Review.


Acidity promotes tumour progression by altering macrophage phenotype in prostate cancer.

El-Kenawi A, Gatenbee C, Robertson-Tessi M, Bravo R, Dhillon J, Balagurunathan Y, Berglund A, Visvakarma N, Ibrahim-Hashim A, Choi J, Luddy K, Gatenby R, Pilon-Thomas S, Anderson A, Ruffell B, Gillies R.

Br J Cancer. 2019 Oct;121(7):556-566. doi: 10.1038/s41416-019-0542-2. Epub 2019 Aug 16.


The Goldilocks Window of Personalized Chemotherapy: Getting the Immune Response Just Right.

Park DS, Robertson-Tessi M, Luddy KA, Maini PK, Bonsall MB, Gatenby RA, Anderson ARA.

Cancer Res. 2019 Oct 15;79(20):5302-5315. doi: 10.1158/0008-5472.CAN-18-3712. Epub 2019 Aug 6.


ENvironmental Dynamics Underlying Responsive Extreme Survivors (ENDURES) of Glioblastoma: A Multidisciplinary Team-based, Multifactorial Analytical Approach.

Johnston SK, Whitmire P, Massey SC, Kumthekar P, Porter AB, Raghunand N, Gonzalez-Cuyar LF, Mrugala MM, Hawkins-Daarud A, Jackson PR, Hu LS, Sarkaria JN, Wang L, Gatenby RA, Egan KM, Canoll P, Swanson KR; ENDURES consortium.

Am J Clin Oncol. 2019 Aug;42(8):655-661. doi: 10.1097/COC.0000000000000564.


Cancer treatment innovators discover Charles Darwin.

Gatenby R, Whelan C.

Evol Med Public Health. 2019 Jun 13;2019(1):108-110. doi: 10.1093/emph/eoz018. eCollection 2019. No abstract available.


Obesity paradox in cancer: Is bigger really better?

Ujvari B, Jacqueline C, Misse D, Amar V, Fitzpatrick JC, Jennings G, Beckmann C, Rome S, Biro PA, Gatenby R, Brown J, Almeida L, Thomas F.

Evol Appl. 2019 Apr 24;12(6):1092-1095. doi: 10.1111/eva.12790. eCollection 2019 Jun.


First Strike-Second Strike Strategies in Metastatic Cancer: Lessons from the Evolutionary Dynamics of Extinction.

Gatenby RA, Zhang J, Brown JS.

Cancer Res. 2019 Jul 1;79(13):3174-3177. doi: 10.1158/0008-5472.CAN-19-0807. Epub 2019 Jun 20.


Illuminating the Numbers: Integrating Mathematical Models to Optimize Photomedicine Dosimetry and Combination Therapies.

Spring BQ, Lang RT, Kercher EM, Rizvi I, Wenham RM, Conejo-Garcia JR, Hasan T, Gatenby RA, Enderling H.

Front Phys. 2019 Apr;7. pii: 46. doi: 10.3389/fphy.2019.00046. Epub 2019 Apr 2.


The Physics of Cancer.

White FM, Gatenby RA, Fischbach C.

Cancer Res. 2019 May 1;79(9):2107-2110. doi: 10.1158/0008-5472.CAN-18-3937. Epub 2019 Apr 24.


Signal transmission through elements of the cytoskeleton form an optimized information network in eukaryotic cells.

Frieden BR, Gatenby RA.

Sci Rep. 2019 Apr 16;9(1):6110. doi: 10.1038/s41598-019-42343-2. Erratum in: Sci Rep. 2019 Oct 8;9(1):14726.


Multidrug Cancer Therapy in Metastatic Castrate-Resistant Prostate Cancer: An Evolution-Based Strategy.

West JB, Dinh MN, Brown JS, Zhang J, Anderson AR, Gatenby RA.

Clin Cancer Res. 2019 Jul 15;25(14):4413-4421. doi: 10.1158/1078-0432.CCR-19-0006. Epub 2019 Apr 16.


The 2019 mathematical oncology roadmap.

Rockne RC, Hawkins-Daarud A, Swanson KR, Sluka JP, Glazier JA, Macklin P, Hormuth DA, Jarrett AM, Lima EABF, Tinsley Oden J, Biros G, Yankeelov TE, Curtius K, Al Bakir I, Wodarz D, Komarova N, Aparicio L, Bordyuh M, Rabadan R, Finley SD, Enderling H, Caudell J, Moros EG, Anderson ARA, Gatenby RA, Kaznatcheev A, Jeavons P, Krishnan N, Pelesko J, Wadhwa RR, Yoon N, Nichol D, Marusyk A, Hinczewski M, Scott JG.

Phys Biol. 2019 Jun 19;16(4):041005. doi: 10.1088/1478-3975/ab1a09.


Multiparameter MRI Predictors of Long-Term Survival in Glioblastoma Multiforme.

Stringfield O, Arrington JA, Johnston SK, Rognin NG, Peeri NC, Balagurunathan Y, Jackson PR, Clark-Swanson KR, Swanson KR, Egan KM, Gatenby RA, Raghunand N.

Tomography. 2019 Mar;5(1):135-144. doi: 10.18383/j.tom.2018.00052.


Is adaptive therapy natural?

Thomas F, Donnadieu E, Charriere GM, Jacqueline C, Tasiemski A, Pujol P, Renaud F, Roche B, Hamede R, Brown J, Gatenby R, Ujvari B.

PLoS Biol. 2018 Oct 2;16(10):e2007066. doi: 10.1371/journal.pbio.2007066. eCollection 2018 Oct.


Optimal control to develop therapeutic strategies for metastatic castrate resistant prostate cancer.

Cunningham JJ, Brown JS, Gatenby RA, Staňková K.

J Theor Biol. 2018 Dec 14;459:67-78. doi: 10.1016/j.jtbi.2018.09.022. Epub 2018 Sep 20.


Optimizing Cancer Treatment Using Game Theory: A Review.

Stanková K, Brown JS, Dalton WS, Gatenby RA.

JAMA Oncol. 2019 Jan 1;5(1):96-103. doi: 10.1001/jamaoncol.2018.3395.


Eco-evolutionary causes and consequences of temporal changes in intratumoural blood flow.

Gillies RJ, Brown JS, Anderson ARA, Gatenby RA.

Nat Rev Cancer. 2018 Sep;18(9):576-585. doi: 10.1038/s41568-018-0030-7. Review.


Chiral Monomers Ensure Orientational Specificity of Monomer Binding During Polymer Self-Replication.

Subramanian H, Gatenby RA.

J Mol Evol. 2018 Jun;86(5):255-263. doi: 10.1007/s00239-018-9845-9. Epub 2018 May 3.


Evolutionary advantage of directional symmetry breaking in self-replicating polymers.

Subramanian H, Gatenby RA.

J Theor Biol. 2018 Jun 7;446:128-136. doi: 10.1016/j.jtbi.2018.03.012. Epub 2018 Mar 12.


Spatial Heterogeneity and Evolutionary Dynamics Modulate Time to Recurrence in Continuous and Adaptive Cancer Therapies.

Gallaher JA, Enriquez-Navas PM, Luddy KA, Gatenby RA, Anderson ARA.

Cancer Res. 2018 Apr 15;78(8):2127-2139. doi: 10.1158/0008-5472.CAN-17-2649. Epub 2018 Jan 30.


Integrating evolutionary dynamics into treatment of metastatic castrate-resistant prostate cancer.

Zhang J, Cunningham JJ, Brown JS, Gatenby RA.

Nat Commun. 2017 Nov 28;8(1):1816. doi: 10.1038/s41467-017-01968-5.


Cellular information dynamics through transmembrane flow of ions.

Gatenby RA, Frieden BR.

Sci Rep. 2017 Nov 8;7(1):15075. doi: 10.1038/s41598-017-15182-2.


Radiomics in Brain Tumor: Image Assessment, Quantitative Feature Descriptors, and Machine-Learning Approaches.

Zhou M, Scott J, Chaudhury B, Hall L, Goldgof D, Yeom KW, Iv M, Ou Y, Kalpathy-Cramer J, Napel S, Gillies R, Gevaert O, Gatenby R.

AJNR Am J Neuroradiol. 2018 Feb;39(2):208-216. doi: 10.3174/ajnr.A5391. Epub 2017 Oct 5. Review.


The Warburg effect as an adaptation of cancer cells to rapid fluctuations in energy demand.

Epstein T, Gatenby RA, Brown JS.

PLoS One. 2017 Sep 18;12(9):e0185085. doi: 10.1371/journal.pone.0185085. eCollection 2017.


Classifying the evolutionary and ecological features of neoplasms.

Maley CC, Aktipis A, Graham TA, Sottoriva A, Boddy AM, Janiszewska M, Silva AS, Gerlinger M, Yuan Y, Pienta KJ, Anderson KS, Gatenby R, Swanton C, Posada D, Wu CI, Schiffman JD, Hwang ES, Polyak K, Anderson ARA, Brown JS, Greaves M, Shibata D.

Nat Rev Cancer. 2017 Oct;17(10):605-619. doi: 10.1038/nrc.2017.69. Epub 2017 Sep 15. Review.


Radiologic Pearls for Internists: A Case-Based Review.

McGettigan MJ, Gatenby RA.

Am J Med. 2018 Jan;131(1):9-16. doi: 10.1016/j.amjmed.2017.08.022. Epub 2017 Sep 7. Review.


Spatial vs. non-spatial eco-evolutionary dynamics in a tumor growth model.

You L, Brown JS, Thuijsman F, Cunningham JJ, Gatenby RA, Zhang J, Staňková K.

J Theor Biol. 2017 Dec 21;435:78-97. doi: 10.1016/j.jtbi.2017.08.022. Epub 2017 Sep 21.


Evolutionary Ecology of Organs: A Missing Link in Cancer Development?

Thomas F, Nesse RM, Gatenby R, Gidoin C, Renaud F, Roche B, Ujvari B.

Trends Cancer. 2016 Aug;2(8):409-415. doi: 10.1016/j.trecan.2016.06.009. Epub 2016 Aug 9. Review.


The Evolution and Ecology of Resistance in Cancer Therapy.

Gatenby R, Brown J.

Cold Spring Harb Perspect Med. 2018 Mar 1;8(3). pii: a033415. doi: 10.1101/cshperspect.a033415. Review.


Is the Genetic Paradigm of Cancer Complete?

Gatenby RA.

Radiology. 2017 Jul;284(1):1-3. doi: 10.1148/radiol.2017171004. No abstract available.


Tris-base buffer: a promising new inhibitor for cancer progression and metastasis.

Ibrahim-Hashim A, Abrahams D, Enriquez-Navas PM, Luddy K, Gatenby RA, Gillies RJ.

Cancer Med. 2017 Jul;6(7):1720-1729. doi: 10.1002/cam4.1032. Epub 2017 May 29.


Adaptation to Stochastic Temporal Variations in Intratumoral Blood Flow: The Warburg Effect as a Bet Hedging Strategy.

Gravenmier CA, Siddique M, Gatenby RA.

Bull Math Biol. 2018 May;80(5):954-970. doi: 10.1007/s11538-017-0261-x. Epub 2017 May 15.


Innovations in Diagnostic Imaging and the Transformation of the Clinical Practice of Radiology in Collaborative, Multidisciplinary Cancer Care.

Arrington JA, Klippenstein DL, Gatenby RA.

Cancer Control. 2017 Apr;24(2):115-117. No abstract available.


Cancer biology and Mr. Darwin.

Gatenby R.

Biochim Biophys Acta Rev Cancer. 2017 Apr;1867(2):67-68. doi: 10.1016/j.bbcan.2017.04.003. Epub 2017 Apr 12. No abstract available.


An Ex Vivo Platform for the Prediction of Clinical Response in Multiple Myeloma.

Silva A, Silva MC, Sudalagunta P, Distler A, Jacobson T, Collins A, Nguyen T, Song J, Chen DT, Chen L, Cubitt C, Baz R, Perez L, Rebatchouk D, Dalton W, Greene J, Gatenby R, Gillies R, Sontag E, Meads MB, Shain KH.

Cancer Res. 2017 Jun 15;77(12):3336-3351. doi: 10.1158/0008-5472.CAN-17-0502. Epub 2017 Apr 11.


Mutations, evolution and the central role of a self-defined fitness function in the initiation and progression of cancer.

Gatenby RA, Brown J.

Biochim Biophys Acta Rev Cancer. 2017 Apr;1867(2):162-166. doi: 10.1016/j.bbcan.2017.03.005. Epub 2017 Mar 21. Review.


Defining Cancer Subpopulations by Adaptive Strategies Rather Than Molecular Properties Provides Novel Insights into Intratumoral Evolution.

Ibrahim-Hashim A, Robertson-Tessi M, Enriquez-Navas PM, Damaghi M, Balagurunathan Y, Wojtkowiak JW, Russell S, Yoonseok K, Lloyd MC, Bui MM, Brown JS, Anderson ARA, Gillies RJ, Gatenby RA.

Cancer Res. 2017 May 1;77(9):2242-2254. doi: 10.1158/0008-5472.CAN-16-2844. Epub 2017 Mar 1.


Aggregation Effects and Population-Based Dynamics as a Source of Therapy Resistance in Cancer.

Brown JS, Cunningham JJ, Gatenby RA.

IEEE Trans Biomed Eng. 2017 Mar;64(3):512-518. doi: 10.1109/TBME.2016.2623564. Epub 2016 Nov 1.


Stem Cell Plasticity and Niche Dynamics in Cancer Progression.

Picco N, Gatenby RA, Anderson ARA.

IEEE Trans Biomed Eng. 2017 Mar;64(3):528-537. doi: 10.1109/TBME.2016.2607183. Epub 2016 Sep 8.


Quantitative Clinical Imaging Methods for Monitoring Intratumoral Evolution.

Kim JY, Gatenby RA.

Methods Mol Biol. 2017;1513:61-81. Review.


Subcellular and in-vivo Nano-Endoscopy.

Cheemalapati SV, Winskas J, Wang H, Konnaiyan K, Zhdanov A, Roth A, Adapa SR, Deonarine A, Noble M, Das T, Gatenby R, Westerheide SD, Jiang RH, Pyayt A.

Sci Rep. 2016 Oct 3;6:34400. doi: 10.1038/srep34400.


Identifying spatial imaging biomarkers of glioblastoma multiforme for survival group prediction.

Zhou M, Chaudhury B, Hall LO, Goldgof DB, Gillies RJ, Gatenby RA.

J Magn Reson Imaging. 2017 Jul;46(1):115-123. doi: 10.1002/jmri.25497. Epub 2016 Sep 28.


Predicting Malignant Nodules from Screening CT Scans.

Hawkins S, Wang H, Liu Y, Garcia A, Stringfield O, Krewer H, Li Q, Cherezov D, Gatenby RA, Balagurunathan Y, Goldgof D, Schabath MB, Hall L, Gillies RJ.

J Thorac Oncol. 2016 Dec;11(12):2120-2128. doi: 10.1016/j.jtho.2016.07.002. Epub 2016 Jul 13. Erratum in: J Thorac Oncol. 2018 Feb;13(2):280-281.


Transmissible cancers, are they more common than thought?

Ujvari B, Gatenby RA, Thomas F.

Evol Appl. 2016 May 17;9(5):633-4. doi: 10.1111/eva.12372. eCollection 2016 Jun. No abstract available.


Investigating Information Dynamics in Living Systems through the Structure and Function of Enzymes.

Gatenby R, Frieden BR.

PLoS One. 2016 May 5;11(5):e0154867. doi: 10.1371/journal.pone.0154867. eCollection 2016.

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